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Items: 1 to 50 of 387

1.

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.

Yang YH, Istomine R, Alvarez F, Al-Aubodah TA, Shi XQ, Takano T, Thornton AM, Shevach EM, Zhang J, Piccirillo CA.

Cell Rep. 2020 Feb 4;30(5):1515-1529.e4. doi: 10.1016/j.celrep.2020.01.002.

2.

Helios: still behind the clouds.

Thornton AM, Shevach EM.

Immunology. 2019 Nov;158(3):161-170. doi: 10.1111/imm.13115. Epub 2019 Oct 13. Review.

PMID:
31517385
3.

Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity.

Gokhale AS, Gangaplara A, Lopez-Occasio M, Thornton AM, Shevach EM.

J Autoimmun. 2019 Dec;105:102300. doi: 10.1016/j.jaut.2019.06.011. Epub 2019 Jul 8.

PMID:
31296356
4.

Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells.

Skadow M, Penna VR, Galant-Swafford J, Shevach EM, Thornton AM.

J Immunol. 2019 Jul 15;203(2):370-378. doi: 10.4049/jimmunol.1900388. Epub 2019 Jun 5.

PMID:
31167776
5.

CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus.

Nath PR, Gangaplara A, Pal-Nath D, Mandal A, Maric D, Sipes JM, Cam M, Shevach EM, Roberts DD.

Front Immunol. 2018 Dec 20;9:2985. doi: 10.3389/fimmu.2018.02985. eCollection 2018.

6.

Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells.

Akkaya B, Oya Y, Akkaya M, Al Souz J, Holstein AH, Kamenyeva O, Kabat J, Matsumura R, Dorward DW, Glass DD, Shevach EM.

Nat Immunol. 2019 Feb;20(2):218-231. doi: 10.1038/s41590-018-0280-2. Epub 2019 Jan 14.

7.

Helios+ and Helios- Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.

Thornton AM, Lu J, Korty PE, Kim YC, Martens C, Sun PD, Shevach EM.

Eur J Immunol. 2019 Mar;49(3):398-412. doi: 10.1002/eji.201847935. Epub 2019 Jan 15.

PMID:
30620397
8.

IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.

Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG.

Cell Stem Cell. 2019 Jan 3;24(1):153-165.e7. doi: 10.1016/j.stem.2018.10.016. Epub 2018 Nov 21.

9.

SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells.

Kim YC, Kim KK, Yoon J, Scott DW, Shevach EM.

J Immunol. 2018 Sep 15;201(6):1671-1680. doi: 10.4049/jimmunol.1800613. Epub 2018 Aug 13.

10.

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells.

Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt FA, Liniany LP, Knight D, Samsel LA, Berlinguer-Palmini R, Yim JJ, Felizardo TC, Eckhaus MA, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler DH, van Kasteren SI, Laurence A, Bogyo M, Watts C, Shevach EM, Amarnath S.

Immunity. 2018 Aug 21;49(2):247-263.e7. doi: 10.1016/j.immuni.2018.05.006. Epub 2018 Jul 24.

11.

Foxp3+ T Regulatory Cells: Still Many Unanswered Questions-A Perspective After 20 Years of Study.

Shevach EM.

Front Immunol. 2018 May 15;9:1048. doi: 10.3389/fimmu.2018.01048. eCollection 2018. Review.

12.

Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment.

Gangaplara A, Martens C, Dahlstrom E, Metidji A, Gokhale AS, Glass DD, Lopez-Ocasio M, Baur R, Kanakabandi K, Porcella SF, Shevach EM.

PLoS Pathog. 2018 Apr 19;14(4):e1006985. doi: 10.1371/journal.ppat.1006985. eCollection 2018 Apr.

13.

The role of platelet and endothelial GARP in thrombosis and hemostasis.

Vermeersch E, Denorme F, Maes W, De Meyer SF, Vanhoorelbeke K, Edwards J, Shevach EM, Unutmaz D, Fujii H, Deckmyn H, Tersteeg C.

PLoS One. 2017 Mar 9;12(3):e0173329. doi: 10.1371/journal.pone.0173329. eCollection 2017.

14.

TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis.

Holt MP, Punkosdy GA, Glass DD, Shevach EM.

J Immunol. 2017 Feb 15;198(4):1503-1511. doi: 10.4049/jimmunol.1601670. Epub 2017 Jan 4.

15.

Garp as a therapeutic target for modulation of T regulatory cell function.

Shevach EM.

Expert Opin Ther Targets. 2017 Feb;21(2):191-200. doi: 10.1080/14728222.2017.1275568. Epub 2016 Dec 29. Review.

PMID:
28001437
16.

Ex-vivo iTreg differentiation revisited: Convenient alternatives to existing strategies.

Akkaya B, Holstein AH, Isaac C, Maz MP, Glass DD, Shevach EM, Akkaya M.

