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What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus?

Mouyna I, Dellière S, Beauvais A, Gravelat F, Snarr B, Lehoux M, Zacharias C, Sun Y, de Jesus Carrion S, Pearlman E, Sheppard DC, Latgé JP.

Front Cell Infect Microbiol. 2020 Feb 6;10:28. doi: 10.3389/fcimb.2020.00028. eCollection 2020.


Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway.

Stewart JIP, Fava VM, Kerkaert JD, Subramanian AS, Gravelat FN, Lehoux M, Howell PL, Cramer RA, Sheppard DC.

mBio. 2020 Feb 4;11(1). pii: e03202-19. doi: 10.1128/mBio.03202-19.


Galactosaminogalactan secreted from Aspergillus fumigatus and Aspergillus flavus induces platelet activation.

Deshmukh H, Rambach G, Sheppard DC, Lee M, Hagleitner M, Hermann M, Würzner R, Lass-Flörl C, Speth C.

Microbes Infect. 2020 Jan 18. pii: S1286-4579(20)30006-X. doi: 10.1016/j.micinf.2019.12.004. [Epub ahead of print]


Efficacies and merits of the cotton swab technique for diagnosing tinea capitis in the pediatric population.

Le M, Gabrielli S, Ghazawi FM, Alkhodair R, Sheppard DC, Jafarian F.

J Am Acad Dermatol. 2020 Jan 12. pii: S0190-9622(20)30052-9. doi: 10.1016/j.jaad.2020.01.009. [Epub ahead of print] No abstract available.


Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.

Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-León DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild MJGT, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A; Mucormycosis ECMM MSG Global Guideline Writing Group.

Lancet Infect Dis. 2019 Dec;19(12):e405-e421. doi: 10.1016/S1473-3099(19)30312-3. Epub 2019 Nov 5. Review.


Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms.

Bamford NC, Le Mauff F, Subramanian AS, Yip P, Millán C, Zhang Y, Zacharias C, Forman A, Nitz M, Codée JDC, Usón I, Sheppard DC, Howell PL.

J Biol Chem. 2019 Sep 13;294(37):13833-13849. doi: 10.1074/jbc.RA119.009910. Epub 2019 Aug 15.


Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn).

Salmanton-García J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Ráčil Z, Falces-Romero I, Ingram P, Benítez-Peñuela MÁ, Rodríguez JY, Desoubeaux G, Barać A, García-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Iqbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild MJGT; FungiScope® ECMM/ISHAM Working Group .

J Antimicrob Chemother. 2019 Nov 1;74(11):3315-3327. doi: 10.1093/jac/dkz344.


Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases.

Le Mauff F, Bamford NC, Alnabelseya N, Zhang Y, Baker P, Robinson H, Codée JDC, Howell PL, Sheppard DC.

J Biol Chem. 2019 Jul 12;294(28):10760-10772. doi: 10.1074/jbc.RA119.008511. Epub 2019 Jun 5.


The role of Aspergillus fumigatus polysaccharides in host-pathogen interactions.

Zacharias CA, Sheppard DC.

Curr Opin Microbiol. 2019 Dec;52:20-26. doi: 10.1016/j.mib.2019.04.006. Epub 2019 May 20. Review.


Triazole Antifungal Susceptibility Patterns among Aspergillus Species in Québec, Canada.

Cheng MP, Lawandi A, Lee TC, Dufresne PJ, Seidel D, Verweij PE, Cornely OA, Sheppard DC.

J Clin Microbiol. 2019 May 24;57(6). pii: e00404-19. doi: 10.1128/JCM.00404-19. Print 2019 Jun. No abstract available.


The mitochondrial thiamine pyrophosphate transporter TptA promotes adaptation to low iron conditions and virulence in fungal pathogen Aspergillus fumigatus.

Huang J, Ma Z, Zhong G, Sheppard DC, Lu L, Zhang S.

Virulence. 2019 Dec;10(1):234-247. doi: 10.1080/21505594.2019.1596505.


Circulating (1→3)-β-D-glucan Is Associated With Immune Activation During Human Immunodeficiency Virus Infection.

Mehraj V, Ramendra R, Isnard S, Dupuy FP, Ponte R, Chen J, Kema I, Jenabian MA, Costinuik CT, Lebouché B, Thomas R, Coté P, Leblanc R, Baril JG, Durand M, Chartrand-Lefebvre C, Tremblay C, Ancuta P, Bernard NF, Sheppard DC, Routy JP; Montreal Primary HIV Infection Study and Canadian HIV and Aging Cohort Study Groups .

