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PromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington's Disease.

Sundaram JR, Wu Y, Lee IC, George SE, Hota M, Ghosh S, Kesavapany S, Ahmed M, Tan EK, Shenolikar S.

ACS Chem Neurosci. 2019 Aug 21;10(8):3575-3589. doi: 10.1021/acschemneuro.9b00185. Epub 2019 Jul 30.


Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.

Wabnitz GH, Kirchgessner H, Jahraus B, Umansky L, Shenolikar S, Samstag Y.

Mol Cell Biol. 2018 Oct 29;38(22). pii: e00041-18. doi: 10.1128/MCB.00041-18. Print 2018 Nov 15.


Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates.

Brautigan DL, Shenolikar S.

Annu Rev Biochem. 2018 Jun 20;87:921-964. doi: 10.1146/annurev-biochem-062917-012332. Review.


Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.

Goh CW, Lee IC, Sundaram JR, George SE, Yusoff P, Brush MH, Sze NSK, Shenolikar S.

J Biol Chem. 2018 Jan 5;293(1):163-176. doi: 10.1074/jbc.M117.814111. Epub 2017 Nov 6.


Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.

Lee IC, Ho XY, George SE, Goh CW, Sundaram JR, Pang KKL, Luo W, Yusoff P, Sze NSK, Shenolikar S.

Cell Death Differ. 2018 Feb;25(2):255-267. doi: 10.1038/cdd.2017.152. Epub 2017 Oct 6.


A SMAP in the face for cancer.

Shenolikar S.

J Clin Invest. 2017 Jun 1;127(6):2048-2050. doi: 10.1172/JCI94763. Epub 2017 May 15.


Translating protein phosphatase research into treatments for neurodegenerative diseases.

Sundaram JR, Lee IC, Shenolikar S.

Biochem Soc Trans. 2017 Feb 8;45(1):101-112. doi: 10.1042/BST20160157. Review.


Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response.

Reid DW, Tay AS, Sundaram JR, Lee IC, Chen Q, George SE, Nicchitta CV, Shenolikar S.

Mol Cell Biol. 2016 Jun 15;36(13):1868-80. doi: 10.1128/MCB.00190-16. Print 2016 Jul 1.


Simple and inexpensive ribosome profiling analysis of mRNA translation.

Reid DW, Shenolikar S, Nicchitta CV.

Methods. 2015 Dec;91:69-74. doi: 10.1016/j.ymeth.2015.07.003. Epub 2015 Jul 8.


Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

Choy MS, Yusoff P, Lee IC, Newton JC, Goh CW, Page R, Shenolikar S, Peti W.

Cell Rep. 2015 Jun 30;11(12):1885-91. doi: 10.1016/j.celrep.2015.05.043. Epub 2015 Jun 18.


The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.

Reid DW, Chen Q, Tay AS, Shenolikar S, Nicchitta CV.

Cell. 2014 Sep 11;158(6):1362-1374. doi: 10.1016/j.cell.2014.08.012.


Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas.

Shenolikar S.

J Clin Invest. 2014 Mar;124(3):973-6. doi: 10.1172/JCI74609. Epub 2014 Feb 24.


Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.

Zhou W, Jeyaraman K, Yusoff P, Shenolikar S.

J Biol Chem. 2013 Nov 15;288(46):33146-55. doi: 10.1074/jbc.M113.504407. Epub 2013 Oct 3.


Reversible protein phosphorylation. Preface.

Shenolikar S.

Prog Mol Biol Transl Sci. 2012;106:xv-xvii. doi: 10.1016/B978-0-12-396456-4.00021-3. No abstract available.


Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.

Fullwood MJ, Zhou W, Shenolikar S.

Prog Mol Biol Transl Sci. 2012;106:75-106. doi: 10.1016/B978-0-12-396456-4.00005-5. Review.


Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations.

Fullwood MJ, Lee J, Lin L, Li G, Huss M, Ng P, Sung WK, Shenolikar S.

PLoS One. 2011;6(11):e26054. doi: 10.1371/journal.pone.0026054. Epub 2011 Nov 8.


Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.

Weinman EJ, Steplock D, Shenolikar S, Biswas R.

J Biol Chem. 2011 Oct 28;286(43):37216-21. doi: 10.1074/jbc.M111.288357. Epub 2011 Sep 9.


Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.

Zhou W, Brush MH, Choy MS, Shenolikar S.

J Biol Chem. 2011 Jun 17;286(24):21687-96. doi: 10.1074/jbc.M110.212787. Epub 2011 Apr 25.


Increased renal dopamine and acute renal adaptation to a high-phosphate diet.

Weinman EJ, Biswas R, Steplock D, Wang P, Lau YS, Desir GV, Shenolikar S.

Am J Physiol Renal Physiol. 2011 May;300(5):F1123-9. doi: 10.1152/ajprenal.00744.2010. Epub 2011 Feb 16.


Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells.

Weinman EJ, Steplock D, Shenolikar S, Blanpied TA.

Am J Physiol Renal Physiol. 2011 Jan;300(1):F231-5. doi: 10.1152/ajprenal.00532.2010. Epub 2010 Nov 3.


Role of NHERF and scaffolding proteins in proximal tubule transport.

Cunningham R, Biswas R, Steplock D, Shenolikar S, Weinman E.

Urol Res. 2010 Aug;38(4):257-62. doi: 10.1007/s00240-010-0294-1. Epub 2010 Jul 15. Review.


Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport.

Weinman EJ, Steplock D, Zhang Y, Biswas R, Bloch RJ, Shenolikar S.

J Biol Chem. 2010 Aug 13;285(33):25134-8. doi: 10.1074/jbc.M110.132423. Epub 2010 Jun 22.


Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney.

Weinman EJ, Biswas R, Steplock D, Douglass TS, Cunningham R, Shenolikar S.

J Biol Chem. 2010 Apr 30;285(18):13454-60. doi: 10.1074/jbc.M109.094359. Epub 2010 Mar 3.


PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.

Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1560-5. doi: 10.1152/ajprenal.90657.2008. Epub 2009 Sep 30.


From promiscuity to precision: protein phosphatases get a makeover.

Virshup DM, Shenolikar S.

Mol Cell. 2009 Mar 13;33(5):537-45. doi: 10.1016/j.molcel.2009.02.015. Review.


Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells.

Cunningham R, Biswas R, Brazie M, Steplock D, Shenolikar S, Weinman EJ.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F355-61. doi: 10.1152/ajprenal.90426.2008. Epub 2008 Nov 5.


Control of cellular GADD34 levels by the 26S proteasome.

Brush MH, Shenolikar S.

Mol Cell Biol. 2008 Dec;28(23):6989-7000. doi: 10.1128/MCB.00724-08. Epub 2008 Sep 15.


Use of protein phosphatase inhibitors.

Weiser DC, Shenolikar S.

Curr Protoc Protein Sci. 2003 May;Chapter 13:Unit 13.10. doi: 10.1002/0471140864.ps1310s31.


Detection of phosphorylation by enzymatic techniques.

Shenolikar S.

Curr Protoc Protein Sci. 2001 May;Chapter 13:Unit13.5. doi: 10.1002/0471140864.ps1305s05.


Overview of protein phosphorylation.

Sefton BM, Shenolikar S.

Curr Protoc Protein Sci. 2001 May;Chapter 13:Unit13.1. doi: 10.1002/0471140864.ps1301s00. Review.


Use of protein phosphatase inhibitors.

Weiser DC, Shenolikar S.

Curr Protoc Mol Biol. 2003 May;Chapter 18:Unit 18.10. doi: 10.1002/0471142727.mb1810s62.


Detection of phosphorylation by enzymatic techniques.

Shenolikar S.

Curr Protoc Mol Biol. 2001 May;Chapter 18:Unit 18.5. doi: 10.1002/0471142727.mb1805s33.


Overview of protein phosphorylation.

Sefton BM, Shenolikar S.

Curr Protoc Mol Biol. 2001 May;Chapter 18:Unit 18.1. doi: 10.1002/0471142727.mb1801s33.


Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.

Cunningham R, Esmaili A, Brown E, Biswas RS, Murtazina R, Donowitz M, Dijkman HB, van der Vlag J, Hogema BM, De Jonge HR, Shenolikar S, Wade JB, Weinman EJ.

Am J Physiol Renal Physiol. 2008 Apr;294(4):F1001-7. doi: 10.1152/ajprenal.00504.2007. Epub 2008 Feb 6.


Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.

Weinman EJ, Biswas RS, Peng G, Shen L, Turner CL, E X, Steplock D, Shenolikar S, Cunningham R.

J Clin Invest. 2007 Nov;117(11):3412-20. Erratum in: J Clin Invest. 2008 Jan;118(1):387. Peng, Quihong [corrected to Peng, Guihong]. Erratum in: J Clin Invest. 2013 Jun;123(6):2752.


Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.

Broere N, Hillesheim J, Tuo B, Jorna H, Houtsmuller AB, Shenolikar S, Weinman EJ, Donowitz M, Seidler U, de Jonge HR, Hogema BM.

J Biol Chem. 2007 Dec 28;282(52):37575-84. Epub 2007 Oct 18.


Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.

Voltz JW, Brush M, Sikes S, Steplock D, Weinman EJ, Shenolikar S.

J Biol Chem. 2007 Nov 16;282(46):33879-87. Epub 2007 Sep 25. Erratum in: J Biol Chem. 2008 Feb 15;283(7):4459.


Expression of human protein phosphatase-1 in Saccharomyces cerevisiae highlights the role of phosphatase isoforms in regulating eukaryotic functions.

Gibbons JA, Kozubowski L, Tatchell K, Shenolikar S.

J Biol Chem. 2007 Jul 27;282(30):21838-47. Epub 2007 Jun 1.


Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.

Cunningham D, Danley DE, Geoghegan KF, Griffor MC, Hawkins JL, Subashi TA, Varghese AH, Ammirati MJ, Culp JS, Hoth LR, Mansour MN, McGrath KM, Seddon AP, Shenolikar S, Stutzman-Engwall KJ, Warren LC, Xia D, Qiu X.

Nat Struct Mol Biol. 2007 May;14(5):413-9. Epub 2007 Apr 15.


Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport.

Cunningham R, Brazie M, Kanumuru S, E X, Biswas R, Wang F, Steplock D, Wade JB, Anzai N, Endou H, Shenolikar S, Weinman EJ.

J Am Soc Nephrol. 2007 May;18(5):1419-25. Epub 2007 Apr 4.


Identification of cellular protein phosphatase-1 regulators.

Roadcap DW, Brush MH, Shenolikar S.

Methods Mol Biol. 2007;365:181-96.


Analysis of protein phosphatases: toolbox for unraveling cell signaling networks.

Shenolikar S.

Methods Mol Biol. 2007;365:1-8. Review.


Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.

Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, Hahn WC, Virshup DM, Kornbluth S.

Cell. 2006 Nov 17;127(4):759-73.


Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory.

Mansuy IM, Shenolikar S.

Trends Neurosci. 2006 Dec;29(12):679-86. Epub 2006 Nov 3. Review.


Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.

Capuano P, Bacic D, Roos M, Gisler SM, Stange G, Biber J, Kaissling B, Weinman EJ, Shenolikar S, Wagner CA, Murer H.

Am J Physiol Cell Physiol. 2007 Feb;292(2):C927-34. Epub 2006 Sep 20.


Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.

Hu XD, Huang Q, Roadcap DW, Shenolikar SS, Xia H.

J Neurochem. 2006 Sep;98(6):1841-51. Epub 2006 Aug 8.


Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone.

Cunningham R, Steplock D, E X, Biswas RS, Wang F, Shenolikar S, Weinman EJ.

Am J Physiol Renal Physiol. 2006 Oct;291(4):F896-901. Epub 2006 May 16.


The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases.

Weinman EJ, Hall RA, Friedman PA, Liu-Chen LY, Shenolikar S.

Annu Rev Physiol. 2006;68:491-505. Review.


Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice.

Weinman EJ, Mohanlal V, Stoycheff N, Wang F, Steplock D, Shenolikar S, Cunningham R.

Am J Physiol Renal Physiol. 2006 Apr;290(4):F838-43. Epub 2005 Oct 25. Erratum in: Am J Physiol Renal Physiol. 2006 Jul;291(1):F254-5.


Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.

Cunningham R, E X, Steplock D, Shenolikar S, Weinman EJ.

Am J Physiol Renal Physiol. 2005 Oct;289(4):F933-8. Epub 2005 Jun 7.

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