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Items: 1 to 50 of 228


Osteochondral Lesion in Diffuse Pigmented Villonodular Synovitis of the Knee.

Shekhar A, Singh S, Patil SS, Tapasvi SR.

Knee Surg Relat Res. 2019 Mar 1;31(1):67-71. doi: 10.5792/ksrr.18.015.


Assessment of fear and anxiety associated behaviors, physiology and neural circuits in rats with reduced serotonin transporter (SERT) levels.

Johnson PL, Molosh AI, Federici LM, Bernabe C, Haggerty D, Fitz SD, Nalivaiko E, Truitt W, Shekhar A.

Transl Psychiatry. 2019 Jan 22;9(1):33. doi: 10.1038/s41398-019-0368-y.


Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear.

Dustrude ET, Caliman IF, Bernabe CS, Fitz SD, Grafe LA, Bhatnagar S, Bonaventure P, Johnson PL, Molosh AI, Shekhar A.

Front Neurosci. 2018 Dec 18;12:934. doi: 10.3389/fnins.2018.00934. eCollection 2018.


The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.

Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J Jr, Szabo S, Murrough J, Shekhar A, Potter W.

Nat Rev Drug Discov. 2018 Dec 28;18(1):82-84. doi: 10.1038/nrd.2018.222. No abstract available.


Select panicogenic drugs and stimuli induce consistent increases in tail skin flushes and decreases in core body temperature.

Federici LM, Caliman IF, Fitz SD, Shekhar A, Johnson PL.

Behav Pharmacol. 2019 Jun;30(4):376-382. doi: 10.1097/FBP.0000000000000440.



Shekhar A.

Prog Brain Res. 2018;241:xi. doi: 10.1016/S0079-6123(18)30200-0. No abstract available.


Neurofibromatosis type 1 as a model system to study molecular mechanisms of autism spectrum disorder symptoms.

Molosh AI, Shekhar A.

Prog Brain Res. 2018;241:37-62. doi: 10.1016/bs.pbr.2018.09.014. Epub 2018 Oct 25. Review.


From bedside to bench and back: Translating ASD models.

Drozd HP, Karathanasis SF, Molosh AI, Lukkes JL, Clapp DW, Shekhar A.

Prog Brain Res. 2018;241:113-158. doi: 10.1016/bs.pbr.2018.10.003. Epub 2018 Nov 7. Review.


Overview of genetic models of autism spectrum disorders.

Patel J, Lukkes JL, Shekhar A.

Prog Brain Res. 2018;241:1-36. doi: 10.1016/bs.pbr.2018.10.002. Epub 2018 Nov 7. Review.


Role of medial hypothalamic orexin system in panic, phobia and hypertension.

Abreu AR, Molosh AI, Johnson PL, Shekhar A.

Brain Res. 2018 Sep 8. pii: S0006-8993(18)30467-0. doi: 10.1016/j.brainres.2018.09.010. [Epub ahead of print]


Exploring the role of Morinda citrifolia and Triphala juice in root canal irrigation: An ex vivo study.

Choudhary E, Indushekar KR, Saraf BG, Sheoran N, Sardana D, Shekhar A.

J Conserv Dent. 2018 Jul-Aug;21(4):443-449. doi: 10.4103/JCD.JCD_58_18.


Panic results in unique molecular and network changes in the amygdala that facilitate fear responses.

Molosh AI, Dustrude ET, Lukkes JL, Fitz SD, Caliman IF, Abreu ARR, Dietrich AD, Truitt WA, Ver Donck L, Ceusters M, Kent JM, Johnson PL, Shekhar A.

Mol Psychiatry. 2018 Aug 14. doi: 10.1038/s41380-018-0119-0. [Epub ahead of print]


PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD.

Li LP, Dustrude ET, Haulcomb MM, Abreu AR, Fitz SD, Johnson PL, Thakur GA, Molosh AI, Lai Y, Shekhar A.

Transl Psychiatry. 2018 Aug 14;8(1):155. doi: 10.1038/s41398-018-0208-5.


ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.

