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Items: 38

1.

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor.

Smelt CLC, Sanders VR, Newcombe J, Burt RP, Sheppard TD, Topf M, Millar NS.

Neuropharmacology. 2018 Jul 12. pii: S0028-3908(18)30367-8. doi: 10.1016/j.neuropharm.2018.07.009. [Epub ahead of print]

PMID:
30009834
2.

One-pot, two-step transaminase and transketolase synthesis of l-gluco-heptulose from l-arabinose.

Bawn M, Subrizi F, Lye GJ, Sheppard TD, Hailes HC, Ward JM.

Enzyme Microb Technol. 2018 Sep;116:16-22. doi: 10.1016/j.enzmictec.2018.05.006. Epub 2018 May 15.

3.

An Accessible Method for DFT Calculation of 11B NMR Shifts of Organoboron Compounds.

Rzepa HS, Arkhipenko S, Wan E, Sabatini MT, Karaluka V, Whiting A, Sheppard TD.

J Org Chem. 2018 Jul 11. doi: 10.1021/acs.joc.8b00859. [Epub ahead of print]

PMID:
29786438
4.

Mechanistic insights into boron-catalysed direct amidation reactions.

Arkhipenko S, Sabatini MT, Batsanov AS, Karaluka V, Sheppard TD, Rzepa HS, Whiting A.

Chem Sci. 2018 Jan 2;9(4):1058-1072. doi: 10.1039/c7sc03595k. eCollection 2018 Jan 28.

5.

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts.

Sabatini MT, Karaluka V, Lanigan RM, Boulton LT, Badland M, Sheppard TD.

Chemistry. 2018 May 11;24(27):7033-7043. doi: 10.1002/chem.201800372. Epub 2018 Apr 30.

6.

Silver-Free Palladium-Catalyzed C(sp3)-H Arylation of Saturated Bicyclic Amine Scaffolds.

Coomber CE, Benhamou L, Bučar DK, Smith PD, Porter MJ, Sheppard TD.

J Org Chem. 2018 Mar 2;83(5):2495-2503. doi: 10.1021/acs.joc.7b02665. Epub 2017 Dec 19.

PMID:
29241011
7.

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.

Newcombe J, Chatzidaki A, Sheppard TD, Topf M, Millar NS.

Mol Pharmacol. 2018 Feb;93(2):128-140. doi: 10.1124/mol.117.110551. Epub 2017 Dec 1.

8.

Borate esters: Simple catalysts for the sustainable synthesis of complex amides.

Sabatini MT, Boulton LT, Sheppard TD.

Sci Adv. 2017 Sep 22;3(9):e1701028. doi: 10.1126/sciadv.1701028. eCollection 2017 Sep.

9.

An integrated biorefinery concept for conversion of sugar beet pulp into value-added chemicals and pharmaceutical intermediates.

Cárdenas-Fernández M, Bawn M, Hamley-Bennett C, Bharat PKV, Subrizi F, Suhaili N, Ward DP, Bourdin S, Dalby PA, Hailes HC, Hewitson P, Ignatova S, Kontoravdi C, Leak DJ, Shah N, Sheppard TD, Ward JM, Lye GJ.

Faraday Discuss. 2017 Sep 21;202:415-431. doi: 10.1039/c7fd00094d.

10.

Synthesis of substituted benzooxaborinin-1-ols via palladium-catalysed cyclisation of alkenyl- and alkynyl-boronic acids.

Benhamou L, Walker DW, Bučar DK, Aliev AE, Sheppard TD.

Org Biomol Chem. 2016 Sep 14;14(34):8039-43. doi: 10.1039/c6ob01419d. Epub 2016 Aug 10.

PMID:
27506186
11.

Direct amidation of unprotected amino acids using B(OCH2CF3)3.

Lanigan RM, Karaluka V, Sabatini MT, Starkov P, Badland M, Boulton L, Sheppard TD.

Chem Commun (Camb). 2016 Jul 7;52(57):8846-9. doi: 10.1039/c6cc05147b.

PMID:
27346362
12.

Intercepting the Gold-Catalysed Meyer-Schuster Rearrangement by Controlled Protodemetallation: A Regioselective Hydration of Propargylic Alcohols.

