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Items: 1 to 50 of 181


Flavored E-liquids Increase Cytoplasmic Ca2+ Levels in Airway Epithelia.

Rowell TR, Keating JE, Zorn BT, Glish GL, Shears SB, Tarran R.

Am J Physiol Lung Cell Mol Physiol. 2019 Nov 6. doi: 10.1152/ajplung.00123.2019. [Epub ahead of print]


Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7.

Riley AM, Wang H, Shears SB, Potter BVL.

Medchemcomm. 2019 Jun 7;10(7):1165-1172. doi: 10.1039/c9md00163h. eCollection 2019 Jul 1.


Functional Multiplicity of an Insect Cytokine Family Assists Defense Against Environmental Stress.

Shears SB, Hayakawa Y.

Front Physiol. 2019 Mar 22;10:222. doi: 10.3389/fphys.2019.00222. eCollection 2019. Review.


Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine.

An Y, Jessen HJ, Wang H, Shears SB, Kireev D.

Structure. 2019 Jun 4;27(6):1022-1028.e2. doi: 10.1016/j.str.2019.03.007. Epub 2019 Apr 4.


Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

Gu C, Stashko MA, Puhl-Rubio AC, Chakraborty M, Chakraborty A, Frye SV, Pearce KH, Wang X, Shears SB, Wang H.

J Med Chem. 2019 Feb 14;62(3):1443-1454. doi: 10.1021/acs.jmedchem.8b01593. Epub 2019 Jan 25.


Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold.

Shears SB, Wang H.

Adv Biol Regul. 2019 Jan;71:118-127. doi: 10.1016/j.jbior.2018.10.006. Epub 2018 Oct 27. Review.


Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors.

Puhl-Rubio AC, Stashko MA, Wang H, Hardy PB, Tyagi V, Li B, Wang X, Kireev D, Jessen HJ, Frye SV, Shears SB, Pearce KH.

SLAS Discov. 2018 Oct;23(9):982-988. doi: 10.1177/2472555218775323. Epub 2018 May 29.


Corrigendum to 'Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells' [Cellular Signalling 46 (2018) 120-128].

Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, de Souza Ferreira S, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO.

Cell Signal. 2019 Jan;53:415. doi: 10.1016/j.cellsig.2018.05.004. Epub 2018 May 25. No abstract available.


Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.

Yousaf R, Gu C, Ahmed ZM, Khan SN, Friedman TB, Riazuddin S, Shears SB, Riazuddin S.

PLoS Genet. 2018 Mar 28;14(3):e1007297. doi: 10.1371/journal.pgen.1007297. eCollection 2018 Mar.


Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates.

Wang H, Gu C, Rolfes RJ, Jessen HJ, Shears SB.

J Biol Chem. 2018 May 4;293(18):6905-6914. doi: 10.1074/jbc.RA117.001670. Epub 2018 Mar 14.


Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.

Rajasekaran SS, Kim J, Gaboardi GC, Gromada J, Shears SB, Dos Santos KT, Nolasco EL, Ferreira SS, Illies C, Köhler M, Gu C, Ryu SH, Martins JO, Darè E, Barker CJ, Berggren PO.

Cell Signal. 2018 Jun;46:120-128. doi: 10.1016/j.cellsig.2018.03.001. Epub 2018 Mar 6. Erratum in: Cell Signal. 2019 Jan;53:415.


Inositol Pyrophosphate Synthesis by Diphosphoinositol Pentakisphosphate Kinase-1 is Regulated by Phosphatidylinositol(4,5)bisphosphate.

Nair VS, Gu C, Janoshazi AK, Jessen HJ, Wang H, Shears SB.

Biosci Rep. 2018 Feb 19. pii: BSR20171549. doi: 10.1042/BSR20171549. [Epub ahead of print]


The Drosophila cytokine, GBP: A model that illuminates the yin-yang of inflammation and longevity in humans?

Shears SB, Hayakawa Y.

Cytokine. 2018 Oct;110:298-300. doi: 10.1016/j.cyto.2018.02.016. Epub 2018 Feb 16.


Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress.

Sung EJ, Ryuda M, Matsumoto H, Uryu O, Ochiai M, Cook ME, Yi NY, Wang H, Putney JW, Bird GS, Shears SB, Hayakawa Y.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13786-13791. doi: 10.1073/pnas.1712453115. Epub 2017 Dec 11.


KO of 5-InsP7 kinase activity transforms the HCT116 colon cancer cell line into a hypermetabolic, growth-inhibited phenotype.

