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Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora.

Hsieh H, Vignesh KS, Deepe GS Jr, Choubey D, Shertzer HG, Genter MB.

Toxicol In Vitro. 2016 Sep;35:24-30. doi: 10.1016/j.tiv.2016.05.003. Epub 2016 May 12.


Cytochrome b5 reductase and the control of lipid metabolism and healthspan.

Martin-Montalvo A, Sun Y, Diaz-Ruiz A, Ali A, Gutierrez V, Palacios HH, Curtis J, Siendones E, Ariza J, Abulwerdi GA, Sun X, Wang AX, Pearson KJ, Fishbein KW, Spencer RG, Wang M, Han X, Scheibye-Knudsen M, Baur JA, Shertzer HG, Navas P, Villalba JM, Zou S, Bernier M, de Cabo R.

NPJ Aging Mech Dis. 2016 May 12;2:16006. doi: 10.1038/npjamd.2016.6. eCollection 2016.


Branched-Chain Amino Acid Supplementation in Combination with Voluntary Running Improves Body Composition in Female C57BL/6 Mice.

Platt KM, Charnigo RJ, Shertzer HG, Pearson KJ.

J Diet Suppl. 2016;13(5):473-86. doi: 10.3109/19390211.2015.1112866. Epub 2015 Dec 30.


Glutathione defense mechanism in liver injury: insights from animal models.

Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V.

Food Chem Toxicol. 2013 Oct;60:38-44. doi: 10.1016/j.fct.2013.07.008. Epub 2013 Jul 12. Review.


Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain.

Shertzer HG, Krishan M, Genter MB.

Neurosci Lett. 2013 Aug 26;548:159-64. doi: 10.1016/j.neulet.2013.05.061. Epub 2013 Jun 6.


Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.

Dong H, Shertzer HG, Genter MB, Gonzalez FJ, Vasiliou V, Jefcoate C, Nebert DW.

Biochem Biophys Res Commun. 2013 Jun 14;435(4):727-32. doi: 10.1016/j.bbrc.2013.05.051. Epub 2013 May 18.


Distribution and systemic effects of intranasally administered 25 nm silver nanoparticles in adult mice.

Genter MB, Newman NC, Shertzer HG, Ali SF, Bolon B.

Toxicol Pathol. 2012 Oct;40(7):1004-13. Epub 2012 May 1.


Glutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosis.

Chen Y, Krishan M, Nebert DW, Shertzer HG.

Chem Res Toxicol. 2012 Jan 13;25(1):94-100. doi: 10.1021/tx200242a. Epub 2011 Dec 6.


Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action.

Thompson CM, Proctor DM, Suh M, Haws LC, Hébert CD, Mann JF, Shertzer HG, Hixon JG, Harris MA.

Toxicol Sci. 2012 Jan;125(1):79-90. doi: 10.1093/toxsci/kfr280. Epub 2011 Oct 19.


Lipid metabolism and body composition in Gclm(-/-) mice.

Kendig EL, Chen Y, Krishan M, Johansson E, Schneider SN, Genter MB, Nebert DW, Shertzer HG.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):338-48. doi: 10.1016/j.taap.2011.09.017. Epub 2011 Sep 24.


Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.

Thompson CM, Proctor DM, Haws LC, Hébert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG, Zacharewski TR, Harris MA.

Toxicol Sci. 2011 Sep;123(1):58-70. doi: 10.1093/toxsci/kfr164. Epub 2011 Jun 28.


Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet.

Shertzer HG, Woods SE, Krishan M, Genter MB, Pearson KJ.

J Nutr. 2011 Apr 1;141(4):582-7. doi: 10.3945/jn.110.133736. Epub 2011 Feb 10.


Oral N-acetylcysteine rescues lethality of hepatocyte-specific Gclc-knockout mice, providing a model for hepatic cirrhosis.

Chen Y, Johansson E, Yang Y, Miller ML, Shen D, Orlicky DJ, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP.

J Hepatol. 2010 Dec;53(6):1085-94. doi: 10.1016/j.jhep.2010.05.028. Epub 2010 Aug 11.


Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury.

