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Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet.

Shen HH, Huang SY, Kung CW, Chen SY, Chen YF, Cheng PY, Lam KK, Lee YM.

J Nutr Biochem. 2019 Feb 19;67:111-122. doi: 10.1016/j.jnutbio.2019.02.001. [Epub ahead of print]


Prevalence of and Factors Influencing Anti-Tuberculosis Treatment Non-Adherence Among Patients with Pulmonary Tuberculosis: A Cross-Sectional Study in Anhui Province, Eastern China.

Fang XH, Shen HH, Hu WQ, Xu QQ, Jun L, Zhang ZP, Kan XH, Ma DC, Wu GC.

Med Sci Monit. 2019 Mar 14;25:1928-1935. doi: 10.12659/MSM.913510.


Core Concept: Can deep brain stimulation find success beyond Parkinson's disease?

Shen HH.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4764-4766. doi: 10.1073/pnas.1900442116. No abstract available.


Microbe-metabolite-host axis, two-way action in the pathogenesis and treatment of human autoimmunity.

Meng X, Zhou HY, Shen HH, Lufumpa E, Li XM, Guo B, Li BZ.

Autoimmun Rev. 2019 Mar 4. pii: S1568-9972(19)30059-X. doi: 10.1016/j.autrev.2019.03.006. [Epub ahead of print] Review.


Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation.

Jiang JH, Bhuiyan MS, Shen HH, Cameron DR, Rupasinghe TWT, Wu CM, Le Brun AP, Kostoulias X, Domene C, Fulcher AJ, McConville MJ, Howden BP, Lieschke GJ, Peleg AY.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3722-3727. doi: 10.1073/pnas.1812066116. Epub 2019 Feb 11.


Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Gutu AD, Hertzog P, Purcell T, Shen HH, Moskowitz SM, Velkov T, Li J.

mSystems. 2019 Jan 8;4(1). pii: e00149-18. doi: 10.1128/mSystems.00149-18. eCollection 2019 Jan-Feb.


Augmentation of DMLS Biomimetic Dental Implants with Weight-Bearing Strut to Balance of Biologic and Mechanical Demands: From Bench to Animal.

Chang JZ, Tsai PI, Kuo MY, Sun JS, Chen SY, Shen HH.

Materials (Basel). 2019 Jan 7;12(1). pii: E164. doi: 10.3390/ma12010164.


Author Correction: Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.

Xia LX, Hua W, Jin Y, Tian BP, Qiu ZW, Zhang C, Che LQ, Zhou HB, Wu YF, Huang HQ, Lan F, Ke YH, Lee JJ, Li W, Ying SM, Chen ZH, Shen HH.

Cell Death Differ. 2018 Dec 13. doi: 10.1038/s41418-018-0247-8. [Epub ahead of print]


Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury.

Lou J, Hu Y, Wu MD, Che LQ, Wu YF, Zhao Y, Tian BP, Bao ZQ, Zhu C, Wu YP, He LL, Bai CX, Zhou J, Ying SM, Li W, Chen ZH, Chen DX, Dorling A, Shen HH.

Acta Pharmacol Sin. 2018 Nov 16. doi: 10.1038/s41401-018-0175-7. [Epub ahead of print]


Aerosolized antibiotics for ventilator-associated pneumonia: a pairwise and Bayesian network meta-analysis.

Xu F, He LL, Che LQ, Li W, Ying SM, Chen ZH, Shen HH.

Crit Care. 2018 Nov 15;22(1):301. doi: 10.1186/s13054-018-2106-x. Review.


[Airway epithelial ATG5 suppresses asthmatic inflammation in mice].

Wang SB, Wu YF, Chen ZH, Li W, Shen HH.

Zhonghua Jie He He Hu Xi Za Zhi. 2018 Nov 12;41(11):873-877. doi: 10.3760/cma.j.issn.1001-0939.2018.11.009. Chinese.


Corrigendum: Effect of Cigarette Smoke Extract on Lipopolysaccharide-Activated Mitogen-Activated Protein Kinase Signal Transduction Pathway in Cultured Cells.

Li W, Xu YJ, Shen HH.

Chin Med J (Engl). 2018 Oct 20;131(20):2517. doi: 10.4103/0366-6999.243576. No abstract available.


