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Predictive biomarkers for immune checkpoint blockade and opportunities for combination therapies.

Shen H, Yang ES, Conry M, Fiveash J, Contreras C, Bonner JA, Shi LZ.

Genes Dis. 2019 Jul 3;6(3):232-246. doi: 10.1016/j.gendis.2019.06.006. eCollection 2019 Sep. Review.


Metabolic checkpoints in neurodegenerative T helper 17 (TH17) and neuroregenerative regulatory T (Treg) cells as new therapeutic targets for multiple sclerosis.

Shen H, Bonner JA, Shi LZ.

Neural Regen Res. 2020 Feb;15(2):267-269. doi: 10.4103/1673-5374.265552. No abstract available.


Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner.

Shi LZ, Goswami S, Fu T, Guan B, Chen J, Xiong L, Zhang J, Ng Tang D, Zhang X, Vence L, Blando J, Allison JP, Collazo R, Gao J, Sharma P.

Cancer Immunol Res. 2019 Nov;7(11):1803-1812. doi: 10.1158/2326-6066.CIR-18-0873. Epub 2019 Aug 29.


rhEPO inhibited cell apoptosis to alleviate acute kidney injury in sepsis by AMPK/SIRT1 activated autophagy.

Li K, Liu TX, Li JF, Ma YR, Liu ML, Wang YQ, Wu R, Li B, Shi LZ, Chen C.

Biochem Biophys Res Commun. 2019 Oct 1;517(4):557-565. doi: 10.1016/j.bbrc.2019.07.027. Epub 2019 Aug 2.


Visualizing Spatiotemporal Dynamics of Intercellular Mechanotransmission upon Wounding.

Wang P, Liang J, Shi LZ, Wang Y, Zhang P, Ouyang M, Preece D, Peng Q, Shao L, Fan J, Sun J, Li SS, Berns MW, Zhao H, Wang Y.

ACS Photonics. 2018 Sep 19;5(9):3565-3574. doi: 10.1021/acsphotonics.8b00383. Epub 2018 Aug 20.


Metabolic regulation of TH17 cells.

Shen H, Shi LZ.

Mol Immunol. 2019 May;109:81-87. doi: 10.1016/j.molimm.2019.03.005. Epub 2019 Mar 20. Review.


[A study of the correlation between low back pain and occupational stress in coal miners].

Shi LZ, Zhao ZH, Yang ZZ, Li ZJ, Shen XJ.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2018 Nov 20;36(11):849-852. doi: 10.3760/cma.j.issn.1001-9391.2018.11.014. Chinese.


Association Between Metformin and Sulfonylurea Monotherapies and Cancer Incidence: A Real-World Cohort Study in Shanghai, China.

Ye JH, Qian MH, Shi LZ, Ye L.

Diabetes Ther. 2019 Feb;10(1):245-258. doi: 10.1007/s13300-018-0557-3. Epub 2019 Jan 8.


LSD1 mediated changes in the local redox environment during the DNA damage response.

Duquette ML, Kim J, Shi LZ, Berns MW.

PLoS One. 2018 Aug 10;13(8):e0201907. doi: 10.1371/journal.pone.0201907. eCollection 2018.


A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans.

Khaliullin RN, Green RA, Shi LZ, Gomez-Cavazos JS, Berns MW, Desai A, Oegema K.

Elife. 2018 Jul 2;7. pii: e36073. doi: 10.7554/eLife.36073.


Association Between Uric Acid and Metabolic Syndrome in Elderly Women.

Wang HJ, Shi LZ, Liu CF, Liu SM, Shi ST.

Open Med (Wars). 2018 May 9;13:172-177. doi: 10.1515/med-2018-0027. eCollection 2018.


VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.

Gao J, Ward JF, Pettaway CA, Shi LZ, Subudhi SK, Vence LM, Zhao H, Chen J, Chen H, Efstathiou E, Troncoso P, Allison JP, Logothetis CJ, Wistuba II, Sepulveda MA, Sun J, Wargo J, Blando J, Sharma P.

Nat Med. 2017 May;23(5):551-555. doi: 10.1038/nm.4308. Epub 2017 Mar 27.


Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes.

Shi LZ, Saravia J, Zeng H, Kalupahana NS, Guy CS, Neale G, Chi H.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E67-E74. doi: 10.1073/pnas.1617669114. Epub 2016 Dec 19.


Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.

Gao J, Shi LZ, Zhao H, Chen J, Xiong L, He Q, Chen T, Roszik J, Bernatchez C, Woodman SE, Chen PL, Hwu P, Allison JP, Futreal A, Wargo JA, Sharma P.

Cell. 2016 Oct 6;167(2):397-404.e9. doi: 10.1016/j.cell.2016.08.069. Epub 2016 Sep 22.


Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.

Shi LZ, Fu T, Guan B, Chen J, Blando JM, Allison JP, Xiong L, Subudhi SK, Gao J, Sharma P.

