Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 286


Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase.

Dan Q, Newmister SA, Klas KR, Fraley AE, McAfoos TJ, Somoza AD, Sunderhaus JD, Ye Y, Shende VV, Yu F, Sanders JN, Brown WC, Zhao L, Paton RS, Houk KN, Smith JL, Sherman DH, Williams RM.

Nat Chem. 2019 Sep 23. doi: 10.1038/s41557-019-0326-6. [Epub ahead of print]


DDAP: docking domain affinity and biosynthetic pathway prediction tool for type I polyketide synthases.

Li T, Tripathi A, Yu F, Sherman DH, Rao A.

Bioinformatics. 2019 Sep 3. pii: btz677. doi: 10.1093/bioinformatics/btz677. [Epub ahead of print]


Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450.

DeMars MD 2nd, Samora NL, Yang S, Garcia-Borràs M, Sanders JN, Houk KN, Podust LM, Sherman DH.

J Biol Chem. 2019 Sep 5. pii: jbc.RA119.010352. doi: 10.1074/jbc.RA119.010352. [Epub ahead of print]


Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.

Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15895-15900. doi: 10.1073/pnas.1818547116. Epub 2019 Jul 23.


Engineered Production of Hapalindole Alkaloids in the Cyanobacterium Synechococcus sp. UTEX 2973.

Knoot CJ, Khatri Y, Hohlman RM, Sherman DH, Pakrasi HB.

ACS Synth Biol. 2019 Aug 16;8(8):1941-1951. doi: 10.1021/acssynbio.9b00229. Epub 2019 Jul 19.


Isolation of a new indoxyl alkaloid, Amoenamide B, from Aspergillus amoenus NRRL 35600: biosynthetic implications and correction of the structure of Speramide B.

Kai A, Kato H, Sherman DH, Williams RM, Tsukamoto S.

Tetrahedron Lett. 2018 Nov 28;50(48):4236-4240. doi: 10.1016/j.tetlet.2018.10.034. Epub 2018 Oct 20.


Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units.

Kalkreuter E, CroweTipton JM, Lowell AN, Sherman DH, Williams GJ.

J Am Chem Soc. 2019 Feb 6;141(5):1961-1969. doi: 10.1021/jacs.8b10521. Epub 2019 Jan 24.


Structural Basis of Polyketide Synthase O-Methylation.

Skiba MA, Bivins MM, Schultz JR, Bernard SM, Fiers WD, Dan Q, Kulkarni S, Wipf P, Gerwick WH, Sherman DH, Aldrich CC, Smith JL.

ACS Chem Biol. 2018 Dec 21;13(12):3221-3228. doi: 10.1021/acschembio.8b00687. Epub 2018 Dec 3.


Petrobactin Protects against Oxidative Stress and Enhances Sporulation Efficiency in Bacillus anthracis Sterne.

Hagan AK, Plotnick YM, Dingle RE, Mendel ZI, Cendrowski SR, Sherman DH, Tripathi A, Hanna PC.

MBio. 2018 Nov 6;9(6). pii: e02079-18. doi: 10.1128/mBio.02079-18.


Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.

Newmister SA, Romminger S, Schmidt JJ, Williams RM, Smith JL, Berlinck RGS, Sherman DH.

Org Biomol Chem. 2018 Sep 11;16(35):6450-6459. doi: 10.1039/c8ob01565a.


A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster.

McDonnell KJ, Chemler JA, Bartels PL, O'Brien E, Marvin ML, Ortega J, Stern RH, Raskin L, Li GM, Sherman DH, Barton JK, Gruber SB.

Nat Chem. 2018 Aug;10(8):873-880. doi: 10.1038/s41557-018-0068-x. Epub 2018 Jun 18.


Chemoenzymatic Dissection of Polyketide β-Branching in the Bryostatin Pathway.

Slocum ST, Lowell AN, Tripathi A, Shende VV, Smith JL, Sherman DH.

Methods Enzymol. 2018;604:207-236. doi: 10.1016/bs.mie.2018.01.034. Epub 2018 Apr 9.


A Defined and Flexible Pocket Explains Aryl Substrate Promiscuity of the Cahuitamycin Starter Unit-Activating Enzyme CahJ.

Tripathi A, Park SR, Sikkema AP, Cho HJ, Wu J, Lee B, Xi C, Smith JL, Sherman DH.

Chembiochem. 2018 Aug 6;19(15):1595-1600. doi: 10.1002/cbic.201800233. Epub 2018 Jun 21.


Halogenase engineering and its utility in medicinal chemistry.

Fraley AE, Sherman DH.

Bioorg Med Chem Lett. 2018 Jun 15;28(11):1992-1999. doi: 10.1016/j.bmcl.2018.04.066. Epub 2018 Apr 30. Review.


Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.

Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL.

ACS Chem Biol. 2018 Jun 15;13(6):1640-1650. doi: 10.1021/acschembio.8b00252. Epub 2018 May 8.


Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi.

Klas KR, Kato H, Frisvad JC, Yu F, Newmister SA, Fraley AE, Sherman DH, Tsukamoto S, Williams RM.

