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Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbial biofilms.

Bamford NC, Le Mauff F, Subramanian AS, Yip P, Millán C, Zhang Y, Zacharias C, Forman A, Nitz M, Codée JDC, Usón I, Sheppard DC, Howell PL.

J Biol Chem. 2019 Sep 13;294(37):13833-13849. doi: 10.1074/jbc.RA119.009910. Epub 2019 Aug 15.


Development of therapeutic anti-JAGGED1 antibodies for cancer therapy.

Masiero M, Li D, Whiteman P, Bentley C, Greig J, Hassanali T, Watts S, Stribbling S, Yates J, Bealing E, Li JL, Chillakuri C, Sheppard D, Serres S, Sarmiento-Soto M, Larkin J, Sibson NR, Handford PA, Harris AL, Banham AH.

Mol Cancer Ther. 2019 Aug 8. pii: molcanther.1176.2018. doi: 10.1158/1535-7163.MCT-18-1176. [Epub ahead of print]


Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn).

Salmanton-García J, Seidel D, Koehler P, Mellinghoff SC, Herbrecht R, Klimko N, Ráčil Z, Falces-Romero I, Ingram P, Benítez-Peñuela MÁ, Rodríguez JY, Desoubeaux G, Barać A, García-Vidal C, Hoenigl M, Mehta SR, Cheng MP, Klyasova G, Heinz WJ, Iqbal N, Krause R, Ostermann H, Penack O, Schalk E, Sheppard DC, Willinger B, Wisplinghoff H, Vehreschild JJ, Cornely OA, Vehreschild MJGT; FungiScope® ECMM/ISHAM Working Group .

J Antimicrob Chemother. 2019 Aug 8. pii: dkz344. doi: 10.1093/jac/dkz344. [Epub ahead of print]


Prospective memory partially mediates the association between aging and everyday functioning.

Sheppard DP, Matchanova A, Sullivan KL, Kazimi SI, Woods SP.

Clin Neuropsychol. 2019 Jul 14:1-20. doi: 10.1080/13854046.2019.1637461. [Epub ahead of print]


Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases.

Le Mauff F, Bamford NC, Alnabelseya N, Zhang Y, Baker P, Robinson H, Codée JDC, Howell PL, Sheppard DC.

J Biol Chem. 2019 Jul 12;294(28):10760-10772. doi: 10.1074/jbc.RA119.008511. Epub 2019 Jun 5.


The role of Aspergillus fumigatus polysaccharides in host-pathogen interactions.

Zacharias CA, Sheppard DC.

Curr Opin Microbiol. 2019 May 20;52:20-26. doi: 10.1016/j.mib.2019.04.006. [Epub ahead of print] Review.


Where have I heard that before? A validity study of source memory indices from the California Verbal Learning Test - Second edition.

Babicz MA, Sheppard DP, Morgan EE, Paul Woods S.

Clin Neuropsychol. 2019 May 14:1-20. doi: 10.1080/13854046.2019.1613559. [Epub ahead of print]


Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca2+-Activated Potassium Channels.

Higham J, Sahu G, Wazen RM, Colarusso P, Gregorie A, Harvey BSJ, Goudswaard L, Varley G, Sheppard DN, Turner RW, Marrion NV.

Mol Pharmacol. 2019 Jul;96(1):115-126. doi: 10.1124/mol.118.115634. Epub 2019 May 2.


Do importance instructions improve time-based prospective remembering in autism spectrum conditions?

Altgassen M, Sheppard DP, Hendriks MPH.

Res Dev Disabil. 2019 Jul;90:1-13. doi: 10.1016/j.ridd.2019.04.008. Epub 2019 Apr 20.


Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR.

Bose SJ, Bijvelds MJC, Wang Y, Liu J, Cai Z, Bot AGM, de Jonge HR, Sheppard DN.

Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L71-L86. doi: 10.1152/ajplung.00034.2019. Epub 2019 Apr 10.


Triazole Antifungal Susceptibility Patterns among Aspergillus Species in Québec, Canada.

Cheng MP, Lawandi A, Lee TC, Dufresne PJ, Seidel D, Verweij PE, Cornely OA, Sheppard DC.

J Clin Microbiol. 2019 May 24;57(6). pii: e00404-19. doi: 10.1128/JCM.00404-19. Print 2019 Jun. No abstract available.


