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The Tumor Microenvironment Innately Modulates Cancer Progression.

Hinshaw DC, Shevde LA.

Cancer Res. 2019 Sep 15;79(18):4557-4566. doi: 10.1158/0008-5472.CAN-18-3962. Epub 2019 Jul 26. Review.


Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer.

Hanna A, Metge BJ, Bailey SK, Chen D, Chandrashekar DS, Varambally S, Samant RS, Shevde LA.

Oncoimmunology. 2018 Dec 12;8(3):1548241. doi: 10.1080/2162402X.2018.1548241. eCollection 2019.


O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity.

Das S, Bailey SK, Metge BJ, Hanna A, Hinshaw DC, Mota M, Forero-Torres A, Chatham JC, Samant RS, Shevde LA.

Lab Invest. 2019 Feb;99(2):260-270. doi: 10.1038/s41374-018-0122-8. Epub 2018 Nov 12.


Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer.

Mota MSV, Jackson WP, Bailey SK, Vayalil P, Landar A, Rostas JW 3rd, Mulekar MS, Samant RS, Shevde LA.

Carcinogenesis. 2018 Sep 21;39(9):1165-1175. doi: 10.1093/carcin/bgy078.


Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.

Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde LA, Samant RS.

Oncogene. 2018 Mar;37(12):1610-1623. doi: 10.1038/s41388-017-0037-7. Epub 2018 Jan 12.


Developing Cures: Targeting Ontogenesis in Cancer.

Lin VTG, Pruitt HC, Samant RS, Shevde LA.

Trends Cancer. 2017 Feb;3(2):126-136. doi: 10.1016/j.trecan.2016.12.007. Epub 2017 Jan 27. Review.


Biomimetic strategies to recapitulate organ specific microenvironments for studying breast cancer metastasis.

Narkhede AA, Shevde LA, Rao SS.

Int J Cancer. 2017 Sep 15;141(6):1091-1109. doi: 10.1002/ijc.30748. Epub 2017 May 10. Review.


Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.

Das S, Jackson WP, Prasain JK, Hanna A, Bailey SK, Tucker JA, Bae S, Wilson LS, Samant RS, Barnes S, Shevde LA.

Sci Rep. 2017 Jan 23;7:40773. doi: 10.1038/srep40773.


BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells.

Graham CD, Kaza N, Pruitt HC, Gibson LM, Klocke BJ, Shevde LA, Carroll SL, Roth KA.

Oncotarget. 2017 Jan 31;8(5):8670-8678. doi: 10.18632/oncotarget.14398.


Genomic regulation of invasion by STAT3 in triple negative breast cancer.

McDaniel JM, Varley KE, Gertz J, Savic DS, Roberts BS, Bailey SK, Shevde LA, Ramaker RC, Lasseigne BN, Kirby MK, Newberry KM, Partridge EC, Jones AL, Boone B, Levy SE, Oliver PG, Sexton KC, Grizzle WE, Forero A, Buchsbaum DJ, Cooper SJ, Myers RM.

Oncotarget. 2017 Jan 31;8(5):8226-8238. doi: 10.18632/oncotarget.14153.


Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma.

Graham CD, Kaza N, Klocke BJ, Gillespie GY, Shevde LA, Carroll SL, Roth KA.

J Neuropathol Exp Neurol. 2016 Oct;75(10):946-954. Epub 2016 Aug 11.


Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer.

Meng E, Shevde LA, Samant RS.

Oncotarget. 2016 Aug 16;7(33):53984-53996. doi: 10.18632/oncotarget.9803. Review.


Erratum to: 'Hedgehog signaling: modulation of cancer properties and tumor microenvironment'.

Hanna A, Shevde LA.

Mol Cancer. 2016 May 11;15(1):35. No abstract available.


Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment.

Hanna A, Shevde LA.

Mol Cancer. 2016 Mar 18;15:24. doi: 10.1186/s12943-016-0509-3. Review. Erratum in: Mol Cancer. 2016;15(1):35.


Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer.

Morrow KA, Das S, Meng E, Menezes ME, Bailey SK, Metge BJ, Buchsbaum DJ, Samant RS, Shevde LA.

Oncotarget. 2016 Apr 5;7(14):17991-8005. doi: 10.18632/oncotarget.7494.


Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancer.

Tzou YM, Bailey SK, Yuan K, Shin R, Zhang W, Chen Y, Singh RK, Shevde LA, Krishna NR.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1237-44. doi: 10.1016/j.bmcl.2016.01.027. Epub 2016 Jan 12.