Nat Prod Rep. 2018 Jun 20;35(6):532-558. doi: 10.1039/c7np00042a. Review.


Isolation of amoenamide A and five antipodal prenylated alkaloids from Aspergillus amoenus NRRL 35600.

Sugimoto K, Sadahiro Y, Kagiyama I, Kato H, Sherman DH, Williams RM, Tsukamoto S.

Tetrahedron Lett. 2017 Jul 19;58(29):2797-2800. doi: 10.1016/j.tetlet.2017.05.057. Epub 2017 May 18.


Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis.

Newmister SA, Li S, Garcia-Borràs M, Sanders JN, Yang S, Lowell AN, Yu F, Smith JL, Williams RM, Houk KN, Sherman DH.

Nat Chem Biol. 2018 Apr;14(4):345-351. doi: 10.1038/s41589-018-0003-x. Epub 2018 Mar 12.


Synthesis of Diverse 11- and 12-Membered Macrolactones from a Common Linear Substrate Using a Single Biocatalyst.

Gilbert MM, DeMars MD 2nd, Yang S, Grandner JM, Wang S, Wang H, Narayan ARH, Sherman DH, Houk KN, Montgomery J.

ACS Cent Sci. 2017 Dec 27;3(12):1304-1310. doi: 10.1021/acscentsci.7b00450. Epub 2017 Nov 15.


Correction to "Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Terrestrial Fungus Aspergillus amoenus: Biogenetic Implications".

Kato H, Nakahara T, Sugimoto K, Matsuo K, Kagiyama I, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S.

Org Lett. 2018 Jan 5;20(1):315. doi: 10.1021/acs.orglett.7b03781. Epub 2017 Dec 13. No abstract available.


Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.

Mike LA, Tripathi A, Blankenship CM, Saluk A, Schultz PJ, Tamayo-Castillo G, Sherman DH, Mobley HLT.

Chem Commun (Camb). 2017 Nov 28;53(95):12778-12781. doi: 10.1039/c7cc07732g.


A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL.

ACS Chem Biol. 2017 Dec 15;12(12):3039-3048. doi: 10.1021/acschembio.7b00746. Epub 2017 Nov 14.


Erratum for Hagan et al., "Petrobactin Is Exported from Bacillus anthracis by the RND-Type Exporter ApeX".

Hagan AK, Tripathi A, Berger D, Sherman DH, Hanna PC.

MBio. 2017 Oct 17;8(5). pii: e01686-17. doi: 10.1128/mBio.01686-17. No abstract available.


Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.

Zhang X, Li Z, Du L, Chlipala GE, Lopez PC, Zhang W, Sherman DH, Li S.

Tetrahedron Lett. 2016 Dec 28;57(52):5919-5923. doi: 10.1016/j.tetlet.2016.11.080. Epub 2016 Nov 19.


Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.

Almutairi MM, Svetlov MS, Hansen DA, Khabibullina NF, Klepacki D, Kang HY, Sherman DH, Vázquez-Laslop N, Polikanov YS, Mankin AS.

Nucleic Acids Res. 2017 Sep 19;45(16):9573-9582. doi: 10.1093/nar/gkx673.


Petrobactin Is Exported from Bacillus anthracis by the RND-Type Exporter ApeX.

Hagan AK, Tripathi A, Berger D, Sherman DH, Hanna PC.

MBio. 2017 Sep 12;8(5). pii: e01238-17. doi: 10.1128/mBio.01238-17. Erratum in: MBio. 2017 Oct 17;8(5):.


Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides.

Hansen DA, Koch AA, Sherman DH.

J Am Chem Soc. 2017 Sep 27;139(38):13450-13455. doi: 10.1021/jacs.7b06432. Epub 2017 Sep 19.


A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst.

Koch AA, Hansen DA, Shende VV, Furan LR, Houk KN, Jiménez-Osés G, Sherman DH.

J Am Chem Soc. 2017 Sep 27;139(38):13456-13465. doi: 10.1021/jacs.7b06436. Epub 2017 Sep 19.


Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.

Fraley AE, Garcia-Borràs M, Tripathi A, Khare D, Mercado-Marin EV, Tran H, Dan Q, Webb GP, Watts KR, Crews P, Sarpong R, Williams RM, Smith JL, Houk KN, Sherman DH.

J Am Chem Soc. 2017 Aug 30;139(34):12060-12068. doi: 10.1021/jacs.7b06773. Epub 2017 Aug 21.


High-quality draft genome sequence of a biofilm forming lignocellulolytic Aspergillus niger strain ATCC 10864.

Paul S, Ludeña Y, Villena GK, Yu F, Sherman DH, Gutiérrez-Correa M.

Stand Genomic Sci. 2017 Jul 17;12:37. doi: 10.1186/s40793-017-0254-2. eCollection 2017.


Regiodivergent Glycosylations of 6-Deoxy-erythronolide B and Oleandomycin-Derived Macrolactones Enabled by Chiral Acid Catalysis.

Tay JH, Argüelles AJ, DeMars MD 2nd, Zimmerman PM, Sherman DH, Nagorny P.

