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Items: 1 to 50 of 111

1.

A national survey of approaches to manage the ICU patient with opioid use disorder.

Reichheld AM, Hills-Evans K, Sheehan JK, Tocci NX, Tandon M, Hsu D, Marshall J, O'Donoghue S, Stevens JP.

J Crit Care. 2019 Jun 29;54:42-47. doi: 10.1016/j.jcrc.2019.06.032. [Epub ahead of print]

2.

Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure.

Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M.

J Clin Invest. 2014 Jul;124(7):3047-60. doi: 10.1172/JCI73469. Epub 2014 Jun 2.

3.

The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status.

Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, Sheehan JK, Griffith JD, Li X.

Sci Rep. 2012;2:640. doi: 10.1038/srep00640. Epub 2012 Sep 7.

4.

Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways.

Kesimer M, Ehre C, Burns KA, Davis CW, Sheehan JK, Pickles RJ.

Mucosal Immunol. 2013 Mar;6(2):379-92. doi: 10.1038/mi.2012.81. Epub 2012 Aug 29.

5.

A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia.

Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M.

Science. 2012 Aug 24;337(6097):937-41. doi: 10.1126/science.1223012.

6.

Mapping the protein domain structures of the respiratory mucins: a mucin proteome coverage study.

Cao R, Wang TT, DeMaria G, Sheehan JK, Kesimer M.

J Proteome Res. 2012 Aug 3;11(8):4013-23. doi: 10.1021/pr300058z. Epub 2012 Jun 28.

7.

Studying mucin secretion from human bronchial epithelial cell primary cultures.

Abdullah LH, Wolber C, Kesimer M, Sheehan JK, Davis CW.

Methods Mol Biol. 2012;842:259-77. doi: 10.1007/978-1-61779-513-8_16.

8.

Mass spectrometric analysis of mucin core proteins.

Kesimer M, Sheehan JK.

Methods Mol Biol. 2012;842:67-79. doi: 10.1007/978-1-61779-513-8_4.

9.

Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures.

Sears PR, Davis CW, Chua M, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L181-6. doi: 10.1152/ajplung.00321.2010. Epub 2011 Apr 29.

10.

Unpacking a gel-forming mucin: a view of MUC5B organization after granular release.

Kesimer M, Makhov AM, Griffith JD, Verdugo P, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L15-22. doi: 10.1152/ajplung.00194.2009. Epub 2009 Sep 25.

11.

Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii.

Kesimer M, Kiliç N, Mehrotra R, Thornton DJ, Sheehan JK.

BMC Microbiol. 2009 Aug 11;9:163. doi: 10.1186/1471-2180-9-163.

12.

Investigating the molecular basis for the virulence of Escherichia coli K5 by nuclear magnetic resonance analysis of the capsule polysaccharide.

Blundell CD, Roberts IS, Sheehan JK, Almond A.

J Mol Microbiol Biotechnol. 2009;17(2):71-82. doi: 10.1159/000215933. Epub 2009 Apr 25.

PMID:
19401610
13.

Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment.

Livraghi A, Grubb BR, Hudson EJ, Wilkinson KJ, Sheehan JK, Mall MA, O'Neal WK, Boucher RC, Randell SH.

J Immunol. 2009 Apr 1;182(7):4357-67. doi: 10.4049/jimmunol.0802557.

14.

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.

Kesimer M, Scull M, Brighton B, DeMaria G, Burns K, O'Neal W, Pickles RJ, Sheehan JK.

FASEB J. 2009 Jun;23(6):1858-68. doi: 10.1096/fj.08-119131. Epub 2009 Feb 3.

15.

Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

Kesimer M, Kirkham S, Pickles RJ, Henderson AG, Alexis NE, Demaria G, Knight D, Thornton DJ, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L92-L100. doi: 10.1152/ajplung.90388.2008. Epub 2008 Oct 17.

16.

Analyzing the functions of large glycoconjugates through the dissipative properties of their absorbed layers using the gel-forming mucin MUC5B as an example.

Kesimer M, Sheehan JK.

Glycobiology. 2008 Jun;18(6):463-72. doi: 10.1093/glycob/cwn024. Epub 2008 Mar 13.

PMID:
18339669
17.

Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.

Zhu Y, Ehre C, Abdullah LH, Sheehan JK, Roy M, Evans CM, Dickey BF, Davis CW.

J Physiol. 2008 Apr 1;586(7):1977-92. doi: 10.1113/jphysiol.2007.149310. Epub 2008 Feb 7.

18.

Innate immunity and mucus structure and function.

Sheehan JK, Kesimer M, Pickles R.

Novartis Found Symp. 2006;279:155-66; discussion 167-9, 216-9. Review.

PMID:
17278393
19.

Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans.

Scott PG, Dodd CM, Bergmann EM, Sheehan JK, Bishop PN.

J Biol Chem. 2006 May 12;281(19):13324-32. Epub 2006 Mar 17.

20.

The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.

Thelin WR, Kesimer M, Tarran R, Kreda SM, Grubb BR, Sheehan JK, Stutts MJ, Milgram SL.

J Biol Chem. 2005 Dec 16;280(50):41512-20. Epub 2005 Oct 20.

21.

From mucins to mucus: toward a more coherent understanding of this essential barrier.

Thornton DJ, Sheehan JK.

Proc Am Thorac Soc. 2004;1(1):54-61. Review.

PMID:
16113413
22.

Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces.

Matsui H, Verghese MW, Kesimer M, Schwab UE, Randell SH, Sheehan JK, Grubb BR, Boucher RC.

J Immunol. 2005 Jul 15;175(2):1090-9.

23.

Mucins and their O-Glycans from human bronchial epithelial cell cultures.

