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Interferon Is Superior to Direct Acting Antiviral Therapy in Tertiary Prevention of Early Recurrence of Hepatocellular Carcinoma.

Teng W, Jeng WJ, Yang HI, Chen WT, Hsieh YC, Huang CH, Lin CC, Lin CY, Lin SM, Sheen IS.

Cancers (Basel). 2019 Dec 19;12(1). pii: E23. doi: 10.3390/cancers12010023.


Add-on sorafenib is beneficial for hepatocellular carcinoma patients with transarterial chemoembolization refractoriness: a real-world experience.

Lin PT, Teng W, Jeng WJ, Hsieh YC, Hung CF, Huang CH, Lui KW, Chen YC, Lin CC, Lin CY, Sheen IS, Lin SM.

Eur J Gastroenterol Hepatol. 2019 Dec 16. doi: 10.1097/MEG.0000000000001637. [Epub ahead of print]


Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma.

Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Li SY, Leu CM, Tsay YG, Chang CF.

Oncol Lett. 2019 Nov;18(5):4377-4384. doi: 10.3892/ol.2019.10826. Epub 2019 Sep 9. Review.


The incidence and predictors of post transarterial chemoembolization variceal bleeding in hepatocellular carcinoma patients.

Lin PT, Teng W, Jeng WJ, Hsieh YC, Hung CF, Huang CH, Lui KW, Chen YC, Lin CC, Lin SM, Sheen IS, Lin CY.

J Formos Med Assoc. 2019 Sep 5. pii: S0929-6646(19)30227-X. doi: 10.1016/j.jfma.2019.08.019. [Epub ahead of print]


Evolution of renal function under direct-acting antivirals treatment for chronic hepatitis C: A real-world experience.

Tsai MC, Lin CY, Hung CH, Lu SN, Tung SY, Chien RN, Lin CL, Wang JH, Chien-Hung C, Chang KC, Hu TH, Sheen IS.

J Viral Hepat. 2019 Dec;26(12):1404-1412. doi: 10.1111/jvh.13193. Epub 2019 Oct 7.


In HCV-related liver cirrhosis, local pulse wave velocity increases and in decompensated patients correlates with poorer survival.

Huang CH, Wu LS, Jeng WJ, Cheng YF, Ko YS, Sheen IS, Lin CY.

PLoS One. 2019 Mar 19;14(3):e0212770. doi: 10.1371/journal.pone.0212770. eCollection 2019.


Timely eradication of HCV viremia by PegIFN/RBV is crucial in prevention of post RFA recurrence in CHC-HCC patients.

Chen YC, Teng W, Hsieh YC, Chen WT, Jeng WJ, Huang CH, Lin CC, Chen YC, Lin SM, Lin CY, Sheen IS.

J Formos Med Assoc. 2019 Aug;118(8):1239-1246. doi: 10.1016/j.jfma.2018.11.014. Epub 2018 Dec 21.


Hepatic decompensation during paritaprevir/ritonavir/ombitasvir/dasabuvir treatment for genotype 1b chronic hepatitis C patients with advanced fibrosis and compensated cirrhosis.

Hsieh YC, Jeng WJ, Huang CH, Teng W, Chen WT, Chen YC, Lin SM, Tai DI, Lin CY, Sheen IS.

PLoS One. 2018 Aug 23;13(8):e0202777. doi: 10.1371/journal.pone.0202777. eCollection 2018.


Elbasvir/grazoprevir in Asia-Pacific/Russian participants with chronic hepatitis C virus genotype 1, 4, or 6 infection.

George J, Burnevich E, Sheen IS, Heo J, Kinh NV, Tanwandee T, Cheng PN, Kim DY, Tak WY, Kizhlo S, Zhdanov K, Isakov V, Liang L, Lindore P, Ginanni J, Nguyen BY, Wahl J, Barr E, Robertson M, Ingravallo P, Talwani R; C‐CORAL Study Investigators.

Hepatol Commun. 2018 Apr 4;2(5):595-606. doi: 10.1002/hep4.1177. eCollection 2018 May.


Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer.

Jeng KS, Jeng CJ, Sheen IS, Wu SH, Lu SJ, Wang CH, Chang CF.

Int J Mol Sci. 2018 May 5;19(5). pii: E1375. doi: 10.3390/ijms19051375.


CCL4 is the only predictor for non-responder in GT-1 CHC patients with favorable IL28B genotype when treated with PegIFN/RBV.

Lin CC, Su SH, Jeng WJ, Huang CH, Teng W, Chen WT, Chen YC, Lin CY, Sheen IS.