J Immunol Methods. 2017 Feb;441:67-71. doi: 10.1016/j.jim.2016.11.013. Epub 2016 Dec 2.

17.

Deep sequencing of the TCR-β repertoire of human forkhead box protein 3 (FoxP3)+ and FoxP3- T cells suggests that they are completely distinct and non-overlapping.

Golding A, Darko S, Wylie WH, Douek DC, Shevach EM.

Clin Exp Immunol. 2017 Apr;188(1):12-21. doi: 10.1111/cei.12904. Epub 2017 Jan 9.

18.

Tregs, Helios and tumor immunity: the sun has not yet risen.

Thornton AM, Shevach EM.

Transl Cancer Res. 2016 Oct;5(Suppl 4):S672-S674. doi: 10.21037/tcr.2016.10.47. No abstract available.

19.

A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry.

Akkaya B, Miozzo P, Holstein AH, Shevach EM, Pierce SK, Akkaya M.

J Immunol. 2016 Sep 1;197(5):2027-38. doi: 10.4049/jimmunol.1600727. Epub 2016 Jul 20.

20.

Cardiac myosin-Th17 responses promote heart failure in human myocarditis.

Myers JM, Cooper LT, Kem DC, Stavrakis S, Kosanke SD, Shevach EM, Fairweather D, Stoner JA, Cox CJ, Cunningham MW.

JCI Insight. 2016 Jun 16;1(9). pii: 85851. doi: 10.1172/jci.insight.85851.

21.

The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance.

Edwards JP, Hand TW, Morais da Fonseca D, Glass DD, Belkaid Y, Shevach EM.

Eur J Immunol. 2016 Jun;46(6):1480-9. doi: 10.1002/eji.201546204. Epub 2016 Apr 23.

22.

γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes.

Ujiie H, Shevach EM.

J Immunol. 2016 Feb 15;196(4):1517-28. doi: 10.4049/jimmunol.1501774. Epub 2016 Jan 15.

23.

Transcriptome profiling of human FoxP3+ regulatory T cells.

Bhairavabhotla R, Kim YC, Glass DD, Escobar TM, Patel MC, Zahr R, Nguyen CK, Kilaru GK, Muljo SA, Shevach EM.

Hum Immunol. 2016 Feb;77(2):201-13. doi: 10.1016/j.humimm.2015.12.004. Epub 2015 Dec 10.

24.

Helios Controls a Limited Subset of Regulatory T Cell Functions.

Sebastian M, Lopez-Ocasio M, Metidji A, Rieder SA, Shevach EM, Thornton AM.

J Immunol. 2016 Jan 1;196(1):144-55. doi: 10.4049/jimmunol.1501704. Epub 2015 Nov 18.

25.

William E. Paul 1936-2015.

Shevach EM, Margulies DH.

Nat Immunol. 2015 Dec;16(12):1205. doi: 10.1038/ni.3316. No abstract available.

PMID:
26580498
26.

Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry.

Santegoets SJ, Dijkgraaf EM, Battaglia A, Beckhove P, Britten CM, Gallimore A, Godkin A, Gouttefangeas C, de Gruijl TD, Koenen HJ, Scheffold A, Shevach EM, Staats J, Taskén K, Whiteside TL, Kroep JR, Welters MJ, van der Burg SH.

Cancer Immunol Immunother. 2015 Oct;64(10):1271-86. doi: 10.1007/s00262-015-1729-x. Epub 2015 Jun 28.

27.

Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.

Rieder SA, Metidji A, Glass DD, Thornton AM, Ikeda T, Morgan BA, Shevach EM.

J Immunol. 2015 Jul 15;195(2):553-63. doi: 10.4049/jimmunol.1500627. Epub 2015 Jun 10.

28.

IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions.

Metidji A, Rieder SA, Glass DD, Cremer I, Punkosdy GA, Shevach EM.

J Immunol. 2015 May 1;194(9):4265-76. doi: 10.4049/jimmunol.1500036. Epub 2015 Mar 20.

29.

Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.

Bin Dhuban K, d'Hennezel E, Nashi E, Bar-Or A, Rieder S, Shevach EM, Nagata S, Piccirillo CA.

J Immunol. 2015 Apr 15;194(8):3687-96. doi: 10.4049/jimmunol.1401803. Epub 2015 Mar 11.

30.

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses.

Kim YC, Zhang AH, Su Y, Rieder SA, Rossi RJ, Ettinger RA, Pratt KP, Shevach EM, Scott DW.

Blood. 2015 Feb 12;125(7):1107-15. doi: 10.1182/blood-2014-04-566786. Epub 2014 Dec 10.

31.

Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells.

Basu S, Hubbard B, Shevach EM.

J Leukoc Biol. 2015 Feb;97(2):279-83. doi: 10.1189/jlb.2AB0514-273RR. Epub 2014 Dec 9.

32.

TCR signaling fuels T(reg) cell suppressor function.

Zhu J, Shevach EM.

