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Items: 1 to 50 of 51

1.

The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat.

Stanhope KJ, Mirza NR, Bickerdike MJ, Bright JL, Harrington NR, Hesselink MB, Kennett GA, Lightowler S, Sheardown MJ, Syed R, Upton RL, Wadsworth G, Weiss SM, Wyatt A.

J Pharmacol Exp Ther. 2001 Nov;299(2):782-92.

PMID:
11602695
2.

Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells.

Porter RH, Malcolm CS, Allen NH, Lamb H, Revell DF, Sheardown MJ.

Biochem Pharmacol. 2001 Aug 15;62(4):431-8.

PMID:
11448452
3.

The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.

Rasmussen T, Fink-Jensen A, Sauerberg P, Swedberg MD, Thomsen C, Sheardown MJ, Jeppesen L, Calligaro DO, DeLapp NW, Whitesitt C, Ward JS, Shannon HE, Bymaster FP.

Schizophr Res. 2001 Apr 15;49(1-2):193-201.

PMID:
11343877
4.

Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function.

Empson RM, Gee VJ, Sheardown MJ, Newberry NR.

Brain Res. 2000 Nov 24;884(1--2):31-4.

PMID:
11082484
5.

Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.

Rasmussen T, Sauerberg P, Nielsen EB, Swedberg MD, Thomsen C, Sheardown MJ, Jeppesen L, Calligaro DO, DeLapp NW, Whitesitt C, Ward JS, Shannon HE, Bymaster FP, Fink-Jensen A.

Eur J Pharmacol. 2000 Aug 25;402(3):241-6.

PMID:
10958890
6.

Modulation of gamma-aminobutyric acid responses in the rat optic nerve.

Empson RM, Sheardown MJ, Newberry NR.

Eur J Pharmacol. 2000 Aug 11;401(3):339-42.

PMID:
10936491
7.

Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.

Shannon HE, Rasmussen K, Bymaster FP, Hart JC, Peters SC, Swedberg MD, Jeppesen L, Sheardown MJ, Sauerberg P, Fink-Jensen A.

Schizophr Res. 2000 May 5;42(3):249-59.

PMID:
10785583
8.

Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.

Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ.

Br J Pharmacol. 1999 Sep;128(1):13-20.

9.

N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.

Knutsen LJ, Lau J, Petersen H, Thomsen C, Weis JU, Shalmi M, Judge ME, Hansen AJ, Sheardown MJ.

J Med Chem. 1999 Sep 9;42(18):3463-77.

PMID:
10479279
10.

Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.

Shannon HE, Hart JC, Bymaster FP, Calligaro DO, DeLapp NW, Mitch CH, Ward JS, Fink-Jensen A, Sauerberg P, Jeppesen L, Sheardown MJ, Swedberg MD.

J Pharmacol Exp Ther. 1999 Aug;290(2):901-7.

PMID:
10411607
11.

1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.

Jeppesen L, Olesen PH, Hansen L, Sheardown MJ, Thomsen C, Rasmussen T, Jensen AF, Christensen MS, Rimvall K, Ward JS, Whitesitt C, Calligaro DO, Bymaster FP, Delapp NW, Felder CC, Shannon HE, Sauerberg P.

J Med Chem. 1999 Jun 3;42(11):1999-2006.

PMID:
10354408
12.

Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic m1 receptor activation.

Sauerberg P, Jeppesen L, Olesen PH, Sheardown MJ, Fink-Jensen A, Rasmussen T, Rimvall K, Shannon HE, Bymaster FP, DeLapp NW, Calligaro DO, Ward JS, Whitesitt CA, Thomsen C.

Bioorg Med Chem Lett. 1998 Oct 20;8(20):2897-902.

PMID:
9873644
13.

Muscarinic agonists exhibit functional dopamine antagonism in unilaterally 6-OHDA lesioned rats.

Fink-Jensen A, Kristensen P, Shannon HE, Calligaro DO, Delapp NW, Whitesitt C, Ward JS, Thomsen C, Rasmusseen T, Sheardown MJ, Jeppesen L, Sauerberg P, Bymaster FP.