Pennell MN, Kyle MP, Gibson SM, Male L, Turner PG, Grainger RS, Sheppard TD.

Adv Synth Catal. 2016 Apr 28;358(9):1519-1525. doi: 10.1002/adsc.201600101. Epub 2016 Apr 27.

13.

The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry.

Murray PM, Bellany F, Benhamou L, Bučar DK, Tabor AB, Sheppard TD.

Org Biomol Chem. 2016 Feb 28;14(8):2373-84. doi: 10.1039/c5ob01892g. Epub 2015 Dec 24.

PMID:
26699438
14.

HBF4-Catalysed Nucleophilic Substitutions of Propargylic Alcohols.

Barreiro E, Sanz-Vidal A, Tan E, Lau SH, Sheppard TD, Díez-González S.

European J Org Chem. 2015 Dec;2015(34):7544-7549. Epub 2015 Oct 29.

15.

Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses.

Foster RW, Tame CJ, Bučar DK, Hailes HC, Sheppard TD.

Chemistry. 2015 Nov 2;21(45):15947-50. doi: 10.1002/chem.201503510. Epub 2015 Sep 25.

16.

B(OCH2CF3)3-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether.

Karaluka V, Lanigan RM, Murray PM, Badland M, Sheppard TD.

Org Biomol Chem. 2015 Nov 28;13(44):10888-94. doi: 10.1039/c5ob01801c. Epub 2015 Sep 14.

PMID:
26366853
17.

A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines.

Gibson SM, Lanigan RM, Benhamou L, Aliev AE, Sheppard TD.

Org Biomol Chem. 2015 Sep 14;13(34):9050-4. doi: 10.1039/c5ob01398d. Epub 2015 Jul 29.

PMID:
26219531
18.

The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors.

Chatzidaki A, D'Oyley JM, Gill-Thind JK, Sheppard TD, Millar NS.

Neuropharmacology. 2015 Oct;97:75-85. doi: 10.1016/j.neuropharm.2015.05.006. Epub 2015 May 19.

19.

Irreversible endo-selective diels-alder reactions of substituted alkoxyfurans: a general synthesis of endo-cantharimides.

Foster RW, Benhamou L, Porter MJ, Bučar DK, Hailes HC, Tame CJ, Sheppard TD.

Chemistry. 2015 Apr 13;21(16):6107-14. doi: 10.1002/chem.201406286. Epub 2015 Mar 10.

20.

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.

Gill-Thind JK, Dhankher P, D'Oyley JM, Sheppard TD, Millar NS.

J Biol Chem. 2015 Feb 6;290(6):3552-62. doi: 10.1074/jbc.M114.619221. Epub 2014 Dec 16.

21.

Rapid assembly of functionalised spirocyclic indolines by palladium-catalysed dearomatising diallylation of indoles with allyl acetate.

Dhankher P, Benhamou L, Sheppard TD.

Chemistry. 2014 Oct 6;20(41):13375-81. doi: 10.1002/chem.201403940. Epub 2014 Aug 29.

22.

Regioselective dihalohydration reactions of propargylic alcohols: gold-catalyzed and noncatalyzed reactions.

D'Oyley JM, Aliev AE, Sheppard TD.

Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10747-50. doi: 10.1002/anie.201405348. Epub 2014 Aug 21.

23.

Gold catalysed synthesis of 3-alkoxyfurans at room temperature.

Pennell MN, Foster RW, Turner PG, Hailes HC, Tame CJ, Sheppard TD.

Chem Commun (Camb). 2014 Feb 9;50(11):1302-4. doi: 10.1039/c3cc48290a.

PMID:
24346257
24.

Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations.

Foster RW, Tame CJ, Hailes HC, Sheppard TD.

Adv Synth Catal. 2013 Aug 12;355(11-12):2353-2360.

25.

A rapid route to aminocyclopropanes via carbamatoorganozinc carbenoids.

Ishikawa S, Sheppard TD, D'Oyley JM, Kamimura A, Motherwell WB.

Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10060-3. doi: 10.1002/anie.201304720. Epub 2013 Aug 1.

