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Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial.

Loughren MJ, Kharasch ED, Kelton-Rehkopf MC, Syrjala KL, Shen DD.

Anesthesiology. 2019 Nov 26. doi: 10.1097/ALN.0000000000003065. [Epub ahead of print]


Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Morris Brown L, Ren Z, Brown Z, Easterling TR, Hebert MF.

J Clin Pharmacol. 2019 Nov 19. doi: 10.1002/jcph.1549. [Epub ahead of print]


Liuweibuqi capsules improve pulmonary function in stable chronic obstructive pulmonary disease with lung-qi deficiency syndrome by regulating STAT4/STAT6 and MMP-9/TIMP-1.

Shen DD, Yang ZH, Huang J, Yang F, Lin ZW, Ou YF, Hu MH.

Pharm Biol. 2019 Dec;57(1):744-752. doi: 10.1080/13880209.2019.1666151.


Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.

Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Wong LH, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, Gaedigk A, Thummel KE, Woodahl EL.

Clin Transl Sci. 2019 Sep 19. doi: 10.1111/cts.12695. [Epub ahead of print]


Analysis of nifH DNA and RNA reveals a disproportionate contribution to nitrogenase activities by rare plankton-associated diazotrophs.

Yang QS, Dong JD, Ahmad M, Ling J, Zhou WG, Tan YH, Zhang YZ, Shen DD, Zhang YY.

BMC Microbiol. 2019 Aug 15;19(1):188. doi: 10.1186/s12866-019-1565-9.


Effect of N-Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy.

Han LW, Ryu RJ, Cusumano M, Easterling TR, Phillips BR, Risler LJ, Shen DD, Hebert MF.

J Clin Pharmacol. 2019 Dec;59(12):1678-1689. doi: 10.1002/jcph.1477. Epub 2019 Jun 30.


Chemically synthesized LYRM03 could inhibit the metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo.

Yang YK, Shen DD, He P, Du LD, Wan DJ, Wang P, Wang T, Feng MQ.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1719-1726. doi: 10.1016/j.bmcl.2019.05.027. Epub 2019 May 16.


Structure and dynamics of the active human parathyroid hormone receptor-1.

Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y.

Science. 2019 Apr 12;364(6436):148-153. doi: 10.1126/science.aav7942.


Physicochemical properties, phenolic profiles, antioxidant capacities, and inhibitory effects on digestive enzymes of okra (Abelmoschus esculentus) fruit at different maturation stages.

Shen DD, Li X, Qin YL, Li MT, Han QH, Zhou J, Lin S, Zhao L, Zhang Q, Qin W, Wu DT.

J Food Sci Technol. 2019 Mar;56(3):1275-1286. doi: 10.1007/s13197-019-03592-1. Epub 2019 Feb 22.


Quantitative Assessment of Tumor Cell Proliferation in Brain Gliomas with Dynamic Contrast-Enhanced MRI.

Jiang JS, Hua Y, Zhou XJ, Shen DD, Shi JL, Ge M, Geng QN, Jia ZZ.

Acad Radiol. 2019 Sep;26(9):1215-1221. doi: 10.1016/j.acra.2018.10.012. Epub 2018 Nov 8.


Development of formaldehyde dehydrogenase-coupled assay and antibody-based assays for ALKBH5 activity evaluation.

Shen DD, Suo FZ, Song QM, Chang J, Zhang T, Hong JJ, Zheng YC, Liu HM.

J Pharm Biomed Anal. 2019 Jan 5;162:9-15. doi: 10.1016/j.jpba.2018.09.018. Epub 2018 Sep 7.


Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates.

Perazzolo S, Shireman LM, Koehn J, McConnachie LA, Kraft JC, Shen DD, Ho RJY.

J Pharm Sci. 2018 Dec;107(12):3153-3162. doi: 10.1016/j.xphs.2018.07.032. Epub 2018 Aug 16.


Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system

Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE.

ALTEX. 2018;35(4):504-515. doi: 10.14573/altex.1803161. Epub 2018 Jul 8.


Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 in Tissue-Selective Accumulation of Para-Hydroxymethamphetamine.

Wagner DJ, Shireman LM, Ahn S, Shen DD, Wang J.

Drug Metab Dispos. 2018 Sep;46(9):1277-1284. doi: 10.1124/dmd.118.082131. Epub 2018 Jun 18.


Recommended Approaches for Pharmacokinetic Natural Product-Drug Interaction Research: a NaPDI Center Commentary.

Paine MF, Shen DD, McCune JS.

Drug Metab Dispos. 2018 Jul;46(7):1041-1045. doi: 10.1124/dmd.117.079962. Epub 2018 May 7.


Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach.

Johnson EJ, González-Peréz V, Tian DD, Lin YS, Unadkat JD, Rettie AE, Shen DD, McCune JS, Paine MF.

Drug Metab Dispos. 2018 Jul;46(7):1046-1052. doi: 10.1124/dmd.118.081273. Epub 2018 May 7.


Prednisone Pharmacokinetics During Pregnancy and Lactation.