Shekhar A, Lin X, Lin B, Liu FY, Zhang J, Khodadadi-Jamayran A, Tsirigos A, Bu L, Fishman GI, Park DS.

Sci Rep. 2018 Jul 2;8(1):9944. doi: 10.1038/s41598-018-28239-7.


Knotless Medial Meniscus Posterior Root Repair.

Tapasvi SR, Shekhar A, Patil SS.

Arthrosc Tech. 2018 Apr 2;7(5):e429-e435. doi: 10.1016/j.eats.2017.11.002. eCollection 2018 May.


Primary Anterior Cruciate Ligament Repair With Augmentation.

Tapasvi SR, Shekhar A, Patil SS.

Arthrosc Tech. 2018 Jan 22;7(2):e139-e145. doi: 10.1016/j.eats.2017.08.063. eCollection 2018 Feb.


Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine: Effective Target Uptake and Reduced Nontarget Organ Radiation Burden.

Kawai H, Chaudhry F, Shekhar A, Petrov A, Nakahara T, Tanimoto T, Kim D, Chen J, Lebeche D, Blankenberg FG, Pak KY, Kolodgie FD, Virmani R, Sengupta P, Narula N, Hajjar RJ, Strauss HW, Narula J.

JACC Cardiovasc Imaging. 2018 Dec;11(12):1823-1833. doi: 10.1016/j.jcmg.2017.11.037. Epub 2018 Feb 14.


A comparative analysis of salivary factors and maxillary denture retention in different arch forms: An in vivo study.

Shekhar A, Das S, Bhattacharyya J, Goel P, Majumdar S, Ghosh S.

J Indian Prosthodont Soc. 2018 Jan-Mar;18(1):53-60. doi: 10.4103/jips.jips_110_17.


Targeted Imaging for Cell Death in Cardiovascular Disorders.

Shekhar A, Heeger P, Reutelingsperger C, Arbustini E, Narula N, Hofstra L, Bax JJ, Narula J.

JACC Cardiovasc Imaging. 2018 Mar;11(3):476-493. doi: 10.1016/j.jcmg.2017.11.018. Epub 2018 Jan 17. Review.


Cannabinoid Receptor 1 Positive Allosteric Modulators for Posttraumatic Stress Disorder.

Shekhar A, Thakur GA.

Neuropsychopharmacology. 2018 Jan;43(1):226-227. doi: 10.1038/npp.2017.230. No abstract available.


Meniscal Preservation is Important for the Knee Joint.

Patil SS, Shekhar A, Tapasvi SR.

Indian J Orthop. 2017 Sep-Oct;51(5):576-587. doi: 10.4103/ortho.IJOrtho_247_17.


Localized pigmented villonodular synovitis of posterior compartment of the knee.

Shekhar A, Patil SS, Dixit C, Tapasvi SR.

J Orthop Surg (Hong Kong). 2017 Sep-Dec;25(3):2309499017727923. doi: 10.1177/2309499017727923.


Precision medicine for suicidality: from universality to subtypes and personalization.

Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR.

Mol Psychiatry. 2017 Sep;22(9):1250-1273. doi: 10.1038/mp.2017.128. Epub 2017 Aug 15.


Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.

Bonaventure P, Dugovic C, Shireman B, Preville C, Yun S, Lord B, Nepomuceno D, Wennerholm M, Lovenberg T, Carruthers N, Fitz SD, Shekhar A, Johnson PL.

Front Pharmacol. 2017 Jun 9;8:357. doi: 10.3389/fphar.2017.00357. eCollection 2017.


Event-related potentials reflect impaired temporal interval learning following haloperidol administration.

Forster SE, Zirnheld P, Shekhar A, Steinhauer SR, O'Donnell BF, Hetrick WP.

Psychopharmacology (Berl). 2017 Sep;234(17):2545-2562. doi: 10.1007/s00213-017-4645-2. Epub 2017 Jun 10.


Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells.

