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Vascular anomaly: Cause of infant respiratory distress and dysphagia.

Baig A, Fortner C, Rivera M, Merrow J, Gupta S, Sher E, Mortelliti A.

Respir Med Case Rep. 2019 Jul 16;28:100908. doi: 10.1016/j.rmcr.2019.100908. eCollection 2019.


Correlation of miRNA expression with intensity of neuropathic pain in man.

Tavares-Ferreira D, Lawless N, Bird EV, Atkins S, Collier D, Sher E, Malki K, Lambert DW, Boissonade FM.

Mol Pain. 2019 Jan-Dec;15:1744806919860323. doi: 10.1177/1744806919860323. No abstract available.


Modulation of TARP γ8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain.

Knopp KL, Simmons RMA, Guo W, Adams BL, Gardinier KM, Gernert DL, Ornstein PL, Porter W, Reel J, Ding C, Wang H, Qian Y, Burris KD, Need A, Barth V, Swanson S, Catlow J, Witkin JM, Zwart R, Sher E, Choong KC, Wall TM, Schober D, Felder CC, Kato AS, Bredt DS, Nisenbaum ES.

J Pharmacol Exp Ther. 2019 Jun;369(3):345-363. doi: 10.1124/jpet.118.250126. Epub 2019 Mar 25.


AR101 Oral Immunotherapy for Peanut Allergy.

PALISADE Group of Clinical Investigators, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW.

N Engl J Med. 2018 Nov 22;379(21):1991-2001. doi: 10.1056/NEJMoa1812856. Epub 2018 Nov 18.


Microtransplantation of human brain receptors into oocytes to tackle key questions in drug discovery.

Zwart R, Mazzo F, Sher E.

Drug Discov Today. 2019 Feb;24(2):533-543. doi: 10.1016/j.drudis.2018.10.015. Epub 2018 Nov 3. Review.


Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M1 receptors.

Broad LM, Sanger HE, Mogg AJ, Colvin EM, Zwart R, Evans DA, Pasqui F, Sher E, Wishart GN, Barth VN, Felder CC, Goldsmith PJ.

Br J Pharmacol. 2019 Jan;176(1):110-126. doi: 10.1111/bph.14510. Epub 2018 Nov 16.


Safety of a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in children: A randomized clinical trial.

Berger W, Sher E, Gawchik S, Fineman S.

Allergy Asthma Proc. 2018 Mar 1;39(2):110-116. doi: 10.2500/aap.2018.39.4116.


Real-world use of omalizumab in patients with chronic idiopathic/spontaneous urticaria in the United States.

Eghrari-Sabet J, Sher E, Kavati A, Pilon D, Zhdanava M, Balp MM, Lefebvre P, Ortiz B, Bernstein JA.

Allergy Asthma Proc. 2018 May 7;39(3):191-200. doi: 10.2500/aap.2018.39.4132. Epub 2018 Feb 19.


A snapshot of health information exchange across five nations: an investigation of frontline clinician experiences in emergency care.

Klapman S, Sher E, Adler-Milstein J.

J Am Med Inform Assoc. 2018 Jun 1;25(6):686-693. doi: 10.1093/jamia/ocx153.


Proteomic analysis of postsynaptic proteins in regions of the human neocortex.

Roy M, Sorokina O, Skene N, Simonnet C, Mazzo F, Zwart R, Sher E, Smith C, Armstrong JD, Grant SGN.

Nat Neurosci. 2018 Jan;21(1):130-138. doi: 10.1038/s41593-017-0025-9. Epub 2017 Dec 4.


Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay.

Fouillet A, Watson JF, Piekarz AD, Huang X, Li B, Priest B, Nisenbaum E, Sher E, Ursu D.

Mol Pain. 2017 Jan-Dec;13:1744806917745179. doi: 10.1177/1744806917745179. Epub 2017 Nov 22.


Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.

