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Completely Stereoselective Synthesis of Sulfonated 1,3-Dihydroisobenzofurans via Radical Multicomponent Reactions.

Shi HN, Huang MH, He CL, Lu HP, Hao WJ, Tu XC, Tu SJ, Jiang B.

J Org Chem. 2019 Oct 9. doi: 10.1021/acs.joc.9b01918. [Epub ahead of print]


T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

Biton M, Haber AL, Rogel N, Burgin G, Beyaz S, Schnell A, Ashenberg O, Su CW, Smillie C, Shekhar K, Chen Z, Wu C, Ordovas-Montanes J, Alvarez D, Herbst RH, Zhang M, Tirosh I, Dionne D, Nguyen LT, Xifaras ME, Shalek AK, von Andrian UH, Graham DB, Rozenblatt-Rosen O, Shi HN, Kuchroo V, Yilmaz OH, Regev A, Xavier RJ.

Cell. 2018 Nov 15;175(5):1307-1320.e22. doi: 10.1016/j.cell.2018.10.008. Epub 2018 Nov 1.


[Accordion operation for the bone transport in treating tibial bone defect].

Peng RJ, Zhang YH, Li XH, Shi HN, Lu YJ, Yang Q.

Zhongguo Gu Shang. 2018 Sep 25;31(9):824-828. doi: 10.3969/j.issn.1003-0034.2018.09.009. Chinese.


The effect of exposure to high altitude and low oxygen on intestinal microbial communities in mice.

Zhang W, Jiao L, Liu R, Zhang Y, Ji Q, Zhang H, Gao X, Ma Y, Shi HN.

PLoS One. 2018 Sep 12;13(9):e0203701. doi: 10.1371/journal.pone.0203701. eCollection 2018.


Visible-light photocatalytic bicyclization of β-alkynyl propenones for accessing diastereoenriched syn-fluoren-9-ones.

Shen ZJ, Shi HN, Hao WJ, Tu SJ, Jiang B.

Chem Commun (Camb). 2018 Oct 11;54(82):11542-11545. doi: 10.1039/c8cc06086j.


Majorization involving the cyclic moving average.

Zhang T, Shi HN, Xi BY, Chen A.

J Inequal Appl. 2018;2018(1):152. doi: 10.1186/s13660-018-1737-4. Epub 2018 Jun 28.


[History of processing of Sojae Semen Praeparatum].

Wang SQ, Wang MY, Guan H, Ruan JQ, Shi HN.

Zhongguo Zhong Yao Za Zhi. 2018 May;43(10):1985-1989. doi: 10.19540/j.cnki.cjcmm.20180117.008. Review. Chinese.


Real-time shear wave elastography (SWE) assessment of short- and long-term treatment outcome in Budd-Chiari syndrome: A pilot study.

Wang HW, Shi HN, Cheng J, Xie F, Luo YK, Tang J.

PLoS One. 2018 May 30;13(5):e0197550. doi: 10.1371/journal.pone.0197550. eCollection 2018.


Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages.

Su CW, Chen CY, Li Y, Long SR, Massey W, Kumar DV, Walker WA, Shi HN.

Sci Rep. 2018 Mar 15;8(1):4607. doi: 10.1038/s41598-018-22920-7.


Schur convexity of the generalized geometric Bonferroni mean and the relevant inequalities.

Shi HN, Wu SH.

J Inequal Appl. 2018;2018(1):8. doi: 10.1186/s13660-017-1605-7. Epub 2018 Jan 8.


A single-cell survey of the small intestinal epithelium.

Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Y, Tirosh I, Beyaz S, Dionne D, Zhang M, Raychowdhury R, Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A.

Nature. 2017 Nov 16;551(7680):333-339. doi: 10.1038/nature24489. Epub 2017 Nov 8.


p40 phox -Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection.

Li Y, Lv M, Su C, Long S, Zhang W, Conway KL, Li W, Xavier RJ, Shi HN.

Front Immunol. 2017 Oct 9;8:1270. doi: 10.3389/fimmu.2017.01270. eCollection 2017.


Recombinant Trichinella pseudospiralis Serine Protease Inhibitors Alter Macrophage Polarization In Vitro.

