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Items: 27

1.

Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.

Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, Fischer P, Sher X, Gupta P, Lacy DB, Therien AG.

J Mol Biol. 2017 Apr 7;429(7):1030-1044. doi: 10.1016/j.jmb.2017.02.010. Epub 2017 Feb 21.

PMID:
28232034
2.

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.

Berejnaia O, Wang H, Labroli M, Yang C, Gill C, Xiao J, Hesk D, DeJesus R, Su J, Tan CM, Sheth PR, Kavana M, McLaren DG.

Anal Biochem. 2017 Feb 1;518:9-15. doi: 10.1016/j.ab.2016.10.027. Epub 2016 Nov 2.

PMID:
27815077
3.

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

Yang SW, Pan J, Yang C, Labroli M, Pan W, Caldwell J, Ha S, Koseoglu S, Xiao JC, Mayhood T, Sheth PR, Garlisi CG, Wu J, Lee SH, Wang H, Tan CM, Roemer T, Su J.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4743-4747. doi: 10.1016/j.bmcl.2016.08.036. Epub 2016 Aug 16.

PMID:
27575474
4.

Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.

Mann PA, Müller A, Wolff KA, Fischmann T, Wang H, Reed P, Hou Y, Li W, Müller CE, Xiao J, Murgolo N, Sher X, Mayhood T, Sheth PR, Mirza A, Labroli M, Xiao L, McCoy M, Gill CJ, Pinho MG, Schneider T, Roemer T.

PLoS Pathog. 2016 May 4;12(5):e1005585. doi: 10.1371/journal.ppat.1005585. eCollection 2016 May.

5.

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Lee SH, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, Gill C, Mann P, Sher X, Ha S, Yang SW, Mandal M, Yang C, Liang L, Tan Z, Tawa P, Hou Y, Kuvelkar R, DeVito K, Wen X, Xiao J, Batchlett M, Balibar CJ, Liu J, Xiao J, Murgolo N, Garlisi CG, Sheth PR, Flattery A, Su J, Tan C, Roemer T.

Sci Transl Med. 2016 Mar 9;8(329):329ra32. doi: 10.1126/scitranslmed.aad7364.

PMID:
26962156
6.

Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T.

Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30.

PMID:
26416753
7.

Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling.

Hernandez LD, Racine F, Xiao L, DiNunzio E, Hairston N, Sheth PR, Murgolo NJ, Therien AG.

Antimicrob Agents Chemother. 2015 Feb;59(2):1052-60. doi: 10.1128/AAC.04433-14. Epub 2014 Dec 1.

8.

Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.

Orth P, Xiao L, Hernandez LD, Reichert P, Sheth PR, Beaumont M, Yang X, Murgolo N, Ermakov G, DiNunzio E, Racine F, Karczewski J, Secore S, Ingram RN, Mayhood T, Strickland C, Therien AG.

J Biol Chem. 2014 Jun 27;289(26):18008-21. doi: 10.1074/jbc.M114.560748. Epub 2014 May 12.

9.

Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901.

Sheth PR, Liu Y, Hesson T, Zhao J, Vilenchik L, Liu YH, Mayhood TW, Le HV.

Biochemistry. 2011 Sep 20;50(37):7964-76. doi: 10.1021/bi200542r. Epub 2011 Aug 26.

PMID:
21793567
10.

Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution.

Vilenchik LZ, Sheth PR, Chuang CC, Le HV.

Anal Biochem. 2011 Nov 1;418(1):10-8. doi: 10.1016/j.ab.2011.06.007. Epub 2011 Jun 13.

PMID:
21726521
11.

Structural basis of CX-4945 binding to human protein kinase CK2.

Ferguson AD, Sheth PR, Basso AD, Paliwal S, Gray K, Fischmann TO, Le HV.

FEBS Lett. 2011 Jan 3;585(1):104-10. doi: 10.1016/j.febslet.2010.11.019. Epub 2010 Nov 18.

12.

SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics.

Basso AD, Liu M, Dai C, Gray K, Nale L, Tevar S, Lee S, Liang L, Ponery A, Yaremko B, Smith E, Tang H, Sheth PR, Siddiqui MA, Hicklin DJ, Kirschmeier P.

Mol Cancer Ther. 2010 Nov;9(11):2993-3002. doi: 10.1158/1535-7163.MCT-10-0548. Epub 2010 Oct 26.

