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Items: 35

1.

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles.

An H, Skelt L, Notaro A, Highley JR, Fox AH, La Bella V, Buchman VL, Shelkovnikova TA.

Acta Neuropathol Commun. 2019 Jan 14;7(1):7. doi: 10.1186/s40478-019-0658-x.

2.

NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?

An H, Williams NG, Shelkovnikova TA.

Noncoding RNA Res. 2018 Nov 15;3(4):243-252. doi: 10.1016/j.ncrna.2018.11.003. eCollection 2018 Dec. Review.

3.

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis.

Shelkovnikova TA, Kukharsky MS, An H, Dimasi P, Alexeeva S, Shabir O, Heath PR, Buchman VL.

Mol Neurodegener. 2018 Jun 1;13(1):30. doi: 10.1186/s13024-018-0263-7.

4.

Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.

Shelkovnikova TA, Dimasi P, Kukharsky MS, An H, Quintiero A, Schirmer C, Buée L, Galas MC, Buchman VL.

Cell Death Dis. 2017 May 11;8(5):e2788. doi: 10.1038/cddis.2017.199.

5.

Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose.

Dimasi P, Quintiero A, Shelkovnikova TA, Buchman VL.

Sci Rep. 2017 Mar 9;7:44088. doi: 10.1038/srep44088.

6.

Assessment of radiological techniques application possibility for non-invasive diagnostics of latent inflammatory processes in myocardium in patients with atrial fibrillation.

Sazonova SI, Ilyushenkova JN, Lishmanov YB, Batalov RE, Sazonov AE, Larionova LA, Nesterov EA, Varlamova NV, Rogovskaya JV, Shelkovnikova TA, Popov SV.

Ann Nucl Med. 2016 Dec;30(10):738-748. Epub 2016 Aug 24.

PMID:
27558361
7.

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.

Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM.

PLoS Genet. 2016 Mar 10;12(3):e1005916. doi: 10.1371/journal.pgen.1005916. eCollection 2016 Mar.

8.

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

Scekic-Zahirovic J, Sendscheid O, El Oussini H, Jambeau M, Sun Y, Mersmann S, Wagner M, Dieterlé S, Sinniger J, Dirrig-Grosch S, Drenner K, Birling MC, Qiu J, Zhou Y, Li H, Fu XD, Rouaux C, Shelkovnikova T, Witting A, Ludolph AC, Kiefer F, Storkebaum E, Lagier-Tourenne C, Dupuis L.

EMBO J. 2016 May 17;35(10):1077-97. doi: 10.15252/embj.201592559. Epub 2016 Mar 7.

9.

A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression.

Ninkina N, Connor-Robson N, Ustyugov AA, Tarasova TV, Shelkovnikova TA, Buchman VL.

Sci Rep. 2015 Nov 13;5:16615. doi: 10.1038/srep16615.

10.

Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.

Robinson HK, Deykin AV, Bronovitsky EV, Ovchinnikov RK, Ustyugov AA, Shelkovnikova TA, Kukharsky MS, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Bachurin SO, Buchman VL, Ninkina NN.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):402-9. doi: 10.3109/21678421.2015.1040994. Epub 2015 May 20.

11.

Calcium-responsive transactivator (CREST) protein shares a set of structural and functional traits with other proteins associated with amyotrophic lateral sclerosis.

Kukharsky MS, Quintiero A, Matsumoto T, Matsukawa K, An H, Hashimoto T, Iwatsubo T, Buchman VL, Shelkovnikova TA.

Mol Neurodegener. 2015 Apr 10;10:20. doi: 10.1186/s13024-015-0014-y.

12.

Gamma-synuclein pathology in amyotrophic lateral sclerosis.

Peters OM, Shelkovnikova T, Highley JR, Cooper-Knock J, Hortobágyi T, Troakes C, Ninkina N, Buchman VL.

Ann Clin Transl Neurol. 2015 Jan;2(1):29-37. doi: 10.1002/acn3.143. Epub 2014 Dec 12.

13.

[A mice model of amyotrophic lateral sclerosis expressing mutant human FUS protein].

