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Adhesive and Cohesive Peel Force Measurement of Human Airway Mucus.

Goodell HP, Shenoy SK, Shenkute NT, Lackey E, Dennis RG, Button B.

Bio Protoc. 2019 Jul 5;9(13). pii: e3287. doi: 10.21769/BioProtoc.3287.


Borderline personality disorder and its association with bipolar spectrum and binge eating disorder in college students from South India.

Shenoy SK, Praharaj SK.

Asian J Psychiatr. 2019 Aug;44:20-24. doi: 10.1016/j.ajp.2019.07.017. Epub 2019 Jul 8.


Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD.

Chisholm JF, Shenoy SK, Shade JK, Kim V, Putcha N, Carson KA, Wise R, Hansel NN, Hanes JS, Suk JS, Neptune E.

Eur Respir J. 2019 Aug 1;54(2). pii: 1900088. doi: 10.1183/13993003.00088-2019. Print 2019 Aug.


Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET.

Nagi K, Shenoy SK.

Methods Mol Biol. 2019;1957:93-104. doi: 10.1007/978-1-4939-9158-7_6.


The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.

Yu SM, Jean-Charles PY, Abraham DM, Kaur S, Gareri C, Mao L, Rockman HA, Shenoy SK.

J Biol Chem. 2019 Feb 15;294(7):2500-2518. doi: 10.1074/jbc.RA118.004926. Epub 2018 Dec 11.


USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.

Jean-Charles PY, Wu JH, Zhang L, Kaur S, Nepliouev I, Stiber JA, Brian L, Qi R, Wertman V, Shenoy SK, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2295-2305. doi: 10.1161/ATVBAHA.118.311071.


Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7650. doi: 10.1126/scisignal.aat7650.


Drebrin regulates angiotensin II-induced aortic remodelling.

Zhang L, Wu JH, Huang TQ, Nepliouev I, Brian L, Zhang Z, Wertman V, Rudemiller NP, McMahon TJ, Shenoy SK, Miller FJ, Crowley SD, Freedman NJ, Stiber JA.

Cardiovasc Res. 2018 Nov 1;114(13):1806-1815. doi: 10.1093/cvr/cvy151.


Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.

Zhang L, Wu JH, Otto JC, Gurley SB, Hauser ER, Shenoy SK, Nagi K, Brian L, Wertman V, Mattocks N, Lawson JH, Freedman NJ.

Cardiovasc Res. 2017 Nov 1;113(13):1551-1559. doi: 10.1093/cvr/cvx177.


Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.

Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman HA, Shenoy SK.

JCI Insight. 2017 Sep 7;2(17). pii: 95998. doi: 10.1172/jci.insight.95998. eCollection 2017 Sep 7.


G Protein-Coupled Receptor Signaling Through β-Arrestin-Dependent Mechanisms.

Jean-Charles PY, Kaur S, Shenoy SK.

J Cardiovasc Pharmacol. 2017 Sep;70(3):142-158. doi: 10.1097/FJC.0000000000000482. Review.


Regulation of inflammation by β-arrestins: Not just receptor tales.

Freedman NJ, Shenoy SK.

Cell Signal. 2018 Jan;41:41-45. doi: 10.1016/j.cellsig.2017.02.008. Epub 2017 Feb 9. Review.


GPCR desensitization: Acute and prolonged phases.

Rajagopal S, Shenoy SK.

Cell Signal. 2018 Jan;41:9-16. doi: 10.1016/j.cellsig.2017.01.024. Epub 2017 Jan 28. Review.


Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.

Feger BJ, Thompson JW, Dubois LG, Kommaddi RP, Foster MW, Mishra R, Shenoy SK, Shibata Y, Kidane YH, Moseley MA, Carnell LS, Bowles DE.

Sci Rep. 2016 Sep 27;6:34091. doi: 10.1038/srep34091.



Shenoy SK.