Johansson E, Wesselkamper SC, Shertzer HG, Leikauf GD, Dalton TP, Chen Y.

Biochem Biophys Res Commun. 2010 May 28;396(2):407-12. doi: 10.1016/j.bbrc.2010.04.105. Epub 2010 Apr 22.


Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione.

Peng Z, Geh E, Chen L, Meng Q, Fan Y, Sartor M, Shertzer HG, Liu ZG, Puga A, Xia Y.

Mol Pharmacol. 2010 May;77(5):784-92. doi: 10.1124/mol.109.061424. Epub 2010 Feb 16.


Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole.

Shertzer HG, Kendig EL, Nasrallah HA, Johansson E, Genter MB.

Int J Obes (Lond). 2010 Jun;34(6):970-9. doi: 10.1038/ijo.2009.291. Epub 2010 Jan 12.


Protective effects of the antioxidant 4b,5,9b,10-tetrahydroindeno[1,2-b]indole against TCDD toxicity in C57BL/6J mice.

Shertzer HG.

Int J Toxicol. 2010 Jan-Feb;29(1):40-8. doi: 10.1177/1091581809352885. Epub 2009 Nov 19.


Early onset senescence occurs when fibroblasts lack the glutamate-cysteine ligase modifier subunit.

Chen Y, Johansson E, Fan Y, Shertzer HG, Vasiliou V, Nebert DW, Dalton TP.

Free Radic Biol Med. 2009 Aug 15;47(4):410-8. doi: 10.1016/j.freeradbiomed.2009.05.003. Epub 2009 May 8.


Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.

Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW.

Mol Pharmacol. 2009 Mar;75(3):555-67. doi: 10.1124/mol.108.051888. Epub 2008 Dec 1. Erratum in: Mol Pharmacol. 2009 Aug;76(2):452.


Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice.

Eismann T, Huber N, Shin T, Kuboki S, Galloway E, Wyder M, Edwards MJ, Greis KD, Shertzer HG, Fisher AB, Lentsch AB.

Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G266-74. doi: 10.1152/ajpgi.90583.2008. Epub 2008 Nov 25.


Tetrahydroindenoindole inhibits the progression of diabetes in mice.

Shertzer HG, Schneider SN, Kendig EL, Clegg DJ, D'Alessio DA, Johansson E, Genter MB.

Chem Biol Interact. 2009 Jan 15;177(1):71-80. doi: 10.1016/j.cbi.2008.09.001. Epub 2008 Sep 7.


Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor.

Reichard JF, Dalton TP, Shertzer HG, Puga A.

Dose Response. 2006 May 1;3(3):306-31. doi: 10.2203/dose-response.003.03.003.


Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet.

Kendig EL, Schneider SN, Clegg DJ, Genter MB, Shertzer HG.

Biochem Pharmacol. 2008 Jul 15;76(2):216-24. doi: 10.1016/j.bcp.2008.05.001. Epub 2008 May 7.


Acetaminophen normalizes glucose homeostasis in mouse models for diabetes.

Shertzer HG, Schneider SN, Kendig EL, Clegg DJ, D'Alessio DA, Genter MB.

Biochem Pharmacol. 2008 Mar 15;75(6):1402-10. doi: 10.1016/j.bcp.2007.12.003. Epub 2007 Dec 15.


A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity.

Peng Z, Peng L, Fan Y, Zandi E, Shertzer HG, Xia Y.

J Biol Chem. 2007 Jul 20;282(29):21487-96. Epub 2007 May 25.


Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase.

Yang Y, Chen Y, Johansson E, Schneider SN, Shertzer HG, Nebert DW, Dalton TP.

Biochem Pharmacol. 2007 Jul 15;74(2):372-81. Epub 2007 Feb 12.


Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure.

Chen Y, Yang Y, Miller ML, Shen D, Shertzer HG, Stringer KF, Wang B, Schneider SN, Nebert DW, Dalton TP.

Hepatology. 2007 May;45(5):1118-28.


7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.

Shertzer HG, Genter MB, Talaska G, Curran CP, Nebert DW, Dalton TP.