Zwart R, Reed H, Sher E.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):481-486. doi: 10.1016/j.bbrc.2017.11.036. Epub 2017 Nov 7.


Medical therapy versus dietary avoidance in eosinophilic esophagitis: Which approach is better?

Chehade M, Sher E.

Allergy Asthma Proc. 2017 May 1;38(3):170-176. doi: 10.2500/aap.2017.38.4036. Review.


Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.

Kato AS, Burris KD, Gardinier KM, Gernert DL, Porter WJ, Reel J, Ding C, Tu Y, Schober DA, Lee MR, Heinz BA, Fitch TE, Gleason SD, Catlow JT, Yu H, Fitzjohn SM, Pasqui F, Wang H, Qian Y, Sher E, Zwart R, Wafford KA, Rasmussen K, Ornstein PL, Isaac JT, Nisenbaum ES, Bredt DS, Witkin JM.

Nat Med. 2016 Dec;22(12):1496-1501. doi: 10.1038/nm.4221. Epub 2016 Nov 7.


A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M.

Zwart R, Reed H, Clarke S, Sher E.

Eur J Pharmacol. 2016 Nov 15;791:221-228. doi: 10.1016/j.ejphar.2016.08.037. Epub 2016 Aug 31.


An assessment of the central disposition of intranasally administered insulin lispro in the cerebrospinal fluid of healthy volunteers and beagle dogs.

Lowe S, Sher E, Wishart G, Jackson K, Yuen E, Brittain C, Fong SC, Clarke DO, Landschulz WH.

Drug Deliv Transl Res. 2017 Feb;7(1):11-15. doi: 10.1007/s13346-016-0325-8.


Reconstitution of synaptic Ion channels from rodent and human brain in Xenopus oocytes: a biochemical and electrophysiological characterization.

Mazzo F, Zwart R, Serratto GM, Gardinier KM, Porter W, Reel J, Maraula G, Sher E.

J Neurochem. 2016 Aug;138(3):384-96. doi: 10.1111/jnc.13675. Epub 2016 Jun 13.


Electrophysiological characterization of human and mouse sodium-dependent citrate transporters (NaCT/SLC13A5) reveal species differences with respect to substrate sensitivity and cation dependence.

Zwart R, Peeva PM, Rong JX, Sher E.

J Pharmacol Exp Ther. 2015 Nov;355(2):247-54. doi: 10.1124/jpet.115.226902. Epub 2015 Aug 31.


α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.

Thomsen MS, Zwart R, Ursu D, Jensen MM, Pinborg LH, Gilmour G, Wu J, Sher E, Mikkelsen JD.

PLoS One. 2015 Jun 18;10(6):e0130572. doi: 10.1371/journal.pone.0130572. eCollection 2015.


Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.

Chatzidaki A, Fouillet A, Li J, Dage J, Millar NS, Sher E, Ursu D.

PLoS One. 2015 Apr 23;10(4):e0125116. doi: 10.1371/journal.pone.0125116. eCollection 2015.


Can gas replace protein function? CO abrogates the oxidative toxicity of myoglobin.

Sher EA, Sholto AY, Shaklai M, Shaklai N.

PLoS One. 2014 Aug 11;9(8):e104075. doi: 10.1371/journal.pone.0104075. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e111565.


Perampanel, an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, for the treatment of epilepsy: studies in human epileptic brain and nonepileptic brain and in rodent models.

Zwart R, Sher E, Ping X, Jin X, Sims JR Jr, Chappell AS, Gleason SD, Hahn PJ, Gardinier K, Gernert DL, Hobbs J, Smith JL, Valli SN, Witkin JM.

J Pharmacol Exp Ther. 2014 Oct;351(1):124-33. doi: 10.1124/jpet.114.212779. Epub 2014 Jul 15.


Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.

Ursu D, Ebert P, Langron E, Ruble C, Munsie L, Zou W, Fijal B, Qian YW, McNearney TA, Mogg A, Grubisha O, Merchant K, Sher E.

