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Integrin nanoclusters can bridge thin matrix fibres to form cell-matrix adhesions.

Changede R, Cai H, Wind SJ, Sheetz MP.

Nat Mater. 2019 Sep 2. doi: 10.1038/s41563-019-0460-y. [Epub ahead of print]


A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing.

Sheetz M.

Annu Rev Cell Dev Biol. 2019 Aug 14. doi: 10.1146/annurev-cellbio-100818-125227. [Epub ahead of print]


Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion.

Alieva NO, Efremov AK, Hu S, Oh D, Chen Z, Natarajan M, Ong HT, Jégou A, Romet-Lemonne G, Groves JT, Sheetz MP, Yan J, Bershadsky AD.

Nat Commun. 2019 Aug 9;10(1):3593. doi: 10.1038/s41467-019-10964-w.


Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading.

Kalappurakkal JM, Anilkumar AA, Patra C, van Zanten TS, Sheetz MP, Mayor S.

Cell. 2019 Jun 13;177(7):1738-1756.e23. doi: 10.1016/j.cell.2019.04.037. Epub 2019 May 16.


Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease.

Sheetz M, Barrington P, Callies S, Berg PH, McColm J, Marbury T, Decker B, Dyas GL, Truhlar SME, Benschop R, Leung D, Berg J, Witcher DR.

Br J Clin Pharmacol. 2019 May;85(5):935-948. doi: 10.1111/bcp.13877. Epub 2019 Mar 4.


Steps in Mechanotransduction Pathways that Control Cell Morphology.

Wolfenson H, Yang B, Sheetz MP.

Annu Rev Physiol. 2019 Feb 10;81:585-605. doi: 10.1146/annurev-physiol-021317-121245. Epub 2018 Nov 7.


Correction: Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus.

Karni-Schmidt O, Friedler A, Zupnick A, McKinney K, Mattia M, Beckerman R, Bouvet P, Sheetz M, Fersht A, Prives C.

Oncogene. 2018 Aug;37(35):4901-4902. doi: 10.1038/s41388-018-0321-1.


Compliance with the U.S. Nuclear Regulatory Commission Revised Licensing Guidance for Radioactive Seed Localization.

Sheetz M, Steiner C.

Health Phys. 2018 Sep;115(3):402-408. doi: 10.1097/HP.0000000000000889.


Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.

Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M, Iskratsch T.

Dev Cell. 2018 Jun 4;45(5):661. doi: 10.1016/j.devcel.2018.05.016. No abstract available.


Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering.

Cai H, Muller J, Depoil D, Mayya V, Sheetz MP, Dustin ML, Wind SJ.

Nat Nanotechnol. 2018 Jul;13(7):610-617. doi: 10.1038/s41565-018-0113-3. Epub 2018 Apr 30.


Health Physics Society Comments to U.S. Environmental Protection Agency Regulatory Reform Task Force.

Ring J, Tupin E, Elder D, Hiatt J, Sheetz M, Kirner N, Little C.

Health Phys. 2018 May;114(5):507-510. doi: 10.1097/HP.0000000000000809.


Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.

Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M, Iskratsch T.

Dev Cell. 2018 Feb 5;44(3):326-336.e3. doi: 10.1016/j.devcel.2017.12.024. Epub 2018 Jan 26. Erratum in: Dev Cell. 2018 Jun 4;45(5):661.


EGFR family and Src family kinase interactions: mechanics matters?

Chen Z, Oh D, Dubey AK, Yao M, Yang B, Groves JT, Sheetz M.

Curr Opin Cell Biol. 2018 Apr;51:97-102. doi: 10.1016/ Epub 2017 Dec 28. Review.


DNA damage causes rapid accumulation of phosphoinositides for ATR signaling.

Wang YH, Hariharan A, Bastianello G, Toyama Y, Shivashankar GV, Foiani M, Sheetz MP.

Nat Commun. 2017 Dec 14;8(1):2118. doi: 10.1038/s41467-017-01805-9.


Mechanotransmission and Mechanosensing of Human alpha-Actinin 1.

Le S, Hu X, Yao M, Chen H, Yu M, Xu X, Nakazawa N, Margadant FM, Sheetz MP, Yan J.

Cell Rep. 2017 Dec 5;21(10):2714-2723. doi: 10.1016/j.celrep.2017.11.040.


mDia1 senses both force and torque during F-actin filament polymerization.

Yu M, Yuan X, Lu C, Le S, Kawamura R, Efremov AK, Zhao Z, Kozlov MM, Sheetz M, Bershadsky A, Yan J.

Nat Commun. 2017 Nov 21;8(1):1650. doi: 10.1038/s41467-017-01745-4.


Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing.

