Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 191


Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils.

Shen HC, Chen YH, Lin YS, Chu BK, Liang CS, Yang CC, Chen RP.

Neurochem Res. 2019 Jan 2. doi: 10.1007/s11064-018-02709-w. [Epub ahead of print]


Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus.

Buckley MA, Woods NT, Tyrer JP, Mendoza-Fandiño G, Lawrenson K, Hazelett DJ, Najafabadi HS, Gjyshi A, Carvalho RS, Lyra PC Jr, Coetzee SG, Shen HC, Yang AW, Earp MA, Yoder SJ, Risch H, Chenevix-Trench G, Ramus SJ, Phelan CM, Coetzee GA, Noushmehr H, Hughes TR, Sellers TA, Goode EL, Pharoah PD, Gayther SA, Monteiro ANA; Ovarian Cancer Association Consortium.

Cancer Res. 2019 Feb 1;79(3):467-481. doi: 10.1158/0008-5472.CAN-17-3864. Epub 2018 Nov 28.


Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors.

Zheng X, Liang C, Wang L, Wang B, Liu Y, Feng S, Wu JZ, Gao L, Feng L, Chen L, Guo T, Shen HC, Yun H.

J Med Chem. 2018 Nov 21;61(22):10228-10241. doi: 10.1021/acs.jmedchem.8b01394. Epub 2018 Nov 2.


Instantaneous frequency as a new approach for evaluating the clinical severity of Duchenne muscular dystrophy through ultrasound imaging.

Weng WC, Lin CW, Shen HC, Chang CC, Tsui PH.

Ultrasonics. 2018 Sep 20. pii: S0041-624X(18)30299-3. doi: 10.1016/j.ultras.2018.09.004. [Epub ahead of print]


Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action.

Han X, Zhou C, Jiang M, Wang Y, Wang J, Cheng Z, Wang M, Liu Y, Liang C, Wang J, Wang Z, Weikert R, Lv W, Xie J, Yu X, Zhou X, Luangsay S, Shen HC, Mayweg AV, Javanbakht H, Yang S.

J Med Chem. 2018 Oct 4. doi: 10.1021/acs.jmedchem.8b01245. [Epub ahead of print]


Minimally invasive treatment for anterior pelvic ring injuries with modified pedicle screw-rod fixation: a retrospective study.

Hung CC, Wu JL, Li YT, Cheng YW, Wu CC, Shen HC, Yeh TT.

J Orthop Surg Res. 2018 Sep 17;13(1):238. doi: 10.1186/s13018-018-0945-4.


Pre-operative virtual simulation and three-dimensional printing techniques for the surgical management of acetabular fractures.

Hsu CL, Chou YC, Li YT, Chen JE, Hung CC, Wu CC, Shen HC, Yeh TT.

Int Orthop. 2018 Aug 20. doi: 10.1007/s00264-018-4111-8. [Epub ahead of print]


Potassium Iodide-Promoted One-Pot Synthesis of Fluoroalkylated Quinoxalines via a Tandem Michael Addition/Azidation/Cycloamination Approach.

Wu J, Zhang H, Ding X, Tan X, Chen J, He W, Deng H, Song L, Shen HC, Cao W.

J Org Chem. 2018 Aug 17;83(16):9422-9429. doi: 10.1021/acs.joc.8b01030. Epub 2018 Aug 1.


Highly Chemo- and Regioselective Vinylation of N-Heteroarenes with Vinylsulfonium Salts.

Zhou M, Tan X, Hu Y, Shen HC, Qian X.

J Org Chem. 2018 Aug 3;83(15):8627-8635. doi: 10.1021/acs.joc.8b00682. Epub 2018 Jun 8.


Conventional plate fixation method versus pre-operative virtual simulation and three-dimensional printing-assisted contoured plate fixation method in the treatment of anterior pelvic ring fracture.

Hung CC, Li YT, Chou YC, Chen JE, Wu CC, Shen HC, Yeh TT.

Int Orthop. 2018 May 3. doi: 10.1007/s00264-018-3963-2. [Epub ahead of print]


Modified Essex-Lopresti procedure with percutaneous calcaneoplasty for comminuted intra-articular calcaneal fractures: a retrospective case analysis.

Shih JT, Kuo CL, Yeh TT, Shen HC, Pan RY, Wu CC.

BMC Musculoskelet Disord. 2018 Mar 9;19(1):77. doi: 10.1186/s12891-018-1995-9.


Discovery of Small Molecule Therapeutics for Treatment of Chronic HBV Infection.

Feng S, Gao L, Han X, Hu T, Hu Y, Liu H, Thomas AW, Yan Z, Yang S, Young JAT, Yun H, Zhu W, Shen HC.