Salazar TE, Richardson MR, Beli E, Ripsch MS, George J, Kim Y, Duan Y, Moldovan L, Yan Y, Bhatwadekar A, Jadhav V, Smith JA, McGorray S, Bertone AL, Traktuev DO, March KL, Colon-Perez LM, Avin KG, Sims E, Mund JA, Case J, Deng X, Kim MS, McDavitt B, Boulton ME, Thinschmidt J, Li Calzi S, Fitz SD, Fuchs RK, Warden SJ, McKinley T, Shekhar A, Febo M, Johnson PL, Chang LJ, Gao Z, Kolonin MG, Lai S, Ma J, Dong X, White FA, Xie H, Yoder MC, Grant MB.

Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613.


Comment on article entitled "The RIPASA score is sensitive and specific for the diagnosis of acute appendicitis in a western population".

Chandra G, Shekhar A, Kumar RR, Yadav SK.

Int J Colorectal Dis. 2017 May;32(5):761. doi: 10.1007/s00384-017-2764-1. Epub 2017 Jan 27. No abstract available.


Anxiogenic CO2 stimulus elicits exacerbated hot flash-like responses in a rat menopause model and hot flashes in postmenopausal women.

Federici LM, Roth SD, Krier C, Fitz SD, Skaar T, Shekhar A, Carpenter JS, Johnson PL.

Menopause. 2016 Nov;23(11):1257-1266.


Transcription factor ETV1 is essential for rapid conduction in the heart.

Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS.

J Clin Invest. 2016 Dec 1;126(12):4444-4459. doi: 10.1172/JCI87968. Epub 2016 Oct 24.


Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure.

Park DS, Shekhar A, Marra C, Lin X, Vasquez C, Solinas S, Kelley K, Morley G, Goldfarb M, Fishman GI.

Nat Commun. 2016 Oct 4;7:12966. doi: 10.1038/ncomms12966.


Sigmoid endometriosis in a post-menopausal woman leading to acute large bowel obstruction: A case report.

Bidarmaghz B, Shekhar A, Hendahewa R.

Int J Surg Case Rep. 2016;28:65-67. doi: 10.1016/j.ijscr.2016.09.008. Epub 2016 Sep 22.


Corrigendum to "Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model" [Psychoneuroendocrinology 65 (2016) 127-137].

Federici LM, Caliman IF, Molosh AI, Fitz SD, Truitt WA, Bonaventure P, Carpenter JS, Shekhar A, Johnson PL.

Psychoneuroendocrinology. 2016 Nov;73:275. doi: 10.1016/j.psyneuen.2016.08.001. Epub 2016 Sep 3. No abstract available.


Bizarre cause for abdominal pain in a young female.

Shekhar A, Hendahewa R, Jayanna M, Ratnayake S.

ANZ J Surg. 2018 Oct;88(10):E739-E740. doi: 10.1111/ans.13707. Epub 2016 Aug 25. No abstract available.


Evaluation of Low versus High Volume per Minute Displacement CO₂ Methods of Euthanasia in the Induction and Duration of Panic-Associated Behavior and Physiology.

Hickman DL, Fitz SD, Bernabe CS, Caliman IF, Haulcomb MM, Federici LM, Shekhar A, Johnson PL.

Animals (Basel). 2016 Aug 2;6(8). pii: E45. doi: 10.3390/ani6080045.


Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.

Levey DF, Niculescu EM, Le-Niculescu H, Dainton HL, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB.

Mol Psychiatry. 2016 Jun;21(6):768-85. doi: 10.1038/mp.2016.31. Epub 2016 Apr 5.


Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model.

Federici LM, Caliman IF, Molosh AI, Fitz SD, Truitt WA, Bonaventure P, Carpenter JS, Shekhar A, Johnson PL.

Psychoneuroendocrinology. 2016 Mar;65:127-37. doi: 10.1016/j.psyneuen.2015.12.011. Epub 2015 Dec 18.


Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning.

Johnson PL, Molosh A, Fitz SD, Arendt D, Deehan GA, Federici LM, Bernabe C, Engleman EA, Rodd ZA, Lowry CA, Shekhar A.