26.

Motional timescale predictions by molecular dynamics simulations: case study using proline and hydroxyproline sidechain dynamics.

Aliev AE, Kulke M, Khaneja HS, Chudasama V, Sheppard TD, Lanigan RM.

Proteins. 2014 Feb;82(2):195-215. doi: 10.1002/prot.24350. Epub 2013 Sep 17.

27.

Direct synthesis of amides from carboxylic acids and amines using B(OCH2CF3)3.

Lanigan RM, Starkov P, Sheppard TD.

J Org Chem. 2013 May 3;78(9):4512-23. doi: 10.1021/jo400509n. Epub 2013 Apr 16.

28.

Gold- and silver-catalyzed reactions of propargylic alcohols in the presence of protic additives.

Pennell MN, Turner PG, Sheppard TD.

Chemistry. 2012 Apr 10;18(15):4748-58. doi: 10.1002/chem.201102830. Epub 2012 Feb 28.

PMID:
22374879
29.

A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.

Gill JK, Dhankher P, Sheppard TD, Sher E, Millar NS.

Mol Pharmacol. 2012 May;81(5):710-8. doi: 10.1124/mol.111.076026. Epub 2012 Feb 10.

30.

Rapid synthesis of highly functionalised α-amino amides and medium ring lactones using multicomponent reactions of amino alcohols and isocyanides.

Bachman M, Mann SE, Sheppard TD.

Org Biomol Chem. 2012 Jan 7;10(1):162-70. doi: 10.1039/c1ob06534c. Epub 2011 Nov 10.

PMID:
22076284
31.

A general procedure for the synthesis of enones via gold-catalyzed Meyer-Schuster rearrangement of propargylic alcohols at room temperature.

Pennell MN, Unthank MG, Turner P, Sheppard TD.

J Org Chem. 2011 Mar 4;76(5):1479-82. doi: 10.1021/jo102263t. Epub 2011 Jan 25.

PMID:
21265538
32.

Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides.

Starkov P, Sheppard TD.

Org Biomol Chem. 2011 Mar 7;9(5):1320-3. doi: 10.1039/c0ob01069c. Epub 2011 Jan 6.

PMID:
21212879
33.

How adolescents use SMS (short message service) to micro-coordinate contact with youth mental health outreach services.

Furber GV, Crago AE, Meehan K, Sheppard TD, Hooper K, Abbot DT, Allison S, Skene C.

J Adolesc Health. 2011 Jan;48(1):113-5. doi: 10.1016/j.jadohealth.2010.05.022.

PMID:
21185535
34.

An alternative approach to aldol reactions: gold-catalyzed formation of boron enolates from alkynes.

Körner C, Starkov P, Sheppard TD.

J Am Chem Soc. 2010 May 5;132(17):5968-9. doi: 10.1021/ja102129c.

PMID:
20380452
35.

Metal-catalysed halogen exchange reactions of aryl halides.

Sheppard TD.

Org Biomol Chem. 2009 Mar 21;7(6):1043-52. doi: 10.1039/b818155a. Epub 2009 Jan 30. Erratum in: Org Biomol Chem. 2009 Dec 21;7(24):5272.

PMID:
19262919
36.

Michael, Michael-aldol and Michael-Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives.

Ley SV, Dixon DJ, Guy RT, Rodríguez F, Sheppard TD.

Org Biomol Chem. 2005 Nov 21;3(22):4095-107. Epub 2005 Oct 19.

PMID:
16267589
37.

Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides.

Ley SV, Dixon DJ, Guy RT, Palomero MA, Polara A, Rodriguez F, Sheppard TD.

Org Biomol Chem. 2004 Dec 21;2(24):3618-27. Epub 2004 Nov 17.

PMID:
15592620
38.

Preparation of enantiopure butane-2,3-diacetals of glycolic acid and alkylation reactions leading to alpha-hydroxyacid and amide derivatives.

Ley SV, Diez E, Dixon DJ, Guy RT, Michel P, Nattrass GL, Sheppard TD.

Org Biomol Chem. 2004 Dec 21;2(24):3608-17. Epub 2004 Nov 17.

PMID:
15592619

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