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The association between diabetes medication and weight change in a non-surgical weight management intervention: an intervention cohort study.

Aldekhail NM, Morrison DS, Khojah H, Sloan B, McLoone P, MacNaughton S, Shearer R, Logue J.

Diabet Med. 2020 Feb;37(2):248-255. doi: 10.1111/dme.14093. Epub 2019 Sep 3.


A principled strategy for mapping enhancers to genes.

Kim D, An H, Shearer RS, Sharif M, Fan C, Choi JO, Ryu S, Park Y.

Sci Rep. 2019 Jul 30;9(1):11043. doi: 10.1038/s41598-019-47521-w.


Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

Kennedy SP, Han JZR, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O'Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR.

Breast Cancer Res. 2019 Mar 21;21(1):43. doi: 10.1186/s13058-019-1127-y.


Discussing Weight Management With Type 2 Diabetes Patients in Primary Care Using the Small Talk Big Difference Intervention: Protocol for a Randomized Controlled Trial.

Brooksbank K, O'Donnell J, Corbett V, Shield S, Ainsworth R, Shearer R, Montgomery S, Gallagher A, Duncan H, Hamilton L, Laszlo V, Noone R, Baxendale A, Blane D, Logue J.

JMIR Res Protoc. 2019 Feb 15;8(2):e12162. doi: 10.2196/12162.


Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer.

Balaban S, Nassar ZD, Zhang AY, Hosseini-Beheshti E, Centenera MM, Schreuder M, Lin HM, Aishah A, Varney B, Liu-Fu F, Lee LS, Nagarajan SR, Shearer RF, Hardie RA, Raftopulos NL, Kakani MS, Saunders DN, Holst J, Horvath LG, Butler LM, Hoy AJ.

Mol Cancer Res. 2019 Apr;17(4):949-962. doi: 10.1158/1541-7786.MCR-18-0347. Epub 2019 Jan 15.


Process evaluation of a cluster-randomised controlled trial of multi-component weight management programme in adults with intellectual disabilities and obesity.

Harris L, Hankey C, Jones N, Murray H, Pert C, Tobin J, Boyle S, Shearer R, Melville CA.

J Intellect Disabil Res. 2019 Jan;63(1):49-63. doi: 10.1111/jir.12563. Epub 2018 Nov 11.


Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis.

Balaban S, Lee LS, Varney B, Aishah A, Gao Q, Shearer RF, Saunders DN, Grewal T, Hoy AJ.

Mol Oncol. 2018 Sep;12(9):1623-1638. doi: 10.1002/1878-0261.12368. Epub 2018 Aug 29.


Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification (BiCAP).

Hastings JF, Han JZR, Shearer RF, Kennedy SP, Iconomou M, Saunders DN, Croucher DR.

J Vis Exp. 2018 Jun 15;(136). doi: 10.3791/57109.


Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.

Conway JRW, Warren SC, Herrmann D, Murphy KJ, Cazet AS, Vennin C, Shearer RF, Killen MJ, Magenau A, Mélénec P, Pinese M, Nobis M, Zaratzian A, Boulghourjian A, Da Silva AM, Del Monte-Nieto G, Adam ASA, Harvey RP, Haigh JJ, Wang Y, Croucher DR, Sansom OJ, Pajic M, Caldon CE, Morton JP, Timpson P.

Cell Rep. 2018 Jun 12;23(11):3312-3326. doi: 10.1016/j.celrep.2018.05.038.


The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia.

Shearer RF, Frikstad KM, McKenna J, McCloy RA, Deng N, Burgess A, Stokke T, Patzke S, Saunders DN.

Mol Biol Cell. 2018 Jul 1;29(13):1542-1554. doi: 10.1091/mbc.E17-04-0248. Epub 2018 May 9.


ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.

Haahr P, Borgermann N, Guo X, Typas D, Achuthankutty D, Hoffmann S, Shearer R, Sixma TK, Mailand N.

Mol Cell. 2018 Apr 5;70(1):165-174.e6. doi: 10.1016/j.molcel.2018.02.024. Epub 2018 Mar 22.


Effect of non-surgical weight management on weight and glycaemic control in people with type 2 diabetes: A comparison of interventional and non-interventional outcomes at 3 years.