Pharmacol Biochem Behav. 2015 Nov;138:174-9. doi: 10.1016/j.pbb.2015.09.021.


A controlled trial of quetiapine XR coadministration treatment of SSRI-resistant panic disorder.

Goddard AW, Mahmud W, Medlock C, Shin YW, Shekhar A.

Ann Gen Psychiatry. 2015 Sep 15;14:26. doi: 10.1186/s12991-015-0064-0. eCollection 2015.



Johnson PL, Federici LM, Fitz SD, Renger JJ, Shireman B, Winrow CJ, Bonaventure P, Shekhar A.

Depress Anxiety. 2015 Sep;32(9):671-83. doi: 10.1002/da.22403. Epub 2015 Aug 19.


Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia.

Wang C, Gao S, Hendrie HC, Kesterson J, Campbell NL, Shekhar A, Callahan CM.

Alzheimer Dis Assoc Disord. 2016 Apr-Jun;30(2):99-104. doi: 10.1097/WAD.0000000000000103.


Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.

Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD, Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR.

Mol Psychiatry. 2015 Nov;20(11):1266-85. doi: 10.1038/mp.2015.112. Epub 2015 Aug 18.


The dilemma of stump appendicitis - A case report and literature review.

Hendahewa R, Shekhar A, Ratnayake S.

Int J Surg Case Rep. 2015;14:101-3. doi: 10.1016/j.ijscr.2015.07.017. Epub 2015 Jul 26.


A diagnostic dilemma: Left-sided appendicitis in a 10 year old boy with previously undiagnosed intestinal malrotation. A case report.

Shekhar A, Hendahewa R, Premaratne G.

Int J Surg Case Rep. 2015;14:10-2. doi: 10.1016/j.ijscr.2015.06.036. Epub 2015 Jul 13.


A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction.

Yan J, Zhang L, Sultana N, Park DS, Shekhar A, Bu L, Hu J, Razzaque S, Cai CL.

PLoS One. 2015 Jul 23;10(7):e0133472. doi: 10.1371/journal.pone.0133472. eCollection 2015.


Ewing's sarcoma of proximal phalanx of the hand with skip metastases to metacarpals.

Shekhar A, Korlhalli S, Murgod G.

Indian J Orthop. 2015 May-Jun;49(3):365-8. doi: 10.4103/0019-5413.156229.


Generation of a tamoxifen inducible Tnnt2MerCreMer knock-in mouse model for cardiac studies.

Yan J, Sultana N, Zhang L, Park DS, Shekhar A, Hu J, Bu L, Cai CL.

Genesis. 2015 Jun;53(6):377-86. doi: 10.1002/dvg.22861. Epub 2015 Jun 13.


Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts.

Lin X, O'Malley H, Chen C, Auerbach D, Foster M, Shekhar A, Zhang M, Coetzee W, Jalife J, Fishman GI, Isom L, Delmar M.

J Physiol. 2015 Mar 15;593(6):1389-407. doi: 10.1113/jphysiol.2014.277699. Epub 2014 Sep 17.


Joining forces to drive biomedical translation.

Shi TZ, Liang H, Liang X, Zhan Q, Dai K, Alving BM, Liu D, Dai J, Shekhar A, Fu X.

Sci Transl Med. 2015 Feb 18;7(275):275ed1. doi: 10.1126/scitranslmed.aaa2363. No abstract available.


Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma.

Lakhter AJ, Hamilton J, Dagher PC, Mukkamala S, Hato T, Dong XC, Mayo LD, Harris RA, Shekhar A, Ivan M, Brustovetsky N, Naidu SR.

Oncotarget. 2014 Dec 30;5(24):12694-703.


A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.

Bonaventure P, Yun S, Johnson PL, Shekhar A, Fitz SD, Shireman BT, Lebold TP, Nepomuceno D, Lord B, Wennerholm M, Shelton J, Carruthers N, Lovenberg T, Dugovic C.

J Pharmacol Exp Ther. 2015 Mar;352(3):590-601. doi: 10.1124/jpet.114.220392. Epub 2015 Jan 12.

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