ACS Infect Dis. 2018 Mar 9;4(3):257-277. doi: 10.1021/acsinfecdis.7b00144. Epub 2018 Feb 12.


Palladium-Catalyzed Asymmetric Aminohydroxylation of 1,3-Dienes.

Shen HC, Wu YF, Zhang Y, Fan LF, Han ZY, Gong LZ.

Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2372-2376. doi: 10.1002/anie.201712350. Epub 2018 Feb 6.


Palladium-Catalyzed Difluoromethylation of Aryl Chlorides and Triflates and Its Applications in the Preparation of Difluoromethylated Derivatives of Drug/Agrochemical Molecules.

Lu C, Lu H, Wu J, Shen HC, Hu T, Gu Y, Shen Q.

J Org Chem. 2018 Jan 19;83(2):1077-1083. doi: 10.1021/acs.joc.7b02989. Epub 2018 Jan 10.


Brain Worms with Cerebrospinal Fluid Eosinophilia.

Shen HC, Chao CM, Hsieh CF.

Am J Trop Med Hyg. 2017 Dec;97(6):1633-1634. doi: 10.4269/ajtmh.17-0588. No abstract available.


C-H Bond Functionalization of Tetrahydropyridopyrimidines and Other Related Hetereocycles.

Cheng Z, Yu Z, Yang S, Shen HC, Zhao W, Zhong S.

J Org Chem. 2017 Dec 15;82(24):13678-13685. doi: 10.1021/acs.joc.7b02382. Epub 2017 Nov 22.


Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance.

Liu Z, Shen HC, Lian TH, Mao L, Tang SX, Sun L, Huang XY, Guo P, Cao CJ, Yu SY, Zuo LJ, Wang XM, Chen SD, Chan P, Zhang W.

Sci Rep. 2017 Nov 2;7(1):14973. doi: 10.1038/s41598-017-14721-1.


Reply: A Comparison of the Efficacy and Tolerability of the Treatments for Sciatica: A Network Meta-analysis.

Guo JR, Jin XJ, Shen HC, Wang H, Zhou X, Liu XQ, Zhu NN.

Ann Pharmacother. 2018 Jan;52(1):99. doi: 10.1177/1060028017733094. Epub 2017 Sep 26. No abstract available.


Loss of β-arrestin-2 and Activation of CXCR2 Correlate with Lymph Node Metastasis in Non-small Cell Lung Cancer.

Cong L, Qiu ZY, Zhao Y, Wang WB, Wang CX, Shen HC, Han JQ.

J Cancer. 2017 Aug 23;8(14):2785-2792. doi: 10.7150/jca.19631. eCollection 2017.


Comparison of arthroplasty vs. osteosynthesis for displaced femoral neck fractures: a meta-analysis.

Tseng FJ, Chia WT, Pan RY, Lin LC, Shen HC, Wang CH, Shyu JF, Weng CF.

J Orthop Surg Res. 2017 Sep 15;12(1):131. doi: 10.1186/s13018-017-0629-5.


Gait Speed rather than Dynapenia Is a Simple Indicator for Complex Care Needs: A Cross-sectional Study Using Minimum Data Set.

Huang TY, Liang CK, Shen HC, Chen HI, Liao MC, Chou MY, Lin YT, Chen LK.

Sci Rep. 2017 Aug 21;7(1):8418. doi: 10.1038/s41598-017-08791-4.


Discovery of methylsulfonyl indazoles as potent and orally active respiratory syncytial Virus(RSV) fusion inhibitors.

Feng S, Li C, Chen D, Zheng X, Yun H, Gao L, Shen HC.

Eur J Med Chem. 2017 Sep 29;138:1147-1157. doi: 10.1016/j.ejmech.2017.07.032. Epub 2017 Jul 20.


A Comparison of the Efficacy and Tolerability of the Treatments for Sciatica: A Network Meta-Analysis.

Guo JR, Jin XJ, Shen HC, Wang H, Zhou X, Liu XQ, Zhu NN.

Ann Pharmacother. 2017 Dec;51(12):1041-1052. doi: 10.1177/1060028017722008. Epub 2017 Jul 26.


Semaphorin-1a prevents Drosophila olfactory projection neuron dendrites from mis-targeting into select antennal lobe regions.

Shen HC, Chu SY, Hsu TC, Wang CH, Lin IY, Yu HH.

PLoS Genet. 2017 Apr 27;13(4):e1006751. doi: 10.1371/journal.pgen.1006751. eCollection 2017 Apr.


Prevalence and Metabolic Factors of Hyperuricemia in an Elderly Agricultural and Fishing Population in Taiwan.

