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Items: 1 to 50 of 93

1.

A first order phase transition mechanism underlies protein aggregation in mammalian cells.

Narayanan A, Meriin A, Andrews JO, Spille JH, Sherman MY, Cisse II.

Elife. 2019 Feb 4;8. pii: e39695. doi: 10.7554/eLife.39695.

2.

p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model.

Kolosova NG, Kozhevnikova OS, Telegina DV, Fursova AZ, Stefanova NA, Muraleva NA, Venanzi F, Sherman MY, Kolesnikov SI, Sufianov AA, Gabai VL, Shneider AM.

Aging (Albany NY). 2018 Aug 28;10(8):2136-2147. doi: 10.18632/aging.101537.

3.

New somatostatin-drug conjugates for effective targeting pancreatic cancer.

Ragozin E, Hesin A, Bazylevich A, Tuchinsky H, Bovina A, Shekhter Zahavi T, Oron-Herman M, Kostenich G, Firer MA, Rubinek T, Wolf I, Luboshits G, Sherman MY, Gellerman G.

Bioorg Med Chem. 2018 Jul 30;26(13):3825-3836. doi: 10.1016/j.bmc.2018.06.032. Epub 2018 Jun 30.

PMID:
30017114
4.

Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation.

Meriin AB, Narayanan A, Meng L, Alexandrov I, Varelas X, Cissé II, Sherman MY.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7043-E7052. doi: 10.1073/pnas.1803130115. Epub 2018 Jul 9.

5.

Translation inhibition corrects aberrant localization of mutant alanine-glyoxylate aminotransferase: possible therapeutic approach for hyperoxaluria.

Belostotsky R, Lyakhovetsky R, Sherman MY, Shkedy F, Tzvi-Behr S, Bar R, Hoppe B, Reusch B, Beck BB, Frishberg Y.

J Mol Med (Berl). 2018 Jul;96(7):621-630. doi: 10.1007/s00109-018-1651-8. Epub 2018 May 18.

PMID:
29777253
6.

Author Correction: Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.

Yaglom JA, Wang Y, Li A, Li Z, Monti S, Alexandrov I, Lu X, Sherman MY.

Sci Rep. 2018 May 2;8(1):7177. doi: 10.1038/s41598-018-24992-x.

7.

Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.

Yaglom JA, Wang Y, Li A, Li Z, Monti S, Alexandrov I, Lu X, Sherman MY.

Sci Rep. 2018 Feb 14;8(1):3010. doi: 10.1038/s41598-017-14900-0. Erratum in: Sci Rep. 2018 May 2;8(1):7177.

8.

Correction for Gabai et al., "Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR".

Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY.

Mol Cell Biol. 2017 Sep 26;37(20). pii: e00415-17. doi: 10.1128/MCB.00415-17. Print 2017 Oct 15. No abstract available.

9.

P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions.

Halenova T, Savchuk O, Ostapchenko L, Chursov A, Fridlyand N, Komissarov AB, Venanzi F, Kolesnikov SI, Sufianov AA, Sherman MY, Gabai VL, Shneider AM.

Oncotarget. 2017 Aug 3;8(34):56030-56040. doi: 10.18632/oncotarget.19840. eCollection 2017 Aug 22.

10.

The Damaging Effect of Passenger Mutations on Cancer Progression.

McFarland CD, Yaglom JA, Wojtkowiak JW, Scott JG, Morse DL, Sherman MY, Mirny LA.

Cancer Res. 2017 Sep 15;77(18):4763-4772. doi: 10.1158/0008-5472.CAN-15-3283-T. Epub 2017 May 23.

11.

Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration.

Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME.

Hum Mol Genet. 2017 Jan 15;26(2):305-319. doi: 10.1093/hmg/ddw387.

12.

Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells.

Gabai VL, Yaglom JA, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY.

Cancer Res. 2016 Oct 15;76(20):5926-5932. Epub 2016 Aug 8.

13.

The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins.

Lee do H, Sherman MY, Goldberg AL.

Biochem Biophys Res Commun. 2016 Jun 17;475(1):100-6. doi: 10.1016/j.bbrc.2016.05.046. Epub 2016 May 10.

14.

RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.

Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY.

EMBO J. 2015 Sep 14;34(18):2363-82. doi: 10.15252/embj.201591245. Epub 2015 Aug 24.

15.

Plasmid DNA-coding p62 as a bone effective anti-inflammatory/anabolic agent.