J Am Chem Soc. 2017 Jun 28;139(25):8570-8578. doi: 10.1021/jacs.7b03198. Epub 2017 Jun 19.


Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

Lowell AN, DeMars MD 2nd, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH.

J Am Chem Soc. 2017 Jun 14;139(23):7913-7920. doi: 10.1021/jacs.7b02875. Epub 2017 Jun 5.


Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG.

Tietz DR, Podust LM, Sherman DH, Pochapsky TC.

Biochemistry. 2017 May 30;56(21):2701-2714. doi: 10.1021/acs.biochem.7b00291. Epub 2017 May 16.


Insights from the genome of a high alkaline cellulase producing Aspergillus fumigatus strain obtained from Peruvian Amazon rainforest.

Paul S, Zhang A, Ludeña Y, Villena GK, Yu F, Sherman DH, Gutiérrez-Correa M.

J Biotechnol. 2017 Jun 10;251:53-58. doi: 10.1016/j.jbiotec.2017.04.010. Epub 2017 Apr 12.


Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii.

Li Z, Du L, Zhang W, Zhang X, Jiang Y, Liu K, Men P, Xu H, Fortman JL, Sherman DH, Yu B, Gao S, Li S.

J Biol Chem. 2017 Apr 28;292(17):7095-7104. doi: 10.1074/jbc.M116.751255. Epub 2017 Mar 14.


Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.

Li S, Lowell AN, Newmister SA, Yu F, Williams RM, Sherman DH.

Nat Chem Biol. 2017 May;13(5):467-469. doi: 10.1038/nchembio.2327. Epub 2017 Mar 13.


Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.

Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ.

ACS Chem Biol. 2017 Jan 20;12(1):114-123. doi: 10.1021/acschembio.6b00732. Epub 2016 Nov 29.


Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.

Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC.

J Am Chem Soc. 2016 Dec 14;138(49):16024-16036. Epub 2016 Nov 30.


Environmental Pseudomonads Inhibit Cystic Fibrosis Patient-Derived Pseudomonas aeruginosa.

Chatterjee P, Davis E, Yu F, James S, Wildschutte JH, Wiegmann DD, Sherman DH, McKay RM, LiPuma JJ, Wildschutte H.

Appl Environ Microbiol. 2016 Dec 30;83(2). pii: e02701-16. doi: 10.1128/AEM.02701-16. Print 2017 Jan 15.


Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL.

ACS Chem Biol. 2016 Dec 16;11(12):3319-3327. Epub 2016 Oct 18.


Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.

Maloney FP, Gerwick L, Gerwick WH, Sherman DH, Smith JL.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10316-21. doi: 10.1073/pnas.1607210113. Epub 2016 Aug 29.


OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30.

Newmister SA, Gober CM, Romminger S, Yu F, Tripathi A, Parra LL, Williams RM, Berlinck RG, Joullié MM, Sherman DH.

J Am Chem Soc. 2016 Sep 7;138(35):11176-84. doi: 10.1021/jacs.6b04915. Epub 2016 Aug 24.


Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.

DeMars MD 2nd, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH.

ACS Chem Biol. 2016 Sep 16;11(9):2642-54. doi: 10.1021/acschembio.6b00479. Epub 2016 Aug 5.


Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.

Tripathi A, Choi SS, Sherman DH, Kim ES.

J Ind Microbiol Biotechnol. 2016 Aug;43(8):1189-93. doi: 10.1007/s10295-016-1790-2. Epub 2016 Jun 9.


Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway.

Park SR, Tripathi A, Wu J, Schultz PJ, Yim I, McQuade TJ, Yu F, Arevang CJ, Mensah AY, Tamayo-Castillo G, Xi C, Sherman DH.

Nat Commun. 2016 Feb 16;7:10710. doi: 10.1038/ncomms10710.


The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide.

Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH.

Chembiochem. 2016 Jan;17(2):164-73. doi: 10.1002/cbic.201500467. Epub 2015 Dec 23.


Unique marine derived cyanobacterial biosynthetic genes for chemical diversity.

Kleigrewe K, Gerwick L, Sherman DH, Gerwick WH.

Nat Prod Rep. 2016 Feb;33(2):348-64. doi: 10.1039/c5np00097a. Review.


Taichunamides: Prenylated Indole Alkaloids from Aspergillus taichungensis (IBT 19404).

Kagiyama I, Kato H, Nehira T, Frisvad JC, Sherman DH, Williams RM, Tsukamoto S.

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1128-32. doi: 10.1002/anie.201509462. Epub 2015 Dec 8.


Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.

Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH.

J Am Chem Soc. 2015 Dec 16;137(49):15366-9. doi: 10.1021/jacs.5b10136. Epub 2015 Dec 2.


Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.

Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, Tamayo-Castillo G, Sherman DH, Kaufman RJ, Fribley AM.

ACS Med Chem Lett. 2015 Sep 8;6(11):1122-7. doi: 10.1021/acsmedchemlett.5b00133. eCollection 2015 Nov 12.

Supplemental Content

Loading ...
Support Center