Yu Q, Shen HC, Hu YC, Chen YF, Tung TH.

Arch Rheumatol. 2017 Apr 13;32(2):149-157. doi: 10.5606/ArchRheumatol.2017.6075. eCollection 2017 Jun.


An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice.

Cheng YS, Chen ZT, Liao TY, Lin C, Shen HC, Wang YH, Chang CW, Liu RS, Chen RP, Tu PH.

EMBO Mol Med. 2017 May;9(5):703-715. doi: 10.15252/emmm.201606666.


Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

Qiu Z, Lin X, Zhang W, Zhou M, Guo L, Kocer B, Wu G, Zhang Z, Liu H, Shi H, Kou B, Hu T, Hu Y, Huang M, Yan SF, Xu Z, Zhou Z, Qin N, Wang YF, Ren S, Qiu H, Zhang Y, Zhang Y, Wu X, Sun K, Zhong S, Xie J, Ottaviani G, Zhou Y, Zhu L, Tian X, Shi L, Shen F, Mao Y, Zhou X, Gao L, Young JAT, Wu JZ, Yang G, Mayweg AV, Shen HC, Tang G, Zhu W.

J Med Chem. 2017 Apr 27;60(8):3352-3371. doi: 10.1021/acs.jmedchem.7b00083. Epub 2017 Apr 5.


[Genital Chlamydia trachomatis infection and associated risk factors in male clients attending sexually transmitted disease clinics in 9 cities in Guangdong province].

Shen HC, Huang SJ, Qin XL, Zhao PZ, Lan YY, Zou HC, Ou JL, Chen L, Luo XM, Zheng HP, Li Y, Yang B.

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Mar 10;38(3):364-368. doi: 10.3760/cma.j.issn.0254-6450.2017.03.018. Chinese.


Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM.

Shen HC, Hsu TC, Chung PC, Yu HH.

J Vis Exp. 2017 Mar 2;(121). doi: 10.3791/55278.


Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.

Zhou Z, Hu T, Zhou X, Wildum S, Garcia-Alcalde F, Xu Z, Wu D, Mao Y, Tian X, Zhou Y, Shen F, Zhang Z, Tang G, Najera I, Yang G, Shen HC, Young JA, Qin N.

Sci Rep. 2017 Feb 13;7:42374. doi: 10.1038/srep42374.


Radiologic features of primary intracranial ectopic germinomas: Case reports and literature review.

Wei XH, Shen HC, Tang SX, Gao CH, Ren JL, Ai L, Dai JP.

Medicine (Baltimore). 2016 Dec;95(52):e5543. doi: 10.1097/MD.0000000000005543. Review.


Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

Qiu Z, Kuhn B, Aebi J, Lin X, Ding H, Zhou Z, Xu Z, Xu D, Han L, Liu C, Qiu H, Zhang Y, Haap W, Riemer C, Stahl M, Qin N, Shen HC, Tang G.

ACS Med Chem Lett. 2016 Jun 25;7(8):802-6. doi: 10.1021/acsmedchemlett.6b00208. eCollection 2016 Aug 11.


Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.

Qiu Z, Lin X, Zhou M, Liu Y, Zhu W, Chen W, Zhang W, Guo L, Liu H, Wu G, Huang M, Jiang M, Xu Z, Zhou Z, Qin N, Ren S, Qiu H, Zhong S, Zhang Y, Zhang Y, Wu X, Shi L, Shen F, Mao Y, Zhou X, Yang W, Wu JZ, Yang G, Mayweg AV, Shen HC, Tang G.

J Med Chem. 2016 Aug 25;59(16):7651-66. doi: 10.1021/acs.jmedchem.6b00879. Epub 2016 Aug 10.


Combined Innovative Portal Arthroscopy and Fluoroscopy-Assisted Reduction and Fixation in Subtle Injury of the Lisfranc Joint Complex: Analysis of 10 Cases.

Lien SB, Shen HC, Lin LC.

J Foot Ankle Surg. 2017 Jan - Feb;56(1):142-147. doi: 10.1053/j.jfas.2016.05.003. Epub 2016 Jun 21.


Discovery of Piperazinylquinoline Derivatives as Novel Respiratory Syncytial Virus Fusion Inhibitors.

Zheng X, Wang L, Wang B, Miao K, Xiang K, Feng S, Gao L, Shen HC, Yun H.

ACS Med Chem Lett. 2016 Apr 20;7(6):558-62. doi: 10.1021/acsmedchemlett.5b00234. eCollection 2016 Jun 9.


Possible Mechanism of Therapeutic Effect of 3-Methyl-1-phenyl-2-pyrazolin-5-one and Bone Marrow Stromal Cells Combination Treatment in Rat Ischemic Stroke Model.

