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Items: 29


Overexpression of heat shock protein 72 attenuates NF-κB activation using a combination of regulatory mechanisms in microglia.

Sheppard PW, Sun X, Khammash M, Giffard RG.

PLoS Comput Biol. 2014 Feb 6;10(2):e1003471. doi: 10.1371/journal.pcbi.1003471. eCollection 2014 Feb.


Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain.

Giannini C, Kloß A, Gohlke S, Mishto M, Nicholson TP, Sheppard PW, Kloetzel PM, Dahlmann B.

PLoS One. 2013 May 7;8(5):e64042. doi: 10.1371/journal.pone.0064042. Print 2013.


SPSens: a software package for stochastic parameter sensitivity analysis of biochemical reaction networks.

Sheppard PW, Rathinam M, Khammash M.

Bioinformatics. 2013 Jan 1;29(1):140-2. doi: 10.1093/bioinformatics/bts642. Epub 2012 Oct 25.


A pathwise derivative approach to the computation of parameter sensitivities in discrete stochastic chemical systems.

Sheppard PW, Rathinam M, Khammash M.

J Chem Phys. 2012 Jan 21;136(3):034115. doi: 10.1063/1.3677230.


Quantitative characterization and analysis of the dynamic NF-κB response in microglia.

Sheppard PW, Sun X, Emery JF, Giffard RG, Khammash M.

BMC Bioinformatics. 2011 Jul 5;12:276. doi: 10.1186/1471-2105-12-276.


Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies.

Shen D, Coleman J, Chan E, Nicholson TP, Dai L, Sheppard PW, Patton WF.

Cell Biochem Biophys. 2011 Jul;60(3):173-85. doi: 10.1007/s12013-010-9138-4.


USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.

Aichem A, Pelzer C, Lukasiak S, Kalveram B, Sheppard PW, Rani N, Schmidtke G, Groettrup M.

Nat Commun. 2010 May 4;1:13. doi: 10.1038/ncomms1012.


Assembly, structure, and function of the 26S proteasome.

Bedford L, Paine S, Sheppard PW, Mayer RJ, Roelofs J.

Trends Cell Biol. 2010 Jul;20(7):391-401. doi: 10.1016/j.tcb.2010.03.007. Epub 2010 Apr 26. Review.


Efficient computation of parameter sensitivities of discrete stochastic chemical reaction networks.

Rathinam M, Sheppard PW, Khammash M.

J Chem Phys. 2010 Jan 21;132(3):034103. doi: 10.1063/1.3280166.


Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration.

Paine S, Bedford L, Thorpe JR, Mayer RJ, Cavey JR, Bajaj N, Sheppard PW, Lowe J, Layfield R.

Neurosci Lett. 2009 Sep 4;460(3):205-8. doi: 10.1016/j.neulet.2009.05.074. Epub 2009 Jun 7.


Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin.

Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Häcker H, Karin M, Vignali DA.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20197-202. doi: 10.1073/pnas.0810461105. Epub 2008 Dec 17.


Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone.

Najat D, Garner T, Hagen T, Shaw B, Sheppard PW, Falchetti A, Marini F, Brandi ML, Long JE, Cavey JR, Searle MS, Layfield R.

J Bone Miner Res. 2009 Apr;24(4):632-42. doi: 10.1359/jbmr.081204.


The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities.

Kloss A, Henklein P, Siele D, Schmolke M, Apcher S, Kuehn L, Sheppard PW, Dahlmann B.

Eur J Pharm Biopharm. 2009 May;72(1):219-25. doi: 10.1016/j.ejpb.2008.10.016. Epub 2008 Nov 7.


Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

Bedford L, Hay D, Devoy A, Paine S, Powe DG, Seth R, Gray T, Topham I, Fone K, Rezvani N, Mee M, Soane T, Layfield R, Sheppard PW, Ebendal T, Usoskin D, Lowe J, Mayer RJ.

J Neurosci. 2008 Aug 13;28(33):8189-98. doi: 10.1523/JNEUROSCI.2218-08.2008.


Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.

Reynolds CH, Garwood CJ, Wray S, Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM, Hanger DP, Anderton BH.

