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Items: 39

1.

Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.

Shearn CT, Fennimore B, Orlicky DJ, Gao YR, Saba LM, Battista KD, Aivazidis S, Assiri M, Harris PS, Michel C, Merrill GF, Schmidt EE, Colgan SP, Petersen DR.

Free Radic Biol Med. 2019 Nov 1;143:101-114. doi: 10.1016/j.freeradbiomed.2019.07.036. Epub 2019 Aug 1.

PMID:
31377417
2.

Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.

Ali H, Assiri MA, Shearn CT, Fritz KS.

Curr Opin Toxicol. 2019 Feb;13:110-117. doi: 10.1016/j.cotox.2018.10.003. Epub 2018 Oct 15.

PMID:
31263795
3.

TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.

McLoughlin MR, Orlicky DJ, Prigge JR, Krishna P, Talago EA, Cavigli IR, Eriksson S, Miller CG, Kundert JA, Sayin VI, Sabol RA, Heinemann J, Brandenberger LO, Iverson SV, Bothner B, Papagiannakopoulos T, Shearn CT, Arnér ESJ, Schmidt EE.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11408-11417. doi: 10.1073/pnas.1903244116. Epub 2019 May 16.

4.

Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.

Ali HR, Assiri MA, Harris PS, Michel CR, Yun Y, Marentette JO, Huynh FK, Orlicky DJ, Shearn CT, Saba LM, Reisdorph R, Reisdorph N, Hirschey MD, Fritz KS.

J Proteome Res. 2019 Apr 5;18(4):1513-1531. doi: 10.1021/acs.jproteome.8b00800. Epub 2019 Jan 31.

PMID:
30644754
5.

Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.

Petersen DR, Orlicky DJ, Roede JR, Shearn CT.

Exp Mol Pathol. 2018 Aug;105(1):32-36. doi: 10.1016/j.yexmp.2018.05.012. Epub 2018 May 29.

PMID:
29852184
6.

Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.

Petersen DR, Saba LM, Sayin VI, Papagiannakopoulos T, Schmidt EE, Merrill GF, Orlicky DJ, Shearn CT.

PLoS One. 2018 May 25;13(5):e0198139. doi: 10.1371/journal.pone.0198139. eCollection 2018.

7.

Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.

Shearn CT, Pulliam CF, Pedersen K, Meredith K, Mercer KE, Saba LM, Orlicky DJ, Ronis MJ, Petersen DR.

Alcohol Clin Exp Res. 2018 Jul;42(7):1192-1205. doi: 10.1111/acer.13766. Epub 2018 May 30.

8.

Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.

Kharbanda KK, Ronis MJJ, Shearn CT, Petersen DR, Zakhari S, Warner DR, Feldstein AE, McClain CJ, Kirpich IA.

Biomolecules. 2018 Mar 26;8(2). pii: E16. doi: 10.3390/biom8020016.

9.

Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease.

Shearn CT, Orlicky DJ, Petersen DR.

Exp Mol Pathol. 2018 Feb;104(1):1-8. doi: 10.1016/j.yexmp.2017.11.012. Epub 2017 Nov 24.

10.

Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.

Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR.

FASEB J. 2018 Mar;32(3):1265-1280. doi: 10.1096/fj.201700586R. Epub 2018 Jan 3.

PMID:
29101223
11.

Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.

Shearn CT, Saba LM, Roede JR, Orlicky DJ, Shearn AH, Petersen DR.

Free Radic Biol Med. 2017 Dec;113:280-290. doi: 10.1016/j.freeradbiomed.2017.10.004. Epub 2017 Oct 6.

12.

Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS.

Alcohol Clin Exp Res. 2017 Oct;41(10):1705-1714. doi: 10.1111/acer.13473. Epub 2017 Sep 14.

13.

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.

Prigge JR, Coppo L, Martin SS, Ogata F, Miller CG, Bruschwein MD, Orlicky DJ, Shearn CT, Kundert JA, Lytchier J, Herr AE, Mattsson Å, Taylor MP, Gustafsson TN, Arnér ESJ, Holmgren A, Schmidt EE.

Cell Rep. 2017 Jun 27;19(13):2771-2781. doi: 10.1016/j.celrep.2017.06.019.

14.

Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease.

Sundaram SS, Halbower A, Pan Z, Robbins K, Capocelli KE, Klawitter J, Shearn CT, Sokol RJ.

J Hepatol. 2016 Sep;65(3):560-9. doi: 10.1016/j.jhep.2016.04.010. Epub 2016 Aug 5.

15.

