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Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.

Breitbach ME, Newman CM, Dudley DM, Stewart LM, Aliota MT, Koenig MR, Shepherd PM, Yamamoto K, Crooks CM, Young G, Semler MR, Weiler AM, Barry GL, Heimsath H, Mohr EL, Eichkoff J, Newton W, Peterson E, Schultz-Darken N, Permar SR, Dean H, Capuano S 3rd, Osorio JE, Friedrich TC, O'Connor DH.

PLoS Pathog. 2019 Aug 1;15(8):e1007766. doi: 10.1371/journal.ppat.1007766. eCollection 2019 Aug.


Screening for Anaplastic Lymphoma Kinase (ALK) gene rearrangements in non-small cell lung cancer (NSCLC) in New Zealand.

McKeage MJ, Tin Tin S, Khwaounjoo P, Sheath K, Dixon-McIver A, Ng D, Sullivan R, Cameron L, Shepherd P, Laking GR, Kingston N, Strauss M, Lewis C, Elwood M, Love DR.

Intern Med J. 2019 Jul 18. doi: 10.1111/imj.14435. [Epub ahead of print]


The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice.

Merry TL, Brooks AES, Masson SW, Adams SE, Jaiswal JK, Jamieson SMF, Shepherd PR.

Int J Obes (Lond). 2019 Mar 29. doi: 10.1038/s41366-019-0355-7. [Epub ahead of print]


Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

Giddens AC, Gamage SA, Kendall JD, Lee WJ, Baguley BC, Buchanan CM, Jamieson SMF, Dickson JMJ, Shepherd PR, Denny WA, Rewcastle GW.

Bioorg Med Chem. 2019 Apr 15;27(8):1529-1545. doi: 10.1016/j.bmc.2019.02.050. Epub 2019 Feb 25.


Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors.

Gamage SA, Spicer JA, Tsang KY, O'Connor PD, Flanagan JU, Lee WJ, Dickson JMJ, Shepherd PR, Denny WA, Rewcastle GW.

Chem Asian J. 2019 Apr 15;14(8):1249-1261. doi: 10.1002/asia.201801762. Epub 2019 Mar 12.


The estrogen receptor variants β2 and β5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling.

Faria M, Shepherd P, Pan Y, Chatterjee SS, Navone N, Gustafsson JÅ, Strom A.

Oncotarget. 2018 Nov 20;9(91):36273-36288. doi: 10.18632/oncotarget.26345. eCollection 2018 Nov 20.


Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.

Wang C, Wang G, Feng X, Shepherd P, Zhang J, Tang M, Chen Z, Srivastava M, McLaughlin ME, Navone NM, Hart GT, Chen J.

Oncogene. 2019 Apr;38(14):2451-2463. doi: 10.1038/s41388-018-0606-4. Epub 2018 Dec 7.


"We think globally": the rise of Paraguay's Tabacalera del Este as a threat to global tobacco control.

Gomis B, Lee K, Carrillo Botero N, Shepherd P, Iglesias RM.

Global Health. 2018 Nov 19;14(1):110. doi: 10.1186/s12992-018-0412-3.


Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model.

Britto DD, Wyroba B, Chen W, Lockwood RA, Tran KB, Shepherd PR, Hall CJ, Crosier KE, Crosier PS, Astin JW.

Dis Model Mech. 2018 Nov 29;11(12). pii: dmm035998. doi: 10.1242/dmm.035998.


TRUFU: Therapeutic radiographer undertaking follow up for prostate cancer patients.

Hetherington SM, Gilleece T, Shepherd P, Crowther K, O'Sullivan J, Jain S, Mitchell D, Shum L, Turner P.

Radiography (Lond). 2018 Nov;24(4):298-303. doi: 10.1016/j.radi.2018.06.001. Epub 2018 Jul 3.


Movember GAP1 PDX project: An international collection of serially transplantable prostate cancer patient-derived xenograft (PDX) models.

Navone NM, van Weerden WM, Vessella RL, Williams ED, Wang Y, Isaacs JT, Nguyen HM, Culig Z, van der Pluijm G, Rentsch CA, Marques RB, de Ridder CMA, Bubendorf L, Thalmann GN, Brennen WN, Santer FR, Moser PL, Shepherd P, Efstathiou E, Xue H, Lin D, Buijs J, Bosse T, Collins A, Maitland N, Buzza M, Kouspou M, Achtman A, Taylor RA, Risbridger G, Corey E.