Holmén JM, Karlsson NG, Abdullah LH, Randell SH, Sheehan JK, Hansson GC, Davis CW.

Am J Physiol Lung Cell Mol Physiol. 2004 Oct;287(4):L824-34. Epub 2004 Jun 11.

24.

Partial characterisation of high-molecular weight glycoconjugates in the trail mucus of the freshwater pond snail Lymnaea stagnalis.

Ballance S, Howard M, White KN, McCrohan CR, Thornton DJ, Sheehan JK.

Comp Biochem Physiol B Biochem Mol Biol. 2004 Apr;137(4):475-86.

PMID:
15081999
25.

Interaction between mycobacteria and mucus on a human respiratory tissue organ culture model with an air interface.

Middleton AM, Chadwick MV, Nicholson AG, Wilson R, Thornton DJ, Kirkham S, Sheehan JK.

Exp Lung Res. 2004 Jan-Feb;30(1):17-29.

PMID:
14967601
26.

Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin.

Sheehan JK, Kirkham S, Howard M, Woodman P, Kutay S, Brazeau C, Buckley J, Thornton DJ.

J Biol Chem. 2004 Apr 9;279(15):15698-705. Epub 2004 Jan 28.

27.

Prognostic value of serum MUC5AC mucin in patients with cholangiocarcinoma.

Boonla C, Wongkham S, Sheehan JK, Wongkham C, Bhudhisawasdi V, Tepsiri N, Pairojkul C.

Cancer. 2003 Oct 1;98(7):1438-43.

28.

Serum MUC5AC mucin as a potential marker for cholangiocarcinoma.

Wongkham S, Sheehan JK, Boonla C, Patrakitkomjorn S, Howard M, Kirkham S, Sripa B, Wongkham C, Bhudhisawasdi V.

Cancer Lett. 2003 May 30;195(1):93-9.

PMID:
12767517
29.

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus.

Raynal BD, Hardingham TE, Sheehan JK, Thornton DJ.

J Biol Chem. 2003 Aug 1;278(31):28703-10. Epub 2003 May 19.

30.

Predicting the molecular shape of polysaccharides from dynamic interactions with water.

Almond A, Sheehan JK.

Glycobiology. 2003 Apr;13(4):255-64. Epub 2002 Dec 17.

PMID:
12626381
31.

Light and X-ray scattering show decorin to be a dimer in solution.

Scott PG, Grossmann JG, Dodd CM, Sheehan JK, Bishop PN.

J Biol Chem. 2003 May 16;278(20):18353-9. Epub 2003 Feb 21.

32.

Making More MUCS.

Perez-Vilar J, Sheehan JK, Randell SH.

Am J Respir Cell Mol Biol. 2003 Mar;28(3):267-70. Review. No abstract available.

PMID:
12594051
33.

Interaction of mucus with freshly neutralised aluminium in freshwater.

Ballance S, Sheehan JK, Tkachenko A, McCrohan CR, White KN.

J Inorg Biochem. 2002 Sep 30;92(1):11-8.

PMID:
12230983
34.

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva.

Raynal BD, Hardingham TE, Thornton DJ, Sheehan JK.

Biochem J. 2002 Mar 1;362(Pt 2):289-96.

35.

Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.

Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ.

Biochem J. 2002 Feb 1;361(Pt 3):537-46.

36.

Hyaluronan: polysaccharide chaos to protein organisation.

Day AJ, Sheehan JK.

Curr Opin Struct Biol. 2001 Oct;11(5):617-22. Review.

PMID:
11785764
37.

Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin.

Thornton DJ, Davies JR, Kirkham S, Gautrey A, Khan N, Richardson PS, Sheehan JK.

Glycobiology. 2001 Nov;11(11):969-77.

PMID:
11744631
39.

Phosphorylation by cdc2-CyclinB1 kinase releases cytoplasmic dynein from membranes.

Addinall SG, Mayr PS, Doyle S, Sheehan JK, Woodman PG, Allan VJ.

J Biol Chem. 2001 May 11;276(19):15939-44. Epub 2001 Feb 15.

40.
41.

Characterization of mucins from cultured normal human tracheobronchial epithelial cells.

Thornton DJ, Gray T, Nettesheim P, Howard M, Koo JS, Sheehan JK.

Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1118-28.

42.

Heterogeneity and size distribution of gel-forming mucins.

Sheehan JK, Thornton DJ.

Methods Mol Biol. 2000;125:87-96. Review. No abstract available.

PMID:
10820752
43.

Separation and identification of mucins and their glycoforms.

Thornton DJ, Khan N, Sheehan JK.

Methods Mol Biol. 2000;125:77-85. Review. No abstract available.

PMID:
10820751
44.
45.
46.

Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix.

Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN.

J Biol Chem. 2000 Jan 21;275(3):2123-9.

47.

A study of the intracellular and secreted forms of the MUC2 mucin from the PC/AA intestinal cell line.

Aksoy N, Thornton DJ, Corfield A, Paraskeva C, Sheehan JK.

Glycobiology. 1999 Jul;9(7):739-46.

PMID:
10362844
48.

Mucin gene expression during differentiation of human airway epithelia in vitro. Muc4 and muc5b are strongly induced.

Bernacki SH, Nelson AL, Abdullah L, Sheehan JK, Harris A, Davis CW, Randell SH.

Am J Respir Cell Mol Biol. 1999 Apr;20(4):595-604.

PMID:
10100990
49.

Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product.

Thornton DJ, Khan N, Mehrotra R, Howard M, Veerman E, Packer NH, Sheehan JK.

Glycobiology. 1999 Mar;9(3):293-302.

PMID:
10024667
50.

Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug.

Sheehan JK, Howard M, Richardson PS, Longwill T, Thornton DJ.

Biochem J. 1999 Mar 1;338 ( Pt 2):507-13.

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