BMC Gastroenterol. 2017 Dec 29;17(1):169. doi: 10.1186/s12876-017-0724-4.


Tropism of liver epithelial cells toward hepatocellular carcinoma in vitro and in vivo with altering gene expression of cancer stem cells.

Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Li SY, Lu SJ, Chang CF.

Am J Surg. 2018 Apr;215(4):735-743. doi: 10.1016/j.amjsurg.2017.11.041. Epub 2017 Dec 6.


Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV.

Liu CJ, Chuang WL, Sheen IS, Wang HY, Chen CY, Tseng KC, Chang TT, Massetto B, Yang JC, Yun C, Knox SJ, Osinusi A, Camus G, Jiang D, Brainard DM, McHutchison JG, Hu TH, Hsu YC, Lo GH, Chu CJ, Chen JJ, Peng CY, Chien RN, Chen PJ.

Gastroenterology. 2018 Mar;154(4):989-997. doi: 10.1053/j.gastro.2017.11.011. Epub 2017 Nov 22.


Memory Regulatory T cells Increase Only In Inflammatory Phase of Chronic Hepatitis B Infection and Related to Galectin-9/Tim-3 interaction.

Hu CC, Jeng WJ, Chen YC, Fang JH, Huang CH, Teng W, Hsieh YC, Lin YC, Chien RN, Sheen IS, Lin CY.

Sci Rep. 2017 Nov 10;7(1):15280. doi: 10.1038/s41598-017-15527-x.


Incidence and predictors of hepatitis B surface antigen seroclearance after cessation of nucleos(t)ide analogue therapy in hepatitis B e antigen-negative chronic hepatitis B.

Jeng WJ, Chen YC, Chien RN, Sheen IS, Liaw YF.

Hepatology. 2018 Aug;68(2):425-434. doi: 10.1002/hep.29640. Epub 2018 May 6.


Orantinib versus placebo combined with transcatheter arterial chemoembolisation in patients with unresectable hepatocellular carcinoma (ORIENTAL): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study.

Kudo M, Cheng AL, Park JW, Park JH, Liang PC, Hidaka H, Izumi N, Heo J, Lee YJ, Sheen IS, Chiu CF, Arioka H, Morita S, Arai Y.

Lancet Gastroenterol Hepatol. 2018 Jan;3(1):37-46. doi: 10.1016/S2468-1253(17)30290-X. Epub 2017 Oct 4.


Role of C-X-C chemokine ligand 12/C-X-C chemokine receptor 4 in the progression of hepatocellular carcinoma.

Jeng KS, Jeng CJ, Jeng WJ, Chang CF, Sheen IS.

Oncol Lett. 2017 Aug;14(2):1905-1910. doi: 10.3892/ol.2017.6396. Epub 2017 Jun 16.


Eradication of hepatitis C virus profoundly prolongs survival in hepatocellular carcinoma patients receiving transarterial chemoembolization.

Teng W, Hsieh YC, Lui KW, Chen WT, Hung CF, Huang CH, Chen YC, Jeng WJ, Lin CC, Lin CY, Lin SM, Sheen IS.

J Viral Hepat. 2017 Dec;24(12):1160-1167. doi: 10.1111/jvh.12745. Epub 2017 Aug 16.


Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients.

Lee MH, Huang CF, Lai HC, Lin CY, Dai CY, Liu CJ, Wang JH, Huang JF, Su WP, Yang HC, Kee KM, Yeh ML, Chuang PH, Hsu SJ, Huang CI, Kao JT, Chen CC, Chen SH, Jeng WJ, Yang HI, Yuan Y, Lu SN, Sheen IS, Liu CH, Peng CY, Kao JH, Yu ML, Chuang WL, Chen CJ.

Sci Rep. 2017 Jun 16;7(1):3718. doi: 10.1038/s41598-017-02313-y.


Percutaneous radiofrequency ablation of tumor feeding artery before target tumor ablation may reduce local tumor progression in hepatocellular carcinoma.

Cheng YT, Jeng WJ, Lin CC, Chen WT, Sheen IS, Lin CY, Lin SM.

Biomed J. 2016 Dec;39(6):400-406. doi: 10.1016/ Epub 2016 Dec 24.


Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients.

Huang CH, Jeng WJ, Ho YP, Teng W, Hsieh YC, Chen WT, Chen YC, Lin HH, Sheen IS, Lin CY.

Sci Rep. 2016 Dec 1;6:38250. doi: 10.1038/srep38250.


Ritonavir-boosted danoprevir plus peginterferon alfa-2a and ribavirin in Asian chronic hepatitis C patients with or without cirrhosis.