Gu C, Nguyen HN, Ganini D, Chen Z, Jessen HJ, Gu Z, Wang H, Shears SB.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11968-11973. doi: 10.1073/pnas.1702370114. Epub 2017 Oct 25.


Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity.

Rajasekaran SS, Illies C, Shears SB, Wang H, Ayala TS, Martins JO, Daré E, Berggren PO, Barker CJ.

Cell Signal. 2018 Jan;42:127-133. doi: 10.1016/j.cellsig.2017.10.008. Epub 2017 Oct 16.


Structural features of human inositol phosphate multikinase rationalize its inositol phosphate kinase and phosphoinositide 3-kinase activities.

Wang H, Shears SB.

J Biol Chem. 2017 Nov 3;292(44):18192-18202. doi: 10.1074/jbc.M117.801845. Epub 2017 Sep 7.


Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.

Baughman BM, Wang H, An Y, Kireev D, Stashko MA, Jessen HJ, Pearce KH, Frye SV, Shears SB.

PLoS One. 2017 Jun 21;12(6):e0180272. doi: 10.1371/journal.pone.0180272. eCollection 2017. No abstract available.


Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.

Shears SB.

J Cell Physiol. 2018 Mar;233(3):1897-1912. doi: 10.1002/jcp.26017. Epub 2017 Jun 15. Review.


The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.

Gu C, Nguyen HN, Hofer A, Jessen HJ, Dai X, Wang H, Shears SB.

J Biol Chem. 2017 Mar 17;292(11):4544-4555. doi: 10.1074/jbc.M116.765743. Epub 2017 Jan 26.


Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.

Gu C, Wilson MS, Jessen HJ, Saiardi A, Shears SB.

PLoS One. 2016 Oct 27;11(10):e0165286. doi: 10.1371/journal.pone.0165286. eCollection 2016.


The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family.

Shears SB, Baughman BM, Gu C, Nair VS, Wang H.

Adv Biol Regul. 2017 Jan;63:98-106. doi: 10.1016/j.jbior.2016.10.003. Epub 2016 Oct 17. Review.


A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.

Baughman BM, Wang H, An Y, Kireev D, Stashko MA, Jessen HJ, Pearce KH, Frye SV, Shears SB.

PLoS One. 2016 Oct 13;11(10):e0164378. doi: 10.1371/journal.pone.0164378. eCollection 2016. Retraction in: PLoS One. 2017 Jun 21;12 (6):e0180272.


Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.

Hager A, Wu M, Wang H, Brown NW Jr, Shears SB, Veiga N, Fiedler D.

Chemistry. 2016 Aug 22;22(35):12406-14. doi: 10.1002/chem.201601754. Epub 2016 Jul 27.


Towards pharmacological intervention in inositol pyrophosphate signalling.

Shears SB.

Biochem Soc Trans. 2016 Feb;44(1):191-6. doi: 10.1042/BST20150184. Review.


Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.

Wang H, Nair VS, Holland AA, Capolicchio S, Jessen HJ, Johnson MK, Shears SB.

Biochemistry. 2015 Oct 27;54(42):6462-74. doi: 10.1021/acs.biochem.5b00532. Epub 2015 Oct 9.


Synthetic tools for studying the chemical biology of InsP8.

Riley AM, Wang H, Shears SB, L Potter BV.

Chem Commun (Camb). 2015 Aug 14;51(63):12605-8. doi: 10.1039/c5cc05017k.


Identification of a functional nuclear translocation sequence in hPPIP5K2.

Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB.

BMC Cell Biol. 2015 Jun 18;16:17. doi: 10.1186/s12860-015-0063-7.


Inositol pyrophosphates: why so many phosphates?

Shears SB.

Adv Biol Regul. 2015 Jan;57:203-16. doi: 10.1016/j.jbior.2014.09.015. Epub 2014 Oct 5. Review.


Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP.

Tsuzuki S, Matsumoto H, Furihata S, Ryuda M, Tanaka H, Sung EJ, Bird GS, Zhou Y, Shears SB, Hayakawa Y.

Nat Commun. 2014 Aug 18;5:4628. doi: 10.1038/ncomms5628.


Synthesis of densely phosphorylated bis-1,5-diphospho-myo-inositol tetrakisphosphate and its enantiomer by bidirectional P-anhydride formation.

Capolicchio S, Wang H, Thakor DT, Shears SB, Jessen HJ.

Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9508-11. doi: 10.1002/anie.201404398. Epub 2014 Jul 14.


IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.

Wang H, DeRose EF, London RE, Shears SB.