Botha S, Forde L, MacNaughton S, Shearer R, Lindsay R, Sattar N, Morrison D, Welsh P, Logue J.

Diabetes Obes Metab. 2018 Apr;20(4):879-888. doi: 10.1111/dom.13171. Epub 2018 Jan 11.


Flow injection gas chromatography with sulfur chemiluminescence detection for the analysis of total sulfur in complex hydrocarbon matrixes.

Hua Y, Hawryluk M, Gras R, Shearer R, Luong J.

J Sep Sci. 2018 Jan;41(2):469-474. doi: 10.1002/jssc.201700897. Epub 2017 Dec 11.


Bone Mineral Density in Boys Diagnosed with Autism Spectrum Disorder: A Case-Control Study.

Barnhill K, Ramirez L, Gutierrez A, Richardson W, Marti CN, Potts A, Shearer R, Schutte C, Hewitson L.

J Autism Dev Disord. 2017 Nov;47(11):3608-3619. doi: 10.1007/s10803-017-3277-z.


Presence of obesity is associated with lower mortality in elderly patients with implantable cardioverter defibrillator.

Jahangir A, Mirza M, Shahreyar M, Mengesha T, Shearer R, Sultan S, Jahangir A, Choudhuri I, Nangia V, Dhala A, Bhatia A, Niazi I, Sra J, Tajik AJ.

Int J Obes (Lond). 2018 Feb;42(2):169-174. doi: 10.1038/ijo.2017.211. Epub 2017 Aug 30.


SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.

Harris NLE, Vennin C, Conway JRW, Vine KL, Pinese M, Cowley MJ, Shearer RF, Lucas MC, Herrmann D, Allam AH, Pajic M, Morton JP; Australian Pancreatic Cancer Genome Initiative, Biankin AV, Ranson M, Timpson P, Saunders DN.

Oncogene. 2017 Jul 27;36(30):4288-4298. doi: 10.1038/onc.2017.63. Epub 2017 Mar 27.


Mitochondrial mutations and metabolic adaptation in pancreatic cancer.

Hardie RA, van Dam E, Cowley M, Han TL, Balaban S, Pajic M, Pinese M, Iconomou M, Shearer RF, McKenna J, Miller D, Waddell N, Pearson JV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative, Sazanov L, Biankin AV, Villas-Boas S, Hoy AJ, Turner N, Saunders DN.

Cancer Metab. 2017 Jan 30;5:2. doi: 10.1186/s40170-017-0164-1. eCollection 2017.


Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation.

Kim D, Choi JO, Fan C, Shearer RS, Sharif M, Busch P, Park Y.

Nucleic Acids Res. 2017 May 19;45(9):5112-5125. doi: 10.1093/nar/gkx080.


Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration.

Balaban S, Shearer RF, Lee LS, van Geldermalsen M, Schreuder M, Shtein HC, Cairns R, Thomas KC, Fazakerley DJ, Grewal T, Holst J, Saunders DN, Hoy AJ.

Cancer Metab. 2017 Jan 13;5:1. doi: 10.1186/s40170-016-0163-7. eCollection 2017.


Regulation of primary cilia formation by the ubiquitin-proteasome system.

Shearer RF, Saunders DN.

Biochem Soc Trans. 2016 Oct 15;44(5):1265-1271. Review.


Factors associated with patients in the Scottish Highlands who chose mastectomy when suitable for breast conservation.

Shearer R, Rashid M, Hubbard G, Abbott N, Daltrey I, Mullen R.

Gland Surg. 2016 Aug;5(4):385-90. doi: 10.21037/gs.2016.03.02.


Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases.

Liu L, Phua YW, Lee RS, Ma X, Jenkins Y, Novy K, Humphrey ES, Chan H, Shearer R, Ong PC, Dai W, Saunders DN, Lucet IS, Daly RJ.

J Biol Chem. 2016 Oct 7;291(41):21571-21583. Epub 2016 Aug 16.


Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers.

Croucher DR, Iconomou M, Hastings JF, Kennedy SP, Han JZ, Shearer RF, McKenna J, Wan A, Lau J, Aparicio S, Saunders DN.

Sci Signal. 2016 Jul 12;9(436):ra69. doi: 10.1126/scisignal.aaf0793.