Prostate. 2018 Dec;78(16):1262-1282. doi: 10.1002/pros.23701. Epub 2018 Aug 2.


Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds.

Gong GQ, Wang K, Dai XC, Zhou Y, Basnet R, Chen Y, Yang DH, Lee WJ, Buchanan CM, Flanagan JU, Shepherd PR, Chen Y, Wang MW.

Acta Pharmacol Sin. 2018 Dec;39(12):1902-1912. doi: 10.1038/s41401-018-0087-6. Epub 2018 Jul 23.


High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds.

Wang J, Gong GQ, Zhou Y, Lee WJ, Buchanan CM, Denny WA, Rewcastle GW, Kendall JD, Dickson JMJ, Flanagan JU, Shepherd PR, Yang DH, Wang MW.

Acta Pharmacol Sin. 2018 Nov;39(11):1816-1822. doi: 10.1038/s41401-018-0057-z. Epub 2018 Jul 10.


Feeding and GLP-1 receptor activation stabilize β-catenin in specific hypothalamic nuclei in male rats.

McEwen HJL, Cognard E, Ladyman SR, Khant-Aung Z, Tups A, Shepherd PR, Grattan DR.

J Neuroendocrinol. 2018 May 11:e12607. doi: 10.1111/jne.12607. [Epub ahead of print]


Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.

Krishnan M, Major TJ, Topless RK, Dewes O, Yu L, Thompson JMD, McCowan L, de Zoysa J, Stamp LK, Dalbeth N, Harré Hindmarsh J, Rapana N, Deka R, Eng WWH, Weeks DE, Minster RL, McGarvey ST, Viali S, Naseri T, Sefuiva Reupena M, Wilcox P, Grattan D, Shepherd PR, Shelling AN, Murphy R, Merriman TR.

Diabetologia. 2018 Jul;61(7):1603-1613. doi: 10.1007/s00125-018-4623-1. Epub 2018 May 2.


Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.


β-catenin is important for the development of an insulin responsive pool of GLUT4 glucose transporters in 3T3-L1 adipocytes.

Dissanayake WC, Sorrenson B, Cognard E, Hughes WE, Shepherd PR.

Exp Cell Res. 2018 May 1;366(1):49-54. doi: 10.1016/j.yexcr.2018.03.011. Epub 2018 Mar 11.


Re: "Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood".

Major TJ, Krishnan M, Topless RK, Dewes O, Thompson J, Zoysa J, Stamp LK, Dalbeth N, Deka R, Weeks DE, Minster RL, Wilcox P, Grattan D, Shepherd PR, Shelling AN, Murphy R, Merriman TR.

Int J Obes (Lond). 2018 Jul;42(7):1389-1391. doi: 10.1038/s41366-018-0025-1. Epub 2018 Mar 6. No abstract available.


Real world experience of BRAFV600E mutation specific immunohistochemistry in colorectal carcinoma.

Reagh J, Clarkson A, Bullock M, Shepherd P, Gill AJ.

Pathology. 2018 Apr;50(3):342-344. doi: 10.1016/j.pathol.2017.09.025. Epub 2018 Feb 22. No abstract available.


The role of adherens junction proteins in the regulation of insulin secretion.

Dissanayake WC, Sorrenson B, Shepherd PR.

Biosci Rep. 2018 Mar 21;38(2). pii: BSR20170989. doi: 10.1042/BSR20170989. Print 2018 Apr 27. Review.


Lung cancer mutation testing: a clinical retesting study of agreement between a real-time PCR and a mass spectrometry test.

Shepherd P, Sheath KL, Tin ST, Khwaounjoo P, Aye PS, Li A, Laking GR, Kingston NJ, Lewis CA, Mark Elwood J, Love DR, McKeage MJ.

Oncotarget. 2017 Sep 16;8(60):101437-101451. doi: 10.18632/oncotarget.21023. eCollection 2017 Nov 24.


Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

Gamage SA, Giddens AC, Tsang KY, Flanagan JU, Kendall JD, Lee WJ, Baguley BC, Buchanan CM, Jamieson SMF, Shepherd PR, Denny WA, Rewcastle GW.

Bioorg Med Chem. 2017 Oct 15;25(20):5859-5874. doi: 10.1016/j.bmc.2017.09.025. Epub 2017 Sep 20.


Indirect regulation of CYP2C19 gene expression via DNA methylation.

Burns KE, Shepherd P, Finlay G, Tingle MD, Helsby NA.

Xenobiotica. 2018 Aug;48(8):781-792. doi: 10.1080/00498254.2017.1372648. Epub 2017 Sep 19.