Core Concept: Perineuronal nets gain prominence for their role in learning, memory, and plasticity.

Shen HH.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9813-9815. doi: 10.1073/pnas.1815273115. Review. No abstract available.


Akt/PKB signaling regulates cigarette smoke-induced pulmonary epithelial-mesenchymal transition.

Jiang B, Guan Y, Shen HJ, Zhang LH, Jiang JX, Dong XW, Shen HH, Xie QM.

Lung Cancer. 2018 Aug;122:44-53. doi: 10.1016/j.lungcan.2018.05.019. Epub 2018 May 21.


Treatment of osteoarthritis with collagen-based scaffold: A porcine animal model with xenograft mesenchymal stem cells.

Tseng WJ, Huang SW, Fang CH, Hsu LT, Chen CY, Shen HH, Chang JZ, Sun JS, Lin FH.

Histol Histopathol. 2018 Dec;33(12):1271-1286. doi: 10.14670/HH-18-013. Epub 2018 Jun 15.


NLRP3: A promising therapeutic target for autoimmune diseases.

Shen HH, Yang YX, Meng X, Luo XY, Li XM, Shuai ZW, Ye DQ, Pan HF.

Autoimmun Rev. 2018 Jul;17(7):694-702. doi: 10.1016/j.autrev.2018.01.020. Epub 2018 May 3. Review.


Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Anderson D, Shen HH, Tsuji B, Gutu AD, Moskowitz SM, Velkov T, Li J.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02656-17. doi: 10.1128/AAC.02656-17. Print 2018 Jun.


WeChat Public Account Use Improves Clinical Control of Cough-Variant Asthma: A Randomized Controlled Trial.

Cao Y, Lin SH, Zhu D, Xu F, Chen ZH, Shen HH, Li W.

Med Sci Monit. 2018 Mar 14;24:1524-1532.


[Comparison of Chinese guideline for asthma managment and prevention (2016 update) and global initiative for asthma (2017 update)].

Shen HH, Du XF, Ying SM.

Zhonghua Jie He He Hu Xi Za Zhi. 2018 Mar 12;41(3):166-168. doi: 10.3760/cma.j.issn.1001-0939.2018.03.003. Chinese. No abstract available.


MTOR Suppresses Cigarette Smoke-Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease.

Wang Y, Liu J, Zhou JS, Huang HQ, Li ZY, Xu XC, Lai TW, Hu Y, Zhou HB, Chen HP, Ying SM, Li W, Shen HH, Chen ZH.

J Immunol. 2018 Apr 15;200(8):2571-2580. doi: 10.4049/jimmunol.1701681. Epub 2018 Mar 5.


Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium.

Wang Y, Zhou JS, Xu XC, Li ZY, Chen HP, Ying SM, Li W, Shen HH, Chen ZH.

Int J Chron Obstruct Pulmon Dis. 2018 Feb 9;13:571-581. doi: 10.2147/COPD.S150633. eCollection 2018.


Knockdown of TFPI-Anchored Endothelial Cells Exacerbates Lipopolysaccharide-Induced Acute Lung Injury Via NF-κB Signaling Pathway.

Wang BQ, Shi M, Zhang JP, Wu X, Chang MJ, Chen ZH, Shen HH, Song YL, Zhou J, Bai CX.

Shock. 2019 Feb;51(2):235-246. doi: 10.1097/SHK.0000000000001120.


Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.

Han ML, Velkov T, Zhu Y, Roberts KD, Le Brun AP, Chow SH, Gutu AD, Moskowitz SM, Shen HH, Li J.

ACS Chem Biol. 2018 Jan 19;13(1):121-130. doi: 10.1021/acschembio.7b00836. Epub 2017 Dec 11.


Efficacy and safety of bronchoscopic lung volume reduction therapy in patients with severe emphysema: a meta-analysis of randomized controlled trials.

Wang Y, Lai TW, Xu F, Zhou JS, Li ZY, Xu XC, Chen HP, Ying SM, Li W, Shen HH, Chen ZH.

Oncotarget. 2017 Jul 18;8(44):78031-78043. doi: 10.18632/oncotarget.19352. eCollection 2017 Sep 29.


Core Concept: Circumventing the blood-brain barrier.

