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Items: 45

1.

Lifting the fog in intermediate-risk (submassive) PE: full dose, low dose, or no thrombolysis?

Bhamani A, Pepke-Zaba J, Sheares K.

F1000Res. 2019 Mar 25;8. pii: F1000 Faculty Rev-330. doi: 10.12688/f1000research.17861.1. eCollection 2019. Review.

2.

Real world experience at a single centre using low dose direct oral anticoagulants after unprovoked venous thromboembolism.

Thomas W, Symington E, Besser M, Sheares K.

Br J Haematol. 2019 Mar 28. doi: 10.1111/bjh.15880. [Epub ahead of print] No abstract available.

PMID:
30919932
3.

The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension.

Newnham M, South K, Bleda M, Auger WR, Barberà JA, Bogaard H, Bunclark K, Cannon JE, Delcroix M, Hadinnapola C, Howard LS, Jenkins D, Mayer E, Ng C, Rhodes CJ, Screaton N, Sheares K, Simpson MA, Southwood M, Su L, Taboada D, Traylor M, Trembath RC, Villar SS, Wilkins MR, Wharton J, Gräf S, Pepke-Zaba J, Laffan M, Lane DA, Morrell NW, Toshner M.

Eur Respir J. 2019 Mar 28;53(3). pii: 1801805. doi: 10.1183/13993003.01805-2018. Print 2019 Mar.

4.

Utility of the DASH score after unprovoked venous thromboembolism; a single centre study.

MacDonald S, Chengal R, Hanxhiu A, Symington E, Sheares K, Besser M, Thomas W.

Br J Haematol. 2019 May;185(3):631-633. doi: 10.1111/bjh.15597. Epub 2018 Nov 15. No abstract available.

PMID:
30443905
5.

Limitations of resting haemodynamics in chronic thromboembolic disease without pulmonary hypertension.

Swietlik EM, Ruggiero A, Fletcher AJ, Taboada D, Knightbridge E, Harlow L, Harvey I, Screaton N, Cannon JE, Sheares KKK, Ng C, Jenkins DP, Pepke-Zaba J, Toshner MR.

Eur Respir J. 2019 Jan 17;53(1). pii: 1801787. doi: 10.1183/13993003.01787-2018. Print 2019 Jan. No abstract available.

PMID:
30409818
6.

British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism.

Howard LS, Barden S, Condliffe R, Connolly V, Davies C, Donaldson J, Everett B, Free C, Horner D, Hunter L, Kaler J, Nelson-Piercy C, O'Dowd E, Patel R, Preston W, Sheares K, Tait C.

BMJ Open Respir Res. 2018 Jun 13;5(1):e000281. doi: 10.1136/bmjresp-2018-000281. eCollection 2018.

7.

British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism (PE).

Howard LSGE, Barden S, Condliffe R, Connolly V, Davies CWH, Donaldson J, Everett B, Free C, Horner D, Hunter L, Kaler J, Nelson-Piercy C, O-Dowd E, Patel R, Preston W, Sheares K, Campbell T.

Thorax. 2018 Jul;73(Suppl 2):ii1-ii29. doi: 10.1136/thoraxjnl-2018-211539. Epub 2018 Jun 13. Review. No abstract available.

PMID:
29898978
8.

The outcome of reoperative pulmonary endarterectomy surgery.

Ali JM, Dunning J, Ng C, Tsui S, Cannon JE, Sheares KK, Taboada D, Toshner M, Screaton N, Pepke-Zaba J, Jenkins DP.

Interact Cardiovasc Thorac Surg. 2018 Jun 1;26(6):932-937. doi: 10.1093/icvts/ivx424.

PMID:
29373658
9.

The potential effects of pregnancy in a patient with idiopathic pulmonary arterial hypertension responding to calcium channel blockade.

Bostock S, Sheares K, Cannon J, Taboada D, Pepke-Zaba J, Toshner M.

Eur Respir J. 2017 Dec 14;50(6). pii: 1701141. doi: 10.1183/13993003.01141-2017. Print 2017 Dec. No abstract available.

10.

Age should not be a barrier for pulmonary endarterectomy in carefully selected patients.

Newnham M, Hernández-Sánchez J, Dunning J, Ng C, Tsui S, Bunclark K, Sheares K, Taboada D, Toshner M, Pepke-Zaba J, Jenkins D, Cannon J.

Eur Respir J. 2017 Dec 7;50(6). pii: 1701804. doi: 10.1183/13993003.01804-2017. Print 2017 Dec. No abstract available.

11.

Survival in portopulmonary hypertension: Outcomes of the United Kingdom National Pulmonary Arterial Hypertension Registry.

