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Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas.

Liu S, Gӧnen M, Stadler ZK, Weiser MR, Hechtman JF, Vakiani E, Wang T, Vyas M, Joneja U, Al-Bayati M, Segal NH, Smith JJ, King S, Guercio S, Ntiamoah P, Markowitz AJ, Zhang L, Cercek A, Garcia-Aguilar J, Saltz LB, Diaz LA, Klimstra DS, Shia J.

Mod Pathol. 2018 Aug 30. doi: 10.1038/s41379-018-0114-7. [Epub ahead of print]


Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.

Hechtman JF, Abou Alfa GK, Stadler ZK, Mandelker DL, Roehrl MHA, Zehir A, Vakiani E, Middha S, Klimstra DS, Shia J.

Hum Pathol. 2018 Aug 16. pii: S0046-8177(18)30308-3. doi: 10.1016/j.humpath.2018.08.004. [Epub ahead of print]


Marked response of a hypermutated adrenocorticotropic hormone-secreting pituitary carcinoma to ipilimumab and nivolumab.

Lin AL, Jonsson P, Tabar V, Yang TJ, Cuaron J, Beal K, Cohen M, Postow M, Rosenblum M, Shia J, DeAngelis LM, Taylor BS, Young RJ, Geer EB.

J Clin Endocrinol Metab. 2018 Aug 1. doi: 10.1210/jc.2018-01347. [Epub ahead of print]


Are Enterocolic Mucosal Mast Cell Aggregates Clinically Relevant in Patients Without Suspected or Established Systemic Mastocytosis?

Johncilla M, Jessurun J, Brown I, Hornick JL, Bellizzi AM, Shia J, Yantiss RK.

Am J Surg Pathol. 2018 Oct;42(10):1390-1395. doi: 10.1097/PAS.0000000000001126.


Quantitative imaging features of pretreatment CT predict volumetric response to chemotherapy in patients with colorectal liver metastases.

Creasy JM, Midya A, Chakraborty J, Adams LB, Gomes C, Gonen M, Seastedt KP, Sutton EJ, Cercek A, Kemeny NE, Shia J, Balachandran VP, Kingham TP, Allen PJ, DeMatteo RP, Jarnagin WR, D'Angelica MI, Do RKG, Simpson AL.

Eur Radiol. 2018 Jun 19. doi: 10.1007/s00330-018-5542-8. [Epub ahead of print]


Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer.

Roxburgh CS, Shia J, Vakiani E, Daniel T, Weiser MR.

Oncoimmunology. 2018 Feb 22;7(6):e1435227. doi: 10.1080/2162402X.2018.1435227. eCollection 2018.


Poorly Differentiated Clusters Predict Colon Cancer Recurrence: An In-Depth Comparative Analysis of Invasive-Front Prognostic Markers.

Konishi T, Shimada Y, Lee LH, Cavalcanti MS, Hsu M, Smith JJ, Nash GM, Temple LK, Guillem JG, Paty PB, Garcia-Aguilar J, Vakiani E, Gonen M, Shia J, Weiser MR.

Am J Surg Pathol. 2018 Jun;42(6):705-714. doi: 10.1097/PAS.0000000000001059.


Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer.

Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR.

JAMA Oncol. 2018 Jun 14;4(6):e180071. doi: 10.1001/jamaoncol.2018.0071. Epub 2018 Jun 14.


Gastric Carcinomas With Lymphoid Stroma: An Evaluation of the Histopathologic and Molecular Features.

Hissong E, Ramrattan G, Zhang P, Zhou XK, Young G, Klimstra DS, Shia J, Fernandes H, Yantiss RK.

Am J Surg Pathol. 2018 Apr;42(4):453-462. doi: 10.1097/PAS.0000000000001018.


Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations.

Hu ZI, Shia J, Stadler ZK, Varghese AM, Capanu M, Salo-Mullen E, Lowery MA, Diaz LA Jr, Mandelker D, Yu KH, Zervoudakis A, Kelsen DP, Iacobuzio-Donahue CA, Klimstra DS, Saltz LB, Sahin IH, O'Reilly EM.