The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer.

Meng E, Hanna A, Samant RS, Shevde LA.

Cancers (Basel). 2015 Jul 21;7(3):1333-48. doi: 10.3390/cancers7030839. Review.


N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells.

Metge BJ, Mitra A, Chen D, Shevde LA, Samant RS.

Sci Rep. 2015 Jul 6;5:11995. doi: 10.1038/srep11995.


NMI and EMT.

Samant RS, Shevde LA.

Oncoscience. 2014 Jun 19;1(7):476-7. eCollection 2014. No abstract available.


ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.

Meng E, Mitra A, Tripathi K, Finan MA, Scalici J, McClellan S, Madeira da Silva L, Reed E, Shevde LA, Palle K, Rocconi RP.

PLoS One. 2014 Sep 12;9(9):e107142. doi: 10.1371/journal.pone.0107142. eCollection 2014.


microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer.

Rostas JW 3rd, Pruitt HC, Metge BJ, Mitra A, Bailey SK, Bae S, Singh KP, Devine DJ, Dyess DL, Richards WO, Tucker JA, Shevde LA, Samant RS.

Mol Cancer. 2014 Aug 29;13:200. doi: 10.1186/1476-4598-13-200.


Role of osteopontin in the pathophysiology of cancer.

Shevde LA, Samant RS.

Matrix Biol. 2014 Jul;37:131-41. doi: 10.1016/j.matbio.2014.03.001. Epub 2014 Mar 19. Review.


GLI1 upregulates C-JUN through a specific 130-kDa isoform.

Amable L, Gavin E, Kudo K, Meng E, Rocconi RP, Shevde LA, Reed E.

Int J Oncol. 2014 Mar;44(3):655-61. doi: 10.3892/ijo.2013.2222. Epub 2013 Dec 20.


Nonclassical hedgehog-GLI signaling and its clinical implications.

Shevde LA, Samant RS.

Int J Cancer. 2014 Jul 1;135(1):1-6. doi: 10.1002/ijc.28424. Epub 2013 Sep 11. Review.


Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signaling.

Devine DJ, Rostas JW, Metge BJ, Das S, Mulekar MS, Tucker JA, Grizzle WE, Buchsbaum DJ, Shevde LA, Samant RS.

Oncogene. 2014 May 15;33(20):2620-8. doi: 10.1038/onc.2013.215. Epub 2013 Jun 17.


Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition.

Das S, Samant RS, Shevde LA.

J Biol Chem. 2013 Apr 26;288(17):11824-33. doi: 10.1074/jbc.M112.432302. Epub 2013 Mar 18.


Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance.

Vincent AJ, Ren S, Harris LG, Devine DJ, Samant RS, Fodstad O, Shevde LA.

FEBS Lett. 2012 Sep 21;586(19):3429-34. doi: 10.1016/j.febslet.2012.07.063. Epub 2012 Jul 31.


Merlin: the wizard requires protein stability to function as a tumor suppressor.

Morrow KA, Shevde LA.

Biochim Biophys Acta. 2012 Dec;1826(2):400-6. doi: 10.1016/j.bbcan.2012.06.005. Epub 2012 Jun 30. Review.


Micro-RNA-632 downregulates DNAJB6 in breast cancer.

Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS.

Lab Invest. 2012 Sep;92(9):1310-7. doi: 10.1038/labinvest.2012.87. Epub 2012 Jun 18.


The influence of the cancer microenvironment on the process of metastasis.

Frost AR, Hurst DR, Shevde LA, Samant RS.

Int J Breast Cancer. 2012;2012:756257. doi: 10.1155/2012/756257. Epub 2012 Apr 18. No abstract available.


Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.

Andrews JF, Sykora LJ, Letostak TB, Menezes ME, Mitra A, Barik S, Shevde LA, Samant RS.

Exp Cell Res. 2012 Jun 10;318(10):1086-93. doi: 10.1016/j.yexcr.2012.03.024. Epub 2012 Apr 3.


Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases.

Das S, Tucker JA, Khullar S, Samant RS, Shevde LA.

PLoS One. 2012;7(3):e34374. doi: 10.1371/journal.pone.0034374. Epub 2012 Mar 29.


DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.

Menezes ME, Mitra A, Shevde LA, Samant RS.

Biochem J. 2012 Jun 15;444(3):573-80. doi: 10.1042/BJ20120205.


The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer.

Das S, Samant RS, Shevde LA.