Sithamparanathan S, Nair A, Thirugnanasothy L, Coghlan JG, Condliffe R, Dimopoulos K, Elliot CA, Fisher AJ, Gaine S, Gibbs JSR, Gatzoulis MA, E Handler C, Howard LS, Johnson M, Kiely DG, Lordan JL, Peacock AJ, Pepke-Zaba J, Schreiber BE, Sheares KKK, Wort SJ, Corris PA; National Pulmonary Hypertension Service Research Collaboration of the United Kingdom and Ireland.

J Heart Lung Transplant. 2017 Jul;36(7):770-779. doi: 10.1016/j.healun.2016.12.014. Epub 2016 Dec 31.

PMID:
28190786
12.

D-dimer test for excluding the diagnosis of pulmonary embolism.

Crawford F, Andras A, Welch K, Sheares K, Keeling D, Chappell FM.

Cochrane Database Syst Rev. 2016 Aug 5;(8):CD010864. doi: 10.1002/14651858.CD010864.pub2. Review.

13.

Exercise physiological responses to drug treatments in chronic thromboembolic pulmonary hypertension.

Charalampopoulos A, Gibbs JS, Davies RJ, Gin-Sing W, Murphy K, Sheares KK, Pepke-Zaba J, Jenkins DP, Howard LS.

J Appl Physiol (1985). 2016 Sep 1;121(3):623-8. doi: 10.1152/japplphysiol.00087.2016. Epub 2016 Jul 14.

14.

Dynamic Risk Stratification of Patient Long-Term Outcome After Pulmonary Endarterectomy: Results From the United Kingdom National Cohort.

Cannon JE, Su L, Kiely DG, Page K, Toshner M, Swietlik E, Treacy C, Ponnaberanam A, Condliffe R, Sheares K, Taboada D, Dunning J, Tsui S, Ng C, Gopalan D, Screaton N, Elliot C, Gibbs S, Howard L, Corris P, Lordan J, Johnson M, Peacock A, MacKenzie-Ross R, Schreiber B, Coghlan G, Dimopoulos K, Wort SJ, Gaine S, Moledina S, Jenkins DP, Pepke-Zaba J.

Circulation. 2016 May 3;133(18):1761-71. doi: 10.1161/CIRCULATIONAHA.115.019470. Epub 2016 Apr 6.

15.

Endothelin ETA receptors predominate in chronic thromboembolic pulmonary hypertension.

Southwood M, MacKenzie Ross RV, Kuc RE, Hagan G, Sheares KK, Jenkins DP, Goddard M, Davenport AP, Pepke-Zaba J.

Life Sci. 2016 Aug 15;159:104-110. doi: 10.1016/j.lfs.2016.02.036. Epub 2016 Feb 10.

16.

Outcome of pulmonary endarterectomy in symptomatic chronic thromboembolic disease.

Taboada D, Pepke-Zaba J, Jenkins DP, Berman M, Treacy CM, Cannon JE, Toshner M, Dunning JJ, Ng C, Tsui SS, Sheares KK.

Eur Respir J. 2014 Dec;44(6):1635-45. doi: 10.1183/09031936.00050114. Epub 2014 Sep 18.

17.

Right ventricular reverse remodeling after pulmonary endarterectomy: magnetic resonance imaging and clinical and right heart catheterization assessment.

Berman M, Gopalan D, Sharples L, Screaton N, Maccan C, Sheares K, Pepke-Zaba J, Dunning J, Tsui S, Jenkins DP.

Pulm Circ. 2014 Mar;4(1):36-44. doi: 10.1086/674884.

18.

Better off blue: BMPR-2 mutation, arteriovenous malformation, and pulmonary arterial hypertension.

Soon E, Southwood M, Sheares K, Pepke-Zaba J, Morrell NW.

Am J Respir Crit Care Med. 2014 Jun 1;189(11):1435-6. doi: 10.1164/rccm.201311-2019IM. No abstract available.

PMID:
24881940
19.

Maximal cardiac output determines 6 minutes walking distance in pulmonary hypertension.

Deboeck G, Taboada D, Hagan G, Treacy C, Page K, Sheares K, Naeije R, Pepke-Zaba J.

PLoS One. 2014 Mar 19;9(3):e92324. doi: 10.1371/journal.pone.0092324. eCollection 2014.

20.

Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension.

Howard LS, Watson GM, Wharton J, Rhodes CJ, Chan K, Khengar R, Robbins PA, Kiely DG, Condliffe R, Elliott CA, Pepke-Zaba J, Sheares K, Morrell NW, Davies R, Ashby D, Gibbs JS, Wilkins MR.

Pulm Circ. 2013 Jan;3(1):100-7. doi: 10.4103/2045-8932.109923.

21.