Clin Cancer Res. 2018 Mar 15;24(6):1326-1336. doi: 10.1158/1078-0432.CCR-17-3099. Epub 2018 Jan 24.


Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.

Yaeger R, Chatila WK, Lipsyc MD, Hechtman JF, Cercek A, Sanchez-Vega F, Jayakumaran G, Middha S, Zehir A, Donoghue MTA, You D, Viale A, Kemeny N, Segal NH, Stadler ZK, Varghese AM, Kundra R, Gao J, Syed A, Hyman DM, Vakiani E, Rosen N, Taylor BS, Ladanyi M, Berger MF, Solit DB, Shia J, Saltz L, Schultz N.

Cancer Cell. 2018 Jan 8;33(1):125-136.e3. doi: 10.1016/j.ccell.2017.12.004.


Case report: primary acinar cell carcinoma of the liver treated with multimodality therapy.

Jordan EJ, Basturk O, Shia J, Klimstra DS, Alago W, D'Angelica MI, Abou-Alfa GK, O'Reilly EM, Lowery MA.

J Gastrointest Oncol. 2017 Oct;8(5):E65-E72. doi: 10.21037/jgo.2017.06.21.


Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer.

Janjigian YY, Sanchez-Vega F, Jonsson P, Chatila WK, Hechtman JF, Ku GY, Riches JC, Tuvy Y, Kundra R, Bouvier N, Vakiani E, Gao J, Heins ZJ, Gross BE, Kelsen DP, Zhang L, Strong VE, Schattner M, Gerdes H, Coit DG, Bains M, Stadler ZK, Rusch VW, Jones DR, Molena D, Shia J, Robson ME, Capanu M, Middha S, Zehir A, Hyman DM, Scaltriti M, Ladanyi M, Rosen N, Ilson DH, Berger MF, Tang L, Taylor BS, Solit DB, Schultz N.

Cancer Discov. 2018 Jan;8(1):49-58. doi: 10.1158/2159-8290.CD-17-0787. Epub 2017 Nov 9.


Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations.

Wang T, Stadler ZK, Zhang L, Weiser MR, Basturk O, Hechtman JF, Vakiani E, Saltz LB, Klimstra DS, Shia J.

Fam Cancer. 2018 Apr;17(2):225-228. doi: 10.1007/s10689-017-0031-9.


Lymph node yield in right colectomy for cancer: a comparison of open, laparoscopic and robotic approaches.

Widmar M, Keskin M, Strombom P, Beltran P, Chow OS, Smith JJ, Nash GM, Shia J, Russell D, Garcia-Aguilar J.

Colorectal Dis. 2017 Oct;19(10):888-894. doi: 10.1111/codi.13786.


Computed Tomography Image Texture: A Noninvasive Prognostic Marker of Hepatic Recurrence After Hepatectomy for Metastatic Colorectal Cancer.

Simpson AL, Doussot A, Creasy JM, Adams LB, Allen PJ, DeMatteo RP, Gönen M, Kemeny NE, Kingham TP, Shia J, Jarnagin WR, Do RKG, D'Angelica MI.

Ann Surg Oncol. 2017 Sep;24(9):2482-2490. doi: 10.1245/s10434-017-5896-1. Epub 2017 May 30.


Contiguous gene deletion of chromosome 2p16.3-p21 as a cause of Lynch syndrome.

Salo-Mullen EE, Lynn PB, Wang L, Walsh M, Gopalan A, Shia J, Tran C, Man FY, McBride S, Schattner M, Zhang L, Weiser MR, Stadler ZK.

Fam Cancer. 2018 Jan;17(1):71-77. doi: 10.1007/s10689-017-0006-x.


Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma.

Vakiani E, Shah RH, Berger MF, Makohon-Moore AP, Reiter JG, Ostrovnaya I, Attiyeh MA, Cercek A, Shia J, Iacobuzio-Donahue CA, Solit DB, Weiser MR.

Oncotarget. 2017 Jun 27;8(26):42487-42494. doi: 10.18632/oncotarget.17200.


Universal screening for microsatellite instability in colorectal cancer in the clinical genomics era: new recommendations, methods, and considerations.

