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Items: 1 to 50 of 127

1.

Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records.

Shephard EA, Hamilton WT.

Br J Gen Pract. 2018 Jul 2. pii: bjgp18X697949. doi: 10.3399/bjgp18X697949. [Epub ahead of print]

PMID:
29970393
2.

Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice.

Varshavi D, Scott FH, Varshavi D, Veeravalli S, Phillips IR, Veselkov K, Strittmatter N, Takats Z, Shephard EA, Everett JR.

Front Mol Biosci. 2018 Apr 9;5:28. doi: 10.3389/fmolb.2018.00028. eCollection 2018.

3.

Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis.

Veeravalli S, Karu K, Scott F, Fennema D, Phillips IR, Shephard EA.

Drug Metab Dispos. 2018 Jan;46(1):20-25. doi: 10.1124/dmd.117.077636. Epub 2017 Oct 25.

4.

A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine.

Veeravalli S, Karu K, Phillips IR, Shephard EA.

MethodsX. 2017 Sep 28;4:310-319. doi: 10.1016/j.mex.2017.09.004. eCollection 2017.

5.

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.

Scott F, Gonzalez Malagon SG, O'Brien BA, Fennema D, Veeravalli S, Coveney CR, Phillips IR, Shephard EA.

Drug Metab Dispos. 2017 Sep;45(9):982-989. doi: 10.1124/dmd.117.076612. Epub 2017 Jun 23.

6.

Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data.

Bailey SE, Ukoumunne OC, Shephard EA, Hamilton W.

Br J Gen Pract. 2017 Jun;67(659):e405-e413. doi: 10.3399/bjgp17X691109.

7.

Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study.

Stapley SA, Rubin GP, Alsina D, Shephard EA, Rutter MD, Hamilton WT.

Br J Gen Pract. 2017 May;67(658):e336-e344. doi: 10.3399/bjgp17X690425. Epub 2017 Mar 27.

8.
9.

Drug metabolism by flavin-containing monooxygenases of human and mouse.

Phillips IR, Shephard EA.

Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181. doi: 10.1080/17425255.2017.1239718. Epub 2016 Sep 29. Review.

PMID:
27678284
10.

The integration and interpretation of pharmacogenomics - a comparative study between the United States of America and Europe: towards better health care.

Bartlett MJ, Shephard EA.

Drug Metab Pers Ther. 2016 Jun 1;31(2):91-6. doi: 10.1515/dmpt-2015-0044. Review.

PMID:
27269898
11.

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

Dona AC, Kyriakides M, Scott F, Shephard EA, Varshavi D, Veselkov K, Everett JR.

Comput Struct Biotechnol J. 2016 Mar 9;14:135-53. doi: 10.1016/j.csbj.2016.02.005. eCollection 2016.

12.

Symptoms of adult chronic and acute leukaemia before diagnosis: large primary care case-control studies using electronic records.

Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton W.

Br J Gen Pract. 2016 Mar;66(644):e182-8. doi: 10.3399/bjgp16X683989.

13.

Primary Trimethylaminuria.

Phillips IR, Shephard EA.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2007 Oct 8 [updated 2015 Oct 1].

14.

Isolation and Culture of Mouse Hepatocytes: Gender-Specific Gene Expression Responses to Chemical Treatments.

Houseman L, Edwards M, Phillips IR, Shephard EA.

Methods Mol Biol. 2015;1250:3-12. doi: 10.1007/978-1-4939-2074-7_1.

PMID:
26272131
15.

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.

Gonzalez Malagon SG, Melidoni AN, Hernandez D, Omar BA, Houseman L, Veeravalli S, Scott F, Varshavi D, Everett J, Tsuchiya Y, Timms JF, Phillips IR, Shephard EA.

Biochem Pharmacol. 2015 Aug 1;96(3):267-77. doi: 10.1016/j.bcp.2015.05.013. Epub 2015 Jun 4.

16.

Quantifying the risk of Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a case-control study using electronic records.

Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton WT.

Br J Gen Pract. 2015 May;65(634):e289-94. doi: 10.3399/bjgp15X684805.

17.

Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case-control study using electronic records.

Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton WT.

Br J Gen Pract. 2015 May;65(634):e281-8. doi: 10.3399/bjgp15X684793.

18.

Quantifying the risk of multiple myeloma from symptoms reported in primary care patients: a large case-control study using electronic records.

Shephard EA, Neal RD, Rose P, Walter FM, Litt EJ, Hamilton WT.

Br J Gen Pract. 2015 Feb;65(631):e106-13. doi: 10.3399/bjgp15X683545.

19.

Clinical utility gene card for: Trimethylaminuria - update 2014.

Shephard EA, Treacy EP, Phillips IR.

