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Items: 15

1.

Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.

Leist SR, Jensen KL, Baric RS, Sheahan TP.

PLoS One. 2019 Jul 24;14(7):e0220126. doi: 10.1371/journal.pone.0220126. eCollection 2019.

2.

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP.

Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21.

PMID:
31233808
3.

Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics?

Sheahan TP, Baric RS.

Future Virol. 2018 Mar;13(3):143-146. doi: 10.2217/fvl-2017-0143. Epub 2018 Feb 21. No abstract available.

4.

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS.

MBio. 2018 Oct 9;9(5). pii: e01753-18. doi: 10.1128/mBio.01753-18.

5.

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.

6.

Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion.

Lindesmith LC, Mallory ML, Debbink K, Donaldson EF, Brewer-Jensen PD, Swann EW, Sheahan TP, Graham RL, Beltramello M, Corti D, Lanzavecchia A, Baric RS.

mSphere. 2018 Feb 7;3(1). pii: e00518-17. doi: 10.1128/mSphere.00518-17. eCollection 2018 Jan-Feb.

7.

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.

8.

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN.

Virology. 2016 Jul;494:236-47. doi: 10.1016/j.virol.2016.04.020. Epub 2016 Apr 27.

9.

SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.

10.

Multi-Modal Imaging with a Toolbox of Influenza A Reporter Viruses.

Tran V, Poole DS, Jeffery JJ, Sheahan TP, Creech D, Yevtodiyenko A, Peat AJ, Francis KP, You S, Mehle A.

Viruses. 2015 Oct 13;7(10):5319-27. doi: 10.3390/v7102873.

11.

New Methods in Tissue Engineering: Improved Models for Viral Infection.

Ramanan V, Scull MA, Sheahan TP, Rice CM, Bhatia SN.

Annu Rev Virol. 2014 Nov;1:475-499. doi: 10.1146/annurev-virology-031413-085437.

12.

Single cell analysis of HCV-infected patient hepatocytes: the science is no longer science fiction.

Sheahan TP, Rice CM.

Gastroenterology. 2013 Dec;145(6):1199-202. doi: 10.1053/j.gastro.2013.10.035. Epub 2013 Oct 29. No abstract available.

13.

Modeling hepatitis C virus infection using human induced pluripotent stem cells.

Schwartz RE, Trehan K, Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice CM, Bhatia SN.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2544-8. doi: 10.1073/pnas.1121400109. Epub 2012 Jan 30.

14.

Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells.

Andrus L, Marukian S, Jones CT, Catanese MT, Sheahan TP, Schoggins JW, Barry WT, Dustin LB, Trehan K, Ploss A, Bhatia SN, Rice CM.

Hepatology. 2011 Dec;54(6):1901-12. doi: 10.1002/hep.24557.

15.

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures.

Marukian S, Andrus L, Sheahan TP, Jones CT, Charles ED, Ploss A, Rice CM, Dustin LB.

Hepatology. 2011 Dec;54(6):1913-23. doi: 10.1002/hep.24580.

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