Shen HH.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11261-11263. doi: 10.1073/pnas.1716187114. No abstract available.


News Feature: Singing in the brain.

Shen HH.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9490-9493. doi: 10.1073/pnas.1711799114. No abstract available.


Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation.

Xu XC, Wu YF, Zhou JS, Chen HP, Wang Y, Li ZY, Zhao Y, Shen HH, Chen ZH.

Toxicol Lett. 2017 Oct 5;280:206-212. doi: 10.1016/j.toxlet.2017.08.081. Epub 2017 Sep 1.


Magnetic hyperthermia enhance the treatment efficacy of peri-implant osteomyelitis.

Fang CH, Tsai PI, Huang SW, Sun JS, Chang JZ, Shen HH, Chen SY, Lin FH, Hsu LT, Chen YC.

BMC Infect Dis. 2017 Jul 25;17(1):516. doi: 10.1186/s12879-017-2621-4.


Activation of autophagy is involved in the protective effect of 17β-oestradiol on endotoxaemia-induced multiple organ dysfunction in ovariectomized rats.

Chung MT, Lee YM, Shen HH, Cheng PY, Huang YC, Lin YJ, Huang YY, Lam KK.

J Cell Mol Med. 2017 Dec;21(12):3705-3717. doi: 10.1111/jcmm.13280. Epub 2017 Jul 17.


Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.

Han ML, Shen HH, Hansford KA, Schneider EK, Sivanesan S, Roberts KD, Thompson PE, Le Brun AP, Zhu Y, Sani MA, Separovic F, Blaskovich MAT, Baker MA, Moskowitz SM, Cooper MA, Li J, Velkov T.

ACS Infect Dis. 2017 Aug 11;3(8):606-619. doi: 10.1021/acsinfecdis.7b00065. Epub 2017 Jul 11.


Early growth response factor 1 is essential for cigarette smoke-induced MUC5AC expression in human bronchial epithelial cells.

Wang SB, Zhang C, Xu XC, Xu F, Zhou JS, Wu YP, Cao C, Li W, Shen HH, Cao JF, Chen ZH.

Biochem Biophys Res Commun. 2017 Aug 19;490(2):147-154. doi: 10.1016/j.bbrc.2017.06.014. Epub 2017 Jun 8.


Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models.

Huang G, Xu XC, Zhou JS, Li ZY, Chen HP, Wang Y, Li W, Shen HH, Chen ZH.

J Immunol Res. 2017;2017:7915975. doi: 10.1155/2017/7915975. Epub 2017 Apr 23. Review.


Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation.

Ochkur SI, Doyle AD, Jacobsen EA, LeSuer WE, Li W, Protheroe CA, Zellner KR, Colbert D, Shen HH, Irvin CG, Lee JJ, Lee NA.

J Leukoc Biol. 2017 Sep;102(3):589-599. doi: 10.1189/jlb.3HI1116-488RR. Epub 2017 May 17.


Autophagy as a double-edged sword in pulmonary epithelial injury: a review and perspective.

Li ZY, Wu YF, Xu XC, Zhou JS, Wang Y, Shen HH, Chen ZH.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L207-L217. doi: 10.1152/ajplung.00562.2016. Epub 2017 May 4. Review.


Sophocarpine Protects Mice from ConA-Induced Hepatitis via Inhibition of the IFN-Gamma/STAT1 Pathway.

Sang XX, Wang RL, Zhang CE, Liu SJ, Shen HH, Guo YM, Zhang YM, Niu M, Wang JB, Bai ZF, Xiao XH.

Front Pharmacol. 2017 Mar 21;8:140. doi: 10.3389/fphar.2017.00140. eCollection 2017.


Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats.

Shen HH, Huang SY, Cheng PY, Chu YJ, Chen SY, Lam KK, Lee YM.

Menopause. 2017 Aug;24(8):959-969. doi: 10.1097/GME.0000000000000864.


Inner Workings: How do mosquitoes smell us? The answers could help eradicate disease.

Shen HH.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2096-2098. doi: 10.1073/pnas.1701738114. No abstract available.


Neural Representation and Causal Models in Motor Cortex.

Chaisanguanthum KS, Shen HH, Sabes PN.