13.

Novel benzimidazole inhibitors bind to a unique site in the kinesin spindle protein motor domain.

Sheth PR, Shipps GW Jr, Seghezzi W, Smith CK, Chuang CC, Sanden D, Basso AD, Vilenchik L, Gray K, Annis DA, Nickbarg E, Ma Y, Lahue B, Herbst R, Le HV.

Biochemistry. 2010 Sep 28;49(38):8350-8. doi: 10.1021/bi1005283.

PMID:
20718440
14.

Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli.

Sheth PR, Ramanathan L, Ranchod A, Basso AD, Barrett D, Zhao J, Gray K, Liu YH, Zhang R, Le HV.

Arch Biochem Biophys. 2010 Nov 15;503(2):191-201. doi: 10.1016/j.abb.2010.08.004. Epub 2010 Aug 10.

PMID:
20699085
15.

Purification and characterization of truncated human AMPK alpha 2 beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells.

Ramanathan L, Sheth PR, Ogas P, Xiao L, Le HV.

Protein Expr Purif. 2010 Mar;70(1):13-22. doi: 10.1016/j.pep.2009.10.007. Epub 2009 Oct 30.

PMID:
19836452
16.

Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein.

Sheth PR, Basso A, Duca JS, Lesburg CA, Ogas P, Gray K, Nale L, Mannarino AF, Prongay AJ, Le HV.

Biochemistry. 2009 Nov 24;48(46):11045-55. doi: 10.1021/bi900946r.

PMID:
19824700
17.

Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation.

Sheth PR, Hays JL, Elferink LA, Watowich SJ.

Biochemistry. 2008 Apr 1;47(13):4028-38. doi: 10.1021/bi701892f. Epub 2008 Mar 7.

18.

Oligomerization-induced differential dephosphorylation of c-Met receptor tyrosine kinase.

Sheth PR, Watowich SJ.

Biochemistry. 2005 Aug 23;44(33):10984-93.

PMID:
16101282
19.

Interaction of thyrotrophin releasing hormone with inhibin in male rats.

Sheth AR, Sheth PR, Roy R.

J Endocrinol. 1983 Jul;98(1):1-6.

PMID:
6408216
20.

Inhibin interaction with LHRH receptors at the pituitary level.

Sheth PR, Dandekar SP, Seethalakshmi N, Sheth AR.

Arch Androl. 1982 May;8(3):185-8.

PMID:
6285843
21.

Effect of weaning on gonadotropin levels in plasma & pituitary of female mice.

Raghavan V, Sheth PR, Nandedkar TD, Sheth AR.

Indian J Exp Biol. 1982 Mar;20(3):252. No abstract available.

PMID:
6811428
22.

Delta-9-tetrahydrocannabinol: its effect on hypothalamo-pituitary system in male rats.

Chakravarty I, Sheth PR, Sheth AR, Ghosh JJ.

Arch Androl. 1982 Feb;8(1):25-7.

PMID:
6279040
23.

Biological studies with low and high molecular weight inhibin preparations.

Vijayalakshmi S, Sheth PR, Dandekar SP, Vaze AY, Moodbidri SB, Sheth AR.

Int J Androl. 1981 Dec;4(6):691-702.

PMID:
6274806
24.

Involvement of GABA-aminergic system in endocrine regulation of prolactin.

Sheth PR, Sheth AR, Naik SR, Sheth UK.

Indian J Exp Biol. 1981 Sep;19(9):865-6. No abstract available.

PMID:
7309171
25.

Carboxymethylcellulose: effect of degree of polymerization and substitution on tablet disintegration and dissolution.

Shah NH, Lazarus JH, Sheth PR, Jarowski CI.

J Pharm Sci. 1981 Jun;70(6):611-3. No abstract available.

PMID:
7252800
26.

Evaluation of drug formulations using LD50 testing in mice.

Sheth PR, Shah NH, Pool W.

J Pharm Sci. 1977 Nov;66(11):1567-70.

PMID:
915733
27.

Effect of moisture on physical characteristics of tablets prepared from direct compression excipients.

Sangekar SA, Sarli M, Sheth PR.

J Pharm Sci. 1972 Jun;61(6):939-44. No abstract available.

PMID:
5046116

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