Attrition and weight loss outcomes for patients with complex obesity, anxiety and depression attending a weight management programme with targeted psychological treatment.

McLean RC, Morrison DS, Shearer R, Boyle S, Logue J.

Clin Obes. 2016 Apr;6(2):133-42. doi: 10.1111/cob.12136. Epub 2016 Feb 3.


Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer.

Shearer RF, Iconomou M, Watts CK, Saunders DN.

Mol Cancer Res. 2015 Dec;13(12):1523-32. doi: 10.1158/1541-7786.MCR-15-0383. Epub 2015 Oct 13. Review.


SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.

Lee JA, Yerbury JJ, Farrawell N, Shearer RF, Constantinescu P, Hatters DM, Schroder WA, Suhrbier A, Wilson MR, Saunders DN, Ranson M.

PLoS One. 2015 Jun 17;10(6):e0130136. doi: 10.1371/journal.pone.0130136. eCollection 2015.


Experimental design for stable genetic manipulation in mammalian cell lines: lentivirus and alternatives.

Shearer RF, Saunders DN.

Genes Cells. 2015 Jan;20(1):1-10. doi: 10.1111/gtc.12183. Epub 2014 Oct 13. Review.


Rational selection of alternative, environmentally compatible surfactants for biotechnological production of pharmaceuticals--a step toward green biotechnology.

Straub JO, Shearer R, Studer M.

Environ Toxicol Chem. 2014 Sep;33(9):2140-6. doi: 10.1002/etc.2660. Epub 2014 Aug 1.


Manganese(III) porphyrins complexed with P22 virus-like particles as T1-enhanced contrast agents for magnetic resonance imaging.

Qazi S, Uchida M, Usselman R, Shearer R, Edwards E, Douglas T.

J Biol Inorg Chem. 2014 Feb;19(2):237-46. doi: 10.1007/s00775-013-1075-4. Epub 2013 Dec 21.


Future human health research directions for the Canadian Northern Contaminants Program.

Donaldson SG, Curren MS, Adlard B, Provost J, Leech T, Tikhonov C, Feeley M, Tomlinson S, Shearer R.

Int J Circumpolar Health. 2013 Nov 22;72:23049. doi: 10.3402/ijch.v72i0.23049. eCollection 2013.


Have early postoperative complications from laparoscopic rectal cancer surgery improved over the past 20 years?

Shearer R, Gale M, Aly OE, Aly EH.

Colorectal Dis. 2013;15(10):1211-26. doi: 10.1111/codi.12302. Review.


Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway.

Croucher DR, Hochgräfe F, Zhang L, Liu L, Lyons RJ, Rickwood D, Tactacan CM, Browne BC, Ali N, Chan H, Shearer R, Gallego-Ortega D, Saunders DN, Swarbrick A, Daly RJ.

Cancer Res. 2013 Mar 15;73(6):1969-80. doi: 10.1158/0008-5472.CAN-12-1472. Epub 2013 Feb 1.


A novel SERPINA1 mutation causing serum alpha(1)-antitrypsin deficiency.

Saunders DN, Tindall EA, Shearer RF, Roberson J, Decker A, Wilson JA, Hayes VM.

PLoS One. 2012;7(12):e51762. doi: 10.1371/journal.pone.0051762. Epub 2012 Dec 12.


TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.

Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C.

Cell. 2012 Aug 17;150(4):697-709. doi: 10.1016/j.cell.2012.06.039. Epub 2012 Aug 9. Erratum in: Cell. 2014 Dec 4;159(6):1476-7.


US Hemophilia Treatment Center population trends 1990-2010: patient diagnoses, demographics, health services utilization.

Baker JR, Riske B, Drake JH, Forsberg AD, Atwood R, Voutsis M, Shearer R.

Haemophilia. 2013 Jan;19(1):21-6. doi: 10.1111/j.1365-2516.2012.02915.x. Epub 2012 Jul 30.


Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

O'Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P, McLeod D, Cooper CL, McNeil CM, McFarland A, Nguyen A, Ormandy CJ, Qiu MR, Rabinovich B, Martelotto LG, Vu D, Hannigan GE, Musgrove EA, Christ D, Sutherland RL, Watkins DN, Swarbrick A.

