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Items: 33

1.

Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.

Gilburt JAH, Sarkar H, Sheldrake P, Blagg J, Ying L, Dodson CA.

Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11409-11414. doi: 10.1002/anie.201704654. Epub 2017 Aug 7.

2.

Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1).

Naud S, Westwood IM, Faisal A, Sheldrake P, Bavetsias V, Atrash B, Cheung KM, Liu M, Hayes A, Schmitt J, Wood A, Choi V, Boxall K, Mak G, Gurden M, Valenti M, de Haven Brandon A, Henley A, Baker R, McAndrew C, Matijssen B, Burke R, Hoelder S, Eccles SA, Raynaud FI, Linardopoulos S, van Montfort RL, Blagg J.

J Med Chem. 2013 Dec 27;56(24):10045-65. doi: 10.1021/jm401395s. Epub 2013 Dec 2.

3.

Benzimidazole inhibitors of the protein kinase CHK2: clarification of the binding mode by flexible side chain docking and protein-ligand crystallography.

Matijssen C, Silva-Santisteban MC, Westwood IM, Siddique S, Choi V, Sheldrake P, van Montfort RL, Blagg J.

Bioorg Med Chem. 2012 Nov 15;20(22):6630-9. doi: 10.1016/j.bmc.2012.09.024. Epub 2012 Sep 21.

4.

Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.

Bavetsias V, Crumpler S, Sun C, Avery S, Atrash B, Faisal A, Moore AS, Kosmopoulou M, Brown N, Sheldrake PW, Bush K, Henley A, Box G, Valenti M, de Haven Brandon A, Raynaud FI, Workman P, Eccles SA, Bayliss R, Linardopoulos S, Blagg J.

J Med Chem. 2012 Oct 25;55(20):8721-34. doi: 10.1021/jm300952s. Epub 2012 Oct 8.

5.

Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.

Stockwell SR, Platt G, Barrie SE, Zoumpoulidou G, Te Poele RH, Aherne GW, Wilson SC, Sheldrake P, McDonald E, Venet M, Soudy C, Elustondo F, Rigoreau L, Blagg J, Workman P, Garrett MD, Mittnacht S.

PLoS One. 2012;7(1):e28568. doi: 10.1371/journal.pone.0028568. Epub 2012 Jan 12.

6.

Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.

Wilson SC, Atrash B, Barlow C, Eccles S, Fischer PM, Hayes A, Kelland L, Jackson W, Jarman M, Mirza A, Moreno J, Nutley BP, Raynaud FI, Sheldrake P, Walton M, Westwood R, Whittaker S, Workman P, McDonald E.

Bioorg Med Chem. 2011 Nov 15;19(22):6949-65. doi: 10.1016/j.bmc.2011.08.051. Epub 2011 Aug 31.

PMID:
21982796
7.

Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements.

Large JM, Torr JE, Raynaud FI, Clarke PA, Hayes A, Stefano Fd, Urban F, Shuttleworth SJ, Saghir N, Sheldrake P, Workman P, McDonald E.

Bioorg Med Chem. 2011 Jan 15;19(2):836-51. doi: 10.1016/j.bmc.2010.12.006. Epub 2010 Dec 9.

PMID:
21216151
8.

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941.

Raynaud FI, Eccles SA, Patel S, Alix S, Box G, Chuckowree I, Folkes A, Gowan S, De Haven Brandon A, Di Stefano F, Hayes A, Henley AT, Lensun L, Pergl-Wilson G, Robson A, Saghir N, Zhyvoloup A, McDonald E, Sheldrake P, Shuttleworth S, Valenti M, Wan NC, Clarke PA, Workman P.

Mol Cancer Ther. 2009 Jul;8(7):1725-38. doi: 10.1158/1535-7163.MCT-08-1200. Epub 2009 Jul 7.

9.

Peritoneal equilibration testing: correcting the correction factor.

Tam P, Sheldrake P, Ng A, Oreopoulos DG, Sloand JA.

Perit Dial Int. 2009 May-Jun;29(3):352-5. No abstract available.

PMID:
19458309
10.

The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.

Wilsher NE, Court WJ, Ruddle R, Newbatt YM, Aherne W, Sheldrake PW, Jones NP, Katan M, Eccles SA, Raynaud FI.

Drug Metab Dispos. 2007 Jul;35(7):1017-22. Epub 2007 Apr 2.

PMID:
17403917
11.

Conformation analyses, dynamic behavior, and amide bond distortions of medium-sized heterocycles. 2. Partially and fully reduced 1-benzazocines, benzazonines, and benzazecines.

Qadir M, Cobb J, Sheldrake PW, Whittall N, White AJ, Hii KK, Horton PN, Hursthouse MB.

J Org Chem. 2005 Mar 4;70(5):1552-7.

PMID:
15730273
12.