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.

Osna NA, Carter WG, Ganesan M, Kirpich IA, McClain CJ, Petersen DR, Shearn CT, Tomasi ML, Kharbanda KK.

World J Gastroenterol. 2016 Jul 21;22(27):6192-200. doi: 10.3748/wjg.v22.i27.6192. Review.

16.

Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.

Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR.

PLoS One. 2016 Apr 28;11(4):e0154152. doi: 10.1371/journal.pone.0154152. eCollection 2016.

17.

Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.

Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR.

Redox Biol. 2016 Apr;7:68-77. doi: 10.1016/j.redox.2015.11.013. Epub 2015 Nov 27.

18.

Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.

Shearn CT, Orlicky DJ, Saba LM, Shearn AH, Petersen DR.

Free Radic Biol Med. 2015 Dec;89:1144-53. doi: 10.1016/j.freeradbiomed.2015.10.420. Epub 2015 Oct 27.

19.

Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney.

Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS.

Redox Biol. 2015 Dec;6:33-40. doi: 10.1016/j.redox.2015.06.021. Epub 2015 Jul 6.

20.

Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease.

Ronis MJ, Mercer KE, Gannon B, Engi B, Zimniak P, Shearn CT, Orlicky DJ, Albano E, Badger TM, Petersen DR.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G403-15. doi: 10.1152/ajpgi.00154.2014. Epub 2014 Dec 11.

21.

Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma.

Shearn CT, Petersen DR.

Adv Exp Med Biol. 2015;815:173-84. doi: 10.1007/978-3-319-09614-8_10. Review.

PMID:
25427907
22.

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR.

Free Radic Biol Med. 2014 Aug;73:411-20. doi: 10.1016/j.freeradbiomed.2014.06.002. Epub 2014 Jun 9.

23.

Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.

Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DR.

PLoS One. 2014 May 12;9(5):e96553. doi: 10.1371/journal.pone.0096553. eCollection 2014.

24.

Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.

Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR.

J Biol Chem. 2014 May 30;289(22):15449-62. doi: 10.1074/jbc.M113.543942. Epub 2014 Apr 10.

25.

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.

Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR.

Free Radic Biol Med. 2013 Dec;65:680-692. doi: 10.1016/j.freeradbiomed.2013.07.011. Epub 2013 Jul 17.

26.

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.

Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR.

J Nutr Biochem. 2013 Aug;24(8):1436-45. doi: 10.1016/j.jnutbio.2012.12.002. Epub 2013 Mar 1.

27.

Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.

Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR.

J Lipid Res. 2013 May;54(5):1335-45. doi: 10.1194/jlr.M034892. Epub 2013 Jan 28.

28.

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.

Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR.

J Toxicol. 2012;2012:207594. doi: 10.1155/2012/207594. Epub 2012 Jul 5.

29.

Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.

Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR.

PLoS One. 2012;7(6):e38459. doi: 10.1371/journal.pone.0038459. Epub 2012 Jun 6.

30.
31.

Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene.

Shearn CT, Fritz KS, Thompson JA.

Chem Biol Interact. 2011 Jul 15;192(3):278-86. doi: 10.1016/j.cbi.2011.04.005. Epub 2011 Apr 21.

PMID:
21536018
32.

4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.

Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR.

Chem Res Toxicol. 2011 May 16;24(5):651-62. doi: 10.1021/tx100355a. Epub 2011 Apr 14.

33.

Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

Shearn CT, Fritz KS, Reigan P, Petersen DR.

Biochemistry. 2011 May 17;50(19):3984-96. doi: 10.1021/bi200029w. Epub 2011 Apr 20.

PMID:
21438592
34.

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.

Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N Jr, Petersen DR.

Mol Pharmacol. 2011 Jun;79(6):941-52. doi: 10.1124/mol.110.069534. Epub 2011 Mar 17.

35.

Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion.

Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR.

J Proteome Res. 2011 Apr 1;10(4):1837-47. doi: 10.1021/pr101101s. Epub 2011 Mar 7.

36.
37.

Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro.

Shearn CT, Fritz KS, Meier BW, Kirichenko OV, Thompson JA.

Chem Res Toxicol. 2008 Aug;21(8):1631-41. doi: 10.1021/tx800162p. Epub 2008 Jul 3.

PMID:
18597497
38.

Biochemical characterization of the type I inositol polyphosphate 4-phosphatase C2 domain.

Shearn CT, Norris FA.

Biochem Biophys Res Commun. 2007 Apr 27;356(1):255-9. Epub 2007 Feb 28.

PMID:
17349979

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