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Neural and behavioural indices of face processing in siblings of children with autism spectrum disorder (ASD): A longitudinal study from infancy to mid-childhood.

Shephard E, Milosavljevic B, Mason L, Elsabbagh M, Tye C, Gliga T, Jones EJ, Charman T, Johnson MH; BASIS Team.

Cortex. 2020 Feb 29;127:162-179. doi: 10.1016/j.cortex.2020.02.008. [Epub ahead of print]


A case report of massive elemental mercury ingestion with air sampling to ensure safe conditions for healthcare personnel.

Shephard EA, Bonnin L, Smolinske SC, Seifert SA, Warrick BJ.

Clin Toxicol (Phila). 2020 Mar 12:1-2. doi: 10.1080/15563650.2020.1737707. [Epub ahead of print] No abstract available.


Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine.

Veeravalli S, Phillips IR, Freire RT, Varshavi D, Everett JR, Shephard EA.

Drug Metab Dispos. 2020 Mar 10. pii: dmd.119.089995. doi: 10.1124/dmd.119.089995. [Epub ahead of print]


Tafamidis: A Novel Treatment for Transthyretin Amyloid Cardiomyopathy.

Nawarskas JJ, Shephard EA.

Cardiol Rev. 2020 May/Jun;28(3):156-160. doi: 10.1097/CRD.0000000000000306.


Flavin-containing monooxygenases: new structures from old proteins.

Phillips IR, Shephard EA.

Nat Struct Mol Biol. 2020 Jan;27(1):3-4. doi: 10.1038/s41594-019-0356-1. No abstract available.


Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil.

Shephard E, Fatori D, Mauro LR, de Medeiros Filho MV, Hoexter MQ, Chiesa AM, Fracolli LA, Brentani H, Ferraro AA, Nelson CA 3rd, Miguel EC, Polanczyk GV.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Oct;4(10):925-934. doi: 10.1016/j.bpsc.2019.05.009. Epub 2019 May 22.


Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease.

Phillips IR, Shephard EA.

Xenobiotica. 2020 Jan;50(1):19-33. doi: 10.1080/00498254.2019.1643515. Epub 2019 Aug 1. Review.


Oscillatory neural networks underlying resting-state, attentional control and social cognition task conditions in children with ASD, ADHD and ASD+ADHD.

Shephard E, Tye C, Ashwood KL, Azadi B, Johnson MH, Charman T, Asherson P, McLoughlin G, Bolton PF.

Cortex. 2019 Aug;117:96-110. doi: 10.1016/j.cortex.2019.03.005. Epub 2019 Mar 19.


Recognising laryngeal cancer in primary care: a large case-control study using electronic records.

Shephard EA, Parkinson MA, Hamilton WT.

Br J Gen Pract. 2019 Feb;69(679):e127-e133. doi: 10.3399/bjgp19X700997. Epub 2019 Jan 28.


Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy.

Ozonoff S, Young GS, Brian J, Charman T, Shephard E, Solish A, Zwaigenbaum L.

J Am Acad Child Adolesc Psychiatry. 2018 Nov;57(11):849-857.e2. doi: 10.1016/j.jaac.2018.06.022. Epub 2018 Sep 3.


Review and Validation of Bayesian Dose-Optimizing Software and Equations for Calculation of the Vancomycin Area Under the Curve in Critically Ill Patients.

Turner RB, Kojiro K, Shephard EA, Won R, Chang E, Chan D, Elbarbry F.

Pharmacotherapy. 2018 Dec;38(12):1174-1183. doi: 10.1002/phar.2191. Epub 2018 Nov 23.


E-referrals: improving the routine interspecialty inpatient referral system.

Shephard E, Stockdale C, May F, Brown A, Lewis H, Jabri S, Robertson D, Moss V, Bethune R.

BMJ Open Qual. 2018 Sep 28;7(3):e000249. doi: 10.1136/bmjoq-2017-000249. eCollection 2018.