Hechtman JF, Middha S, Stadler ZK, Zehir A, Berger MF, Vakiani E, Weiser MR, Ladanyi M, Saltz LB, Klimstra DS, Shia J.

Fam Cancer. 2017 Oct;16(4):525-529. doi: 10.1007/s10689-017-9993-x. No abstract available.


Molecular Screening for Lynch Syndrome in Young Patients With Colorectal Adenomas.

Mendelsohn RB, Herzog K, Shia J, Rahaman N, Stadler ZK, Shike M.

Clin Colorectal Cancer. 2017 Sep;16(3):173-177. doi: 10.1016/j.clcc.2017.01.002. Epub 2017 Feb 2.


Tumor-Associated Macrophage Infiltration in Colorectal Cancer Liver Metastases is Associated With Better Outcome.

Cavnar MJ, Turcotte S, Katz SC, Kuk D, Gönen M, Shia J, Allen PJ, Balachandran VP, D'Angelica MI, Kingham TP, Jarnagin WR, DeMatteo RP.

Ann Surg Oncol. 2017 Jul;24(7):1835-1842. doi: 10.1245/s10434-017-5812-8. Epub 2017 Feb 17.


Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.

Ptashkin RN, Pagan C, Yaeger R, Middha S, Shia J, O'Rourke KP, Berger MF, Wang L, Cimera R, Wang J, Klimstra DS, Saltz L, Ladanyi M, Zehir A, Hechtman JF.

Mol Cancer Res. 2017 Jun;15(6):708-713. doi: 10.1158/1541-7786.MCR-16-0352. Epub 2017 Feb 9.


Reliable Pan-Cancer Microsatellite Instability Assessment by Using Targeted Next-Generation Sequencing Data.

Middha S, Zhang L, Nafa K, Jayakumaran G, Wong D, Kim HR, Sadowska J, Berger MF, Delair DF, Shia J, Stadler Z, Klimstra DS, Ladanyi M, Zehir A, Hechtman JF.

JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.17.00084. Epub 2017 Oct 3.


Diagnosing colorectal medullary carcinoma: interobserver variability and clinicopathological implications.

Lee LH, Yantiss RK, Sadot E, Ren B, Calvacanti MS, Hechtman JF, Ivelja S, Huynh B, Xue Y, Shitilbans T, Guend H, Stadler ZK, Weiser MR, Vakiani E, Gönen M, Klimstra DS, Shia J.

Hum Pathol. 2017 Apr;62:74-82. doi: 10.1016/j.humpath.2016.12.013. Epub 2016 Dec 26.


EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Cancer.

Khan SA, Zeng Z, Shia J, Paty PB.

Pathol Oncol Res. 2017 Jul;23(3):673-677. doi: 10.1007/s12253-016-0166-2. Epub 2016 Dec 26.


Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications.

Shia J, Schultz N, Kuk D, Vakiani E, Middha S, Segal NH, Hechtman JF, Berger MF, Stadler ZK, Weiser MR, Wolchok JD, Boland CR, Gönen M, Klimstra DS.

Mod Pathol. 2017 Apr;30(4):599-609. doi: 10.1038/modpathol.2016.198. Epub 2016 Dec 16.


MicroRNA-203 predicts human survival after resection of colorectal liver metastasis.

Kingham TP, Nguyen HCB, Zheng J, Konstantinidis IT, Sadot E, Shia J, Kuk D, Zhang S, Saltz L, D'Angelica MI, Jarnagin WR, Goodarzi H, Tavazoie SF.

Oncotarget. 2017 Mar 21;8(12):18821-18831. doi: 10.18632/oncotarget.13816.


Clinical and genetic determinants of ovarian metastases from colorectal cancer.

Ganesh K, Shah RH, Vakiani E, Nash GM, Skottowe HP, Yaeger R, Cercek A, Lincoln A, Tran C, Segal NH, Reidy DL, Varghese A, Epstein AS, Sonoda Y, Chi D, Guillem J, Temple L, Paty P, Hechtman J, Shia J, Weiser M, Aguilar JG, Kemeny N, Berger MF, Saltz L, Stadler ZK.