Sabbieti MG, Agas D, Capitani M, Marchetti L, Concetti A, Vullo C, Catone G, Gabai V, Shifrin V, Sherman MY, Shneider A, Venanzi FM.

Oncotarget. 2015 Feb 28;6(6):3590-9.

16.

Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis.

Gong J, Weng D, Eguchi T, Murshid A, Sherman MY, Song B, Calderwood SK.

Oncogene. 2015 Oct;34(43):5460-71. doi: 10.1038/onc.2015.1. Epub 2015 Feb 9.

PMID:
25659585
17.

Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.

Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE.

Mol Cancer Ther. 2015 Mar;14(3):642-8. doi: 10.1158/1535-7163.MCT-14-0650. Epub 2015 Jan 6.

18.

Hsp70 in cancer: back to the future.

Sherman MY, Gabai VL.

Oncogene. 2015 Aug 6;34(32):4153-61. doi: 10.1038/onc.2014.349. Epub 2014 Oct 27. Review.

19.

Pilot study of p62 DNA vaccine in dogs with mammary tumors.

Gabai V, Venanzi FM, Bagashova E, Rud O, Mariotti F, Vullo C, Catone G, Sherman MY, Concetti A, Chursov A, Latanova A, Shcherbinina V, Shifrin V, Shneider A.

Oncotarget. 2014 Dec 30;5(24):12803-10.

20.

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer.

Yaglom JA, McFarland C, Mirny L, Sherman MY.

Oncotarget. 2014 Sep 30;5(18):8367-78.

21.

Hsp70-Bag3 interactions regulate cancer-related signaling networks.

Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY.

Cancer Res. 2014 Sep 1;74(17):4731-40. doi: 10.1158/0008-5472.CAN-14-0747. Epub 2014 Jul 3.

22.

Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70.

Colvin TA, Gabai VL, Sherman MY.

Cell Cycle. 2014;13(14):2306-10. doi: 10.4161/cc.29296. Epub 2014 Jun 9.

23.

Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport.

Zaarur N, Meriin AB, Bejarano E, Xu X, Gabai VL, Cuervo AM, Sherman MY.

Mol Cell Biol. 2014 Apr;34(7):1336-48. doi: 10.1128/MCB.00103-14. Epub 2014 Jan 27.

24.

Less is more: improving proteostasis by translation slow down.

Sherman MY, Qian SB.

Trends Biochem Sci. 2013 Dec;38(12):585-91. doi: 10.1016/j.tibs.2013.09.003. Epub 2013 Oct 11. Review.

PMID:
24126073
25.

ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis.

Bergholz J, Zhang Y, Wu J, Meng L, Walsh EM, Rai A, Sherman MY, Xiao ZX.

Oncogene. 2014 Jan 9;33(2):212-24. doi: 10.1038/onc.2012.564. Epub 2012 Dec 17.

26.

Molecular determinants of selective clearance of protein inclusions by autophagy.

Wong E, Bejarano E, Rakshit M, Lee K, Hanson HH, Zaarur N, Phillips GR, Sherman MY, Cuervo AM.

Nat Commun. 2012;3:1240. doi: 10.1038/ncomms2244.

27.

A novel approach to recovery of function of mutant proteins by slowing down translation.

Meriin AB, Mense M, Colbert JD, Liang F, Bihler H, Zaarur N, Rock KL, Sherman MY.

J Biol Chem. 2012 Oct 5;287(41):34264-72. doi: 10.1074/jbc.M112.397307. Epub 2012 Aug 17.

28.

Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast.

Gong H, Romanova NV, Allen KD, Chandramowlishwaran P, Gokhale K, Newnam GP, Mieczkowski P, Sherman MY, Chernoff YO.

PLoS Genet. 2012;8(4):e1002634. doi: 10.1371/journal.pgen.1002634. Epub 2012 Apr 19.

29.

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype.

Kim G, Meriin AB, Gabai VL, Christians E, Benjamin I, Wilson A, Wolozin B, Sherman MY.

Aging Cell. 2012 Aug;11(4):617-27. doi: 10.1111/j.1474-9726.2012.00827.x. Epub 2012 May 22.

30.

Association of translation factor eEF1A with defective ribosomal products generates a signal for aggresome formation.

Meriin AB, Zaarur N, Sherman MY.

J Cell Sci. 2012 Jun 1;125(Pt 11):2665-74. doi: 10.1242/jcs.098954. Epub 2012 Feb 22.

31.

Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR.

Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY.

Mol Cell Biol. 2012 Mar;32(5):929-40. doi: 10.1128/MCB.05921-11. Epub 2012 Jan 3. Erratum in: Mol Cell Biol. 2017 Sep 26;37(20):.