Decomposition pathway of KAlH4 altered by the addition of Al2S3.

Sheppard DA, Jepsen LH, Rowles MR, Paskevicius M, Jensen TR, Buckley CE.

Dalton Trans. 2019 Apr 9;48(15):5048-5057. doi: 10.1039/c9dt00457b.


Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport.

Spooner MJ, Li H, Marques I, Costa PMR, Wu X, Howe ENW, Busschaert N, Moore SJ, Light ME, Sheppard DN, Félix V, Gale PA.

Chem Sci. 2018 Dec 14;10(7):1976-1985. doi: 10.1039/c8sc05155k. eCollection 2019 Feb 21.


The mitochondrial thiamine pyrophosphate transporter TptA promotes adaptation to low iron conditions and virulence in fungal pathogen Aspergillus fumigatus.

Huang J, Ma Z, Zhong G, Sheppard DC, Lu L, Zhang S.

Virulence. 2019 Dec;10(1):234-247. doi: 10.1080/21505594.2019.1596505.


Pore-forming small molecules offer a promising way to tackle cystic fibrosis.

Sheppard DN, Davis AP.

Nature. 2019 Mar;567(7748):315-317. doi: 10.1038/d41586-019-00781-y. No abstract available.


Circulating (1→3)-β-D-Glucan is associated with immune activation during HIV infection.

Mehraj V, Ramendra R, Isnard S, Dupuy FP, Ponte R, Chen J, Kema I, Jenabian MA, Costiniuk C, Lebouché B, Thomas R, Coté P, Leblanc R, Baril JG, Durand M, Chartrand-Lefebvre C, Tremblay C, Ancuta P, Bernard NF, Sheppard DC, Routy JP; Montreal Primary HIV-infection Study and Canadian HIV and Aging Cohort Study Groups.

Clin Infect Dis. 2019 Mar 16. pii: ciz212. doi: 10.1093/cid/ciz212. [Epub ahead of print]


Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction.

Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D.

J Exp Med. 2019 Apr 1;216(4):900-915. doi: 10.1084/jem.20181290. Epub 2019 Mar 7.


α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.

Dodagatta-Marri E, Meyer DS, Reeves MQ, Paniagua R, To MD, Binnewies M, Broz ML, Mori H, Wu D, Adoumie M, Del Rosario R, Li O, Buchmann T, Liang B, Malato J, Arce Vargus F, Sheppard D, Hann BC, Mirza A, Quezada SA, Rosenblum MD, Krummel MF, Balmain A, Akhurst RJ.

J Immunother Cancer. 2019 Mar 4;7(1):62. doi: 10.1186/s40425-018-0493-9.


Beyond tissue concentrations: antifungal penetration at the site of infection.

Zhao Y, Prideaux B, Baistrocchi S, Sheppard DC, Perlin DS.

Med Mycol. 2019 Apr 1;57(Supplement_2):S161-S167. doi: 10.1093/mmy/myy067. Review.


Clinical features and cause analysis of false positive results of Aspergillus galactomannan assay in pulmonary cryptococcosis patients.

Takazono T, Saijo T, Ashizawa N, Oshima K, Nishimura K, Tashiro M, Yamamoto K, Imamura Y, Miyazaki T, Yanagihara K, Mukae H, Izumikawa K, Sheppard DC.

Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):735-741. doi: 10.1007/s10096-019-03469-3. Epub 2019 Jan 25.


IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility.

Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X.

J Immunol. 2019 Mar 1;202(5):1540-1548. doi: 10.4049/jimmunol.1801025. Epub 2019 Jan 25.


Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis.

Speth C, Rambach G, Lass-Flörl C, Howell PL, Sheppard DC.

Virulence. 2019 Jan 22:1-8. doi: 10.1080/21505594.2019.1568174. [Epub ahead of print]


β6 -integrin serves as a novel serum tumor marker for colorectal carcinoma.

Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M.

Int J Cancer. 2019 Aug 1;145(3):678-685. doi: 10.1002/ijc.32137. Epub 2019 Jan 29.


Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.

Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR.

PLoS One. 2019 Jan 9;14(1):e0209824. doi: 10.1371/journal.pone.0209824. eCollection 2019.


Deacetylated microbial biofilm exopolysaccharides: It pays to be positive.