Saxena M, Changede R, Hone J, Wolfenson H, Sheetz MP.

Nano Lett. 2017 Dec 13;17(12):7242-7251. doi: 10.1021/acs.nanolett.7b02476. Epub 2017 Nov 27.


Molecular stretching modulates mechanosensing pathways.

Hu X, Margadant FM, Yao M, Sheetz MP.

Protein Sci. 2017 Jul;26(7):1337-1351. doi: 10.1002/pro.3188. Epub 2017 Jun 6. Review.


EGFR and HER2 activate rigidity sensing only on rigid matrices.

Saxena M, Liu S, Yang B, Hajal C, Changede R, Hu J, Wolfenson H, Hone J, Sheetz MP.

Nat Mater. 2017 Jul;16(7):775-781. doi: 10.1038/nmat4893. Epub 2017 May 1.


Spatial Control of Biological Ligands on Surfaces Applied to T Cell Activation.

Cai H, Depoil D, Muller J, Sheetz MP, Dustin ML, Wind SJ.

Methods Mol Biol. 2017;1584:307-331. doi: 10.1007/978-1-4939-6881-7_18.


Integrin and cadherin clusters: A robust way to organize adhesions for cell mechanics.

Changede R, Sheetz M.

Bioessays. 2017 Jan;39(1):1-12. doi: 10.1002/bies.201600123. Epub 2016 Dec 8. Review.


α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions.

Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP.

Mol Biol Cell. 2016 Nov 7;27(22):3471-3479. Epub 2016 Apr 27.


Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression.

Nakazawa N, Sathe AR, Shivashankar GV, Sheetz MP.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6813-E6822. Epub 2016 Oct 14.


Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability.

Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML, Sheetz MP.

Immunol Cell Biol. 2016 Nov;94(10):981-993. doi: 10.1038/icb.2016.61. Epub 2016 Jun 30.


Polymer fiber-based models of connective tissue repair and healing.

Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN, Lu HH.

Biomaterials. 2017 Jan;112:303-312. doi: 10.1016/j.biomaterials.2016.10.013. Epub 2016 Oct 12.


Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network.

Luo W, Lieu ZZ, Manser E, Bershadsky AD, Sheetz MP.

PLoS One. 2016 Oct 19;11(10):e0163915. doi: 10.1371/journal.pone.0163915. eCollection 2016.


Anti-TGF-β1 Antibody Therapy in Patients with Diabetic Nephropathy.

Voelker J, Berg PH, Sheetz M, Duffin K, Shen T, Moser B, Greene T, Blumenthal SS, Rychlik I, Yagil Y, Zaoui P, Lewis JB.

J Am Soc Nephrol. 2017 Mar;28(3):953-962. doi: 10.1681/ASN.2015111230. Epub 2016 Sep 19.


Mechanosensing Controlled Directly by Tyrosine Kinases.

Yang B, Lieu ZZ, Wolfenson H, Hameed FM, Bershadsky AD, Sheetz MP.

Nano Lett. 2016 Sep 14;16(9):5951-61. doi: 10.1021/acs.nanolett.6b02995. Epub 2016 Aug 25.


The mechanical response of talin.

Yao M, Goult BT, Klapholz B, Hu X, Toseland CP, Guo Y, Cong P, Sheetz MP, Yan J.

Nat Commun. 2016 Jul 7;7:11966. doi: 10.1038/ncomms11966.


Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy.

Hu X, Jing C, Xu X, Nakazawa N, Cornish VW, Margadant FM, Sheetz MP.

Nano Lett. 2016 Jul 13;16(7):4062-8. doi: 10.1021/acs.nanolett.6b00650. Epub 2016 Jun 1.


Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains.

Sathe AR, Shivashankar GV, Sheetz MP.

J Cell Sci. 2016 May 15;129(10):1981-8. doi: 10.1242/jcs.172643. Epub 2016 Apr 11.


High-Throughput Mechanobiology Screening Platform Using Micro- and Nanotopography.

Hu J, Gondarenko AA, Dang AP, Bashour KT, O'Connor RS, Lee S, Liapis A, Ghassemi S, Milone MC, Sheetz MP, Dustin ML, Kam LC, Hone JC.

Nano Lett. 2016 Apr 13;16(4):2198-204. doi: 10.1021/acs.nanolett.5b04364. Epub 2016 Mar 23.


Molecular Occupancy of Nanodot Arrays.

Cai H, Wolfenson H, Depoil D, Dustin ML, Sheetz MP, Wind SJ.

ACS Nano. 2016 Apr 26;10(4):4173-83. doi: 10.1021/acsnano.5b07425. Epub 2016 Mar 15.


F-actin waves, actin cortex disassembly and focal exocytosis driven by actin-phosphoinositide positive feedback.