Clin Infect Dis. 2020 Jan 2;70(2):232-241. doi: 10.1093/cid/ciz212. Erratum in: Clin Infect Dis. 2020 Mar 3;70(6):1265.


Beyond tissue concentrations: antifungal penetration at the site of infection.

Zhao Y, Prideaux B, Baistrocchi S, Sheppard DC, Perlin DS.

Med Mycol. 2019 Apr 1;57(Supplement_2):S161-S167. doi: 10.1093/mmy/myy067. Review.


Clinical features and cause analysis of false positive results of Aspergillus galactomannan assay in pulmonary cryptococcosis patients.

Takazono T, Saijo T, Ashizawa N, Oshima K, Nishimura K, Tashiro M, Yamamoto K, Imamura Y, Miyazaki T, Yanagihara K, Mukae H, Izumikawa K, Sheppard DC.

Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):735-741. doi: 10.1007/s10096-019-03469-3. Epub 2019 Jan 25.


Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis.

Speth C, Rambach G, Lass-Flörl C, Howell PL, Sheppard DC.

Virulence. 2019 Dec;10(1):976-983. doi: 10.1080/21505594.2019.1568174. Epub 2019 Jan 22.


Deacetylated microbial biofilm exopolysaccharides: It pays to be positive.

Ostapska H, Howell PL, Sheppard DC.

PLoS Pathog. 2018 Dec 27;14(12):e1007411. doi: 10.1371/journal.ppat.1007411. eCollection 2018 Dec. Review. No abstract available.


PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.

Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL.

PLoS Pathog. 2018 Apr 23;14(4):e1006998. doi: 10.1371/journal.ppat.1006998. eCollection 2018 Apr.


Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.

Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA.

Clin Microbiol Infect. 2018 May;24 Suppl 1:e1-e38. doi: 10.1016/j.cmi.2018.01.002. Epub 2018 Mar 12.


Hoisted by their own petard: do microbial enzymes hold the solution to treating and preventing biofilm infections?

Snarr BD, Howell PL, Sheppard DC.

Future Microbiol. 2018 Mar;13:395-398. doi: 10.2217/fmb-2017-0243. Epub 2018 Feb 14. No abstract available.


Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection.

Shourian M, Ralph B, Angers I, Sheppard DC, Qureshi ST.

Front Immunol. 2018 Jan 19;8:1987. doi: 10.3389/fimmu.2017.01987. eCollection 2017.


The Interface between Fungal Biofilms and Innate Immunity.

Kernien JF, Snarr BD, Sheppard DC, Nett JE.

Front Immunol. 2018 Jan 10;8:1968. doi: 10.3389/fimmu.2017.01968. eCollection 2017. Review.


Immune Recognition of Fungal Polysaccharides.

Snarr BD, Qureshi ST, Sheppard DC.

J Fungi (Basel). 2017 Aug 28;3(3). pii: E47. doi: 10.3390/jof3030047. Review.


PtaB, a lim-domain binding protein in Aspergillus fumigatus regulates biofilm formation and conidiation through distinct pathways.

Zhang S, Chen Y, Ma Z, Chen Q, Ostapska H, Gravelat FN, Lu L, Sheppard DC.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12799. Epub 2017 Nov 17. Erratum in: Cell Microbiol. 2018 Mar;20(3):.


Cross-Reacting Ustilago maydis Causing False-Positive Cryptococcal Antigen Test Results.

Cheng MP, Nguyen TT, Parkes LO, Dufresne PJ, Sheppard DC.

J Clin Microbiol. 2017 Oct;55(10):3135-3137. doi: 10.1128/JCM.00920-17. Epub 2017 Jul 26. No abstract available.


FungiScope -Global Emerging Fungal Infection Registry.

Seidel D, Durán Graeff LA, Vehreschild MJGT, Wisplinghoff H, Ziegler M, Vehreschild JJ, Liss B, Hamprecht A, Köhler P, Racil Z, Klimko N, Sheppard DC, Herbrecht R, Chowdhary A, Cornely OA, FungiScope Group.

Mycoses. 2017 Aug;60(8):508-516. doi: 10.1111/myc.12631.


Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity.

Snarr BD, Baker P, Bamford NC, Sato Y, Liu H, Lehoux M, Gravelat FN, Ostapska H, Baistrocchi SR, Cerone RP, Filler EE, Parsek MR, Filler SG, Howell PL, Sheppard DC.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7124-7129. doi: 10.1073/pnas.1702798114. Epub 2017 Jun 20.