Prog Mol Biol Transl Sci. 2016;141:xiii-xiv. doi: 10.1016/S1877-1173(16)30035-7. No abstract available.


Chapter Nine - Cellular Roles of Beta-Arrestins as Substrates and Adaptors of Ubiquitination and Deubiquitination.

Jean-Charles PY, Freedman NJ, Shenoy SK.

Prog Mol Biol Transl Sci. 2016;141:339-69. doi: 10.1016/bs.pmbts.2016.04.003. Epub 2016 May 7. Review.


Chapter One - Ubiquitination and Deubiquitination of G Protein-Coupled Receptors.

Jean-Charles PY, Snyder JC, Shenoy SK.

Prog Mol Biol Transl Sci. 2016;141:1-55. doi: 10.1016/bs.pmbts.2016.05.001. Review.


Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.

Jean-Charles PY, Zhang L, Wu JH, Han SO, Brian L, Freedman NJ, Shenoy SK.

J Biol Chem. 2016 Apr 1;291(14):7450-64. doi: 10.1074/jbc.M115.687129. Epub 2016 Feb 2.


Ubiquitin-Related Roles of β-Arrestins in Endocytic Trafficking and Signal Transduction.

Jean-Charles PY, Rajiv V, Shenoy SK.

J Cell Physiol. 2016 Oct;231(10):2071-80. doi: 10.1002/jcp.25317. Epub 2016 Feb 3. Review.


Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.

Kommaddi RP, Jean-Charles PY, Shenoy SK.

J Biol Chem. 2015 Apr 3;290(14):8888-903. doi: 10.1074/jbc.M114.630541. Epub 2015 Feb 9.


Deubiquitinases and their emerging roles in β-arrestin-mediated signaling.

Shenoy SK.

Methods Enzymol. 2014;535:351-70. doi: 10.1016/B978-0-12-397925-4.00020-1.


Arrestin interaction with E3 ubiquitin ligases and deubiquitinases: functional and therapeutic implications.

Shenoy SK.

Handb Exp Pharmacol. 2014;219:187-203. doi: 10.1007/978-3-642-41199-1_10.


Arrestins and protein ubiquitination.

Kommaddi RP, Shenoy SK.

Prog Mol Biol Transl Sci. 2013;118:175-204. doi: 10.1016/B978-0-12-394440-5.00007-3. Review.


Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.

Han SO, Kommaddi RP, Shenoy SK.

EMBO Rep. 2013 Feb;14(2):164-71. doi: 10.1038/embor.2012.187. Epub 2012 Dec 4.


MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.

Han SO, Xiao K, Kim J, Wu JH, Wisler JW, Nakamura N, Freedman NJ, Shenoy SK.

J Cell Biol. 2012 Nov 26;199(5):817-30. doi: 10.1083/jcb.201208192. Epub 2012 Nov 19.


β-Arrestin and dishevelled coordinate biased signaling.

Schulte G, Shenoy SK.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19839-40. doi: 10.1073/pnas.1117444108. Epub 2011 Nov 28. No abstract available.


G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.

Wu JH, Zhang L, Fanaroff AC, Cai X, Sharma KC, Brian L, Exum ST, Shenoy SK, Peppel K, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):308-16. doi: 10.1161/ATVBAHA.111.239608. Epub 2011 Nov 17.


A tale of two sites: How ubiquitination of a G protein-coupled receptor is coupled to its lysosomal trafficking from distinct receptor domains.

Sarker S, Xiao K, Shenoy SK.

Commun Integr Biol. 2011 Sep;4(5):528-31. doi: 10.4161/cib.4.5.16458. Epub 2011 Sep 1.


Cardiovascular biology: heart fails without pump partner.

Shenoy SK, Rockman HA.

Nature. 2011 Sep 28;477(7366):546-7. doi: 10.1038/477546a. No abstract available.


Visualizing G protein-coupled receptor signalsomes using confocal immunofluorescence microscopy.

Shenoy SK.