Neuroreport. 1998 Oct 26;9(15):3481-6. Erratum in: Neuroreport 1998 Nov 16;9(16):inside back cov.

PMID:
9855303
14.

Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.

Sauerberg P, Jeppesen L, Olesen PH, Rasmussen T, Swedberg MD, Sheardown MJ, Fink-Jensen A, Thomsen C, Thøgersen H, Rimvall K, Ward JS, Calligaro DO, DeLapp NW, Bymaster FP, Shannon HE.

J Med Chem. 1998 Oct 22;41(22):4378-84.

PMID:
9784113
15.

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane .

Bymaster FP, Shannon HE, Rasmussen K, Delapp NW, Mitch CH, Ward JS, Calligaro DO, Ludvigsen TS, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P, Fink-Jensen A.

Eur J Pharmacol. 1998 Sep 4;356(2-3):109-19.

PMID:
9774240
16.

Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.

Bymaster FP, Carter PA, Peters SC, Zhang W, Ward JS, Mitch CH, Calligaro DO, Whitesitt CA, DeLapp N, Shannon HE, Rimvall K, Jeppesen L, Sheardown MJ, Fink-Jensen A, Sauerberg P.

Brain Res. 1998 Jun 8;795(1-2):179-90.

PMID:
9622623
17.

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.

Castillo GM, Cummings JA, Yang W, Judge ME, Sheardown MJ, Rimvall K, Hansen JB, Snow AD.

Diabetes. 1998 Apr;47(4):612-20.

PMID:
9568695
18.

1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.

Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Mitch CH, Whitesitt C, Brunsting D, Sheardown MJ, Olesen PH, Swedberg MD, Jeppesen L, Sauerberg P.

J Med Chem. 1998 Jan 29;41(3):379-92.

PMID:
9464368
19.

Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.

Sauerberg P, Olesen PH, Sheardown MJ, Rimvall K, Thøgersen H, Shannon HE, Sawyer BD, Ward JS, Bymaster FP, DeLapp NW, Calligaro DO, Swedberg MD.

J Med Chem. 1998 Jan 1;41(1):109-16.

PMID:
9438027
20.

The triggering of spreading depression in the chick retina by nicotinic receptor agonists.

Sheardown MJ.

Eur J Pharmacol. 1997 Oct 22;337(2-3):209-12.

PMID:
9430415
21.

Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity.

Shannon HE, Sheardown MJ, Bymaster FP, Calligaro DO, Delapp NW, Gidda J, Mitch CH, Sawyer BD, Stengel PW, Ward JS, Wong DT, Olesen PH, Suzdak PD, Sauerberg P, Swedberg MD.

J Pharmacol Exp Ther. 1997 May;281(2):884-94.

PMID:
9152398
22.

Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic.

Swedberg MD, Sheardown MJ, Sauerberg P, Olesen PH, Suzdak PD, Hansen KT, Bymaster FP, Ward JS, Mitch CH, Calligaro DO, Delapp NW, Shannon HE.

J Pharmacol Exp Ther. 1997 May;281(2):876-83.

PMID:
9152397
23.

M1 receptor agonist activity is not a requirement for muscarinic antinociception.

Sheardown MJ, Shannon HE, Swedberg MD, Suzdak PD, Bymaster FP, Olesen PH, Mitch CH, Ward JS, Sauerberg P.

J Pharmacol Exp Ther. 1997 May;281(2):868-75.

PMID:
9152396
24.

Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.

Mitch CH, Brown TJ, Bymaster FP, Calligaro DO, Dieckman D, Merrit L, Peters SC, Quimby SJ, Shannon HE, Shipley LA, Ward JS, Hansen K, Olesen PH, Sauerberg P, Sheardown MJ, Swedberg MD, Suzdak P, Greenwood B.

J Med Chem. 1997 Feb 14;40(4):538-46.

PMID:
9046345
25.

In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist.

Shannon HE, Womer DE, Bymaster FP, Calligaro DO, DeLapp NC, Mitch CH, Ward JS, Whitesitt CA, Swedberg MD, Sheardown MJ, Fink-Jensen A, Olesen PH, Rimvall K, Sauerberg P.