Nat Commun. 2016 Aug 8;7:12335. doi: 10.1038/ncomms12335.


Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy.

Selfridge A, Hyun N, Chiang CC, Reyna SM, Weissmiller AM, Shi LZ, Preece D, Mobley WC, Berns MW.

Neurophotonics. 2015 Jan;2(1):015006. doi: 10.1117/1.NPh.2.1.015006. Epub 2015 Feb 13.


Laser microbeam targeting of single nerve axons in cell culture.

Hyun N, Shi LZ, Berns MW.

Methods Mol Biol. 2015;1254:211-26. doi: 10.1007/978-1-4939-2152-2_16.


Determination of motility forces on isolated chromosomes with laser tweezers.

Khatibzadeh N, Stilgoe AB, Bui AA, Rocha Y, Cruz GM, Loke V, Shi LZ, Nieminen TA, Rubinsztein-Dunlop H, Berns MW.

Sci Rep. 2014 Oct 31;4:6866. doi: 10.1038/srep06866.


Protective effects of astragaloside IV against ovalbumin-induced lung inflammation are regulated/mediated by T-bet/GATA-3.

Qiu YY, Zhu JX, Bian T, Gao F, Qian XF, Du Q, Yuan MY, Sun H, Shi LZ, Yu MH.

Pharmacology. 2014;94(1-2):51-9. doi: 10.1159/000362843. Epub 2014 Aug 28.


CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.

Wang H, Li Y, Truong LN, Shi LZ, Hwang PY, He J, Do J, Cho MJ, Li H, Negrete A, Shiloach J, Berns MW, Shen B, Chen L, Wu X.

Mol Cell. 2014 Jun 19;54(6):1012-21. doi: 10.1016/j.molcel.2014.04.012. Epub 2014 May 15.


Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis.

Wang X, Shi LZ.

J Zhejiang Univ Sci B. 2014 Mar;15(3):256-63. doi: 10.1631/jzus.B1300088. Review.


Gfi1: a unique controller of T(reg) cells.

Shi LZ, Chi H.

Cell Cycle. 2013 Dec 1;12(23):3581-2. doi: 10.4161/cc.26824. Epub 2013 Oct 21. No abstract available.


Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells.

Shi LZ, Kalupahana NS, Turnis ME, Neale G, Hock H, Vignali DA, Chi H.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3198-205. doi: 10.1073/pnas.1300950110. Epub 2013 Aug 5.


An extensive comparison of the effect of anthelmintic classes on diverse nematodes.

Hu Y, Ellis BL, Yiu YY, Miller MM, Urban JF, Shi LZ, Aroian RV.

PLoS One. 2013 Jul 15;8(7):e70702. doi: 10.1371/journal.pone.0070702. Print 2013.


Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.

Truong LN, Li Y, Shi LZ, Hwang PY, He J, Wang H, Razavian N, Berns MW, Wu X.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7720-5. doi: 10.1073/pnas.1213431110. Epub 2013 Apr 22.


Real-time calcium measurements of live optically trapped microorganisms.

Chandsawangbhuwana C, Shi LZ, Zhu Q, Berns MW.

J Biophotonics. 2014 Aug;7(8):571-9. doi: 10.1002/jbio.201200209. Epub 2013 Apr 11.


Purple sea urchin Strongylocentrotus purpuratus gamete manipulation using optical trapping and microfluidics.

Chandsawangbhuwana C, Shi LZ, Zhu Q, Berns MW.

J Biomed Opt. 2013 Apr;18(4):040501. doi: 10.1117/1.JBO.18.4.040501.


The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair.

Wang H, Shi LZ, Wong CC, Han X, Hwang PY, Truong LN, Zhu Q, Shao Z, Chen DJ, Berns MW, Yates JR 3rd, Chen L, Wu X.

PLoS Genet. 2013;9(2):e1003277. doi: 10.1371/journal.pgen.1003277. Epub 2013 Feb 28.


[Determination of donepezil enantiomer in human plasma by normal-HPLC-MS/MS].

Yu Q, Xiang J, Shi LZ, Liang MZ, Qin YP, Nan F.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Sep;43(5):779-81, 785. Chinese.


CtIP is required to initiate replication-dependent interstrand crosslink repair.

Duquette ML, Zhu Q, Taylor ER, Tsay AJ, Shi LZ, Berns MW, McGowan CH.

PLoS Genet. 2012;8(11):e1003050. doi: 10.1371/journal.pgen.1003050. Epub 2012 Nov 8.


The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination.

Lu CS, Truong LN, Aslanian A, Shi LZ, Li Y, Hwang PY, Koh KH, Hunter T, Yates JR 3rd, Berns MW, Wu X.

J Biol Chem. 2012 Dec 21;287(52):43984-94. doi: 10.1074/jbc.M112.421545. Epub 2012 Oct 31.