Deĭkin AV, Kovrazhkina EA, Ovchinnikov RK, Bronovitskiĭ EV, Razinskaia OD, Smirnov AP, Ermolkevich TG, Eliakov AB, Popov AN, Fedorov EN, Lytkina OA, Kukharskiĭ MS, Tarasova TV, Shelkovnikova TA, Ustiugov AA, Ninkina NN, Gol'dman IL, Sadchikova ER, Bachurin SO, Skvortsova VI.

Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(8):62-9. Russian.

PMID:
25345633
14.

[Study into molecular targets of a neuroprotective compound dimebon using a transgenic mice line].

Shelkovnikova TA, Ustiugov AA, Kokhan VS, Tarasova TV, Medvedeva VK, Khritankova IV, Bachurin SO, Ninkina NN.

Biomed Khim. 2014 May-Jun;60(3):354-63. Russian.

PMID:
25019398
15.

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.

Shelkovnikova TA, Robinson HK, Southcombe JA, Ninkina N, Buchman VL.

Hum Mol Genet. 2014 Oct 1;23(19):5211-26. doi: 10.1093/hmg/ddu243. Epub 2014 May 19.

16.

[Modeling of lateral amyotrophic sclerosis: a transgenic method].

Bachurin SO, Ninkina NN, Tarasova TV, Shelkovnikova TV, Kovrazhkina EA, Smirnov AP, Razinskaia OD, Skvortsova VI.

Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(10):74-9. Review. Russian. No abstract available.

PMID:
24404652
17.

Compromised paraspeckle formation as a pathogenic factor in FUSopathies.

Shelkovnikova TA, Robinson HK, Troakes C, Ninkina N, Buchman VL.

Hum Mol Genet. 2014 May 1;23(9):2298-312. doi: 10.1093/hmg/ddt622. Epub 2013 Dec 11.

18.

Modelling FUSopathies: focus on protein aggregation.

Shelkovnikova TA.

Biochem Soc Trans. 2013 Dec;41(6):1613-7. doi: 10.1042/BST20130212. Review.

PMID:
24256263
19.

[Modeling of lateral amyotrophic sclerosis: a non-genetic method].

Bachurin SO, Ninkina NN, Tarasova TV, Shelkovnikova TV, Kovrazhkina EA, Smirnov AP, Razinskaya O, Skvortsova VI.

Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(9):86-9. Review. Russian. No abstract available.

PMID:
24218707
20.

Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm.

Shelkovnikova TA, Robinson HK, Connor-Robson N, Buchman VL.

Cell Cycle. 2013 Oct 1;12(19):3194-202. doi: 10.4161/cc.26241. Epub 2013 Sep 4.

21.

Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.

Shelkovnikova TA, Peters OM, Deykin AV, Connor-Robson N, Robinson H, Ustyugov AA, Bachurin SO, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Skvortsova VI, Ling SC, Da Cruz S, Parone PA, Buchman VL, Ninkina NN.

J Biol Chem. 2013 Aug 30;288(35):25266-74. doi: 10.1074/jbc.M113.492017. Epub 2013 Jul 18.

22.

Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice.

Peters OM, Shelkovnikova T, Tarasova T, Springe S, Kukharsky MS, Smith GA, Brooks S, Kozin SA, Kotelevtsev Y, Bachurin SO, Ninkina N, Buchman VL.

J Alzheimers Dis. 2013;36(3):589-96. doi: 10.3233/JAD-130071.

PMID:
23645096
23.

[Proteinopathies--forms of neurodegenerative disorders with protein aggregation-based pathology].

Shelkovnikova TA, Kulikova AA, Tsvetkov FO, Peters O, Bachurin SO, Bukhman VL, Ninkina NN.

Mol Biol (Mosk). 2012 May-Jun;46(3):402-15. Review. Russian.

PMID:
22888630
24.

Dimebon reduces the levels of aggregated amyloidogenic protein forms in detergent-insoluble fractions in vivo.

Ustyugov AA, Shelkovnikova TA, Kokhan VS, Khritankova IV, Peters O, Buchman VL, Bachurin SO, Ninkina NN.