Eur J Hum Genet. 2015 Sep;23(9). doi: 10.1038/ejhg.2014.226. Epub 2014 Oct 22. No abstract available.

20.

Non-visible versus visible haematuria and bladder cancer risk: a study of electronic records in primary care.

Price SJ, Shephard EA, Stapley SA, Barraclough K, Hamilton WT.

Br J Gen Pract. 2014 Sep;64(626):e584-9. doi: 10.3399/bjgp14X681409.

21.

The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.

Veeravalli S, Omar BA, Houseman L, Hancock M, Gonzalez Malagon SG, Scott F, Janmohamed A, Phillips IR, Shephard EA.

Biochem Pharmacol. 2014 Jul 1;90(1):88-95. doi: 10.1016/j.bcp.2014.04.007. Epub 2014 Apr 30.

PMID:
24792439
22.

Public perceptions of the risks, benefits and use of natural remedies, pharmaceutical medicines and personalised medicines.

Green DW, Horne R, Shephard EA.

Complement Ther Med. 2013 Oct;21(5):487-91. doi: 10.1016/j.ctim.2013.07.007. Epub 2013 Aug 20.

PMID:
24050584
23.

Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.

Shimizu M, Allerston CK, Shephard EA, Yamazaki H, Phillips IR.

Br J Clin Pharmacol. 2014 May;77(5):839-51. doi: 10.1111/bcp.12240.

24.

Pharmacogenetic testing in the UK clinical setting.

Bartlett MJ, Green DW, Shephard EA.

Lancet. 2013 Jun 1;381(9881):1903. doi: 10.1016/S0140-6736(13)61160-5. No abstract available.

PMID:
23725729
25.

Metabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse.

Palmer AL, Leykam VL, Larkin A, Krueger SK, Phillips IR, Shephard EA, Williams DE.

Pharmaceuticals (Basel). 2012;5(11):1147-59. doi: 10.3390/ph5111147.

26.

Isolation of mouse hepatocytes.

Edwards M, Houseman L, Phillips IR, Shephard EA.

Methods Mol Biol. 2013;987:283-93. doi: 10.1007/978-1-62703-321-3_24.

PMID:
23475686
27.

Detection of regulatory polymorphisms: high-throughput capillary DNase I footprinting.

Hancock M, Shephard EA.

Methods Mol Biol. 2013;987:269-82. doi: 10.1007/978-1-62703-321-3_23.

PMID:
23475685
28.

Clinical features of bladder cancer in primary care.

Shephard EA, Stapley S, Neal RD, Rose P, Walter FM, Hamilton WT.

Br J Gen Pract. 2012 Sep;62(602):e598-604. doi: 10.3399/bjgp12X654560. Erratum in: Br J Gen Pract. 2014 Mar;64(620):126.

29.

Clinical utility gene card for: trimethylaminuria.

Shephard EA, Treacy EP, Phillips IR.

Eur J Hum Genet. 2012 Mar;20(3). doi: 10.1038/ejhg.2011.214. Epub 2011 Nov 30. No abstract available.

30.

The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism.

Shephard EA, Phillips IR.

Expert Opin Drug Metab Toxicol. 2010 Sep;6(9):1083-94. doi: 10.1517/17425255.2010.503705. Review.

PMID:
20629583
31.

A novel mutation in the flavin-containing monooxygenase 3 gene (FMO3) of a Norwegian family causes trimethylaminuria.

Allerston CK, Vetti HH, Houge G, Phillips IR, Shephard EA.

Mol Genet Metab. 2009 Sep-Oct;98(1-2):198-202. doi: 10.1016/j.ymgme.2009.06.002. Epub 2009 Jun 6.

PMID:
19577495
32.

Planning the human variome project: the Spain report.

Kaput J, Cotton RG, Hardman L, Watson M, Al Aqeel AI, Al-Aama JY, Al-Mulla F, Alonso S, Aretz S, Auerbach AD, Bapat B, Bernstein IT, Bhak J, Bleoo SL, Blöcker H, Brenner SE, Burn J, Bustamante M, Calzone R, Cambon-Thomsen A, Cargill M, Carrera P, Cavedon L, Cho YS, Chung YJ, Claustres M, Cutting G, Dalgleish R, den Dunnen JT, Díaz C, Dobrowolski S, dos Santos MR, Ekong R, Flanagan SB, Flicek P, Furukawa Y, Genuardi M, Ghang H, Golubenko MV, Greenblatt MS, Hamosh A, Hancock JM, Hardison R, Harrison TM, Hoffmann R, Horaitis R, Howard HJ, Barash CI, Izagirre N, Jung J, Kojima T, Laradi S, Lee YS, Lee JY, Gil-da-Silva-Lopes VL, Macrae FA, Maglott D, Marafie MJ, Marsh SG, Matsubara Y, Messiaen LM, Möslein G, Netea MG, Norton ML, Oefner PJ, Oetting WS, O'Leary JC, de Ramirez AM, Paalman MH, Parboosingh J, Patrinos GP, Perozzi G, Phillips IR, Povey S, Prasad S, Qi M, Quin DJ, Ramesar RS, Richards CS, Savige J, Scheible DG, Scott RJ, Seminara D, Shephard EA, Sijmons RH, Smith TD, Sobrido MJ, Tanaka T, Tavtigian SV, Taylor GR, Teague J, Töpel T, Ullman-Cullere M, Utsunomiya J, van Kranen HJ, Vihinen M, Webb E, Weber TK, Yeager M, Yeom YI, Yim SH, Yoo HS; Contributors to the Human Variome Project Planning Meeting.