Masters TA, Sheetz MP, Gauthier NC.

Cytoskeleton (Hoboken). 2016 Apr;73(4):180-96. doi: 10.1002/cm.21287. Epub 2016 Apr 7.


Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.

Monzo P, Chong YK, Guetta-Terrier C, Krishnasamy A, Sathe SR, Yim EK, Ng WH, Ang BT, Tang C, Ladoux B, Gauthier NC, Sheetz MP.

Mol Biol Cell. 2016 Apr 15;27(8):1246-61. doi: 10.1091/mbc.E15-08-0565. Epub 2016 Feb 24.


Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate.

Sonam S, Sathe SR, Yim EK, Sheetz MP, Lim CT.

Sci Rep. 2016 Feb 16;6:20415. doi: 10.1038/srep20415.


Effective Radiation Dose in a Skeletal Survey Performed for Suspected Child Abuse.

Berger RP, Panigrahy A, Gottschalk S, Sheetz M.

J Pediatr. 2016 Apr;171:310-2. doi: 10.1016/j.jpeds.2016.01.017. Epub 2016 Jan 28.


Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation.

Changede R, Xu X, Margadant F, Sheetz MP.

Dev Cell. 2015 Dec 7;35(5):614-621. doi: 10.1016/j.devcel.2015.11.001. Epub 2015 Nov 25.


Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices.

Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J, Sheetz MP.

Nat Cell Biol. 2016 Jan;18(1):33-42. doi: 10.1038/ncb3277. Epub 2015 Nov 30.


Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force.

Yu CH, Rafiq NB, Cao F, Zhou Y, Krishnasamy A, Biswas KH, Ravasio A, Chen Z, Wang YH, Kawauchi K, Jones GE, Sheetz MP.

Nat Commun. 2015 Oct 28;6:8672. doi: 10.1038/ncomms9672.



Shivashankar GV, Sheetz M, Matsudaira P.

Integr Biol (Camb). 2015 Oct;7(10):1091-2. doi: 10.1039/c5ib90040a. Epub 2015 Sep 25. No abstract available.


An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.

Song ES, Ozbil M, Zhang T, Sheetz M, Lee D, Tran D, Li S, Prabhakar R, Hersh LB, Rodgers DW.

PLoS One. 2015 Jul 17;10(7):e0133114. doi: 10.1371/journal.pone.0133114. eCollection 2015.


Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.

Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T.

Integr Biol (Camb). 2015 Oct;7(10):1272-84. doi: 10.1039/c5ib00032g. Epub 2015 Jul 9.


Talin Dependent Mechanosensitivity of Cell Focal Adhesions.

Yan J, Yao M, Goult BT, Sheetz MP.

Cell Mol Bioeng. 2015;8(1):151-159. Epub 2014 Nov 4. Review.


Estimated glomerular filtration rate progression in UK primary care patients with type 2 diabetes and diabetic kidney disease: a retrospective cohort study.

Cid Ruzafa J, Paczkowski R, Boye KS, Di Tanna GL, Sheetz MJ, Donaldson R, Breyer MD, Neasham D, Voelker JR.

Int J Clin Pract. 2015 Aug;69(8):871-82. doi: 10.1111/ijcp.12640. Epub 2015 May 25.


Cyclic stretching of soft substrates induces spreading and growth.

Cui Y, Hameed FM, Yang B, Lee K, Pan CQ, Park S, Sheetz M.

Nat Commun. 2015 Feb 23;6:6333. doi: 10.1038/ncomms7333.


Parallel near-field photolithography with metal-coated elastomeric masks.

Wu J, Yu CH, Li S, Zou B, Liu Y, Zhu X, Guo Y, Xu H, Zhang W, Zhang L, Liu B, Tian D, Huang W, Sheetz MP, Huo F.

Langmuir. 2015 Jan 27;31(3):1210-7. doi: 10.1021/la504260x. Epub 2015 Jan 14.


Early events in cell spreading as a model for quantitative analysis of biomechanical events.

Wolfenson H, Iskratsch T, Sheetz MP.

Biophys J. 2014 Dec 2;107(11):2508-14. doi: 10.1016/j.bpj.2014.10.041. Epub 2014 Dec 2. Review.


Can small institutes address some problems facing biomedical researchers?

Sheetz MP.

Mol Biol Cell. 2014 Nov 1;25(21):3267-9. doi: 10.1091/mbc.E14-05-1017.


Appreciating force and shape—the rise of mechanotransduction in cell biology.

Iskratsch T, Wolfenson H, Sheetz MP.

Nat Rev Mol Cell Biol. 2014 Dec;15(12):825-33. doi: 10.1038/nrm3903. Epub 2014 Oct 30. Review.


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