Bull Exp Biol Med. 2012 Apr;152(6):731-3. English, Russian.

PMID:
22803176
25.

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis.

Peters OM, Millership S, Shelkovnikova TA, Soto I, Keeling L, Hann A, Marsh-Armstrong N, Buchman VL, Ninkina N.

Neurobiol Dis. 2012 Oct;48(1):124-31. doi: 10.1016/j.nbd.2012.06.016. Epub 2012 Jun 30.

26.

Impaired spatial and working memory in ageing mice with targeted inactivation of α-synuclein gene.

Kokhan VS, Van'kin GI, Ninkina NN, Shelkovnikova TA, Bachurin SO.

Dokl Biol Sci. 2011 Nov-Dec;441:354-6. doi: 10.1134/S0012496611060081. Epub 2012 Jan 7. No abstract available.

PMID:
22227678
27.

Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice.

Bachurin SO, Shelkovnikova TA, Ustyugov AA, Peters O, Khritankova I, Afanasieva MA, Tarasova TV, Alentov II, Buchman VL, Ninkina NN.

Neurotox Res. 2012 Jul;22(1):33-42. doi: 10.1007/s12640-011-9299-y. Epub 2011 Dec 17.

28.

FUS gene mutations associated with familiar forms of amyotrophic lateral sclerosis affect cellular localization and aggregation properties of the encoded protein.

Shelkovnikova TA, Ustyugov AA, Smirnov AP, Skvortsova VI, Buchman VL, Bachurin SO, Ninkina NN.

Dokl Biochem Biophys. 2011 May-Jun;438:123-6. doi: 10.1134/S1607672911030045. Epub 2011 Jul 3. No abstract available.

PMID:
21725888
29.

[Analysis of the chromocenter DNA composition in polytene chromosomes of Drosophila orena ovarian nurse cells].

Usov KE, Shelkovnikova TA, Stegniĭ VN.

Genetika. 2011 Apr;47(4):475-83. Russian.

PMID:
21675236
30.

Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.

Shelkovnikova TA, Ustyugov AA, Millership S, Peters O, Anichtchik O, Spillantini MG, Buchman VL, Bachurin SO, Ninkina NN.

Neurodegener Dis. 2011;8(6):430-7. doi: 10.1159/000324989. Epub 2011 May 12.

31.

[New aspects of the pathogenesis of lateral amyotrophic sclerosis].

Skvortsova VI, Bachurin SO, Razinskaia OD, Smirnov AP, Kovrazhkina EA, Pochigaeva KI, Ninkina NN, Shelkovnikova TA, Ustiugov AA.

Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(2):4-9. Russian. No abstract available.

PMID:
21510103
32.

[Targeted inactivation of gamma-synuclein gene affects anxiety and exploratory behaviour of mice].

Kokhan VS, Bolkunov AV, Ustiugov AA, Van'kin GI, Shelkovnikova TA, Redkozubova OM, Strekalova TV, Bukhman VL, Ninkina NN, Bachurin SO.

Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Jan-Feb;61(1):85-93. Russian.

PMID:
21469331
33.

Hindering of proteinopathy-induced neurodegeneration as a new mechanism of action for neuroprotectors and cognition enhancing compounds.

Bachurin SO, Ustyugov AA, Peters O, Shelkovnikova TA, Buchman VL, Ninkina NN.

Dokl Biochem Biophys. 2009 Sep-Oct;428:235-8. No abstract available.

PMID:
20848907
34.

[Molecular-cytogenetic analysis of pericentromeric heterochromatin in ovarian nurse cells of Drosophila melanogaster subgroup species].

Usov KE, Shelkovnikova TA, Vasserlauf IE, Stegniĭ VN.

Tsitologiia. 2008;50(12):1044-9. Russian.

PMID:
19198543
35.

[The effects of inbreeding and low temperature on the pattern of chromosome synapsis in the ovarian nurse nuclei of Drosophila melanogaster strains].

Vasserlauf IE, Shelkovnikova TA, Mtrenina EIu, Stegniĭ VN.

Genetika. 2008 Aug;44(8):1066-74. Russian.

PMID:
18825955

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