Cancer. 2017 Apr 1;123(7):1134-1143. doi: 10.1002/cncr.30424. Epub 2016 Nov 22.


Combined intrahepatic cholangiocarcinoma and hepatocellular carcinoma.

Connell LC, Harding JJ, Shia J, Abou-Alfa GK.

Chin Clin Oncol. 2016 Oct;5(5):66. doi: 10.21037/cco.2016.10.02. Review.


Biliary carcinomas: pathology and the role of DNA mismatch repair deficiency.

Silva VW, Askan G, Daniel TD, Lowery M, Klimstra DS, Abou-Alfa GK, Shia J.

Chin Clin Oncol. 2016 Oct;5(5):62. doi: 10.21037/cco.2016.10.04. Review.


Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas.

Basturk O, Chung SM, Hruban RH, Adsay NV, Askan G, Iacobuzio-Donahue C, Balci S, Zee SY, Memis B, Shia J, Klimstra DS.

Virchows Arch. 2016 Nov;469(5):523-532. Epub 2016 Sep 3.


Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma.

Lee LH, Cavalcanti MS, Segal NH, Hechtman JF, Weiser MR, Smith JJ, Garcia-Aguilar J, Sadot E, Ntiamoah P, Markowitz AJ, Shike M, Stadler ZK, Vakiani E, Klimstra DS, Shia J.

Mod Pathol. 2016 Nov;29(11):1433-1442. doi: 10.1038/modpathol.2016.139. Epub 2016 Jul 22.


Hepatocellular adenoma among adult survivors of childhood and young adult cancer.

Tonorezos ES, Barnea D, Abou-Alfa GK, Bromberg J, D'Angelica M, Sklar CA, Shia J, Oeffinger KC.

Pediatr Blood Cancer. 2017 Apr;64(4). doi: 10.1002/pbc.26294. Epub 2016 Oct 26.


Distance to the anal verge is associated with pathologic complete response to neoadjuvant therapy in locally advanced rectal cancer.

Patel SV, Roxburgh CS, Vakiani E, Shia J, Smith JJ, Temple LK, Paty P, Garcia-Aguilar J, Nash G, Guillem J, Wu A, Reyngold M, Weiser MR.

J Surg Oncol. 2016 Oct;114(5):637-641. doi: 10.1002/jso.24358. Epub 2016 Sep 19.


Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients.

Khan SA, Morris M, Idrees K, Gimbel MI, Rosenberg S, Zeng Z, Li F, Gan G, Shia J, LaQuaglia MP, Paty PB.

J Pediatr Surg. 2016 Nov;51(11):1812-1817. doi: 10.1016/j.jpedsurg.2016.07.015. Epub 2016 Aug 5.


Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms:  A Potential Diagnostic Pitfall.

Askan G, Deshpande V, Klimstra DS, Adsay V, Sigel C, Shia J, Basturk O.

Am J Clin Pathol. 2016 Aug;146(2):163-9. doi: 10.1093/ajcp/aqw096. Epub 2016 Jul 17.


Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients.

Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Vinjé J, Atmar RL, Estes MK.

J Gen Virol. 2016 Sep;97(9):2291-300. doi: 10.1099/jgv.0.000545. Epub 2016 Jul 12.


Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma.

Javier BM, Yaeger R, Wang L, Sanchez-Vega F, Zehir A, Middha S, Sadowska J, Vakiani E, Shia J, Klimstra D, Ladanyi M, Iacobuzio-Donahue CA, Hechtman JF.

Oncotarget. 2016 Aug 9;7(32):50875-50882. doi: 10.18632/oncotarget.9682.


Clinicopathologic Features of Colorectal Carcinoma in HIV-Positive Patients.

Sigel C, Cavalcanti MS, Daniel T, Vakiani E, Shia J, Sigel K.

Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1098-104. doi: 10.1158/1055-9965.EPI-15-1179. Epub 2016 May 13.


Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels.

Stadler ZK, Battaglin F, Middha S, Hechtman JF, Tran C, Cercek A, Yaeger R, Segal NH, Varghese AM, Reidy-Lagunes DL, Kemeny NE, Salo-Mullen EE, Ashraf A, Weiser MR, Garcia-Aguilar J, Robson ME, Offit K, Arcila ME, Berger MF, Shia J, Solit DB, Saltz LB.