Nat Immunol. 2014 Nov;15(11):1002-3. doi: 10.1038/ni.3014. No abstract available.

33.

Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8.

Edwards JP, Thornton AM, Shevach EM.

J Immunol. 2014 Sep 15;193(6):2843-9. doi: 10.4049/jimmunol.1401102. Epub 2014 Aug 15.

34.

tTregs, pTregs, and iTregs: similarities and differences.

Shevach EM, Thornton AM.

Immunol Rev. 2014 May;259(1):88-102. doi: 10.1111/imr.12160. Review.

35.

Endogenous mouse mammary tumor viruses (mtv): new roles for an old virus in cancer, infection, and immunity.

Holt MP, Shevach EM, Punkosdy GA.

Front Oncol. 2013 Nov 26;3:287. doi: 10.3389/fonc.2013.00287. Review.

36.

Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism.

Chattopadhyay G, Shevach EM.

J Immunol. 2013 Dec 15;191(12):5875-84. doi: 10.4049/jimmunol.1301693. Epub 2013 Nov 11.

37.

The percentage of FoxP3+Helios+ Treg cells correlates positively with disease activity in systemic lupus erythematosus.

Golding A, Hasni S, Illei G, Shevach EM.

Arthritis Rheum. 2013 Nov;65(11):2898-906. doi: 10.1002/art.38119. Erratum in: Arthritis Rheum. 2014 Jun;66(6):1671.

38.

Modulation of Treg cells/T effector function by GITR signaling is context-dependent.

Ephrem A, Epstein AL, Stephens GL, Thornton AM, Glass D, Shevach EM.

Eur J Immunol. 2013 Sep;43(9):2421-9. doi: 10.1002/eji.201343451. Epub 2013 Jul 3.

39.

Eos, goddess of treg cell reprogramming.

Rieder SA, Shevach EM.

Immunity. 2013 May 23;38(5):849-50. doi: 10.1016/j.immuni.2013.05.001. No abstract available.

40.

Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation.

Edwards JP, Fujii H, Zhou AX, Creemers J, Unutmaz D, Shevach EM.

J Immunol. 2013 Jun 1;190(11):5506-15. doi: 10.4049/jimmunol.1300199. Epub 2013 May 3.

41.

Regulatory T cells: recommendations to simplify the nomenclature.

Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF.

Nat Immunol. 2013 Apr;14(4):307-8. doi: 10.1038/ni.2554. No abstract available.

42.

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

Strainic MG, Shevach EM, An F, Lin F, Medof ME.

Nat Immunol. 2013 Feb;14(2):162-71. doi: 10.1038/ni.2499. Epub 2012 Dec 23.

43.

Application of IL-2 therapy to target T regulatory cell function.

Shevach EM.

Trends Immunol. 2012 Dec;33(12):626-32. doi: 10.1016/j.it.2012.07.007. Epub 2012 Aug 30. Review.

44.

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.

Kim YC, Bhairavabhotla R, Yoon J, Golding A, Thornton AM, Tran DQ, Shevach EM.

Blood. 2012 Mar 22;119(12):2810-8. doi: 10.1182/blood-2011-09-377895. Epub 2012 Jan 31.

45.

Biological functions of regulatory T cells.

Shevach EM.

Adv Immunol. 2011;112:137-76. doi: 10.1016/B978-0-12-387827-4.00004-8. Review.

PMID:
22118408
46.

Highlights of 10 years of immunology in Nature Reviews Immunology.

Medzhitov R, Shevach EM, Trinchieri G, Mellor AL, Munn DH, Gordon S, Libby P, Hansson GK, Shortman K, Dong C, Gabrilovich D, Gabryšová L, Howes A, O'Garra A.

Nat Rev Immunol. 2011 Sep 23;11(10):693-702. doi: 10.1038/nri3063. Review.

47.

The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells.

Zhao Y, Thornton AM, Kinney MC, Ma CA, Spinner JJ, Fuss IJ, Shevach EM, Jain A.

J Biol Chem. 2011 Nov 25;286(47):40520-30. doi: 10.1074/jbc.M111.292961. Epub 2011 Sep 19.

48.

Polyclonal Treg cells modulate T effector cell trafficking.

Davidson TS, Shevach EM.

Eur J Immunol. 2011 Oct;41(10):2862-70. doi: 10.1002/eji.201141503. Epub 2011 Aug 30.

49.

A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.

Killebrew JR, Perdue N, Kwan A, Thornton AM, Shevach EM, Campbell DJ.

J Immunol. 2011 Jul 15;187(2):861-9. doi: 10.4049/jimmunol.1004009. Epub 2011 Jun 20.

50.

IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo.

Chen Q, Kim YC, Laurence A, Punkosdy GA, Shevach EM.

J Immunol. 2011 Jun 1;186(11):6329-37. doi: 10.4049/jimmunol.1100061. Epub 2011 Apr 27.

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