Changing demographics, epidemiology, and survival of incident pulmonary arterial hypertension: results from the pulmonary hypertension registry of the United Kingdom and Ireland.

Ling Y, Johnson MK, Kiely DG, Condliffe R, Elliot CA, Gibbs JS, Howard LS, Pepke-Zaba J, Sheares KK, Corris PA, Fisher AJ, Lordan JL, Gaine S, Coghlan JG, Wort SJ, Gatzoulis MA, Peacock AJ.

Am J Respir Crit Care Med. 2012 Oct 15;186(8):790-6. doi: 10.1164/rccm.201203-0383OC. Epub 2012 Jul 12.

PMID:
22798320
22.

Pulmonary endarterectomy: outcomes in patients aged >70.

Berman M, Hardman G, Sharples L, Pepke-Zaba J, Sheares K, Tsui S, Dunning J, Jenkins DP.

Eur J Cardiothorac Surg. 2012 Jun;41(6):e154-60. doi: 10.1093/ejcts/ezs188.

PMID:
22593260
23.

Predicting survival in pulmonary arterial hypertension in the UK.

Lee WT, Ling Y, Sheares KK, Pepke-Zaba J, Peacock AJ, Johnson MK.

Eur Respir J. 2012 Sep;40(3):604-11. doi: 10.1183/09031936.00196611. Epub 2012 May 3.

24.

(18)FDG PET imaging can quantify increased cellular metabolism in pulmonary arterial hypertension: A proof-of-principle study.

Hagan G, Southwood M, Treacy C, Ross RM, Soon E, Coulson J, Sheares K, Screaton N, Pepke-Zaba J, Morrell NW, Rudd JH.

Pulm Circ. 2011 Oct-Dec;1(4):448-55. doi: 10.4103/2045-8932.93543.

25.

Occlusion pressure analysis role in partitioning of pulmonary vascular resistance in CTEPH.

Toshner M, Suntharalingam J, Fesler P, Soon E, Sheares KK, Jenkins D, White P, Morrell NW, Naeije R, Pepke-Zaba J.

Eur Respir J. 2012 Sep;40(3):612-7. doi: 10.1183/09031936.00134111. Epub 2012 Feb 23.

26.

Imaging in pulmonary hypertension, part 2: Large vessel diseases.

McCann C, Gopalan D, Sheares K, Screaton N.

Postgrad Med J. 2012 Jun;88(1040):317-25. doi: 10.1136/postgradmedj-2011-130274. Epub 2012 Jan 25. Review.

PMID:
22282738
27.

Imaging in pulmonary hypertension, part 1: clinical perspectives, classification, imaging techniques and imaging algorithm.

McCann C, Gopalan D, Sheares K, Screaton N.

Postgrad Med J. 2012 May;88(1039):271-9. doi: 10.1136/postgradmedj-2011-130292. Epub 2012 Jan 21. Review.

PMID:
22267542
28.

Imaging in pulmonary hypertension, part 3: small vessel diseases.

Gopalan D, McCann C, Sheares K, Screaton N.

Postgrad Med J. 2012 Jul;88(1041):397-406. doi: 10.1136/postgradmedj-2011-130276. Epub 2012 Jan 19. Review.

PMID:
22267525
29.

Isolated large vessel pulmonary vasculitis as a cause of chronic obstruction of the pulmonary arteries.

Hagan G, Gopalan D, Church C, Rassl D, Mukhtyar C, Wistow T, Lang C, Sivasothy P, Stewart S, Jayne D, Sheares K, Tsui S, Jenkins DP, Pepke-Zaba J.

Pulm Circ. 2011 Jul-Sep;1(3):425-9. doi: 10.4103/2045-8932.87312.

30.

Log-transformation improves the prognostic value of serial NT-proBNP levels in apparently stable pulmonary arterial hypertension.

Soon E, Doughty NJ, Treacy CM, Ross RM, Toshner M, Upton PD, Sheares K, Morrell NW, Pepke-Zaba J.

Pulm Circ. 2011 Apr-Jun;1(2):244-9. doi: 10.4103/2045-8932.83450.

31.

How do I manage a patient with suspected acute pulmonary embolism?

Sheares KK.

Clin Med (Lond). 2011 Apr;11(2):156-9. Review.

32.

Risk of potentially life-threatening thyroid dysfunction due to amiodarone in idiopathic pulmonary arterial hypertension patients.

Soon E, Toshner M, Mela M, Grace A, Sheares K, Morrell N, Pepke-Zaba J.

J Am Coll Cardiol. 2011 Feb 22;57(8):997-8. doi: 10.1016/j.jacc.2010.09.059. No abstract available.

33.

Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension.