Methods Mol Biol. 2011;756:333-42. doi: 10.1007/978-1-61779-160-4_20.


Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ.

Sci Signal. 2011 Aug 9;4(185):ra51. doi: 10.1126/scisignal.2001707.


A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.

Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.


β-arrestin-biased signaling by the β-adrenergic receptors.

Shenoy SK.

Curr Top Membr. 2011;67:51-78. doi: 10.1016/B978-0-12-384921-2.00003-3. Review. No abstract available.


β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.

Shenoy SK, Han S, Zhao YL, Hara MR, Oliver T, Cao Y, Dewhirst MW.

Oncogene. 2012 Jan 19;31(3):282-92. doi: 10.1038/onc.2011.238. Epub 2011 Jun 20.


β-Arrestin-mediated receptor trafficking and signal transduction.

Shenoy SK, Lefkowitz RJ.

Trends Pharmacol Sci. 2011 Sep;32(9):521-33. doi: 10.1016/ Epub 2011 Jun 15. Review.


Beta2-adrenergic receptor lysosomal trafficking is regulated by ubiquitination of lysyl residues in two distinct receptor domains.

Xiao K, Shenoy SK.

J Biol Chem. 2011 Apr 8;286(14):12785-95. doi: 10.1074/jbc.M110.203091. Epub 2011 Feb 17.


Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4.

Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ.

J Biol Chem. 2010 Sep 24;285(39):30115-25. doi: 10.1074/jbc.M110.141549. Epub 2010 Jul 22.


Large drusen following long-standing retinal detachment.

Shenoy SK, Babu K, Prabhakaran VC.

Indian J Pathol Microbiol. 2010 Apr-Jun;53(2):329-30. doi: 10.4103/0377-4929.64316.


The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

Berthouze M, Venkataramanan V, Li Y, Shenoy SK.

EMBO J. 2009 Jun 17;28(12):1684-96. doi: 10.1038/emboj.2009.128. Epub 2009 May 7.


Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.

Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6650-5. doi: 10.1073/pnas.0901083106. Epub 2009 Apr 10.


Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis.

Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ.

Mol Pharmacol. 2009 Mar;75(3):626-36. doi: 10.1124/mol.108.050278. Epub 2008 Dec 17.


The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning.

Dreixler JC, Hemmert JW, Shenoy SK, Shen Y, Lee HT, Shaikh AR, Rosenbaum DM, Roth S.

Exp Eye Res. 2009 Mar;88(3):512-21. doi: 10.1016/j.exer.2008.11.013. Epub 2008 Dec 3.


Protein kinase C subtypes and retinal ischemic preconditioning.

Dreixler JC, Shaikh AR, Shenoy SK, Shen Y, Roth S.

Exp Eye Res. 2008 Oct;87(4):300-11. doi: 10.1016/j.exer.2008.05.015. Epub 2008 Jun 3.


Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9988-93. doi: 10.1073/pnas.0804246105. Epub 2008 Jul 11.


Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor.

Shenoy SK, Xiao K, Venkataramanan V, Snyder PM, Freedman NJ, Weissman AM.

J Biol Chem. 2008 Aug 8;283(32):22166-76. doi: 10.1074/jbc.M709668200. Epub 2008 Jun 10.


beta-arrestin-biased agonism at the beta2-adrenergic receptor.

Drake MT, Violin JD, Whalen EJ, Wisler JW, Shenoy SK, Lefkowitz RJ.

J Biol Chem. 2008 Feb 29;283(9):5669-76. Epub 2007 Dec 17.


A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.

Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. Epub 2007 Oct 9.


Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.

Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2007 Oct 5;282(40):29549-62. Epub 2007 Jul 31.


Functional specialization of beta-arrestin interactions revealed by proteomic analysis.

Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR 3rd, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12011-6. Epub 2007 Jul 9.


Seven-transmembrane receptors and ubiquitination.

Shenoy SK.

Circ Res. 2007 Apr 27;100(8):1142-54. Review.

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