Organelle size equalization by a constitutive process.

Ludington WB, Shi LZ, Zhu Q, Berns MW, Marshall WF.

Curr Biol. 2012 Nov 20;22(22):2173-9. doi: 10.1016/j.cub.2012.09.040. Epub 2012 Oct 18.


Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.

He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X.

J Biol Chem. 2012 Sep 14;287(38):31747-56. doi: 10.1074/jbc.M112.384750. Epub 2012 Jul 25.


CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.

Wang H, Shao Z, Shi LZ, Hwang PY, Truong LN, Berns MW, Chen DJ, Wu X.

J Biol Chem. 2012 Jun 15;287(25):21471-80. doi: 10.1074/jbc.M112.355354. Epub 2012 Apr 27.


Development of a dual joystick-controlled laser trapping and cutting system for optical micromanipulation of chromosomes inside living cells.

Harsono MS, Zhu Q, Shi LZ, Duquette M, Berns MW.

J Biophotonics. 2013 Feb;6(2):197-204. doi: 10.1002/jbio.201200019. Epub 2012 Apr 20.


Effects of viscosity on sperm motility studied with optical tweezers.

Hyun N, Chandsawangbhuwana C, Zhu Q, Shi LZ, Yang-Wong C, Berns MW.

J Biomed Opt. 2012 Feb;17(2):025005. doi: 10.1117/1.JBO.17.2.025005.


High-throughput optofluidic system for the laser microsurgery of oocytes.

Chandsawangbhuwana C, Shi LZ, Zhu Q, Alliegro MC, Berns MW.

J Biomed Opt. 2012 Jan;17(1):015001. doi: 10.1117/1.JBO.17.1.015001.


The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR.

Immunity. 2011 Dec 23;35(6):871-82. doi: 10.1016/j.immuni.2011.09.021.


Age-related schema reliance of judgments of learning in predicting source memory.

Shi LZ, Tang WH, Liu XP.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2012;19(1-2):301-18. doi: 10.1080/13825585.2011.632616. Epub 2011 Dec 14.


Neuronal growth cones respond to laser-induced axonal damage.

Wu T, Mohanty S, Gomez-Godinez V, Shi LZ, Liaw LH, Miotke J, Meyer RL, Berns MW.

J R Soc Interface. 2012 Mar 7;9(68):535-47. doi: 10.1098/rsif.2011.0351. Epub 2011 Aug 10.


Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates.

Huang G, Wang Y, Shi LZ, Kanneganti TD, Chi H.

Immunity. 2011 Jul 22;35(1):45-58. doi: 10.1016/j.immuni.2011.05.014. Epub 2011 Jun 30.


HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells.

Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H.

J Exp Med. 2011 Jul 4;208(7):1367-76. doi: 10.1084/jem.20110278. Epub 2011 Jun 27.


An interdisciplinary systems approach to study sperm physiology and evolution.

Shi LZ, Nascimento J, Botvinick E, Durrant B, Berns MW.

Wiley Interdiscip Rev Syst Biol Med. 2011 Jan-Feb;3(1):36-47. doi: 10.1002/wsbm.106. Review.


Chromosome tips damaged in anaphase inhibit cytokinesis.

Baker NM, Zeitlin SG, Shi LZ, Shah J, Berns MW.

PLoS One. 2010 Aug 25;5(8):e12398. doi: 10.1371/journal.pone.0012398.


CtIP links DNA double-strand break sensing to resection.

You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T.

Mol Cell. 2009 Dec 25;36(6):954-69. doi: 10.1016/j.molcel.2009.12.002.


Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination.

Huang G, Shi LZ, Chi H.

Cytokine. 2009 Dec;48(3):161-9. doi: 10.1016/j.cyto.2009.08.002. Epub 2009 Sep 8. Review.


Beta-naphthoflavone causes an AhR-independent inhibition of invasion and intracellular multiplication of Listeria monocytogenes in murine hepatocytes.

Shi LZ, Czuprynski CJ.

Microb Pathog. 2009 Nov;47(5):258-66. doi: 10.1016/j.micpath.2009.08.004. Epub 2009 Aug 26.


Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells.

Kong X, Mohanty SK, Stephens J, Heale JT, Gomez-Godinez V, Shi LZ, Kim JS, Yokomori K, Berns MW.

Nucleic Acids Res. 2009 May;37(9):e68. doi: 10.1093/nar/gkp221. Epub 2009 Apr 7.


Comparison of glycolysis and oxidative phosphorylation as energy sources for mammalian sperm motility, using the combination of fluorescence imaging, laser tweezers, and real-time automated tracking and trapping.

Nascimento JM, Shi LZ, Tam J, Chandsawangbhuwana C, Durrant B, Botvinick EL, Berns MW.

J Cell Physiol. 2008 Dec;217(3):745-51. doi: 10.1002/jcp.21549.

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