J Neurosci. 2017 Mar 22;37(12):3413-3424. doi: 10.1523/JNEUROSCI.1000-16.2017. Epub 2017 Feb 20.


Activating transcription factor 3 represses cigarette smoke-induced IL6 and IL8 expression via suppressing NF-κB activation.

Wu YP, Cao C, Wu YF, Li M, Lai TW, Zhu C, Wang Y, Ying SM, Chen ZH, Shen HH, Li W.

Toxicol Lett. 2017 Mar 15;270:17-24. doi: 10.1016/j.toxlet.2017.02.002. Epub 2017 Feb 6.


miR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling.

Wang B, Yao K, Wise AF, Lau R, Shen HH, Tesch GH, Ricardo SD.

Clin Sci (Lond). 2017 Mar 1;131(5):411-423. doi: 10.1042/CS20160571. Epub 2017 Jan 4.


Bcl-2 inhibitors reduce steroid-insensitive airway inflammation.

Tian BP, Xia LX, Bao ZQ, Zhang H, Xu ZW, Mao YY, Cao C, Che LQ, Liu JK, Li W, Chen ZH, Ying S, Shen HH.

J Allergy Clin Immunol. 2017 Aug;140(2):418-430. doi: 10.1016/j.jaci.2016.11.027. Epub 2016 Dec 31.


Modulations of SIR-nucleosome interactions of reconstructed yeast silent pre-heterochromatin by O-acetyl-ADP-ribose and magnesium.

Tung SY, Wang SH, Lee SP, Tsai SP, Shen HH, Chen FJ, Wu YY, Hsiao SP, Liou GG.

Mol Biol Cell. 2017 Feb 1;28(3):381-386. doi: 10.1091/mbc.E16-06-0359. Epub 2016 Dec 8.


Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.

Jacobsen EA, Ochkur SI, Doyle AD, LeSuer WE, Li W, Protheroe CA, Colbert D, Zellner KR, Shen HH, Irvin CG, Lee JJ, Lee NA.

Am J Respir Crit Care Med. 2017 May 15;195(10):1321-1332. doi: 10.1164/rccm.201606-1129OC.


Activating Transcription Factor 3 Is Essential for Cigarette Smoke-Induced Mucin Expression via Interaction with Activator Protein-1.

Wu YP, Wu YF, Zhang C, Zhou HB, Cao C, Li M, Zhu C, Ying SM, Chen ZH, Shen HH, Li W.

Am J Pathol. 2017 Feb;187(2):280-291. doi: 10.1016/j.ajpath.2016.10.012. Epub 2016 Nov 29.


News Feature: To master memory, researchers pursue its roots.

Shen HH.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11376-11379. No abstract available.


Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy.

Shen HH, Liu GS, Chow SH, Wang JH, He Z, Nguyen C, Lin TW, Bui BV.

PLoS One. 2016 Oct 6;11(10):e0164035. doi: 10.1371/journal.pone.0164035. eCollection 2016.


Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury.

Hu Y, Lou J, Mao YY, Lai TW, Liu LY, Zhu C, Zhang C, Liu J, Li YY, Zhang F, Li W, Ying SM, Chen ZH, Shen HH.

Autophagy. 2016 Dec;12(12):2286-2299. Epub 2016 Sep 22.


Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine.

Stubenrauch C, Belousoff MJ, Hay ID, Shen HH, Lillington J, Tuck KL, Peters KM, Phan MD, Lo AW, Schembri MA, Strugnell RA, Waksman G, Lithgow T.

Nat Microbiol. 2016 May 16;1(7):16064. doi: 10.1038/nmicrobiol.2016.64.


New Approach for High-Voltage Electrical Double-Layer Capacitors Using Vertical Graphene Nanowalls with and without Nitrogen Doping.

Chi YW, Hu CC, Shen HH, Huang KP.

Nano Lett. 2016 Sep 14;16(9):5719-27. doi: 10.1021/acs.nanolett.6b02401. Epub 2016 Aug 31.


Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications.

Liu F, Xuan NX, Ying SM, Li W, Chen ZH, Shen HH.

Mediators Inflamm. 2016;2016:6943135. doi: 10.1155/2016/6943135. Epub 2016 Jul 20. Review.

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