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Steps in Mechanotransduction Pathways that Control Cell Morphology.

Wolfenson H, Yang B, Sheetz MP.

Annu Rev Physiol. 2019 Feb 10;81:585-605. doi: 10.1146/annurev-physiol-021317-121245. Epub 2018 Nov 7.


Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering.

Cai H, Muller J, Depoil D, Mayya V, Sheetz MP, Dustin ML, Wind SJ.

Nat Nanotechnol. 2018 Jul;13(7):610-617. doi: 10.1038/s41565-018-0113-3. Epub 2018 Apr 30.


DNA damage causes rapid accumulation of phosphoinositides for ATR signaling.

Wang YH, Hariharan A, Bastianello G, Toyama Y, Shivashankar GV, Foiani M, Sheetz MP.

Nat Commun. 2017 Dec 14;8(1):2118. doi: 10.1038/s41467-017-01805-9.


Mechanotransmission and Mechanosensing of Human alpha-Actinin 1.

Le S, Hu X, Yao M, Chen H, Yu M, Xu X, Nakazawa N, Margadant FM, Sheetz MP, Yan J.

Cell Rep. 2017 Dec 5;21(10):2714-2723. doi: 10.1016/j.celrep.2017.11.040.


Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing.

Saxena M, Changede R, Hone J, Wolfenson H, Sheetz MP.

Nano Lett. 2017 Dec 13;17(12):7242-7251. doi: 10.1021/acs.nanolett.7b02476. Epub 2017 Nov 27.


Molecular stretching modulates mechanosensing pathways.

Hu X, Margadant FM, Yao M, Sheetz MP.

Protein Sci. 2017 Jul;26(7):1337-1351. doi: 10.1002/pro.3188. Epub 2017 Jun 6. Review.


EGFR and HER2 activate rigidity sensing only on rigid matrices.

Saxena M, Liu S, Yang B, Hajal C, Changede R, Hu J, Wolfenson H, Hone J, Sheetz MP.

Nat Mater. 2017 Jul;16(7):775-781. doi: 10.1038/nmat4893. Epub 2017 May 1.


Spatial Control of Biological Ligands on Surfaces Applied to T Cell Activation.

Cai H, Depoil D, Muller J, Sheetz MP, Dustin ML, Wind SJ.

Methods Mol Biol. 2017;1584:307-331. doi: 10.1007/978-1-4939-6881-7_18.


α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions.

Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP.

Mol Biol Cell. 2016 Nov 7;27(22):3471-3479. Epub 2016 Apr 27.


Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression.

Nakazawa N, Sathe AR, Shivashankar GV, Sheetz MP.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6813-E6822. Epub 2016 Oct 14.


Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability.

Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML, Sheetz MP.

Immunol Cell Biol. 2016 Nov;94(10):981-993. doi: 10.1038/icb.2016.61. Epub 2016 Jun 30.


Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network.

Luo W, Lieu ZZ, Manser E, Bershadsky AD, Sheetz MP.

PLoS One. 2016 Oct 19;11(10):e0163915. doi: 10.1371/journal.pone.0163915. eCollection 2016.


Mechanosensing Controlled Directly by Tyrosine Kinases.

Yang B, Lieu ZZ, Wolfenson H, Hameed FM, Bershadsky AD, Sheetz MP.

Nano Lett. 2016 Sep 14;16(9):5951-61. doi: 10.1021/acs.nanolett.6b02995. Epub 2016 Aug 25.


The mechanical response of talin.

Yao M, Goult BT, Klapholz B, Hu X, Toseland CP, Guo Y, Cong P, Sheetz MP, Yan J.

Nat Commun. 2016 Jul 7;7:11966. doi: 10.1038/ncomms11966.


Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy.

Hu X, Jing C, Xu X, Nakazawa N, Cornish VW, Margadant FM, Sheetz MP.

Nano Lett. 2016 Jul 13;16(7):4062-8. doi: 10.1021/acs.nanolett.6b00650. Epub 2016 Jun 1.


Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains.

Sathe AR, Shivashankar GV, Sheetz MP.

J Cell Sci. 2016 May 15;129(10):1981-8. doi: 10.1242/jcs.172643. Epub 2016 Apr 11.


High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography.

Hu J, Gondarenko AA, Dang AP, Bashour KT, O'Connor RS, Lee S, Liapis A, Ghassemi S, Milone MC, Sheetz MP, Dustin ML, Kam LC, Hone JC.

Nano Lett. 2016 Apr 13;16(4):2198-204. doi: 10.1021/acs.nanolett.5b04364. Epub 2016 Mar 23.