Shen LH, Chen J, Shen HC, Ye M, Liu XF, Ding WS, Sheng YF, Ding XS.

Chin Med J (Engl). 2016 Jun 20;129(12):1471-6. doi: 10.4103/0366-6999.183418.


Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron.

Shen HC, Wei JY, Chu SY, Chung PC, Hsu TC, Yu HH.

PLoS One. 2016 May 10;11(5):e0155384. doi: 10.1371/journal.pone.0155384. eCollection 2016.


Divergent copper-mediated dimerization and hydroxylation of benzamides involving C-H bond functionalization.

Wang M, Hu Y, Jiang Z, Shen HC, Sun X.

Org Biomol Chem. 2016 May 4;14(18):4239-46. doi: 10.1039/c6ob00392c.


Catalytic Enantioselective Assembly of Homoallylic Alcohols from Dienes, Aryldiazonium Salts, and Aldehydes.

Tao ZL, Adili A, Shen HC, Han ZY, Gong LZ.

Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4322-6. doi: 10.1002/anie.201600148. Epub 2016 Feb 25.


Comparison of the recurrence risk of parameniscal cysts between patients treated with arthroscopic excision and arthroscopic decompression techniques.

Chang JJ, Li YH, Lin GM, Wu CC, Shen HC, Pan RY.

Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1547-54. doi: 10.1007/s00167-016-3998-0. Epub 2016 Feb 9.


Using a modified Pauwels method to predict the outcome of femoral neck fracture in relatively young patients.

Wang SH, Yang JJ, Shen HC, Lin LC, Lee MS, Pan RY.

Injury. 2015 Oct;46(10):1969-74. doi: 10.1016/j.injury.2015.06.016. Epub 2015 Jun 16.


Predictive and Prognostic Biomarkers for Patients Treated with Anti-EGFR Agents in Lung Cancer: A Systemic Review and Meta-Analysis.

Wang Y, Qu X, Shen HC, Wang K, Liu Q, Du JJ.

Asian Pac J Cancer Prev. 2015;16(11):4759-68. Review.


Evaluation of work stress, turnover intention, work experience, and satisfaction with preceptors of new graduate nurses using a 10-minute preceptor model.

Hu YC, Chen SR, Chen IH, Shen HC, Lin YK, Chang WY.

J Contin Educ Nurs. 2015 Jun;46(6):261-71. doi: 10.3928/00220124-20150518-02.


Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.

Yang C, Balsells J, Chu HD, Cox JM, Crespo A, Ma X, Contino L, Brown P, Gao S, Zamlynny B, Wiltsie J, Clemas J, Lisnock J, Gibson J, Zhou G, Garcia-Calvo M, Bateman TJ, Tong V, Xu L, Crook M, Sinclair P, Shen HC.

ACS Med Chem Lett. 2015 Mar 6;6(4):461-5. doi: 10.1021/acsmedchemlett.5b00010. eCollection 2015 Apr 9.


Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors.

Feng S, Hong D, Wang B, Zheng X, Miao K, Wang L, Yun H, Gao L, Zhao S, Shen HC.

ACS Med Chem Lett. 2015 Jan 25;6(3):359-62. doi: 10.1021/acsmedchemlett.5b00008. eCollection 2015 Mar 12.


Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci.

Coetzee SG, Shen HC, Hazelett DJ, Lawrenson K, Kuchenbaecker K, Tyrer J, Rhie SK, Levanon K, Karst A, Drapkin R, Ramus SJ; Ovarian Cancer Association Consortium, The Consortium of Investigators of Modifiers of BRCA1/2, Couch FJ, Offit K, Chenevix-Trench G, Monteiro AN, Antoniou A, Freedman M, Coetzee GA, Pharoah PD, Noushmehr H, Gayther SA; Ovarian Cancer Association Consortium The Consortium of Investigators of Modifiers of BRCA1/2.

Hum Mol Genet. 2015 Jul 1;24(13):3595-607. doi: 10.1093/hmg/ddv101. Epub 2015 Mar 24.


Effect of acute normovolemic hemodilution combined with controlled low central venous pressure on cerebral oxygen metabolism of patients with hepalobectomy.

Guo JR, Shen HC, Liu Y, Xu F, Zhang YW, Zhang JP, Yang DW.

Hepatogastroenterology. 2014 Nov-Dec;61(136):2321-5.


Regulatory considerations for companion diagnostic devices.

Lee EY, Shen HC.

Biomark Med. 2015;9(1):67-75. doi: 10.2217/bmm.14.98. Review.


Supplemental Content

Support Center