Cancer Res. 2011 Jun 1;71(11):4002-14. doi: 10.1158/0008-5472.CAN-10-3738.


Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

Hochgräfe F, Zhang L, O'Toole SA, Browne BC, Pinese M, Porta Cubas A, Lehrbach GM, Croucher DR, Rickwood D, Boulghourjian A, Shearer R, Nair R, Swarbrick A, Faratian D, Mullen P, Harrison DJ, Biankin AV, Sutherland RL, Raftery MJ, Daly RJ.

Cancer Res. 2010 Nov 15;70(22):9391-401. doi: 10.1158/0008-5472.CAN-10-0911. Epub 2010 Sep 21.


Environmental contaminants and human health in the Canadian Arctic.

Donaldson SG, Van Oostdam J, Tikhonov C, Feeley M, Armstrong B, Ayotte P, Boucher O, Bowers W, Chan L, Dallaire F, Dallaire R, Dewailly E, Edwards J, Egeland GM, Fontaine J, Furgal C, Leech T, Loring E, Muckle G, Nancarrow T, Pereg D, Plusquellec P, Potyrala M, Receveur O, Shearer RG.

Sci Total Environ. 2010 Oct 15;408(22):5165-234. doi: 10.1016/j.scitotenv.2010.04.059. Epub 2010 Aug 21. Review. Erratum in: Sci Total Environ. 2012 Aug 1;431:437-8.


Modeling early retinal development with human embryonic and induced pluripotent stem cells.

Meyer JS, Shearer RL, Capowski EE, Wright LS, Wallace KA, McMillan EL, Zhang SC, Gamm DM.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16698-703. doi: 10.1073/pnas.0905245106. Epub 2009 Aug 25.


Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1.

Gamm DM, Wright LS, Capowski EE, Shearer RL, Meyer JS, Kim HJ, Schneider BL, Melvan JN, Svendsen CN.

Stem Cells. 2008 Dec;26(12):3182-93. doi: 10.1634/stemcells.2008-0300. Epub 2008 Sep 18.


Long-term vision rescue by human neural progenitors in a rat model of photoreceptor degeneration.

Wang S, Girman S, Lu B, Bischoff N, Holmes T, Shearer R, Wright LS, Svendsen CN, Gamm DM, Lund RD.

Invest Ophthalmol Vis Sci. 2008 Jul;49(7):3201-6. doi: 10.1167/iovs.08-1831.


A novel serum-free method for culturing human prenatal retinal pigment epithelial cells.

Gamm DM, Melvan JN, Shearer RL, Pinilla I, Sabat G, Svendsen CN, Wright LS.

Invest Ophthalmol Vis Sci. 2008 Feb;49(2):788-99. doi: 10.1167/iovs.07-0777.


Protection of visual functions by human neural progenitors in a rat model of retinal disease.

Gamm DM, Wang S, Lu B, Girman S, Holmes T, Bischoff N, Shearer RL, Sauvé Y, Capowski E, Svendsen CN, Lund RD.

PLoS One. 2007 Mar 28;2(3):e338.


Readers' responses and author's reply to "emancipating the doctors".

Shearer R.

MedGenMed. 2006;8(2):15; author reply 15. No abstract available.


Truncated form of VACM-1/cul-5 with an extended 3' untranslated region stimulates cell growth via a MAPK-dependent pathway.

Sartor A, Kossoris JB, Wilcox R, Shearer R, Zeneberg AE, Zhao P, Lazdins I, Burnatowska-Hledin MA.

Biochem Biophys Res Commun. 2006 May 19;343(4):1086-93. Epub 2006 Mar 20.


When your nursing student is culturally diverse.

Davidhizar R, Shearer R.

Health Care Manag (Frederick). 2005 Oct-Dec;24(4):356-63.


Cancer in the Commonwealth of the Northern Marianas Islands (CNMI).

Tseng CW, Omphroy G, Songsong JM, Shearer R.

Pac Health Dialog. 2004 Sep;11(2):23-9.


Contaminants in Canadian arctic biota and implications for human health: conclusions and knowledge gaps.

Muir DC, Shearer RG, Van Oostdam J, Donaldson SG, Furgal C.

Sci Total Environ. 2005 Dec 1;351-352:539-46. Epub 2005 Oct 10.


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