Ostapska H, Howell PL, Sheppard DC.

PLoS Pathog. 2018 Dec 27;14(12):e1007411. doi: 10.1371/journal.ppat.1007411. eCollection 2018 Dec. Review. No abstract available.


Ensembl variation resources.

Hunt SE, McLaren W, Gil L, Thormann A, Schuilenburg H, Sheppard D, Parton A, Armean IM, Trevanion SJ, Flicek P, Cunningham F.

Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay119.


Extrapyramidal motor signs in older adults with HIV disease: frequency, 1-year course, and associations with activities of daily living and quality of life.

Tierney SM, Woods SP, Sheppard D, Ellis RJ.

J Neurovirol. 2019 Apr;25(2):162-173. doi: 10.1007/s13365-018-0699-0. Epub 2018 Dec 10.


Medication Management Capacity and Its Neurocognitive Correlates in Huntington's Disease.

Sumida CA, Van Etten EJ, Lopez FV, Sheppard DP, Pirogovsky-Turk E, Corey-Bloom J, Filoteo JV, Woods SP, Gilbert PE, Schmitter-Edgecombe M.

Arch Clin Neuropsychol. 2018 Dec 5. doi: 10.1093/arclin/acy093. [Epub ahead of print]


Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration.

Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EEM, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC.

Am J Pathol. 2019 Feb;189(2):258-271. doi: 10.1016/j.ajpath.2018.10.007. Epub 2018 Nov 16.


Ensembl 2019.

Cunningham F, Achuthan P, Akanni W, Allen J, Amode MR, Armean IM, Bennett R, Bhai J, Billis K, Boddu S, Cummins C, Davidson C, Dodiya KJ, Gall A, Girón CG, Gil L, Grego T, Haggerty L, Haskell E, Hourlier T, Izuogu OG, Janacek SH, Juettemann T, Kay M, Laird MR, Lavidas I, Liu Z, Loveland JE, Marugán JC, Maurel T, McMahon AC, Moore B, Morales J, Mudge JM, Nuhn M, Ogeh D, Parker A, Parton A, Patricio M, Abdul Salam AI, Schmitt BM, Schuilenburg H, Sheppard D, Sparrow H, Stapleton E, Szuba M, Taylor K, Threadgold G, Thormann A, Vullo A, Walts B, Winterbottom A, Zadissa A, Chakiachvili M, Frankish A, Hunt SE, Kostadima M, Langridge N, Martin FJ, Muffato M, Perry E, Ruffier M, Staines DM, Trevanion SJ, Aken BL, Yates AD, Zerbino DR, Flicek P.

Nucleic Acids Res. 2019 Jan 8;47(D1):D745-D751. doi: 10.1093/nar/gky1113.


Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice.

Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M.

JCI Insight. 2018 Nov 2;3(21). pii: 123578. doi: 10.1172/jci.insight.123578.


Frequency and Correlates of Subjective Cognitive Impairment in HIV Disease.

Sheppard DP, Woods SP, Massman PJ, Gilbert PE.

AIDS Behav. 2019 Mar;23(3):617-626. doi: 10.1007/s10461-018-2297-9.


Standardizing the evaluation of community-based conservation success.

Brichieri-Colombi TA, McPherson JM, Sheppard DJ, Mason JJ, Moehrenschlager A.

Ecol Appl. 2018 Dec;28(8):1963-1981. doi: 10.1002/eap.1788. Epub 2018 Sep 10.


Potentiation of the cystic fibrosis transmembrane conductance regulator Cl- channel by ivacaftor is temperature independent.

Wang Y, Cai Z, Gosling M, Sheppard DN.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L846-L857. doi: 10.1152/ajplung.00235.2018. Epub 2018 Aug 23.


N1303K: Leaving no stone unturned in the search for transformational therapeutics.

Noel S, Sermet-Gaudelus I, Sheppard DN.

J Cyst Fibros. 2018 Sep;17(5):555-557. doi: 10.1016/j.jcf.2018.07.009. Epub 2018 Aug 17. No abstract available.


Residual function of cystic fibrosis mutants predicts response to small molecule CFTR modulators.

Han ST, Rab A, Pellicore MJ, Davis EF, McCague AF, Evans TA, Joynt AT, Lu Z, Cai Z, Raraigh KS, Hong JS, Sheppard DN, Sorscher EJ, Cutting GR.