Serious fungal infections in Canada.

Dufresne SF, Cole DC, Denning DW, Sheppard DC.

Eur J Clin Microbiol Infect Dis. 2017 Jun;36(6):987-992. doi: 10.1007/s10096-017-2922-y. Epub 2017 Feb 4.


7th Advances Against Aspergillosis: Basic, diagnostic, clinical and therapeutic studies.

Cramer RA, Sheppard DC, Clemons KV.

Med Mycol. 2017 Jan 1;55(1):1-3. No abstract available.


Aspergillus fumigatus CalA binds to integrin α5β1 and mediates host cell invasion.

Liu H, Lee MJ, Solis NV, Phan QT, Swidergall M, Ralph B, Ibrahim AS, Sheppard DC, Filler SG.

Nat Microbiol. 2016 Nov 14;2:16211. doi: 10.1038/nmicrobiol.2016.211.


Aspergillus in chronic lung disease: Modeling what goes on in the airways.

Takazono T, Sheppard DC.

Med Mycol. 2017 Jan 1;55(1):39-47. Epub 2016 Nov 12. Review.


Posaconazole-Loaded Leukocytes as a Novel Treatment Strategy Targeting Invasive Pulmonary Aspergillosis.

Baistrocchi SR, Lee MJ, Lehoux M, Ralph B, Snarr BD, Robitaille R, Sheppard DC.

J Infect Dis. 2017 Jun 1;215(11):1734-1741. doi: 10.1093/infdis/jiw513.


Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies.

Al-Bader N, Sheppard DC.

Virulence. 2016 Nov 16;7(8):950-966. Epub 2016 Sep 29. Review.


Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms.

Baker P, Hill PJ, Snarr BD, Alnabelseya N, Pestrak MJ, Lee MJ, Jennings LK, Tam J, Melnyk RA, Parsek MR, Sheppard DC, Wozniak DJ, Howell PL.

Sci Adv. 2016 May 20;2(5):e1501632. doi: 10.1126/sciadv.1501632. eCollection 2016 May.


Microbial Biofilms in Pulmonary and Critical Care Diseases.

Boisvert AA, Cheng MP, Sheppard DC, Nguyen D.

Ann Am Thorac Soc. 2016 Sep;13(9):1615-23. doi: 10.1513/AnnalsATS.201603-194FR. Review.


Decreased Cell Wall Galactosaminogalactan in Aspergillus nidulans Mediates Dysregulated Inflammation in the Chronic Granulomatous Disease Host.

Henriet SS, van de Sande WW, Lee MJ, Simonetti E, Momany M, Verweij PE, Rijs AJ, Ferwerda G, Sheppard DC, de Jonge MI, Warris A.

J Interferon Cytokine Res. 2016 Aug;36(8):488-98. doi: 10.1089/jir.2015.0095. Epub 2016 May 4.


Biofilm Exopolysaccharides of Pathogenic Fungi: Lessons from Bacteria.

Sheppard DC, Howell PL.

J Biol Chem. 2016 Jun 10;291(24):12529-37. doi: 10.1074/jbc.R116.720995. Epub 2016 Apr 21. Review.


Deacetylation of Fungal Exopolysaccharide Mediates Adhesion and Biofilm Formation.

Lee MJ, Geller AM, Bamford NC, Liu H, Gravelat FN, Snarr BD, Le Mauff F, Chabot J, Ralph B, Ostapska H, Lehoux M, Cerone RP, Baptista SD, Vinogradov E, Stajich JE, Filler SG, Howell PL, Sheppard DC.

mBio. 2016 Apr 5;7(2):e00252-16. doi: 10.1128/mBio.00252-16.


Recent advances in the understanding of the Aspergillus fumigatus cell wall.

Lee MJ, Sheppard DC.

J Microbiol. 2016 Mar;54(3):232-42. doi: 10.1007/s12275-016-6045-4. Epub 2016 Feb 27. Review.


Eyelid Mycetoma Masquerading as Sebaceous Carcinoma.

Zoroquiain P, Alghamdi S, Arthurs B, Levin L, Sheppard DC, Ralph B, Burnier J, Burnier MN.

Ophthalmic Plast Reconstr Surg. 2017 May/Jun;33(3S Suppl 1):S101-S104. doi: 10.1097/IOP.0000000000000657.


Visual Hallucinations Associated with High Posaconazole Concentrations in Serum.