Life Sci. 1997;60(13-14):969-76. Review.

PMID:
9121363
26.
27.

Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles.

Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Sawyer BD, Mitch CH, Deeter JB, Peters SC, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P.

J Med Chem. 1995 Sep 1;38(18):3469-81.

PMID:
7658434
28.

Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.

Sauerberg P, Olesen PH, Sheardown MJ, Suzdak PD, Shannon HE, Bymaster FP, Calligaro DO, Mitch CH, Ward JS, Swedberg MD.

Life Sci. 1995;56(11-12):807-14.

PMID:
10188779
29.

Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischemia.

Barone FC, Price WJ, Jakobsen P, Sheardown MJ, Feuerstein G.

Pharmacol Biochem Behav. 1994 May;48(1):77-85.

PMID:
8029306
30.

Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232).

Bymaster FP, Wong DT, Mitch CH, Ward JS, Calligaro DO, Schoepp DD, Shannon HE, Sheardown MJ, Olesen PH, Suzdak PD, Swedberg MD, Sauerberg P.

J Pharmacol Exp Ther. 1994 Apr;269(1):282-9.

PMID:
7909558
31.

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.

Shannon HE, Bymaster FP, Calligaro DO, Greenwood B, Mitch CH, Sawyer BD, Ward JS, Wong DT, Olesen PH, Sheardown MJ, Swedberg MD, Suzdak PD, Sauerberg P.

J Pharmacol Exp Ther. 1994 Apr;269(1):271-81.

PMID:
7909557
32.

The pharmacology of AMPA receptors and their antagonists.

Sheardown MJ.

Stroke. 1993 Dec;24(12 Suppl):I146-7; discussion I153-4. Review. No abstract available.

PMID:
7504337
34.

AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h.

Sheardown MJ, Suzdak PD, Nordholm L.

Eur J Pharmacol. 1993 Jun 4;236(3):347-53.

PMID:
7689464
36.
37.

Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats.

Nilsson P, Hillered L, Olsson Y, Sheardown MJ, Hansen AJ.

J Cereb Blood Flow Metab. 1993 Mar;13(2):183-92.

PMID:
8436609
38.
39.

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .

Sauerberg P, Olesen PH, Nielsen S, Treppendahl S, Sheardown MJ, Honoré T, Mitch CH, Ward JS, Pike AJ, Bymaster FP, et al.

J Med Chem. 1992 Jun 12;35(12):2274-83.

PMID:
1613751
41.
42.

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.

Sheardown MJ, Nielsen EO, Hansen AJ, Jacobsen P, Honoré T.

Science. 1990 Feb 2;247(4942):571-4.

PMID:
2154034
43.

A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.

Sheardown MJ, Drejer J, Jensen LH, Stidsen CE, Honoré T.

Eur J Pharmacol. 1989 Dec 19;174(2-3):197-204.

PMID:
2560979
44.
45.

Amino acid receptor mediated excitatory synaptic transmission in the cat red nucleus.

Davies J, Miller AJ, Sheardown MJ.

J Physiol. 1986 Jul;376:13-29.

46.

Selective potentiating effect of beta-p-chlorophenylglutamate on responses induced by certain sulphur-containing excitatory amino acids and quisqualate.

Davies J, Francis AA, Oakes DJ, Sheardown MJ, Watkins JC.

Neuropharmacology. 1985 Feb;24(2):177-80.

PMID:
3887200
47.

Phosphono dipeptides and piperazine derivatives as antagonists of amino acid-induced and synaptic excitation in mammalian and amphibian spinal cord.

Davies J, Jones AW, Sheardown MJ, Smith DA, Watkins JC.

Neurosci Lett. 1984 Nov 23;52(1-2):79-84.

PMID:
6098881
48.
49.

Functional transmitters at retinal ganglion cells in the cat.

Ikeda H, Sheardown MJ.

Vision Res. 1983;23(10):1161-74.

PMID:
6139914

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