EGFR Mutation Testing of non-squamous NSCLC: Impact and Uptake during Implementation of Testing Guidelines in a Population-Based Registry Cohort from Northern New Zealand.

McKeage M, Elwood M, Tin Tin S, Khwaounjoo P, Aye P, Li A, Sheath K, Shepherd P, Laking G, Kingston N, Lewis C, Love D.

Target Oncol. 2017 Oct;12(5):663-675. doi: 10.1007/s11523-017-0515-4.


Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors.

Rewcastle GW, Kolekar S, Buchanan CM, Gamage SA, Giddens AC, Tsang KY, Kendall JD, Singh R, Lee WJ, Smith GC, Han W, Matthews DJ, Denny WA, Shepherd PR, Jamieson SMF.

Oncotarget. 2017 Jul 18;8(29):47725-47740. doi: 10.18632/oncotarget.17730.


Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.

Gong GQ, Kendall JD, Dickson JMJ, Rewcastle GW, Buchanan CM, Denny WA, Shepherd PR, Flanagan JU.

Biochem J. 2017 Jun 26;474(13):2261-2276. doi: 10.1042/BCJ20161098.


Meeting Report: 2016 Annual Meeting of the Endocrine Society Boston, MA (April 1-4, 2016) Selected Highlights.

Colindres JV, Lee YK, Gonzalez MS, Shepherd P.

Pediatr Endocrinol Rev. 2016 Sep;14(1):73-86. doi: 10.17458/PER.2016.CLGS.MR.2016ENDO. No abstract available.


Environmental factors and risk of aggressive prostate cancer among a population of New Zealand men - a genotypic approach.

Vaidyanathan V, Naidu V, Kao CH, Karunasinghe N, Bishop KS, Wang A, Pallati R, Shepherd P, Masters J, Zhu S, Goudie M, Krishnan M, Jabed A, Marlow G, Narayanan A, Ferguson LR.

Mol Biosyst. 2017 Mar 28;13(4):681-698. doi: 10.1039/c6mb00873a.


Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes.

Chowdhury MK, Turner N, Bentley NL, Das A, Wu LE, Richani D, Bustamante S, Gilchrist RB, Morris MJ, Shepherd PR, Smith GC.

Sci Rep. 2017 Jan 5;7:40159. doi: 10.1038/srep40159.


Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors.

Kendall JD, Giddens AC, Tsang KY, Marshall ES, Lill CL, Lee WJ, Kolekar S, Chao M, Malik A, Yu S, Chaussade C, Buchanan C, Jamieson SMF, Rewcastle GW, Baguley BC, Denny WA, Shepherd PR.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):187-190. doi: 10.1016/j.bmcl.2016.11.078. Epub 2016 Nov 25.


A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization.

Sorrenson B, Cognard E, Lee KL, Dissanayake WC, Fu Y, Han W, Hughes WE, Shepherd PR.

J Biol Chem. 2016 Dec 9;291(50):25888-25900. Epub 2016 Oct 24.


Range shifts or extinction? Ancient DNA and distribution modelling reveal past and future responses to climate warming in cold-adapted birds.

Lagerholm VK, Sandoval-Castellanos E, Vaniscotte A, Potapova OR, Tomek T, Bochenski ZM, Shepherd P, Barton N, Van Dyck MC, Miller R, Höglund J, Yoccoz NG, Dalén L, Stewart JR.

Glob Chang Biol. 2017 Apr;23(4):1425-1435. doi: 10.1111/gcb.13522. Epub 2016 Oct 20.


Locally Acquired Eastern Equine Encephalitis Virus Disease, Arkansas, USA.

Garlick J, Lee TJ, Shepherd P, Linam WM, Pastula DM, Weinstein S, Schexnayder SM.

Emerg Infect Dis. 2016 Dec;22(12):2216-2217. doi: 10.3201/eid2212.160844. Epub 2016 Dec 15. No abstract available.


NRASQ61R Mutation-specific Immunohistochemistry Also Identifies the HRASQ61R Mutation in Medullary Thyroid Cancer and May Have a Role in Triaging Genetic Testing for MEN2.

Reagh J, Bullock M, Andrici J, Turchini J, Sioson L, Clarkson A, Watson N, Sheen A, Lim G, Delbridge L, Sidhu S, Sywak M, Aniss A, Shepherd P, Ng D, Oei P, Field M, Learoyd D, Robinson BG, Clifton-Bligh RJ, Gill AJ.