Xu N, Liu X, Tang B, Wang L, Shi HN, Boireau P, Liu M, Bai X.

Front Microbiol. 2017 Sep 21;8:1834. doi: 10.3389/fmicb.2017.01834. eCollection 2017.


Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells.

Belkind-Gerson J, Graham HK, Reynolds J, Hotta R, Nagy N, Cheng L, Kamionek M, Shi HN, Aherne CM, Goldstein AM.

Sci Rep. 2017 May 31;7(1):2525. doi: 10.1038/s41598-017-02890-y.


Influence of adjuvant formulation on inducing immune response in mice immunized with a recombinant serpin from Trichinella spiralis.

Xu J, Bai X, Wang LB, Shi HN, van der Giessen JWB, Boireau P, Liu MY, Liu XL.

Parasite Immunol. 2017 Jul;39(7). doi: 10.1111/pim.12437. Epub 2017 May 15.


Helminth-induced alterations of the gut microbiota exacerbate bacterial colitis.

Su C, Su L, Li Y, Long SR, Chang J, Zhang W, Walker WA, Xavier RJ, Cherayil BJ, Shi HN.

Mucosal Immunol. 2018 Jan;11(1):144-157. doi: 10.1038/mi.2017.20. Epub 2017 Mar 29.


Immune responses in mice vaccinated with a DNA vaccine expressing serine protease-like protein from the new-born larval stage of Trichinella spiralis.

Xu J, Bai X, Wang LB, Shi HN, Van Der Giessen JWB, Boireau P, Liu MY, Liu XL.

Parasitology. 2017 May;144(6):712-719. doi: 10.1017/S0031182016002493. Epub 2017 Jan 10.


Antibiotic Treatment Induces Long-lasting Changes in the Fecal Microbiota that Protect Against Colitis.

Ward NL, Phillips CD, Nguyen DD, Shanmugam NK, Song Y, Hodin R, Shi HN, Cherayil BJ, Goldstein AM.

Inflamm Bowel Dis. 2016 Oct;22(10):2328-40. doi: 10.1097/MIB.0000000000000914.


Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors.

Meng D, Zhu W, Ganguli K, Shi HN, Walker WA.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G744-G753. doi: 10.1152/ajpgi.00090.2016. Epub 2016 Aug 25.


The roles of supernatant of macrophage treated by excretory-secretory products from muscle larvae of Trichinella spiralis on the differentiation of C2C12 myoblasts.

Bai X, Wang XL, Tang B, Shi HN, Boireau P, Rosenthal B, Wu XP, Liu MY, Liu XL.

Vet Parasitol. 2016 Nov 15;231:83-91. doi: 10.1016/j.vetpar.2016.07.033. Epub 2016 Jul 29.


Developmental profile of select immune cells in mice infected with Trichinella spiralis during the intestinal phase.

Ding J, Bai X, Wang XL, Wang YF, Shi HN, Rosenthal B, Boireau P, Wu XP, Liu MY, Liu XL.

Vet Parasitol. 2016 Nov 15;231:77-82. doi: 10.1016/j.vetpar.2016.07.019. Epub 2016 Jul 18.


Schur-convexity, Schur-geometric and Schur-harmonic convexity for a composite function of complete symmetric function.

Shi HN, Zhang J, Ma QH.

Springerplus. 2016 Mar 8;5:296. doi: 10.1186/s40064-016-1940-z. eCollection 2016.


Characterization and functional analysis of Trichinella spiralis Nudix hydrolase.

Long SR, Wang ZQ, Jiang P, Liu RD, Qi X, Liu P, Ren HJ, Shi HN, Cui J.

Exp Parasitol. 2015 Dec;159:264-73. doi: 10.1016/j.exppara.2015.10.009. Epub 2015 Nov 3.


Genetic diversity and taxonomic status of Gymnocypris chilianensis based on the mitochondrial DNA cytochrome b gene.

Zhang JP, Liu Z, Zhang B, Yin XY, Wang L, Shi HN, Kang YJ.

Genet Mol Res. 2015 Aug 10;14(3):9253-60. doi: 10.4238/2015.August.10.5.