Ryu RJ, Easterling TR, Caritis SN, Venkataramanan R, Umans JG, Ahmed MS, Clark S, Kantrowitz-Gordon I, Hays K, Bennett B, Honaker MT, Thummel KE, Shen DD, Hebert MF.

J Clin Pharmacol. 2018 Sep;58(9):1223-1232. doi: 10.1002/jcph.1122. Epub 2018 May 7.


Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation.

Tian DD, Kellogg JJ, Okut N, Oberlies NH, Cech NB, Shen DD, McCune JS, Paine MF.

Drug Metab Dispos. 2018 May;46(5):552-560. doi: 10.1124/dmd.117.079491. Epub 2018 Feb 21.


Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation.

Kraft JC, McConnachie LA, Koehn J, Kinman L, Sun J, Collier AC, Collins C, Shen DD, Ho RJY.

J Control Release. 2018 Apr 10;275:229-241. doi: 10.1016/j.jconrel.2018.02.003. Epub 2018 Feb 10.


An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.

Airhart SE, Shireman LM, Risler LJ, Anderson GD, Nagana Gowda GA, Raftery D, Tian R, Shen DD, O'Brien KD.

PLoS One. 2017 Dec 6;12(12):e0186459. doi: 10.1371/journal.pone.0186459. eCollection 2017.


Pregnancy Increases Norbuprenorphine Clearance in Mice by Induction of Hepatic Glucuronidation.

Liao MZ, Gao C, Phillips BR, Neradugomma NK, Han LW, Bhatt DK, Prasad B, Shen DD, Mao Q.

Drug Metab Dispos. 2018 Feb;46(2):100-108. doi: 10.1124/dmd.117.076745. Epub 2017 Nov 20.


Genetic diversity of Haemonchus contortus isolated from sympatric wild blue sheep (Pseudois nayaur) and sheep in Helan Mountains, China.

Shen DD, Wang JF, Zhang DY, Peng ZW, Yang TY, Wang ZD, Bowman DD, Hou ZJ, Liu ZS.

Parasit Vectors. 2017 Sep 19;10(1):437. doi: 10.1186/s13071-017-2377-0.


Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis.

Chapron A, Shen DD, Kestenbaum BR, Robinson-Cohen C, Himmelfarb J, Yeung CK.

Clin Transl Sci. 2017 Sep;10(5):395-403. doi: 10.1111/cts.12481. Epub 2017 Jul 4.


P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine-Response to 'Letter to the Editor'.

Liao MZ, Shen DD, Mao Q.

Pharmacol Res. 2017 Jul;121:253. doi: 10.1016/j.phrs.2017.04.007. Epub 2017 Apr 12. No abstract available.


P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine.

Liao MZ, Gao C, Shireman LM, Phillips B, Risler LJ, Neradugomma NK, Choudhari P, Prasad B, Shen DD, Mao Q.

Pharmacol Res. 2017 May;119:61-71. doi: 10.1016/j.phrs.2017.01.018. Epub 2017 Jan 19.


Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma.

Kraft JC, McConnachie LA, Koehn J, Kinman L, Collins C, Shen DD, Collier AC, Ho RJ.

AIDS. 2017 Mar 27;31(6):765-770. doi: 10.1097/QAD.0000000000001405.


Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in assessing glioblastoma microvasculature.

Jia ZZ, Shi W, Shi JL, Shen DD, Gu HM, Zhou XJ.

Eur J Radiol. 2017 Feb;87:120-124. doi: 10.1016/j.ejrad.2016.12.016. Epub 2016 Dec 19.


Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial.

Rivara MB, Yeung CK, Robinson-Cohen C, Phillips BR, Ruzinski J, Rock D, Linke L, Shen DD, Ikizler TA, Himmelfarb J.

Am J Kidney Dis. 2017 Mar;69(3):389-399. doi: 10.1053/j.ajkd.2016.08.041. Epub 2016 Dec 4.


Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation.

Duan YC, Guan YY, Zhai XY, Ding LN, Qin WP, Shen DD, Liu XQ, Sun XD, Zheng YC, Liu HM.

Eur J Med Chem. 2017 Jan 27;126:246-258. doi: 10.1016/j.ejmech.2016.11.035. Epub 2016 Nov 16.


Baicalin, a natural LSD1 inhibitor.

Zheng YC, Shen DD, Ren M, Liu XQ, Wang ZR, Liu Y, Zhang QN, Zhao LJ, Zhao LJ, Ma JL, Yu B, Liu HM.

Bioorg Chem. 2016 Dec;69:129-131. doi: 10.1016/j.bioorg.2016.10.004. Epub 2016 Oct 11.


Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors.

Wang S, Zhao LJ, Zheng YC, Shen DD, Miao EF, Qiao XP, Zhao LJ, Liu Y, Huang R, Yu B, Liu HM.

Eur J Med Chem. 2017 Jan 5;125:940-951. doi: 10.1016/j.ejmech.2016.10.021. Epub 2016 Oct 14.


Development of a microphysiological model of human kidney proximal tubule function.

Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ.

Kidney Int. 2016 Sep;90(3):627-37. doi: 10.1016/j.kint.2016.06.011.


Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients.

Robinson-Cohen C, Newitt R, Shen DD, Rettie AE, Kestenbaum BR, Himmelfarb J, Yeung CK.

PLoS One. 2016 Aug 11;11(8):e0161074. doi: 10.1371/journal.pone.0161074. eCollection 2016.


1,2,3-Triazole-Dithiocarbamate Hybrids, a Group of Novel Cell Active SIRT1 Inhibitors.

Zheng YC, Wang LZ, Zhao LJ, Zhao LJ, Zhan QN, Ma JL, Zhang B, Wang MM, Wang ZR, Li JF, Liu Y, Chen ZS, Shen DD, Liu XQ, Ren M, Lv WL, Zhao W, Duan YC, Liu HM.

Cell Physiol Biochem. 2016;38(1):185-93. doi: 10.1159/000438620. Epub 2016 Jan 20.


Pharmacological Treatment of Insomnia.

Lie JD, Tu KN, Shen DD, Wong BM.

P T. 2015 Nov;40(11):759-71.


Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.

Yeung CK, Billings FT 4th, Claessens AJ, Roshanravan B, Linke L, Sundell MB, Ahmad S, Shao B, Shen DD, Ikizler TA, Himmelfarb J.

BMC Nephrol. 2015 Nov 3;16:183. doi: 10.1186/s12882-015-0178-2.


Pharmacokinetics of metoprolol during pregnancy and lactation.

Ryu RJ, Eyal S, Easterling TR, Caritis SN, Venkataraman R, Hankins G, Rytting E, Thummel K, Kelly EJ, Risler L, Phillips B, Honaker MT, Shen DD, Hebert MF.

J Clin Pharmacol. 2016 May;56(5):581-9. doi: 10.1002/jcph.631. Epub 2015 Dec 4.


Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in Pahenu2-/- Mice.

Vogel KR, Ainslie GR, Phillips B, Arning E, Bottiglieri T, Shen DD, Gibson KM.

Mol Genet Metab Rep. 2015 Jun 1;3:80-87.


Rapid and sensitive analysis of reduced and oxidized coenzyme Q10 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and application to studies in healthy human subjects.

Claessens AJ, Yeung CK, Risler LJ, Phillips BR, Himmelfarb J, Shen DD.

Ann Clin Biochem. 2016 Mar;53(Pt 2):265-73. doi: 10.1177/0004563215593097. Epub 2015 Jun 8.


Proximal Roux-en-Y gastric bypass alters drug absorption pattern but not systemic exposure of CYP3A4 and P-glycoprotein substrates.

Chan LN, Lin YS, Tay-Sontheimer JC, Trawick D, Oelschlager BK, Flum DR, Patton KK, Shen DD, Horn JR.

Pharmacotherapy. 2015 Apr;35(4):361-9. doi: 10.1002/phar.1560. Epub 2015 Mar 10.


Dexmedetomidine reduces cranial temperature in hypothermic neonatal rats.

McAdams RM, McPherson RJ, Kapur R, Phillips B, Shen DD, Juul SE.

Pediatr Res. 2015 Jun;77(6):772-8. doi: 10.1038/pr.2015.45. Epub 2015 Mar 9.


Identification of CYP3A7 for glyburide metabolism in human fetal livers.

Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q.

Biochem Pharmacol. 2014 Dec 15;92(4):690-700. doi: 10.1016/j.bcp.2014.09.025. Epub 2014 Oct 22.


Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age.

Shuster DL, Risler LJ, Liang CK, Rice KM, Shen DD, Hebert MF, Thummel KE, Mao Q.

J Pharmacol Exp Ther. 2014 Aug;350(2):425-34. doi: 10.1124/jpet.114.213470. Epub 2014 Jun 4.


Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system.

Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, Asp E, Himmelfarb J.

Stem Cell Res Ther. 2013;4 Suppl 1:S17. doi: 10.1186/scrt378. Epub 2013 Dec 20. Review.


Aspirin use and knowledge in the community: a population- and health facility based survey for measuring local health system performance.

Roth GA, Gillespie CW, Mokdad AA, Shen DD, Fleming DW, Stergachis A, Murray CJ, Mokdad AH.

BMC Cardiovasc Disord. 2014 Feb 7;14:16. doi: 10.1186/1471-2261-14-16.


Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.

Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC; Clinical Pharmacogenetics Implementation Consortium.

Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. Review.


Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport.

Yeung CK, Shen DD, Thummel KE, Himmelfarb J.

Kidney Int. 2014 Mar;85(3):522-8. doi: 10.1038/ki.2013.399. Epub 2013 Oct 16. Review.


Specialty supplement use and biologic measures of oxidative stress and DNA damage.

Kantor ED, Ulrich CM, Owen RW, Schmezer P, Neuhouser ML, Lampe JW, Peters U, Shen DD, Vaughan TL, White E.

Cancer Epidemiol Biomarkers Prev. 2013 Dec;22(12):2312-22. doi: 10.1158/1055-9965.EPI-13-0470. Epub 2013 Aug 5.

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