Early detection of multiple myeloma in primary care using blood tests: a case-control study in primary care.

Koshiaris C, Van den Bruel A, Oke JL, Nicholson BD, Shephard E, Braddick M, Hamilton W.

Br J Gen Pract. 2018 Sep;68(674):e586-e593. doi: 10.3399/bjgp18X698357. Epub 2018 Aug 13.


Implicit sequence learning in young people with Tourette syndrome with and without co-occurring attention-deficit/hyperactivity disorder.

Shephard E, Groom MJ, Jackson GM.

J Neuropsychol. 2019 Sep;13(3):529-549. doi: 10.1111/jnp.12167. Epub 2018 Jul 4.


Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records.

Shephard EA, Hamilton WT.

Br J Gen Pract. 2018 Aug;68(673):e559-e565. doi: 10.3399/bjgp18X697949. Epub 2018 Jul 2. Erratum in: Br J Gen Pract. 2018 Sep;68(674):416.


Early developmental pathways to childhood symptoms of attention-deficit hyperactivity disorder, anxiety and autism spectrum disorder.

Shephard E, Bedford R, Milosavljevic B, Gliga T, Jones EJH, Pickles A, Johnson MH, Charman T; BASIS Team.

J Child Psychol Psychiatry. 2019 Sep;60(9):963-974. doi: 10.1111/jcpp.12947. Epub 2018 Jul 2.


First clinical use of novel ablation catheter incorporating local impedance data.

Martin CA, Martin R, Gajendragadkar PR, Maury P, Takigawa M, Cheniti G, Frontera A, Kitamura T, Duchateau J, Vlachos K, Bourier F, Lam A, Lord S, Murray S, Shephard E, Pambrun T, Denis A, Derval N, Hocini M, Haissaguerre M, Jais P, Sacher F.

J Cardiovasc Electrophysiol. 2018 Sep;29(9):1197-1206. doi: 10.1111/jce.13654. Epub 2018 Jun 19.


Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice.

Varshavi D, Scott FH, Varshavi D, Veeravalli S, Phillips IR, Veselkov K, Strittmatter N, Takats Z, Shephard EA, Everett JR.

Front Mol Biosci. 2018 Apr 9;5:28. doi: 10.3389/fmolb.2018.00028. eCollection 2018.


Adaptive Behaviour and Cognitive Skills: Stability and Change from 7 Months to 7 Years in Siblings at High Familial Risk of Autism Spectrum Disorder.

Salomone E, Shephard E, Milosavljevic B, Johnson MH, Charman T; BASIS Team.

J Autism Dev Disord. 2018 Sep;48(9):2901-2911. doi: 10.1007/s10803-018-3554-5.


Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis.

Veeravalli S, Karu K, Scott F, Fennema D, Phillips IR, Shephard EA.

Drug Metab Dispos. 2018 Jan;46(1):20-25. doi: 10.1124/dmd.117.077636. Epub 2017 Oct 25.


A highly sensitive liquid chromatography electrospray ionization mass spectrometry method for quantification of TMA, TMAO and creatinine in mouse urine.

Veeravalli S, Karu K, Phillips IR, Shephard EA.

MethodsX. 2017 Sep 28;4:310-319. doi: 10.1016/j.mex.2017.09.004. eCollection 2017.


Neurocognitive and observational markers: prediction of autism spectrum disorder from infancy to mid-childhood.

Bedford R, Gliga T, Shephard E, Elsabbagh M, Pickles A, Charman T, Johnson MH.

Mol Autism. 2017 Sep 22;8:49. doi: 10.1186/s13229-017-0167-3. eCollection 2017.


Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD.

Shephard E, Tye C, Ashwood KL, Azadi B, Asherson P, Bolton PF, McLoughlin G.

J Autism Dev Disord. 2018 Jan;48(1):110-122. doi: 10.1007/s10803-017-3300-4.


Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.