Intestinal Inflammation Leads to a Long-lasting Increase in Resistance to Systemic Salmonellosis that Requires Macrophages But Not B or T Lymphocytes at the Time of Pathogen Challenge.

Trebicka E, Shanmugam NK, Chen K, Su CW, Shi HN, Cherayil BJ.

Inflamm Bowel Dis. 2015 Dec;21(12):2758-65. doi: 10.1097/MIB.0000000000000544.


Short Communication: Effect of heat stress on heat-shock protein (Hsp60) mRNA expression in rainbow trout Oncorhynchus mykiss.

Shi HN, Liu Z, Zhang JP, Kang YJ, Wang JF, Huang JQ, Wang WM.

Genet Mol Res. 2015 May 18;14(2):5280-6. doi: 10.4238/2015.May.18.20.


Molecular identification of Trichinella spiralis nudix hydrolase and its induced protective immunity against trichinellosis in BALB/c mice.

Long SR, Wang ZQ, Liu RD, Liu LN, Li LG, Jiang P, Zhang X, Zhang ZF, Shi HN, Cui J.

Parasit Vectors. 2014 Dec 19;7:600. doi: 10.1186/s13071-014-0600-9.


Toll-like receptor-4 in human and mouse colonic epithelium is developmentally regulated: a possible role in necrotizing enterocolitis.

Meng D, Zhu W, Shi HN, Lu L, Wijendran V, Xu W, Walker WA.

Pediatr Res. 2015 Mar;77(3):416-24. doi: 10.1038/pr.2014.207. Epub 2014 Dec 18.


Development of fatal intestinal inflammation in MyD88 deficient mice co-infected with helminth and bacterial enteropathogens.

Su L, Qi Y, Zhang M, Weng M, Zhang X, Su C, Shi HN.

PLoS Negl Trop Dis. 2014 Jul 10;8(7):e2987. doi: 10.1371/journal.pntd.0002987. eCollection 2014 Jul.


Coinfection with an intestinal helminth impairs host innate immunity against Salmonella enterica serovar Typhimurium and exacerbates intestinal inflammation in mice.

Su L, Su CW, Qi Y, Yang G, Zhang M, Cherayil BJ, Zhang X, Shi HN.

Infect Immun. 2014 Sep;82(9):3855-66. doi: 10.1128/IAI.02023-14. Epub 2014 Jun 30.


Intestinal inflammation modulates expression of the iron-regulating hormone hepcidin depending on erythropoietic activity and the commensal microbiota.

Shanmugam NK, Trebicka E, Fu LL, Shi HN, Cherayil BJ.

J Immunol. 2014 Aug 1;193(3):1398-407. doi: 10.4049/jimmunol.1400278. Epub 2014 Jun 27.


Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis.

Tran HT, Lee IA, Low D, Kamba A, Mizoguchi A, Shi HN, Lee CG, Elias JA, Mizoguchi E.

Inflamm Bowel Dis. 2014 May;20(5):835-46. doi: 10.1097/MIB.0000000000000033.


Conditioned medium from Bifidobacteria infantis protects against Cronobacter sakazakii-induced intestinal inflammation in newborn mice.

Weng M, Ganguli K, Zhu W, Shi HN, Walker WA.

Am J Physiol Gastrointest Liver Physiol. 2014 May 1;306(9):G779-87. doi: 10.1152/ajpgi.00183.2013. Epub 2014 Mar 13.


Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota.

Whary MT, Muthupalani S, Ge Z, Feng Y, Lofgren J, Shi HN, Taylor NS, Correa P, Versalovic J, Wang TC, Fox JG.

Microbes Infect. 2014 Apr;16(4):345-55. doi: 10.1016/j.micinf.2014.01.005. Epub 2014 Feb 8.


Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ.

Gastroenterology. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21.


Effects of supplementing different ratios of omega-3 and omega-6 fatty acids in western-style diets on cow's milk protein allergy in a mouse model.

Thang CL, Boye JI, Shi HN, Zhao X.

Mol Nutr Food Res. 2013 Nov;57(11):2029-38. doi: 10.1002/mnfr.201300061. Epub 2013 Jun 19.


Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice.