Mol Pain. 2014 Jun 16;10:37. doi: 10.1186/1744-8069-10-37.


Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes.

Zwart R, Strotton M, Ching J, Astles PC, Sher E.

Eur J Pharmacol. 2014 Mar 5;726:77-86.


Intranasal corticosteroids: the role of patient preference and satisfaction.

Sher ER, Ross JA.

Allergy Asthma Proc. 2014 Jan-Feb;35(1):24-33. doi: 10.2500/aap.2014.35.3725. Review.


Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons.

Dage JL, Colvin EM, Fouillet A, Langron E, Roell WC, Li J, Mathur SX, Mogg AJ, Schmitt MG, Felder CC, Merchant KM, Isaac J, Broad LM, Sher E, Ursu D.

Psychopharmacology (Berl). 2014 Mar;231(6):1105-24. doi: 10.1007/s00213-013-3384-2. Epub 2014 Jan 16.


Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors.

Gill JK, Chatzidaki A, Ursu D, Sher E, Millar NS.

PLoS One. 2013;8(1):e55047. doi: 10.1371/journal.pone.0055047. Epub 2013 Jan 29.


The role of phosphodiesterases in hippocampal synaptic plasticity.

Sanderson TM, Sher E.

Neuropharmacology. 2013 Nov;74:86-95. doi: 10.1016/j.neuropharm.2013.01.011. Epub 2013 Jan 25. Review.


Evidence for anti-inflammatory and putative analgesic effects of a monoclonal antibody to calcitonin gene-related peptide.

Bowler KE, Worsley MA, Broad L, Sher E, Benschop R, Johnson K, Yates JM, Robinson PP, Boissonade FM.

Neuroscience. 2013 Jan 3;228:271-82. doi: 10.1016/j.neuroscience.2012.10.030. Epub 2012 Oct 22.


Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR.

Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, Findlay JD, Vivier RG, Sher E, Lodge D, Monn JA, Broad LM.

Neuropharmacology. 2013 Mar;66:264-73. doi: 10.1016/j.neuropharm.2012.05.023. Epub 2012 May 30.


Carbon monoxide promotes respiratory hemoproteins iron reduction using peroxides as electron donors.

Sher EA, Shaklai M, Shaklai N.

PLoS One. 2012;7(3):e33039. doi: 10.1371/journal.pone.0033039. Epub 2012 Mar 12.


A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.

Gill JK, Dhankher P, Sheppard TD, Sher E, Millar NS.

Mol Pharmacol. 2012 May;81(5):710-8. doi: 10.1124/mol.111.076026. Epub 2012 Feb 10.


The effect of a monoclonal antibody to calcitonin-gene related peptide (CGRP) on injury-induced ectopic discharge following lingual nerve injury.

Bowler KE, Worsley MA, Broad L, Sher E, Benschop R, Johnson K, Boissonade FM, Robinson PP, Yates JM.

Neurosci Lett. 2011 Nov 14;505(2):146-9. doi: 10.1016/j.neulet.2011.09.072. Epub 2011 Oct 8.


The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus.

Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TM, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD, Bahn S.

Neuropsychopharmacology. 2012 Jan;37(2):364-77. doi: 10.1038/npp.2011.219. Epub 2011 Sep 28.


Calcium-dependent inhibition of T-type calcium channels by TRPV1 activation in rat sensory neurons.

Comunanza V, Carbone E, Marcantoni A, Sher E, Ursu D.

Pflugers Arch. 2011 Nov;462(5):709-22. doi: 10.1007/s00424-011-1023-5. Epub 2011 Sep 9.


Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia.

Sanderson TM, Cotel MC, O'Neill MJ, Tricklebank MD, Collingridge GL, Sher E.

Neuropharmacology. 2012 Mar;62(3):1349-58. doi: 10.1016/j.neuropharm.2011.08.005. Epub 2011 Aug 16.