Int J Breast Cancer. 2012;2012:298623. doi: 10.1155/2012/298623. Epub 2011 Dec 1.


Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs.

Li X, Gao L, Cui Q, Gary BD, Dyess DL, Taylor W, Shevde LA, Samant RS, Dean-Colomb W, Piazza GA, Xi Y.

Oncogene. 2012 Nov 29;31(48):4979-86. doi: 10.1038/onc.2011.655. Epub 2012 Jan 30.


Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair.

Kudo K, Gavin E, Das S, Amable L, Shevde LA, Reed E.

Oncogene. 2012 Nov 1;31(44):4718-24. doi: 10.1038/onc.2011.610. Epub 2012 Jan 23.


DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS.

Oncogene. 2012 Oct 11;31(41):4472-83. doi: 10.1038/onc.2011.623. Epub 2012 Jan 23.


Targeted inhibition of telomerase activity combined with chemotherapy demonstrates synergy in eliminating ovarian cancer spheroid-forming cells.

Meng E, Taylor B, Ray A, Shevde LA, Rocconi RP.

Gynecol Oncol. 2012 Mar;124(3):598-605. doi: 10.1016/j.ygyno.2011.11.018. Epub 2011 Nov 22.


Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61.

Harris LG, Pannell LK, Singh S, Samant RS, Shevde LA.

Oncogene. 2012 Jul 12;31(28):3370-80. doi: 10.1038/onc.2011.496. Epub 2011 Nov 7.


Loss of tumor suppressor Merlin in advanced breast cancer is due to post-translational regulation.

Morrow KA, Das S, Metge BJ, Ye K, Mulekar MS, Tucker JA, Samant RS, Shevde LA.

J Biol Chem. 2011 Nov 18;286(46):40376-85. doi: 10.1074/jbc.M111.250035. Epub 2011 Sep 30.


Dickkopf1: a tumor suppressor or metastasis promoter?

Menezes ME, Devine DJ, Shevde LA, Samant RS.

Int J Cancer. 2012 Apr 1;130(7):1477-83. doi: 10.1002/ijc.26449. Epub 2011 Nov 2. Review.


Hedgehog signaling: networking to nurture a promalignant tumor microenvironment.

Harris LG, Samant RS, Shevde LA.

Mol Cancer Res. 2011 Sep;9(9):1165-74. doi: 10.1158/1541-7786.MCR-11-0175. Epub 2011 Jul 20. Review.


Hedgehog signaling pathway regulates the growth of ovarian cancer spheroid forming cells.

Ray A, Meng E, Reed E, Shevde LA, Rocconi RP.

Int J Oncol. 2011 Oct;39(4):797-804. doi: 10.3892/ijo.2011.1093. Epub 2011 Jun 22.


Recent advances in anti-angiogenic therapy of cancer.

Samant RS, Shevde LA.

Oncotarget. 2011 Mar;2(3):122-34. Review.


Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysis.

Das S, Samant RS, Shevde LA.

J Biol Chem. 2011 Mar 18;286(11):9612-22. doi: 10.1074/jbc.M110.174920. Epub 2010 Dec 18.


Mechanisms of transcriptional regulation and prognostic significance of activated leukocyte cell adhesion molecule in cancer.

King JA, Tan F, Mbeunkui F, Chambers Z, Cantrell S, Chen H, Alvarez D, Shevde LA, Ofori-Acquah SF.

Mol Cancer. 2010 Oct 7;9:266. doi: 10.1186/1476-4598-9-266.


DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.

Mitra A, Menezes ME, Shevde LA, Samant RS.

J Biol Chem. 2010 Aug 6;285(32):24686-94. doi: 10.1074/jbc.M109.094847. Epub 2010 Jun 3.


Elevated osteopontin levels in metastatic melanoma correlate with epigenetic silencing of breast cancer metastasis suppressor 1.

Metge BJ, Liu S, Riker AI, Fodstad O, Samant RS, Shevde LA.

Oncology. 2010;78(1):75-86. doi: 10.1159/000292363. Epub 2010 Mar 6.


Osteopontin: an effector and an effect of tumor metastasis.

Shevde LA, Das S, Clark DW, Samant RS.

Curr Mol Med. 2010 Feb;10(1):71-81. Review.


The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.

Das S, Harris LG, Metge BJ, Liu S, Riker AI, Samant RS, Shevde LA.

J Biol Chem. 2009 Aug 21;284(34):22888-97. doi: 10.1074/jbc.M109.021949. Epub 2009 Jun 25.

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