Carcinogenesis. 2007 Jun;28(6):1371-8. Epub 2006 Dec 13.


TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone.

Shertzer HG, Genter MB, Shen D, Nebert DW, Chen Y, Dalton TP.

Toxicol Appl Pharmacol. 2006 Dec 15;217(3):363-74. Epub 2006 Oct 4.


For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.

Dragin N, Dalton TP, Miller ML, Shertzer HG, Nebert DW.

J Biol Chem. 2006 Jul 7;281(27):18591-600. Epub 2006 Apr 24.


Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.

Genter MB, Clay CD, Dalton TP, Dong H, Nebert DW, Shertzer HG.

Biochem Biophys Res Commun. 2006 Apr 21;342(4):1375-81. Epub 2006 Feb 28.


Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.

Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW.

Mol Pharmacol. 2006 Apr;69(4):1103-14. Epub 2005 Dec 23.


Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl.

Curran CP, Miller KA, Dalton TP, Vorhees CV, Miller ML, Shertzer HG, Nebert DW.

Toxicol Sci. 2006 Feb;89(2):454-64. Epub 2005 Nov 16.


Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels.

Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP.

J Biol Chem. 2005 Oct 7;280(40):33766-74. Epub 2005 Aug 4.


Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status.

Kann S, Estes C, Reichard JF, Huang MY, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A.

Toxicol Sci. 2005 Oct;87(2):365-84. Epub 2005 Jul 13.


alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes.

Kadekaro AL, Kavanagh R, Kanto H, Terzieva S, Hauser J, Kobayashi N, Schwemberger S, Cornelius J, Babcock G, Shertzer HG, Scott G, Abdel-Malek ZA.

Cancer Res. 2005 May 15;65(10):4292-9.


Glutathione redox state regulates mitochondrial reactive oxygen production.

Shen D, Dalton TP, Nebert DW, Shertzer HG.

J Biol Chem. 2005 Jul 8;280(27):25305-12. Epub 2005 May 9.


Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.

Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW.

Hum Mutat. 2005 Feb;25(2):196-206.


Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation.

Deshmukh HS, Case LM, Wesselkamper SC, Borchers MT, Martin LD, Shertzer HG, Nadel JA, Leikauf GD.

Am J Respir Crit Care Med. 2005 Feb 15;171(4):305-14. Epub 2004 Nov 5.


Genetically altered mice to evaluate glutathione homeostasis in health and disease.

Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG.

Free Radic Biol Med. 2004 Nov 15;37(10):1511-26. Review.


Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.

Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW.

Mol Pharmacol. 2004 May;65(5):1225-37.


Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW.

Toxicol Appl Pharmacol. 2004 May 1;196(3):410-21.


Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes.

Shertzer HG, Clay CD, Genter MB, Chames MC, Schneider SN, Oakley GG, Nebert DW, Dalton TP.

Free Radic Biol Med. 2004 Mar 1;36(5):618-31.


Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.

Shertzer HG, Clay CD, Genter MB, Schneider SN, Nebert DW, Dalton TP.

Free Radic Biol Med. 2004 Mar 1;36(5):605-17.


Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.

Uno S, Wang B, Shertzer HG, Nebert DW, Dalton TP.

Biochem Biophys Res Commun. 2003 Dec 12;312(2):494-9.


High glucose concentration in isotonic media alters caco-2 cell permeability.

D'Souza VM, Shertzer HG, Menon AG, Pauletti GM.

AAPS PharmSci. 2003;5(3):E24.


Antioxidant perturbations in the olfactory mucosa of alachlor-treated rats.

Burman DM, Shertzer HG, Senft AP, Dalton TP, Genter MB.

Biochem Pharmacol. 2003 Nov 1;66(9):1707-15.


4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice.

Tsuneoka Y, Dalton TP, Miller ML, Clay CD, Shertzer HG, Talaska G, Medvedovic M, Nebert DW.

J Natl Cancer Inst. 2003 Aug 20;95(16):1227-37.


Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress.

Dieter MZ, Freshwater SL, Miller ML, Shertzer HG, Dalton TP, Nebert DW.

Free Radic Biol Med. 2003 Aug 15;35(4):351-67.


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