Sokol H, Conway KL, Zhang M, Choi M, Morin B, Cao Z, Villablanca EJ, Li C, Wijmenga C, Yun SH, Shi HN, Xavier RJ.

Gastroenterology. 2013 Sep;145(3):591-601.e3. doi: 10.1053/j.gastro.2013.05.047. Epub 2013 May 31.


Modulation of inflammatory bowel disease in a mouse model following infection with Trichinella spiralis.

Zhao Y, Liu MY, Wang XL, Liu XL, Yang Y, Zou HB, Sun SM, Yu L, Rosenthal B, Shi HN, Boireau P, Wu XP.

Vet Parasitol. 2013 May 20;194(2-4):211-6. doi: 10.1016/j.vetpar.2013.01.058. Epub 2013 Feb 5.


Unique antigenic gene expression at different developmental stages of Trichinella pseudospiralis.

Wu XP, Liu XL, Wang XL, Blaga R, Fu BQ, Liu P, Bai X, Wang ZJ, Rosenthal BM, Shi HN, Sandrine L, Vallee I, Boireau P, Wang F, Zhou XN, Zhao Y, Liu MY.

Vet Parasitol. 2013 May 20;194(2-4):198-201. doi: 10.1016/j.vetpar.2013.01.055. Epub 2013 Feb 5.


An anti-tumor protein produced by Trichinella spiralis induces apoptosis in human hepatoma H7402 cells.

Wang XL, Liu MY, Sun SM, Liu XL, Yu L, Wang XR, Chu LX, Rosenthal B, Shi HN, Boireau P, Wang F, Zhao Y, Wu XP.

Vet Parasitol. 2013 May 20;194(2-4):186-8. doi: 10.1016/j.vetpar.2013.01.052. Epub 2013 Feb 5.


ATG5 regulates plasma cell differentiation.

Conway KL, Kuballa P, Khor B, Zhang M, Shi HN, Virgin HW, Xavier RJ.

Autophagy. 2013 Apr;9(4):528-37. doi: 10.4161/auto.23484. Epub 2013 Jan 17.


Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages.

Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN.

J Immunol. 2012 Aug 1;189(3):1459-66. doi: 10.4049/jimmunol.1200484. Epub 2012 Jun 25.


Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling.

Foye OT, Huang IF, Chiou CC, Walker WA, Shi HN.

FEMS Immunol Med Microbiol. 2012 Aug;65(3):467-80. doi: 10.1111/j.1574-695X.2012.00978.x. Epub 2012 May 25.


Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory.

Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z.

Ann Neurol. 2012 May;71(5):687-98. doi: 10.1002/ana.23536. Epub 2012 Feb 24.


The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice.

Nishida A, Lau CW, Zhang M, Andoh A, Shi HN, Mizoguchi E, Mizoguchi A.

Gastroenterology. 2012 Apr;142(4):865-874.e2. doi: 10.1053/j.gastro.2011.12.036. Epub 2011 Dec 24.


Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue.

Chen CC, Lin WC, Kong MS, Shi HN, Walker WA, Lin CY, Huang CT, Lin YC, Jung SM, Lin TY.

Br J Nutr. 2012 Jun;107(11):1623-34. doi: 10.1017/S0007114511004934. Epub 2011 Sep 30.


Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation.

Su CW, Cao Y, Kaplan J, Zhang M, Li W, Conroy M, Walker WA, Shi HN.

Infect Immun. 2011 Jun;79(6):2285-94. doi: 10.1128/IAI.01123-10. Epub 2011 Mar 28.


The role of microbes in developmental immunologic programming.

Kaplan JL, Shi HN, Walker WA.

Pediatr Res. 2011 Jun;69(6):465-72. doi: 10.1203/PDR.0b013e318217638a. Review.


Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.

Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ.

J Clin Invest. 2009 Nov;119(11):3322-8. doi: 10.1172/JCI39939. Epub 2009 Oct 5.


The long-term health effects of neonatal microbial flora.

Conroy ME, Shi HN, Walker WA.

Curr Opin Allergy Clin Immunol. 2009 Jun;9(3):197-201. doi: 10.1097/ACI.0b013e32832b3f1d. Review.


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