J Biol Chem. 2008 Jun 27;283(26):18177-86. doi: 10.1074/jbc.M709715200. Epub 2008 May 8.


Proteasome subunit proteins and neuropathology in tauopathies and synucleinopathies: Consequences for proteomic analyses.

Zouambia M, Fischer DF, Hobo B, De Vos RA, Hol EM, Varndell IM, Sheppard PW, Van Leeuwen FW.

Proteomics. 2008 Mar;8(6):1221-36. doi: 10.1002/pmic.200700679.


Ubiquitin recognition by the ubiquitin-associated domain of p62 involves a novel conformational switch.

Long J, Gallagher TR, Cavey JR, Sheppard PW, Ralston SH, Layfield R, Searle MS.

J Biol Chem. 2008 Feb 29;283(9):5427-40. Epub 2007 Dec 14.


p62 mutations, ubiquitin recognition and Paget's disease of bone.

Layfield R, Cavey JR, Najat D, Long J, Sheppard PW, Ralston SH, Searle MS.

Biochem Soc Trans. 2006 Nov;34(Pt 5):735-7.


Loss of ubiquitin binding is a unifying mechanism by which mutations of SQSTM1 cause Paget's disease of bone.

Cavey JR, Ralston SH, Sheppard PW, Ciani B, Gallagher TR, Long JE, Searle MS, Layfield R.

Calcif Tissue Int. 2006 May;78(5):271-7. Epub 2006 May 6.


Loss of ubiquitin-binding associated with Paget's disease of bone p62 (SQSTM1) mutations.

Cavey JR, Ralston SH, Hocking LJ, Sheppard PW, Ciani B, Searle MS, Layfield R.

J Bone Miner Res. 2005 Apr;20(4):619-24. Epub 2004 Dec 6.


Structural and functional studies of mutations affecting the UBA domain of SQSTM1 (p62) which cause Paget's disease of bone.

Layfield R, Ciani B, Ralston SH, Hocking LJ, Sheppard PW, Searle MS, Cavey JR.

Biochem Soc Trans. 2004 Nov;32(Pt 5):728-30. Review.


Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences.

Hocking LJ, Lucas GJ, Daroszewska A, Cundy T, Nicholson GC, Donath J, Walsh JP, Finlayson C, Cavey JR, Ciani B, Sheppard PW, Searle MS, Layfield R, Ralston SH.

J Bone Miner Res. 2004 Jul;19(7):1122-7. Epub 2004 Mar 22.


Structure of the ubiquitin-associated domain of p62 (SQSTM1) and implications for mutations that cause Paget's disease of bone.

Ciani B, Layfield R, Cavey JR, Sheppard PW, Searle MS.

J Biol Chem. 2003 Sep 26;278(39):37409-12. Epub 2003 Jul 11.


Identification of residues which regulate activity of the STE20-related kinase hMINK.

Lim J, Lennard A, Sheppard PW, Kellie S.

Biochem Biophys Res Commun. 2003 Jan 17;300(3):694-8.


Rapid tyrosine phosphorylation of neuronal proteins including tau and focal adhesion kinase in response to amyloid-beta peptide exposure: involvement of Src family protein kinases.

Williamson R, Scales T, Clark BR, Gibb G, Reynolds CH, Kellie S, Bird IN, Varndell IM, Sheppard PW, Everall I, Anderton BH.

J Neurosci. 2002 Jan 1;22(1):10-20.


Presenilin 1 independently regulates beta-catenin stability and transcriptional activity.

Killick R, Pollard CC, Asuni AA, Mudher AK, Richardson JC, Rupniak HT, Sheppard PW, Varndell IM, Brion JP, Levey AI, Levy OA, Vestling M, Cowburn R, Lovestone S, Anderton BH.

J Biol Chem. 2001 Dec 21;276(51):48554-61. Epub 2001 Oct 17.


N-myc gene expression and oncoprotein characterisation in medulloblastoma.

Garson JA, Pemberton LF, Sheppard PW, Varndell IM, Coakham HB, Kemshead JT.

Br J Cancer. 1989 Jun;59(6):889-94.


Demonstration of a matrix calculus using computed tomography.

Sheppard PW, White FE.

Br J Radiol. 1987 Oct;60(718):1028-9. No abstract available.


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