Precise quantification of haemoglobin in erythroid precursors and plasma.

Toobiak S, Sher EA, Shaklai M, Shaklai N.

Int J Lab Hematol. 2011 Dec;33(6):645-50. doi: 10.1111/j.1751-553X.2011.01338.x. Epub 2011 Jun 1.


Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Gill JK, Savolainen M, Young GT, Zwart R, Sher E, Millar NS.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5867-72. doi: 10.1073/pnas.1017975108. Epub 2011 Mar 21.


The subtype-selective nicotinic acetylcholine receptor positive allosteric potentiator 2087101 differentially facilitates neurotransmission in the brain.

de Filippi G, Mogg AJ, Phillips KG, Zwart R, Sher E, Chen Y.

Eur J Pharmacol. 2010 Sep 25;643(2-3):218-24. doi: 10.1016/j.ejphar.2010.06.064. Epub 2010 Jul 15.


Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity.

Ursu D, Knopp K, Beattie RE, Liu B, Sher E.

Eur J Pharmacol. 2010 Sep 1;641(2-3):114-22. doi: 10.1016/j.ejphar.2010.05.029. Epub 2010 Jun 8.


Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Young GT, Zwart R, Walker AS, Sher E, Millar NS.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14686-91. doi: 10.1073/pnas.0804372105. Epub 2008 Sep 12.


Sazetidine-A is a potent and selective agonist at native and recombinant alpha 4 beta 2 nicotinic acetylcholine receptors.

Zwart R, Carbone AL, Moroni M, Bermudez I, Mogg AJ, Folly EA, Broad LM, Williams AC, Zhang D, Ding C, Heinz BA, Sher E.

Mol Pharmacol. 2008 Jun;73(6):1838-43. doi: 10.1124/mol.108.045104. Epub 2008 Mar 26.


Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating.

Young GT, Broad LM, Zwart R, Astles PC, Bodkin M, Sher E, Millar NS.

Mol Pharmacol. 2007 Feb;71(2):389-97. Epub 2006 Oct 25.


Electrophysiological differences in seropositive and seronegative Lambert-Eaton myasthenic syndrome.

Oh SJ, Hatanaka Y, Claussen GC, Sher E.

Muscle Nerve. 2007 Feb;35(2):178-83.


Chaperone protein 14-3-3 and protein kinase A increase the relative abundance of low agonist sensitivity human alpha 4 beta 2 nicotinic acetylcholine receptors in Xenopus oocytes.

Exley R, Moroni M, Sasdelli F, Houlihan LM, Lukas RJ, Sher E, Zwart R, Bermudez I.

J Neurochem. 2006 Aug;98(3):876-85. Epub 2006 Jun 19.


Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation.

Gotti C, Moretti M, Bohr I, Ziabreva I, Vailati S, Longhi R, Riganti L, Gaimarri A, McKeith IG, Perry RH, Aarsland D, Larsen JP, Sher E, Beattie R, Clementi F, Court JA.

Neurobiol Dis. 2006 Aug;23(2):481-9. Epub 2006 Jun 8.


Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.

Broad LM, Zwart R, Pearson KH, Lee M, Wallace L, McPhie GI, Emkey R, Hollinshead SP, Dell CP, Baker SR, Sher E.

J Pharmacol Exp Ther. 2006 Sep;318(3):1108-17. Epub 2006 May 31.


alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.

Moroni M, Zwart R, Sher E, Cassels BK, Bermudez I.

Mol Pharmacol. 2006 Aug;70(2):755-68. Epub 2006 May 23.


5-I A-85380 and TC-2559 differentially activate heterologously expressed alpha4beta2 nicotinic receptors.

Zwart R, Broad LM, Xi Q, Lee M, Moroni M, Bermudez I, Sher E.

Eur J Pharmacol. 2006 Jun 6;539(1-2):10-7. Epub 2006 Apr 5.


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