32.

Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells.

Sherman MY, Meng L, Stampfer M, Gabai VL, Yaglom JA.

Aging Cell. 2011 Dec;10(6):949-61. doi: 10.1111/j.1474-9726.2011.00736.x. Epub 2011 Sep 16.

33.

Proteotoxic stress targeted therapy (PSTT).

Sherman MY.

Oncotarget. 2011 May;2(5):356-7. No abstract available.

34.

Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis.

Meng L, Hunt C, Yaglom JA, Gabai VL, Sherman MY.

Oncogene. 2011 Jun 23;30(25):2836-45. doi: 10.1038/onc.2011.5. Epub 2011 Feb 7.

35.

Induction of heat shock protein 70 inhibits ischemic renal injury.

Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC.

Kidney Int. 2011 Apr;79(8):861-70. doi: 10.1038/ki.2010.527. Epub 2011 Jan 26.

36.

Isolation of aggresomes and other large aggregates.

Meriin AB, Wang Y, Sherman MY.

Curr Protoc Cell Biol. 2010 Sep;Chapter 3:Unit 3.38.1-9. doi: 10.1002/0471143030.cb0338s48.

37.

Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.

Meng L, Gabai VL, Sherman MY.

Oncogene. 2010 Sep 16;29(37):5204-13. doi: 10.1038/onc.2010.277. Epub 2010 Jul 12.

38.

HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling.

Gabai VL, Sherman MY, Yaglom JA.

Oncogene. 2010 Apr 1;29(13):1952-62. doi: 10.1038/onc.2009.480. Epub 2010 Jan 11.

PMID:
20062073
39.

Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells.

Gabai VL, Yaglom JA, Waldman T, Sherman MY.

Mol Cell Biol. 2009 Jan;29(2):559-69. doi: 10.1128/MCB.01041-08. Epub 2008 Nov 10.

40.

Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery.

Wang Y, Meriin AB, Zaarur N, Romanova NV, Chernoff YO, Costello CE, Sherman MY.

FASEB J. 2009 Feb;23(2):451-63. doi: 10.1096/fj.08-117614. Epub 2008 Oct 14.

41.

Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1.

Zaarur N, Meriin AB, Gabai VL, Sherman MY.

J Biol Chem. 2008 Oct 10;283(41):27575-84. doi: 10.1074/jbc.M802216200. Epub 2008 Jul 17.

42.

Adjuvant potential of aggregate-forming polyglutamine domains.

Ilyinskii PO, Thoidis G, Sherman MY, Shneider A.

Vaccine. 2008 Jun 19;26(26):3223-6. doi: 10.1016/j.vaccine.2008.03.078. Epub 2008 Apr 18.

PMID:
18467011
43.

Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses.

Gabai VL, O'Callaghan-Sunol C, Meng L, Sherman MY, Yaglom J.

Cancer Res. 2008 Mar 15;68(6):1834-42. doi: 10.1158/0008-5472.CAN-07-5656.

44.

OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.

Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, Dent P.

Mol Pharmacol. 2008 Apr;73(4):1168-84. doi: 10.1124/mol.107.042697. Epub 2008 Jan 8.

45.

Hsp27 modulates p53 signaling and suppresses cellular senescence.

O'Callaghan-Sunol C, Gabai VL, Sherman MY.

Cancer Res. 2007 Dec 15;67(24):11779-88.

46.

Molecular chaperones regulate p53 and suppress senescence programs.

Sherman MY, Gabai V, O'Callaghan C, Yaglom J.

FEBS Lett. 2007 Jul 31;581(19):3711-5. Epub 2007 May 25. Review. Erratum in: FEBS Lett. 2007 Dec 11;581(29):5732. Sherman, Michael [corrected to Sherman, Michael Y].

47.
48.

Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains.

Meriin AB, Zhang X, Alexandrov IM, Salnikova AB, Ter-Avanesian MD, Chernoff YO, Sherman MY.

FASEB J. 2007 Jun;21(8):1915-25. Epub 2007 Mar 6.

PMID:
17341688
49.

High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways.

Yaglom JA, Gabai VL, Sherman MY.

Cancer Res. 2007 Mar 1;67(5):2373-81.

50.

Heat shock transcription factor (HSF1) plays a critical role in cell migration via maintaining MAP kinase signaling.

O'Callaghan-Sunol C, Sherman MY.

Cell Cycle. 2006 Jul;5(13):1431-7. Epub 2006 Jul 1.

PMID:
16855393

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