Parkes LO, Cheng MP, Sheppard DC.

Antimicrob Agents Chemother. 2015 Dec 7;60(2):1170-1. doi: 10.1128/AAC.02739-15. Print 2016 Feb. No abstract available.


An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.

Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GD.

Cell Rep. 2015 Nov 17;13(7):1481-1492. doi: 10.1016/j.celrep.2015.10.018. Epub 2015 Nov 5.


Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians.

Gavino C, Hamel N, Zeng JB, Legault C, Guiot MC, Chankowsky J, Lejtenyi D, Lemire M, Alarie I, Dufresne S, Boursiquot JN, McIntosh F, Langelier M, Behr MA, Sheppard DC, Foulkes WD, Vinh DC.

J Allergy Clin Immunol. 2016 Apr;137(4):1178-1188.e7. doi: 10.1016/j.jaci.2015.09.016. Epub 2015 Oct 29.


The Fungal Exopolysaccharide Galactosaminogalactan Mediates Virulence by Enhancing Resistance to Neutrophil Extracellular Traps.

Lee MJ, Liu H, Barker BM, Snarr BD, Gravelat FN, Al Abdallah Q, Gavino C, Baistrocchi SR, Ostapska H, Xiao T, Ralph B, Solis NV, Lehoux M, Baptista SD, Thammahong A, Cerone RP, Kaminskyj SG, Guiot MC, Latgé JP, Fontaine T, Vinh DC, Filler SG, Sheppard DC.

PLoS Pathog. 2015 Oct 22;11(10):e1005187. doi: 10.1371/journal.ppat.1005187. eCollection 2015 Oct.


Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus.

Bamford NC, Snarr BD, Gravelat FN, Little DJ, Lee MJ, Zacharias CA, Chabot JC, Geller AM, Baptista SD, Baker P, Robinson H, Howell PL, Sheppard DC.

J Biol Chem. 2015 Nov 13;290(46):27438-50. doi: 10.1074/jbc.M115.679050. Epub 2015 Sep 4.


International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus.

Verweij PE, Ananda-Rajah M, Andes D, Arendrup MC, Brüggemann RJ, Chowdhary A, Cornely OA, Denning DW, Groll AH, Izumikawa K, Kullberg BJ, Lagrou K, Maertens J, Meis JF, Newton P, Page I, Seyedmousavi S, Sheppard DC, Viscoli C, Warris A, Donnelly JP.

Drug Resist Updat. 2015 Jul-Aug;21-22:30-40. doi: 10.1016/j.drup.2015.08.001. Epub 2015 Aug 7.


Evolution of the Immune Response to Chronic Airway Colonization with Aspergillus fumigatus Hyphae.

Urb M, Snarr BD, Wojewodka G, Lehoux M, Lee MJ, Ralph B, Divangahi M, King IL, McGovern TK, Martin JG, Fraser R, Radzioch D, Sheppard DC.

Infect Immun. 2015 Sep;83(9):3590-600. doi: 10.1128/IAI.00359-15. Epub 2015 Jun 29.


Invasive Saccharomyces cerevisiae in a liver transplant patient: case report and review of infection in transplant recipients.

Popiel KY, Wong P, Lee MJ, Langelier M, Sheppard DC, Vinh DC.

Transpl Infect Dis. 2015 Jun;17(3):435-41. doi: 10.1111/tid.12384. Epub 2015 May 26. Review.


Divergent targets of Aspergillus fumigatus AcuK and AcuM transcription factors during growth in vitro versus invasive disease.

Pongpom M, Liu H, Xu W, Snarr BD, Sheppard DC, Mitchell AP, Filler SG.

Infect Immun. 2015 Mar;83(3):923-33. doi: 10.1128/IAI.02685-14. Epub 2014 Dec 22.


Host cell invasion by medically important fungi.

Sheppard DC, Filler SG.

Cold Spring Harb Perspect Med. 2014 Nov 3;5(1):a019687. doi: 10.1101/cshperspect.a019687. Review.


CARD9 deficiency and spontaneous central nervous system candidiasis: complete clinical remission with GM-CSF therapy.

Gavino C, Cotter A, Lichtenstein D, Lejtenyi D, Fortin C, Legault C, Alirezaie N, Majewski J, Sheppard DC, Behr MA, Foulkes WD, Vinh DC.

Clin Infect Dis. 2014 Jul 1;59(1):81-4. doi: 10.1093/cid/ciu215. Epub 2014 Apr 4.

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