JCI Insight. 2018 Jul 26;3(14). pii: 121159. doi: 10.1172/jci.insight.121159. eCollection 2018 Jul 26.


Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation.

Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K.

Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L360-L370. doi: 10.1152/ajplung.00144.2018. Epub 2018 May 24.


Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus?

Sheppard DP, Woods SP, Hasbun R, Salazar L, Nolan MS, Murray KO.

J Neurovirol. 2018 Aug;24(4):506-513. doi: 10.1007/s13365-018-0641-5. Epub 2018 Apr 25.


PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-β(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms.

Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL.

PLoS Pathog. 2018 Apr 23;14(4):e1006998. doi: 10.1371/journal.ppat.1006998. eCollection 2018 Apr.


Big Data in Drug Discovery.

Brown N, Cambruzzi J, Cox PJ, Davies M, Dunbar J, Plumbley D, Sellwood MA, Sim A, Williams-Jones BI, Zwierzyna M, Sheppard DW.

Prog Med Chem. 2018;57(1):277-356. doi: 10.1016/bs.pmch.2017.12.003. Epub 2018 Feb 24. Review.


Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.

Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA.

Clin Microbiol Infect. 2018 May;24 Suppl 1:e1-e38. doi: 10.1016/j.cmi.2018.01.002. Epub 2018 Mar 12.


Five Alternative Myosin Converter Domains Influence Muscle Power, Stretch Activation, and Kinetics.

Glasheen BM, Ramanath S, Patel M, Sheppard D, Puthawala JT, Riley LA, Swank DM.

Biophys J. 2018 Mar 13;114(5):1142-1152. doi: 10.1016/j.bpj.2017.12.045.


Prospective memory in autism: theory and literature review.

Sheppard DP, Bruineberg JP, Kretschmer-Trendowicz A, Altgassen M.

Clin Neuropsychol. 2018 Jul;32(5):748-782. doi: 10.1080/13854046.2018.1435823. Epub 2018 Mar 14. Review.


Hoisted by their own petard: do microbial enzymes hold the solution to treating and preventing biofilm infections?

Snarr BD, Howell PL, Sheppard DC.

Future Microbiol. 2018 Mar;13:395-398. doi: 10.2217/fmb-2017-0243. Epub 2018 Feb 14. No abstract available.


Impaired spatial pattern separation performance in temporal lobe epilepsy is associated with visuospatial memory deficits and hippocampal volume loss.

Reyes A, Holden HM, Chang YA, Uttarwar VS, Sheppard DP, DeFord NE, DeJesus SY, Kansal L, Gilbert PE, McDonald CR.

Neuropsychologia. 2018 Mar;111:209-215. doi: 10.1016/j.neuropsychologia.2018.02.009. Epub 2018 Feb 8.


Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection.

Shourian M, Ralph B, Angers I, Sheppard DC, Qureshi ST.

Front Immunol. 2018 Jan 19;8:1987. doi: 10.3389/fimmu.2017.01987. eCollection 2017.


Anion transport by ortho-phenylene bis-ureas across cell and vesicle membranes.

Dias CM, Li H, Valkenier H, Karagiannidis LE, Gale PA, Sheppard DN, Davis AP.

Org Biomol Chem. 2018 Feb 14;16(7):1083-1087. doi: 10.1039/c7ob02787g.


The Interface between Fungal Biofilms and Innate Immunity.

Kernien JF, Snarr BD, Sheppard DC, Nett JE.

Front Immunol. 2018 Jan 10;8:1968. doi: 10.3389/fimmu.2017.01968. eCollection 2017. Review.


Immune Recognition of Fungal Polysaccharides.

Snarr BD, Qureshi ST, Sheppard DC.

J Fungi (Basel). 2017 Aug 28;3(3). pii: E47. doi: 10.3390/jof3030047. Review.


Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule.

Liu J, Bihler H, Farinha CM, Awatade NT, Romão AM, Mercadante D, Cheng Y, Musisi I, Jantarajit W, Wang Y, Cai Z, Amaral MD, Mense M, Sheppard DN.

Br J Pharmacol. 2018 Apr;175(7):1017-1038. doi: 10.1111/bph.14141. Epub 2018 Feb 22.

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