Conformation analyses, dynamic behavior and amide bond distortions of medium-sized heterocycles. 1. Partially and fully reduced 1-benzazepines.

Qadir M, Cobb J, Sheldrake PW, Whittall N, White AJ, Hii KK, Horton PN, Hursthouse MB.

J Org Chem. 2005 Mar 4;70(5):1545-51.

PMID:
15730272
13.

Partial reduction of electron-deficient pyridines

Donohoe TJ, McRiner AJ, Sheldrake P.

Org Lett. 2000 Nov 30;2(24):3861-3.

PMID:
11101438
14.

Preparation of 5-Hydroxy-2-iodopyridine: A Refutation of Earlier Reports.

Sheldrake PW, Powling LC, Slaich PK.

J Org Chem. 1997 May 2;62(9):3008-3009. No abstract available.

PMID:
11671668
15.

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase.

Gallagher TF, Seibel GL, Kassis S, Laydon JT, Blumenthal MJ, Lee JC, Lee D, Boehm JC, Fier-Thompson SM, Abt JW, Soreson ME, Smietana JM, Hall RF, Garigipati RS, Bender PE, Erhard KF, Krog AJ, Hofmann GA, Sheldrake PL, McDonnell PC, Kumar S, Young PR, Adams JL.

Bioorg Med Chem. 1997 Jan;5(1):49-64.

PMID:
9043657
16.

1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.

Boehm JC, Smietana JM, Sorenson ME, Garigipati RS, Gallagher TF, Sheldrake PL, Bradbeer J, Badger AM, Laydon JT, Lee JC, Hillegass LM, Griswold DE, Breton JJ, Chabot-Fletcher MC, Adams JL.

J Med Chem. 1996 Sep 27;39(20):3929-37.

PMID:
8831759
17.

The selection and training of examiners for clinical examinations.

Newble DI, Hoare J, Sheldrake PF.

Med Educ. 1980 Sep;14(5):345-9.

PMID:
7432220
18.

Predispositions to illness: patterns in the reporting of psychosomatic illness.

Sheldrake P.

J Psychosom Res. 1977;21(3):225-30. No abstract available.

PMID:
894630
19.

Trends in medical education in Great Britain.

Sheldrake P.

J Med Educ. 1976 Jul;51(7 Pt 1):558-64.

PMID:
933133
20.

Dream recall and the contraceptive pill.

Sheldrake P, Cormack M.

J Nerv Ment Dis. 1976 Jul;163(1):59-60.

PMID:
932712
21.

Self-descriptions of applicants to medical school.

Walton HJ, Sheldrake P, Maguire P.

Med Educ. 1976 Jan;10(1):10-4.

PMID:
1263882
22.

Psychosomatic illness, birth order and intellectual preference - II. Women.

Sheldrake P, Cormack M, McGuire J.

J Psychosom Res. 1976;20(1):45-9. No abstract available.

PMID:
1263159
23.

Psychosomatic illness, birth order and intellectual preference - I. Men.

Sheldrake P, Cormack M, McGuire J.

J Psychosom Res. 1976;20(1):37-44. No abstract available.

PMID:
1263158
24.

Variations in menstrual cycle symptom reporting.

Sheldrake P, Cormack M.

J Psychosom Res. 1976;20(3):169-77.

PMID:
987237
26.

How should we select? - A sociologist's VIEW.

Sheldrake P.

Br J Med Educ. 1975 Jun;9(2):91-7.

PMID:
1148134
27.

Dream recall and the menstrual cycle.

Sheldrake P, Cormack M.

J Psychosom Res. 1974 Oct;18(5):347-50. No abstract available.

PMID:
4373359
28.

Behavioural science. Medical students' expectations and reactions.

Sheldrake P.

Br J Med Educ. 1974 Mar;8(1):31-48. No abstract available.

PMID:
4826007
29.

Menstrual cycle variations in cognitive ability: a preliminary report.

Cormack M, Sheldrake P.

Int J Chronobiol. 1974;2(1):53-5. No abstract available.

PMID:
4843902
30.

Cyclicity in dreaming: patterns in dream pre-occupations for men and women.

Sheldrake P, Cormack M.

Int J Chronobiol. 1974;2(3):217-21. No abstract available.

PMID:
4443125
31.

Behavioural science in the medical curriculum.

Sheldrake P.

Soc Sci Med. 1973 Dec;7(12):967-73. No abstract available.

PMID:
4775636
32.

Report on the Cork seminar on behavioural sciences in the medical curriculum.

Sheldrake P.

J Ir Med Assoc. 1973 Oct 13;66(19):535-9. No abstract available.

PMID:
4759087
33.

Student expectations of behavioural science.

Sheldrake P, Reid M.

Br J Med Educ. 1972 Jun;6(2):105-7. No abstract available.

PMID:
5072211

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