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Antimicrob Agents Chemother. 2006 Apr;50(4):1561-3.

Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United States.

Author information

1
Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Pletz.Mathias@mh-hannover.de

Abstract

By use of a PCR-restriction fragment length polymorphism assay, we screened 496 levofloxacin-susceptible invasive pneumococcal strains (MIC<or=2 mg/liter) for quinolone resistance-determining region mutations known to confer fluoroquinolone resistance. Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations.

PMID:
16569885
PMCID:
PMC1426940
DOI:
10.1128/AAC.50.4.1561-1563.2006
[Indexed for MEDLINE]
Free PMC Article

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