Scott F, Gonzalez Malagon SG, O'Brien BA, Fennema D, Veeravalli S, Coveney CR, Phillips IR, Shephard EA.

Drug Metab Dispos. 2017 Sep;45(9):982-989. doi: 10.1124/dmd.117.076612. Epub 2017 Jun 23.


Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data.

Bailey SE, Ukoumunne OC, Shephard EA, Hamilton W.

Br J Gen Pract. 2017 Jun;67(659):e405-e413. doi: 10.3399/bjgp17X691109.


Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study.

Stapley SA, Rubin GP, Alsina D, Shephard EA, Rutter MD, Hamilton WT.

Br J Gen Pract. 2017 May;67(658):e336-e344. doi: 10.3399/bjgp17X690425. Epub 2017 Mar 27.


Anxiety and Attentional Bias to Threat in Children at Increased Familial Risk for Autism Spectrum Disorder.

Milosavljevic B, Shephard E, Happé FG, Johnson MH, Charman T; BASIS Team.

J Autism Dev Disord. 2017 Dec;47(12):3714-3727. doi: 10.1007/s10803-016-3012-1.


DNA-MVA-protein vaccination of rhesus macaques induces HIV-specific immunity in mucosal-associated lymph nodes and functional antibodies.

Chege GK, Burgers WA, Müller TL, Gray CM, Shephard EG, Barnett SW, Ferrari G, Montefiori D, Williamson C, Williamson AL.

Vaccine. 2017 Feb 7;35(6):929-937. doi: 10.1016/j.vaccine.2016.12.060. Epub 2017 Jan 6.


Mid-childhood outcomes of infant siblings at familial high-risk of autism spectrum disorder.

Shephard E, Milosavljevic B, Pasco G, Jones EJ, Gliga T, Happé F, Johnson MH, Charman T; BASIS Team.

Autism Res. 2017 Mar;10(3):546-557. doi: 10.1002/aur.1733. Epub 2016 Nov 29. Erratum in: Autism Res. 2017 Dec;10 (12 ):2056-2057.


How useful is thrombocytosis in predicting an underlying cancer in primary care? a systematic review.

Bailey SE, Ukoumunne OC, Shephard E, Hamilton W.

Fam Pract. 2017 Feb;34(1):4-10. doi: 10.1093/fampra/cmw100. Epub 2016 Sep 28. Review.


Drug metabolism by flavin-containing monooxygenases of human and mouse.

Phillips IR, Shephard EA.

Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181. doi: 10.1080/17425255.2017.1239718. Epub 2016 Sep 29. Review.


The integration and interpretation of pharmacogenomics - a comparative study between the United States of America and Europe: towards better health care.

Bartlett MJ, Shephard EA.

Drug Metab Pers Ther. 2016 Jun 1;31(2):91-6. doi: 10.1515/dmpt-2015-0044. Review.


Is omission of free text records a possible source of data loss and bias in Clinical Practice Research Datalink studies? A case-control study.

Price SJ, Stapley SA, Shephard E, Barraclough K, Hamilton WT.

BMJ Open. 2016 May 13;6(5):e011664. doi: 10.1136/bmjopen-2016-011664.


Electrophysiological correlates of reinforcement learning in young people with Tourette syndrome with and without co-occurring ADHD symptoms.

Shephard E, Jackson GM, Groom MJ.

Int J Dev Neurosci. 2016 Jun;51:17-27. doi: 10.1016/j.ijdevneu.2016.04.005. Epub 2016 Apr 19.


WITHDRAWN: Electrophysiological correlates of reinforcement learning in young people with Tourette syndrome with and without co-occurring ADHD symptoms.

Shephard E, Jackson GM, Groom MJ.

Int J Dev Neurosci. 2016 Apr 19. pii: S0736-5748(15)30159-3. doi: 10.1016/j.ijdevneu.2016.04.006. [Epub ahead of print]


A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments.