J Clin Oncol. 2016 Jun 20;34(18):2141-7. doi: 10.1200/JCO.2015.65.1067. Epub 2016 Mar 28.


ARID1A expression in early stage colorectal adenocarcinoma: an exploration of its prognostic significance.

Lee LH, Sadot E, Ivelja S, Vakiani E, Hechtman JF, Sevinsky CJ, Klimstra DS, Ginty F, Shia J.

Hum Pathol. 2016 Jul;53:97-104. doi: 10.1016/j.humpath.2016.02.004. Epub 2016 Mar 2.


Carcinosarcoma of the bile duct: a case report and review of literature.

Lee SY, Shia J, Kingham TP, Jarnagin WR.

Hepatobiliary Surg Nutr. 2016 Feb;5(1):72-8. doi: 10.3978/j.issn.2304-3881.2015.06.09.


A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis.

Markowitz SD, Nock NL, Schmit SL, Stadler ZK, Joseph V, Zhang L, Willis JE, Scacheri P, Veigl M, Adams MD, Raskin L, Sullivan JF, Stratton K, Shia J, Ellis N, Rennert HS, Manschreck C, Li L, Offit K, Elston RC, Rennert G, Gruber SB.

PLoS One. 2016 Jan 11;11(1):e0146435. doi: 10.1371/journal.pone.0146435. eCollection 2016.


Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation.

Le Rolle AF, Chiu TK, Zeng Z, Shia J, Weiser MR, Paty PB, Chiu VK.

Oncotarget. 2016 Jan 19;7(3):2159-74. doi: 10.18632/oncotarget.6818.


A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases.

Balachandran VP, Arora A, Gönen M, Ito H, Turcotte S, Shia J, Viale A, Snoeren N, van Hooff SR, Rinkes IH, Adam R, Kingham TP, Allen PJ, DeMatteo RP, Jarnagin WR, D'Angelica MI.

Clin Cancer Res. 2016 May 15;22(10):2575-82. doi: 10.1158/1078-0432.CCR-15-1071. Epub 2016 Jan 5.


Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.

Hechtman JF, Zehir A, Yaeger R, Wang L, Middha S, Zheng T, Hyman DM, Solit D, Arcila ME, Borsu L, Shia J, Vakiani E, Saltz L, Ladanyi M.

Mol Cancer Res. 2016 Mar;14(3):296-301. doi: 10.1158/1541-7786.MCR-15-0392-T. Epub 2015 Dec 11.


Resection margin and survival in 2368 patients undergoing hepatic resection for metastatic colorectal cancer: surgical technique or biologic surrogate?

Sadot E, Groot Koerkamp B, Leal JN, Shia J, Gonen M, Allen PJ, DeMatteo RP, Kingham TP, Kemeny N, Blumgart LH, Jarnagin WR, DʼAngelica MI.

Ann Surg. 2015 Sep;262(3):476-85; discussion 483-5. doi: 10.1097/SLA.0000000000001427.


The accuracy of pre-operative imaging in the management of hepatic cysts.

Doussot A, Gluskin J, Groot-Koerkamp B, Allen PJ, De Matteo RP, Shia J, Kingham TP, Jarnagin WR, Gerst SR, D'Angelica MI.

HPB (Oxford). 2015 Oct;17(10):889-95. doi: 10.1111/hpb.12443. Epub 2015 Jul 30.


Cholangiocarcinoma: Correlation between Molecular Profiling and Imaging Phenotypes.

Sadot E, Simpson AL, Do RK, Gonen M, Shia J, Allen PJ, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR.

PLoS One. 2015 Jul 24;10(7):e0132953. doi: 10.1371/journal.pone.0132953. eCollection 2015.


The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts.

le Rolle AF, Chiu TK, Fara M, Shia J, Zeng Z, Weiser MR, Paty PB, Chiu VK.

J Transl Med. 2015 Jun 24;13:199. doi: 10.1186/s12967-015-0555-4.

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