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Items: 1 to 20 of 23

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1.

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.

Stephen LA, ElMaghloob Y, McIlwraith MJ, Yelland T, Castro Sanchez P, Roda-Navarro P, Ismail S.

Dev Cell. 2018 Sep 6. pii: S1534-5807(18)30682-8. doi: 10.1016/j.devcel.2018.08.012. [Epub ahead of print]

2.

Maintaining protein composition in cilia.

Stephen LA, Elmaghloob Y, Ismail S.

Biol Chem. 2017 Dec 20;399(1):1-11. doi: 10.1515/hsz-2017-0168. Review.

PMID:
28850540
3.

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ElMaghloob Y, Hernandez-Fernaud JR, Adams RH, Ismail S, Bryant DM, Salmeron-Sanchez M, Machesky LM, Carlin LM, Blyth K, Mazzone M, Zanivan S.

EMBO J. 2017 Aug 15;36(16):2373-2389. doi: 10.15252/embj.201694912. Epub 2017 Jul 10.

4.

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity.

Hernandez-Fernaud JR, Ruengeler E, Casazza A, Neilson LJ, Pulleine E, Santi A, Ismail S, Lilla S, Dhayade S, MacPherson IR, McNeish I, Ennis D, Ali H, Kugeratski FG, Al Khamici H, van den Biggelaar M, van den Berghe PV, Cloix C, McDonald L, Millan D, Hoyle A, Kuchnio A, Carmeliet P, Valenzuela SM, Blyth K, Yin H, Mazzone M, Norman JC, Zanivan S.

Nat Commun. 2017 Feb 15;8:14206. doi: 10.1038/ncomms14206.

5.

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB.

Gray CH, Konczal J, Mezna M, Ismail S, Bower J, Drysdale M.

Protein Expr Purif. 2017 Apr;132:75-84. doi: 10.1016/j.pep.2017.01.010. Epub 2017 Jan 28.

6.

A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.

Martín-Gago P, Fansa EK, Klein CH, Murarka S, Janning P, Schürmann M, Metz M, Ismail S, Schultz-Fademrecht C, Baumann M, Bastiaens PI, Wittinghofer A, Waldmann H.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428. doi: 10.1002/anie.201610957. Epub 2017 Jan 20.

PMID:
28106325
7.

Shuttling and sorting lipid-modified cargo into the cilia.

Stephen LA, Ismail S.

Biochem Soc Trans. 2016 Oct 15;44(5):1273-1280. Review.

PMID:
27911709
8.

Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.

Murarka S, Martín-Gago P, Schultz-Fademrecht C, Al Saabi A, Baumann M, Fansa EK, Ismail S, Nussbaumer P, Wittinghofer A, Waldmann H.

Chemistry. 2017 May 2;23(25):6083-6093. doi: 10.1002/chem.201603222. Epub 2016 Nov 3.

PMID:
27809361
9.

A GDI/GDF-like system for sorting and shuttling ciliary proteins.

Ismail S.

Small GTPases. 2017 Oct 2;8(4):208-211. doi: 10.1080/21541248.2016.1213782. Epub 2016 Aug 3. Review.

10.

Identification of pyrazolopyridazinones as PDEδ inhibitors.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI.

Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360.

11.

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.

Fansa EK, Kösling SK, Zent E, Wittinghofer A, Ismail S.

Nat Commun. 2016 Apr 11;7:11366. doi: 10.1038/ncomms11366.

12.

The N- and C-terminal ends of RPGR can bind to PDE6δ.

Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A.

EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9. No abstract available.

13.

Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.

Kapoor S, Fansa EK, Möbitz S, Ismail SA, Winter R, Wittinghofer A, Weise K.

Biophys J. 2015 Oct 20;109(8):1619-29. doi: 10.1016/j.bpj.2015.08.033.

14.

Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives.

Bravo-Rodriguez K, Ismail-Ali AF, Klopries S, Kushnir S, Ismail S, Fansa EK, Wittinghofer A, Schulz F, Sanchez-Garcia E.

Chembiochem. 2014 Sep 5;15(13):1991-7. doi: 10.1002/cbic.201402206. Epub 2014 Jul 15.

PMID:
25044264
15.

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site.

Zimmermann G, Schultz-Fademrecht C, Küchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H.

J Med Chem. 2014 Jun 26;57(12):5435-48. doi: 10.1021/jm500632s. Epub 2014 Jun 11.

PMID:
24884780
16.

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H.

Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22.

PMID:
23698361
17.

The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.

Wätzlich D, Vetter I, Gotthardt K, Miertzschke M, Chen YX, Wittinghofer A, Ismail S.

EMBO Rep. 2013 May;14(5):465-72. doi: 10.1038/embor.2013.37. Epub 2013 Apr 5.

18.

Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.

Ismail SA, Chen YX, Miertzschke M, Vetter IR, Koerner C, Wittinghofer A.

EMBO J. 2012 Oct 17;31(20):4085-94. doi: 10.1038/emboj.2012.257. Epub 2012 Sep 7.

19.

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins.

Chandra A, Grecco HE, Pisupati V, Perera D, Cassidy L, Skoulidis F, Ismail SA, Hedberg C, Hanzal-Bayer M, Venkitaraman AR, Wittinghofer A, Bastiaens PI.

Nat Cell Biol. 2011 Dec 18;14(2):148-58. doi: 10.1038/ncb2394. Erratum in: Nat Cell Biol. 2012 Mar;14(3):329.

PMID:
22179043
20.

Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.

Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A.

Nat Chem Biol. 2011 Oct 16;7(12):942-9. doi: 10.1038/nchembio.686.

PMID:
22002721

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