Kao JH, Tung SY, Lee Y, Thongsawat S, Tanwandee T, Sheen IS, Wu JJ, Li H, Brennan BJ, Zhou J, Le Pogam S, Najera I, Thommes JA, Hill G.

J Gastroenterol Hepatol. 2016 Oct;31(10):1757-1765. doi: 10.1111/jgh.13374.


Clinical Relapse After Cessation of Tenofovir Therapy in Hepatitis B e Antigen-Negative Patients.

Jeng WJ, Chen YC, Sheen IS, Lin CL, Hu TH, Chien RN, Liaw YF.

Clin Gastroenterol Hepatol. 2016 Dec;14(12):1813-1820.e1. doi: 10.1016/j.cgh.2016.07.002. Epub 2016 Jul 9.


Ledipasvir/sofosbuvir fixed-dose combination tablet in Taiwanese patients with chronic genotype 1 hepatitis C virus.

Chuang WL, Chien RN, Peng CY, Chang TT, Lo GH, Sheen IS, Wang HY, Chen JJ, Yang JC, Knox SJ, Gao B, Garrison KL, Mo H, Pang PS, Hsu YC, Hu TH, Chu CJ, Kao JH.

J Gastroenterol Hepatol. 2016 Jul;31(7):1323-9. doi: 10.1111/jgh.13305.


A phase 3b study of sofosbuvir plus ribavirin in Taiwanese patients with chronic genotype 2 hepatitis C virus infection.

Kao JH, Chien RN, Chang TT, Peng CY, Hu TH, Lo GH, Wang HY, Chen JJ, Yang JC, Knox SJ, Han L, Mo H, Mathias A, Brainard DM, Sheen IS, Hsu YC, Chu CJ, Chuang WL.

Liver Int. 2016 Aug;36(8):1101-7. doi: 10.1111/liv.13082. Epub 2016 Mar 23.


Liver epithelial cells inhibit proliferation and invasiveness of hepatoma cells.

Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Li SY, Hung ZH, Hsiau HI, Yu MC, Chang CF.

Oncol Rep. 2016 Mar;35(3):1622-8. doi: 10.3892/or.2015.4478. Epub 2015 Dec 8.


Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion.

Chang LY, Lin YC, Chiang JM, Mahalingam J, Su SH, Huang CT, Chen WT, Huang CH, Jeng WJ, Chen YC, Lin SM, Sheen IS, Lin CY.

Oncoimmunology. 2015 Apr 16;4(10):e1040215. eCollection 2015 Oct.


Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma.

Jeng KS, Jeng CJ, Jeng WJ, Sheen IS, Chang CF, Hsiau HI, Hung ZH, Yu MC, Chang FY.

Am J Surg. 2015 Sep;210(3):554-60. doi: 10.1016/j.amjsurg.2015.03.001. Epub 2015 May 8.


Safety and efficacy of tigatuzumab plus sorafenib as first-line therapy in subjects with advanced hepatocellular carcinoma: A phase 2 randomized study.

Cheng AL, Kang YK, He AR, Lim HY, Ryoo BY, Hung CH, Sheen IS, Izumi N, Austin T, Wang Q, Greenberg J, Shiratori S, Beckman RA, Kudo M; Investigators’ Study Group.

J Hepatol. 2015 Oct;63(4):896-904. doi: 10.1016/j.jhep.2015.06.001. Epub 2015 Jun 10.


Insufficient ablative margin determined by early computed tomography may predict the recurrence of hepatocellular carcinoma after radiofrequency ablation.

Teng W, Liu KW, Lin CC, Jeng WJ, Chen WT, Sheen IS, Lin CY, Lin SM.

Liver Cancer. 2015 Mar;4(1):26-38. doi: 10.1159/000343877.


Heterogeneity of hepatocellular carcinoma contributes to cancer progression.

Jeng KS, Chang CF, Jeng WJ, Sheen IS, Jeng CJ.

Crit Rev Oncol Hematol. 2015 Jun;94(3):337-47. doi: 10.1016/j.critrevonc.2015.01.009. Epub 2015 Jan 29. Review.


Predictors of mortality within 6 weeks after treatment of gastric variceal bleeding in cirrhotic patients.

Teng W, Chen WT, Ho YP, Jeng WJ, Huang CH, Chen YC, Lin SM, Chiu CT, Lin CY, Sheen IS.

Medicine (Baltimore). 2014 Dec;93(29):e321. doi: 10.1097/MD.0000000000000321.


Adjuvant therapy for hepatocellular carcinoma after curative treatment.

Jeng WJ, Lin CC, Chen WT, Sheen IS, Lin CY, Lin SM.