Nat Commun. 2014 Jun 24;5:4178. doi: 10.1038/ncomms5178.


Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery.

Wang H, Godage HY, Riley AM, Weaver JD, Shears SB, Potter BV.

Chem Biol. 2014 May 22;21(5):689-99. doi: 10.1016/j.chembiol.2014.03.009. Epub 2014 Apr 24.


Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.

Pulloor NK, Nair S, McCaffrey K, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN.

PLoS Pathog. 2014 Feb 27;10(2):e1003981. doi: 10.1371/journal.ppat.1003981. eCollection 2014 Feb. Erratum in: PLoS Pathog. 2014 Mar;10(3):e1004095. PLoS Pathog. 2014 Oct;10(10):e1004519. McCaffrey, Kathleen [added].


A bacterial homolog of a eukaryotic inositol phosphate signaling enzyme mediates cross-kingdom dialog in the mammalian gut.

Stentz R, Osborne S, Horn N, Li AW, Hautefort I, Bongaerts R, Rouyer M, Bailey P, Shears SB, Hemmings AM, Brearley CA, Carding SR.

Cell Rep. 2014 Feb 27;6(4):646-56. doi: 10.1016/j.celrep.2014.01.021. Epub 2014 Feb 13.


Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPs.

Kilari RS, Weaver JD, Shears SB, Safrany ST.

FEBS Lett. 2013 Nov 1;587(21):3464-70. doi: 10.1016/j.febslet.2013.08.035. Epub 2013 Sep 8.


PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.

Gokhale NA, Zaremba A, Janoshazi AK, Weaver JD, Shears SB.

Biochem J. 2013 Aug 1;453(3):413-26. doi: 10.1042/BJ20121528.


A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA.

Brehm MA, Wundenberg T, Williams J, Mayr GW, Shears SB.

J Cell Sci. 2013 Jan 15;126(Pt 2):437-44. doi: 10.1242/jcs.110031. Epub 2012 Nov 30.


Functional regulation of ClC-3 in the migration of vascular smooth muscle cells.

Ganapathi SB, Wei SG, Zaremba A, Lamb FS, Shears SB.

Hypertension. 2013 Jan;61(1):174-9. doi: 10.1161/HYPERTENSIONAHA.112.194209. Epub 2012 Nov 12.


Structural insight into inositol pyrophosphate turnover.

Shears SB, Weaver JD, Wang H.

Adv Biol Regul. 2013 Jan;53(1):19-27. doi: 10.1016/j.jbior.2012.10.002. Epub 2012 Oct 11. Review.


First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase.

Riley AM, Wang H, Weaver JD, Shears SB, Potter BV.

Chem Commun (Camb). 2012 Nov 28;48(92):11292-4. doi: 10.1039/c2cc36044f.


Activation of PLC by an endogenous cytokine (GBP) in Drosophila S3 cells and its application as a model for studying inositol phosphate signalling through ITPK1.

Zhou Y, Wu S, Wang H, Hayakawa Y, Bird GS, Shears SB.

Biochem J. 2012 Dec 1;448(2):273-83. doi: 10.1042/BJ20120730.


Defining signal transduction by inositol phosphates.

Shears SB, Ganapathi SB, Gokhale NA, Schenk TM, Wang H, Weaver JD, Zaremba A, Zhou Y.

Subcell Biochem. 2012;59:389-412. doi: 10.1007/978-94-007-3015-1_13. Review.


Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.

Wang H, Falck JR, Hall TM, Shears SB.

Nat Chem Biol. 2011 Nov 27;8(1):111-6. doi: 10.1038/nchembio.733.


Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain.

Gokhale NA, Zaremba A, Shears SB.

Biochem J. 2011 Mar 15;434(3):415-26. doi: 10.1042/BJ20101437.


Diphosphoinositol polyphosphates: what are the mechanisms?

Shears SB, Gokhale NA, Wang H, Zaremba A.

Adv Enzyme Regul. 2011;51(1):13-25. doi: 10.1016/j.advenzreg.2010.09.008. Epub 2010 Oct 28. Review.


Diphosphoinositol polyphosphates: metabolic messengers?

Shears SB.

Mol Pharmacol. 2009 Aug;76(2):236-52. doi: 10.1124/mol.109.055897. Epub 2009 May 13. Review.


Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1.

Shears SB.

Adv Enzyme Regul. 2009;49(1):87-96. doi: 10.1016/j.advenzreg.2008.12.008. Epub 2009 Jan 3. Review. No abstract available.

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