Soon E, Treacy CM, Toshner MR, MacKenzie-Ross R, Manglam V, Busbridge M, Sinclair-McGarvie M, Arnold J, Sheares KK, Morrell NW, Pepke-Zaba J.

Thorax. 2011 Apr;66(4):326-32. doi: 10.1136/thx.2010.147272. Epub 2011 Feb 5.

PMID:
21297151
34.

Survival after pulmonary thromboendarterectomy: effect of residual pulmonary hypertension.

Freed DH, Thomson BM, Berman M, Tsui SS, Dunning J, Sheares KK, Pepke-Zaba J, Jenkins DP.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):383-7. doi: 10.1016/j.jtcvs.2009.12.056. Epub 2010 May 13.

35.

Pulmonary arterial size and response to sildenafil in chronic thromboembolic pulmonary hypertension.

Toshner MR, Gopalan D, Suntharalingam J, Treacy C, Soon E, Sheares KK, Morrell NW, Screaton N, Pepke-Zaba J.

J Heart Lung Transplant. 2010 Jun;29(6):610-5. doi: 10.1016/j.healun.2009.12.014. Epub 2010 Mar 15.

36.

Functional and haemodynamic outcome 1 year after pulmonary thromboendarterectomy.

Freed DH, Thomson BM, Tsui SS, Dunning JJ, Sheares KK, Pepke-Zaba J, Jenkins DP.

Eur J Cardiothorac Surg. 2008 Sep;34(3):525-9; discussion 529-30. doi: 10.1016/j.ejcts.2008.04.018. Epub 2008 May 22.

PMID:
18501623
37.

Improved outcomes in medically and surgically treated chronic thromboembolic pulmonary hypertension.

Condliffe R, Kiely DG, Gibbs JS, Corris PA, Peacock AJ, Jenkins DP, Hodgkins D, Goldsmith K, Hughes RJ, Sheares K, Tsui SS, Armstrong IJ, Torpy C, Crackett R, Carlin CM, Das C, Coghlan JG, Pepke-Zaba J.

Am J Respir Crit Care Med. 2008 May 15;177(10):1122-7. doi: 10.1164/rccm.200712-1841OC. Epub 2008 Feb 21.

PMID:
18292468
38.

Long-term use of sildenafil in inoperable chronic thromboembolic pulmonary hypertension.

Suntharalingam J, Treacy CM, Doughty NJ, Goldsmith K, Soon E, Toshner MR, Sheares KK, Hughes R, Morrell NW, Pepke-Zaba J.

Chest. 2008 Aug;134(2):229-236. doi: 10.1378/chest.07-2681. Epub 2008 Feb 8.

PMID:
18263674
39.

Role of NT-proBNP and 6MWD in chronic thromboembolic pulmonary hypertension.

Suntharalingam J, Goldsmith K, Toshner M, Doughty N, Sheares KK, Hughes R, Jenkins D, Pepke-Zaba J.

Respir Med. 2007 Nov;101(11):2254-62. Epub 2007 Aug 13.

40.

Acute haemodynamic responses to inhaled nitric oxide and intravenous sildenafil in distal chronic thromboembolic pulmonary hypertension (CTEPH).

Suntharalingam J, Hughes RJ, Goldsmith K, Doughty N, George P, Toshner M, Sheares KK, Pepke-Zaba J.

Vascul Pharmacol. 2007 Jun;46(6):449-55. Epub 2007 Feb 12.

PMID:
17368113
41.

Demographic features, BMPR2 status and outcomes in distal chronic thromboembolic pulmonary hypertension.

Suntharalingam J, Machado RD, Sharples LD, Toshner MR, Sheares KK, Hughes RJ, Jenkins DP, Trembath RC, Morrell NW, Pepke-Zaba J.

Thorax. 2007 Jul;62(7):617-22. Epub 2007 Feb 7.

42.

Differential effects of TGF-beta1 and BMP-4 on the hypoxic induction of cyclooxygenase-2 in human pulmonary artery smooth muscle cells.

Sheares KK, Jeffery TK, Long L, Yang X, Morrell NW.

Am J Physiol Lung Cell Mol Physiol. 2004 Nov;287(5):L919-27. Epub 2004 Jun 25.

43.

New insights into oxygen sensing at a cellular level.

Walmsley SR, Sheares KK, Sobolewski A, Morrell NW, Chilvers ER.

Thorax. 2004 Feb;59(2):90-2. No abstract available.

44.

Hypoxic induction of cox-2 regulates proliferation of human pulmonary artery smooth muscle cells.

Yang X, Sheares KK, Davie N, Upton PD, Taylor GW, Horsley J, Wharton J, Morrell NW.

Am J Respir Cell Mol Biol. 2002 Dec;27(6):688-96.

PMID:
12444028
45.

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