Molecular Occupancy of Nanodot Arrays.

Cai H, Wolfenson H, Depoil D, Dustin ML, Sheetz MP, Wind SJ.

ACS Nano. 2016 Apr 26;10(4):4173-83. doi: 10.1021/acsnano.5b07425. Epub 2016 Mar 15.


F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback.

Masters TA, Sheetz MP, Gauthier NC.

Cytoskeleton (Hoboken). 2016 Apr;73(4):180-96. doi: 10.1002/cm.21287. Epub 2016 Apr 7.


Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.

Monzo P, Chong YK, Guetta-Terrier C, Krishnasamy A, Sathe SR, Yim EK, Ng WH, Ang BT, Tang C, Ladoux B, Gauthier NC, Sheetz MP.

Mol Biol Cell. 2016 Apr 15;27(8):1246-61. doi: 10.1091/mbc.E15-08-0565. Epub 2016 Feb 24.


Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate.

Sonam S, Sathe SR, Yim EK, Sheetz MP, Lim CT.

Sci Rep. 2016 Feb 16;6:20415. doi: 10.1038/srep20415.


Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation.

Changede R, Xu X, Margadant F, Sheetz MP.

Dev Cell. 2015 Dec 7;35(5):614-621. doi: 10.1016/j.devcel.2015.11.001. Epub 2015 Nov 25.


Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices.

Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP.

Nat Cell Biol. 2016 Jan;18(1):33-42. doi: 10.1038/ncb3277. Epub 2015 Nov 30.


Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force.

Yu CH, Rafiq NB, Cao F, Zhou Y, Krishnasamy A, Biswas KH, Ravasio A, Chen Z, Wang YH, Kawauchi K, Jones GE, Sheetz MP.

Nat Commun. 2015 Oct 28;6:8672. doi: 10.1038/ncomms9672.


Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.

Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T.

Integr Biol (Camb). 2015 Oct;7(10):1272-84. doi: 10.1039/c5ib00032g. Epub 2015 Jul 9.


Talin Dependent Mechanosensitivity of Cell Focal Adhesions.

Yan J, Yao M, Goult BT, Sheetz MP.

Cell Mol Bioeng. 2015;8(1):151-159. Epub 2014 Nov 4. Review.


Parallel near-field photolithography with metal-coated elastomeric masks.

Wu J, Yu CH, Li S, Zou B, Liu Y, Zhu X, Guo Y, Xu H, Zhang W, Zhang L, Liu B, Tian D, Huang W, Sheetz MP, Huo F.

Langmuir. 2015 Jan 27;31(3):1210-7. doi: 10.1021/la504260x. Epub 2015 Jan 14.


Early events in cell spreading as a model for quantitative analysis of biomechanical events.

Wolfenson H, Iskratsch T, Sheetz MP.

Biophys J. 2014 Dec 2;107(11):2508-14. doi: 10.1016/j.bpj.2014.10.041. Epub 2014 Dec 2. Review.


Can small institutes address some problems facing biomedical researchers?

Sheetz MP.

Mol Biol Cell. 2014 Nov 1;25(21):3267-9. doi: 10.1091/mbc.E14-05-1017.


Appreciating force and shape—the rise of mechanotransduction in cell biology.

Iskratsch T, Wolfenson H, Sheetz MP.

Nat Rev Mol Cell Biol. 2014 Dec;15(12):825-33. doi: 10.1038/nrm3903. Epub 2014 Oct 30. Review.


Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility.

Zaburdaev V, Biais N, Schmiedeberg M, Eriksson J, Jonsson AB, Sheetz MP, Weitz DA.

Biophys J. 2014 Oct 7;107(7):1523-31. doi: 10.1016/j.bpj.2014.07.061.


Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation.

Yao M, Goult BT, Chen H, Cong P, Sheetz MP, Yan J.

Sci Rep. 2014 Apr 9;4:4610. doi: 10.1038/srep04610.


N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.

Zhang X, Moore SW, Iskratsch T, Sheetz MP.

J Cell Sci. 2014 Apr 1;127(Pt 7):1394-405. doi: 10.1242/jcs.134692. Epub 2014 Jan 30.


Bifunctional nanoarrays for probing the immune response at the single-molecule level.

Cai H, Depoil D, Palma M, Sheetz MP, Dustin ML, Wind SJ.

J Vac Sci Technol B Nanotechnol Microelectron. 2013 Nov;31(6):6F902. Epub 2013 Oct 8.


Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces.

Yu CH, Rafiq NB, Krishnasamy A, Hartman KL, Jones GE, Bershadsky AD, Sheetz MP.