Hum Mutat. 2009 Apr;30(4):496-510. doi: 10.1002/humu.20972.

33.

Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine.

Hernandez D, Janmohamed A, Chandan P, Omar BA, Phillips IR, Shephard EA.

Pharmacogenet Genomics. 2009 Apr;19(4):289-99. doi: 10.1097/FPC.0b013e328328d507.

PMID:
19262426
34.

Human flavin-containing monooxygenase 2.1 catalyzes oxygenation of the antitubercular drugs thiacetazone and ethionamide.

Francois AA, Nishida CR, de Montellano PR, Phillips IR, Shephard EA.

Drug Metab Dispos. 2009 Jan;37(1):178-86. doi: 10.1124/dmd.108.024158. Epub 2008 Oct 23.

35.

The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa.

Veeramah KR, Thomas MG, Weale ME, Zeitlyn D, Tarekegn A, Bekele E, Mendell NR, Shephard EA, Bradman N, Phillips IR.

Pharmacogenet Genomics. 2008 Oct;18(10):877-86. doi: 10.1097/FPC.0b013e3283097311.

36.

Flavin-containing monooxygenases: mutations, disease and drug response.

Phillips IR, Shephard EA.

Trends Pharmacol Sci. 2008 Jun;29(6):294-301. doi: 10.1016/j.tips.2008.03.004. Epub 2008 Apr 16. Review.

PMID:
18423897
37.

Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3).

Allerston CK, Shimizu M, Fujieda M, Shephard EA, Yamazaki H, Phillips IR.

Pharmacogenet Genomics. 2007 Oct;17(10):827-39.

PMID:
17885620
38.

Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse.

Shephard EA, Chandan P, Stevanovic-Walker M, Edwards M, Phillips IR.

Biochem J. 2007 Sep 15;406(3):491-9.

39.

Microinjection of targeted embryonic stem cells and establishment of knockout mouse lines for Fmo genes.

Hernandez D, Melidoni AN, Phillips lR, Shephard EA.

Methods Mol Biol. 2006;320:329-41.

PMID:
16719404
40.
41.

Deletion of genes from the mouse genome using Cre/loxP technology.

Hernandez D, Chandan P, Janmohamed A, Phillips lR, Shephard EA.

Methods Mol Biol. 2006;320:307-19.

PMID:
16719402
42.
43.

Transfection of primary cultures of rat hepatocytes.

Edwards M, Wong SC, Chotpadiwetkul R, Smirlis D, Phillips lR, Shephard EA.

Methods Mol Biol. 2006;320:273-82.

PMID:
16719399
44.

Expression of recombinant flavin-containing monooxygenases in a baculovirus/insect cell system.

Janmohamed A, Thaunsukon P, Shephard EA, Phillips lR.

Methods Mol Biol. 2006;320:39-59.

PMID:
16719373
45.

Mutation, polymorphism and perspectives for the future of human flavin-containing monooxygenase 3.

Zhou J, Shephard EA.

Mutat Res. 2006 Jun;612(3):165-71. Epub 2006 Feb 14. Review.

PMID:
16481213
46.

Expression of Recombinant Flavin-Containing Monooxygenases in a Baculovirus/Insect Cell System.

Janmohamed A, Thaunsukon P, Shephard EA, Phillips IR.

Methods Mol Biol. 2006;320:39-59.

PMID:
27699678
47.

Microinjection of Targeted Embryonic Stem Cells and Establishment of Knockout Mouse Lines for Fmo Genes.

Hernandez D, Melidoni AN, Phillips IR, Shephard EA.

Methods Mol Biol. 2006;320:329-341.

PMID:
27699676
48.
49.

Deletion of Genes From the Mouse Genome Using Cre/loxP Technology.

Hernandez D, Chandan P, Janmohamed A, Phillips IR, Shephard EA.

Methods Mol Biol. 2006;320:307-319.

PMID:
27699674
50.

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