Am J Surg Pathol. 2017 Jan;41(1):75-81.


NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand.

Jones AM, Ferguson P, Gardner J, Rooker S, Sutton T, Ahn A, Chatterjee A, Bickley VM, Sarwar M, Emanuel P, Kenwright D, Shepherd PR, Eccles MR.

Oncotarget. 2016 Jul 5;7(27):41017-41030. doi: 10.18632/oncotarget.9351.


Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models.

Jones NM, Rowe MR, Shepherd PR, McConnell MJ.

Int J Oncol. 2016 Jul;49(1):207-16. doi: 10.3892/ijo.2016.3510. Epub 2016 May 9.


Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling.

Chowdhury MK, Wu LE, Coleman JL, Smith NJ, Morris MJ, Shepherd PR, Smith GC.

Biochem J. 2016 May 1;473(9):1247-55. doi: 10.1042/BCJ20160121. Epub 2016 Mar 10.


Representation of people of South Asian origin in cardiovascular outcome trials of glucose-lowering therapies in Type 2 diabetes.

Khunti K, Bellary S, Karamat MA, Patel K, Patel V, Jones A, Gray J, Shepherd P, Hanif W; South Asian Health Foundation.

Diabet Med. 2017 Jan;34(1):64-68. doi: 10.1111/dme.13103. Epub 2016 Apr 28. Review.


NRASQ61R Mutation-specific Immunohistochemistry is Highly Specific for Either NRASQ61R or KRASQ61R Mutation in Colorectal Carcinoma.

Turchini J, Andrici J, Sioson L, Clarkson A, Watson N, Toon CW, Shepherd P, Ng D, Dixon-McIver A, Oei P, Gill AJ.

Appl Immunohistochem Mol Morphol. 2017 Aug;25(7):475-480. doi: 10.1097/PAI.0000000000000333.


Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.

Chua EW, Cree SL, Ton KN, Lehnert K, Shepherd P, Helsby N, Kennedy MA.

Front Pharmacol. 2016 Jan 26;7:1. doi: 10.3389/fphar.2016.00001. eCollection 2016.


The natural history of elevated tetradecenoyl-L-carnitine detected by newborn screening in New Zealand: implications for very long chain acyl-CoA dehydrogenase deficiency screening and treatment.

Ryder B, Knoll D, Love DR, Shepherd P, Love JM, Reed PW, de Hora M, Webster D, Glamuzina E, Wilson C.

J Inherit Metab Dis. 2016 May;39(3):409-414. doi: 10.1007/s10545-015-9911-z. Epub 2016 Jan 7.


2015 Annual Meeting of the Pediatric Endocrine Society San Diego, CA (April 25-27, 2015) Selected Highlights.

Serrano-Gonzalez M, Shepherd P, Alvarez G, Ryabets-Lienhard A.

Pediatr Endocrinol Rev. 2015 Sep;13(1):480-9. No abstract available.


What do patients value in the hospital meal experience?

Hartwell HJ, Shepherd PA, Edwards JSA, Johns N.

Appetite. 2016 Jan 1;96:293-298. doi: 10.1016/j.appet.2015.09.023. Epub 2015 Sep 25.


Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth.

Sweetlove M, Wrightson E, Kolekar S, Rewcastle GW, Baguley BC, Shepherd PR, Jamieson SM.

Front Oncol. 2015 Jun 16;5:135. doi: 10.3389/fonc.2015.00135. eCollection 2015.


Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.

Chowdhury MK, Montgomery MK, Morris MJ, Cognard E, Shepherd PR, Smith GC.

Arch Physiol Biochem. 2015;121(3):88-96. doi: 10.3109/13813455.2015.1048693. Epub 2015 Jul 1.


Personalized hypertension management in practice.

Gladding PA, Patrick A, Manley P, Mash L, Shepherd P, Murphy R, Vilas-Boas S, Schlegel TT.

Per Med. 2015 Jun;12(3):297-311. doi: 10.2217/pme.14.83.


Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.

Marshall AJ, Lill CL, Chao M, Kolekar SV, Lee WJ, Marshall ES, Baguley BC, Shepherd PR, Denny WA, Flanagan JU, Rewcastle GW.

Bioorg Med Chem. 2015 Jul 1;23(13):3796-808. doi: 10.1016/j.bmc.2015.03.073. Epub 2015 Apr 4.


Biochemical Journal strengthens links in Asia.

Shepherd PR.

Biochem J. 2014 Nov 15;464(1):1. doi: 10.1042/BJ20140874. No abstract available.


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