Dig Dis. 2014;32(6):747-54. doi: 10.1159/000368017. Epub 2014 Oct 29. Review.


Increased regulatory T cells in patients with liver cirrhosis correlated with hyperbilirubinemia and predict bacterial complications.

Huang CH, Jeng WJ, Ho YP, Teng W, Chen WT, Chen YC, Lin SM, Chiu CT, Sheen IS, Lin CY.

J Gastroenterol Hepatol. 2015 Apr;30(4):775-83. doi: 10.1111/jgh.12781.


High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma.

Jeng KS, Sheen IS, Jeng WJ, Yu MC, Hsiau HI, Chang FY.

Onco Targets Ther. 2013 Dec 27;7:79-86. doi: 10.2147/OTT.S54702. eCollection 2013.


Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1-6 cells.

Jeng KS, Sheen IS, Jeng WJ, Yu MC, Hsiau HI, Chang FY, Tsai HH.

Onco Targets Ther. 2013 Aug 5;6:1047-55. doi: 10.2147/OTT.S44828. eCollection 2013.


Various predictors of sustained virologic response in different age groups of patients with genotype-1 chronic hepatitis C.

Lin CY, Sheen IS, Chen JY, Huang CW, Huang CH, Jeng WJ, Chen WT.

J Clin Gastroenterol. 2013 Oct;47(9):794-9. doi: 10.1097/MCG.0b013e31829d2064.


Off-therapy durability of response to entecavir therapy in hepatitis B e antigen-negative chronic hepatitis B patients.

Jeng WJ, Sheen IS, Chen YC, Hsu CW, Chien RN, Chu CM, Liaw YF.

Hepatology. 2013 Dec;58(6):1888-96. doi: 10.1002/hep.26549. Epub 2013 Oct 17.


Is less than 5 mm as the narrowest surgical margin width in central resections of hepatocellular carcinoma justified?

Jeng KS, Jeng WJ, Sheen IS, Lin CC, Lin CK.

Am J Surg. 2013 Jul;206(1):64-71. doi: 10.1016/j.amjsurg.2012.06.010. Epub 2013 Feb 4.


Blockade of the sonic hedgehog pathway effectively inhibits the growth of hepatoma in mice: An in vivo study.

Jeng KS, Sheen IS, Jeng WJ, Yu MC, Tsai HH, Chang FY, Su JC.

Oncol Lett. 2012 Dec;4(6):1158-1162. Epub 2012 Sep 24.


None of the six SNPs of IL28B could predict treatment responses in genotype 2 chronic HCV infected patients by propensity score matching analysis.

Jeng WJ, Lin CY, Chen JY, Huang CW, Huang CH, Sheen IS.

PLoS One. 2012;7(11):e48217. doi: 10.1371/journal.pone.0048217. Epub 2012 Nov 16.


High expression of patched homolog-1 messenger RNA and glioma-associated oncogene-1 messenger RNA of sonic hedgehog signaling pathway indicates a risk of postresection recurrence of hepatocellular carcinoma.

Jeng KS, Sheen IS, Jeng WJ, Lin CC, Lin CK, Su JC, Yu MC, Fang HY.

Ann Surg Oncol. 2013 Feb;20(2):464-73. doi: 10.1245/s10434-012-2593-y. Epub 2012 Aug 22.


PEDF effectively decreases VEGF to PEDF messenger RNA ratio of the inner edge of rat hepatocellular carcinoma induced by diethyl nitrosamine - an "in vivo" study.

Jeng KS, Sheen IS, Jeng WJ, Su JC.

Hepatogastroenterology. 2012 Jul-Aug;59(117):1484-90. doi: 10.5754/hge11543.


Azidothymidine treatment of hepatocellular carcinoma in rats: an in vivo study of telomerase inhibition.

Jeng KS, Sheen IS, Jeng WJ.

Hepatogastroenterology. 2011 Nov-Dec;58(112):2091-6. doi: 10.5754/hge11087.


The clinical relevance of the expression of the ratio of laminin-5 subchains messenger RNA of hepatocellular carcinoma to non-cancerous liver remnant: a prospective study.

Jeng KS, Jeng WJ, Sheen IS, Su JC.

Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1680-6. doi: 10.5754/hge10843. Epub 2011 Jul 15.


MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding.

Chen WT, Lin CY, Sheen IS, Huang CW, Lin TN, Lin CJ, Jeng WJ, Huang CH, Ho YP, Chiu CT.

World J Gastroenterol. 2011 Apr 28;17(16):2120-5. doi: 10.3748/wjg.v17.i16.2120.

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