Cell Rep. 2013 Dec 12;5(5):1456-68. doi: 10.1016/j.celrep.2013.10.040. Epub 2013 Nov 27.


Analysis of the local organization and dynamics of cellular actin networks.

Luo W, Yu CH, Lieu ZZ, Allard J, Mogilner A, Sheetz MP, Bershadsky AD.

J Cell Biol. 2013 Sep 30;202(7):1057-73. doi: 10.1083/jcb.201210123.


Mechanical perturbation of filamin A immunoglobulin repeats 20-21 reveals potential non-equilibrium mechanochemical partner binding function.

Chen H, Chandrasekar S, Sheetz MP, Stossel TP, Nakamura F, Yan J.

Sci Rep. 2013;3:1642. doi: 10.1038/srep01642.


Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation.

Roca-Cusachs P, del Rio A, Puklin-Faucher E, Gauthier NC, Biais N, Sheetz MP.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1361-70. doi: 10.1073/pnas.1220723110. Epub 2013 Mar 20.


Heart extracellular matrix supports cardiomyocyte differentiation of mouse embryonic stem cells.

Higuchi S, Lin Q, Wang J, Lim TK, Joshi SB, Anand GS, Chung MC, Sheetz MP, Fujita H.

J Biosci Bioeng. 2013 Mar;115(3):320-5. doi: 10.1016/j.jbiosc.2012.10.004. Epub 2012 Nov 17.


Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions.

Lynch CD, Lazar AM, Iskratsch T, Zhang X, Sheetz MP.

Mol Biol Cell. 2013 Jan;24(1):21-30. doi: 10.1091/mbc.E12-05-0377. Epub 2012 Oct 31.


Force-dependent cell signaling in stem cell differentiation.

Yim EK, Sheetz MP.

Stem Cell Res Ther. 2012 Oct 31;3(5):41. doi: 10.1186/scrt132. Review.


Following nature's challenges.

Sheetz MP.

Nat Med. 2012 Oct;18(10):1483-5. doi: 10.1038/nm.2957. No abstract available.


Mechanical feedback between membrane tension and dynamics.

Gauthier NC, Masters TA, Sheetz MP.

Trends Cell Biol. 2012 Oct;22(10):527-35. doi: 10.1016/j.tcb.2012.07.005. Epub 2012 Aug 23. Review.


Netrin-1 attracts axons through FAK-dependent mechanotransduction.

Moore SW, Zhang X, Lynch CD, Sheetz MP.

J Neurosci. 2012 Aug 22;32(34):11574-85. doi: 10.1523/JNEUROSCI.0999-12.2012.


T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse.

Kumari S, Vardhana S, Cammer M, Curado S, Santos L, Sheetz MP, Dustin ML.

Front Immunol. 2012 Aug 17;3:230. doi: 10.3389/fimmu.2012.00230. eCollection 2012.


Substrate topography and size determine the fate of human embryonic stem cells to neuronal or glial lineage.

Ankam S, Suryana M, Chan LY, Moe AA, Teo BK, Law JB, Sheetz MP, Low HY, Yim EK.

Acta Biomater. 2013 Jan;9(1):4535-45. doi: 10.1016/j.actbio.2012.08.018. Epub 2012 Aug 18.


Second-generation covalent TMP-tag for live cell imaging.

Chen Z, Jing C, Gallagher SS, Sheetz MP, Cornish VW.

J Am Chem Soc. 2012 Aug 22;134(33):13692-9. doi: 10.1021/ja303374p. Epub 2012 Aug 9.


Spatial-temporal reorganization of activated integrins.

Yu CH, Luo W, Sheetz MP.

Cell Adh Migr. 2012 May-Jun;6(3):280-4. doi: 10.4161/cam.20753. Epub 2012 May 1.


Microarray with micro- and nano-topographies enables identification of the optimal topography for directing the differentiation of primary murine neural progenitor cells.

Moe AA, Suryana M, Marcy G, Lim SK, Ankam S, Goh JZ, Jin J, Teo BK, Law JB, Low HY, Goh EL, Sheetz MP, Yim EK.

Small. 2012 Oct 8;8(19):3050-61. doi: 10.1002/smll.201200490. Epub 2012 Jul 16.


Finding the weakest link: exploring integrin-mediated mechanical molecular pathways.

Roca-Cusachs P, Iskratsch T, Sheetz MP.

J Cell Sci. 2012 Jul 1;125(Pt 13):3025-38. doi: 10.1242/jcs.095794. Epub 2012 Jul 13. Review.

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