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Items: 15


Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials.

Lin A, Giuliano CJ, Palladino A, John KM, Abramowicz C, Yuan ML, Sausville EL, Lukow DA, Liu L, Chait AR, Galluzzo ZC, Tucker C, Sheltzer JM.

Sci Transl Med. 2019 Sep 11;11(509). pii: eaaw8412. doi: 10.1126/scitranslmed.aaw8412.


Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9.

Giuliano CJ, Lin A, Girish V, Sheltzer JM.

Curr Protoc Mol Biol. 2019 Sep;128(1):e100. doi: 10.1002/cpmb.100.


Understanding the impact of an after-school music program with engaged underserved youth.

Sheltzer JM, Consoli AJ.

J Community Psychol. 2019 Jul;47(6):1364-1379. doi: 10.1002/jcop.22193. Epub 2019 Apr 24.


Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.

Smith JC, Sheltzer JM.

Elife. 2018 Dec 11;7. pii: e39217. doi: 10.7554/eLife.39217.


Gender disparities among independent fellows in biomedical research.

Sheltzer JM.

Nat Biotechnol. 2018 Oct 11;36(10):1018-1021. doi: 10.1038/nbt.4274. No abstract available.


MELK expression correlates with tumor mitotic activity but is not required for cancer growth.

Giuliano CJ, Lin A, Smith JC, Palladino AC, Sheltzer JM.

Elife. 2018 Feb 8;7. pii: e32838. doi: 10.7554/eLife.32838.


CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials.

Lin A, Giuliano CJ, Sayles NM, Sheltzer JM.

Elife. 2017 Mar 24;6. pii: e24179. doi: 10.7554/eLife.24179.


Single-chromosome Gains Commonly Function as Tumor Suppressors.

Sheltzer JM, Ko JH, Replogle JM, Habibe Burgos NC, Chung ES, Meehl CM, Sayles NM, Passerini V, Storchova Z, Amon A.

Cancer Cell. 2017 Feb 13;31(2):240-255. doi: 10.1016/j.ccell.2016.12.004. Epub 2017 Jan 12.


Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast.

Blank HM, Sheltzer JM, Meehl CM, Amon A.

Mol Biol Cell. 2015 Apr 15;26(8):1440-51. doi: 10.1091/mbc.E14-10-1442. Epub 2015 Feb 18.


Elite male faculty in the life sciences employ fewer women.

Sheltzer JM, Smith JC.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10107-12. doi: 10.1073/pnas.1403334111. Epub 2014 Jun 30.


A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis.

Sheltzer JM.

Cancer Res. 2013 Nov 1;73(21):6401-12. doi: 10.1158/0008-5472.CAN-13-0749. Epub 2013 Sep 16.


Transcriptional consequences of aneuploidy.

Sheltzer JM, Torres EM, Dunham MJ, Amon A.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12644-9. doi: 10.1073/pnas.1209227109. Epub 2012 Jul 16.


The aneuploidy paradox: costs and benefits of an incorrect karyotype.

Sheltzer JM, Amon A.

Trends Genet. 2011 Nov;27(11):446-53. doi: 10.1016/j.tig.2011.07.003. Epub 2011 Aug 26. Review.


Aneuploidy drives genomic instability in yeast.

Sheltzer JM, Blank HM, Pfau SJ, Tange Y, George BM, Humpton TJ, Brito IL, Hiraoka Y, Niwa O, Amon A.

Science. 2011 Aug 19;333(6045):1026-30. doi: 10.1126/science.1206412.


The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response.

Sheltzer JM, Rose MD.

Mol Biol Cell. 2009 Jun;20(12):2909-19. doi: 10.1091/mbc.E08-09-0923. Epub 2009 Apr 29.

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