Dona AC, Kyriakides M, Scott F, Shephard EA, Varshavi D, Veselkov K, Everett JR.

Comput Struct Biotechnol J. 2016 Mar 9;14:135-53. doi: 10.1016/j.csbj.2016.02.005. eCollection 2016.


Symptoms of adult chronic and acute leukaemia before diagnosis: large primary care case-control studies using electronic records.

Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton W.

Br J Gen Pract. 2016 Mar;66(644):e182-8. doi: 10.3399/bjgp16X683989.


Primary Trimethylaminuria.

Phillips IR, Shephard EA.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020.
2007 Oct 8 [updated 2015 Oct 1].


Isolation and Culture of Mouse Hepatocytes: Gender-Specific Gene Expression Responses to Chemical Treatments.

Houseman L, Edwards M, Phillips IR, Shephard EA.

Methods Mol Biol. 2015;1250:3-12. doi: 10.1007/978-1-4939-2074-7_1.


The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.

Gonzalez Malagon SG, Melidoni AN, Hernandez D, Omar BA, Houseman L, Veeravalli S, Scott F, Varshavi D, Everett J, Tsuchiya Y, Timms JF, Phillips IR, Shephard EA.

Biochem Pharmacol. 2015 Aug 1;96(3):267-77. doi: 10.1016/j.bcp.2015.05.013. Epub 2015 Jun 4.


Quantifying the risk of Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a case-control study using electronic records.

Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton WT.

Br J Gen Pract. 2015 May;65(634):e289-94. doi: 10.3399/bjgp15X684805.


Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case-control study using electronic records.

Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton WT.

Br J Gen Pract. 2015 May;65(634):e281-8. doi: 10.3399/bjgp15X684793.


The effects of co-occurring ADHD symptoms on electrophysiological correlates of cognitive control in young people with Tourette syndrome.

Shephard E, Jackson GM, Groom MJ.

J Neuropsychol. 2016 Sep;10(2):223-38. doi: 10.1111/jnp.12071. Epub 2015 Apr 20.


Quantifying the risk of multiple myeloma from symptoms reported in primary care patients: a large case-control study using electronic records.

Shephard EA, Neal RD, Rose P, Walter FM, Litt EJ, Hamilton WT.

Br J Gen Pract. 2015 Feb;65(631):e106-13. doi: 10.3399/bjgp15X683545.


Clinical utility gene card for: Trimethylaminuria - update 2014.

Shephard EA, Treacy EP, Phillips IR.

Eur J Hum Genet. 2015 Sep;23(9). doi: 10.1038/ejhg.2014.226. Epub 2014 Oct 22. No abstract available.


Non-visible versus visible haematuria and bladder cancer risk: a study of electronic records in primary care.

Price SJ, Shephard EA, Stapley SA, Barraclough K, Hamilton WT.

Br J Gen Pract. 2014 Sep;64(626):e584-9. doi: 10.3399/bjgp14X681409.


The use of directed evolution to create a stable and immunogenic recombinant BCG expressing a modified HIV-1 Gag antigen.

Chapman R, Bourn WR, Shephard E, Stutz H, Douglass N, Mgwebi T, Meyers A, Chin'ombe N, Williamson AL.

PLoS One. 2014 Jul 25;9(7):e103314. doi: 10.1371/journal.pone.0103314. eCollection 2014.


The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance.

Veeravalli S, Omar BA, Houseman L, Hancock M, Gonzalez Malagon SG, Scott F, Janmohamed A, Phillips IR, Shephard EA.

Biochem Pharmacol. 2014 Jul 1;90(1):88-95. doi: 10.1016/j.bcp.2014.04.007. Epub 2014 Apr 30.


Learning and altering behaviours by reinforcement: neurocognitive differences between children and adults.

Shephard E, Jackson GM, Groom MJ.

Dev Cogn Neurosci. 2014 Jan;7:94-105. doi: 10.1016/j.dcn.2013.12.001. Epub 2013 Dec 7.

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