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Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.

Leist SR, Jensen KL, Baric RS, Sheahan TP.

PLoS One. 2019 Jul 24;14(7):e0220126. doi: 10.1371/journal.pone.0220126. eCollection 2019.


Rapid metagenomics analysis of EMS vehicles for monitoring pathogen load using nanopore DNA sequencing.

Sheahan T, Hakstol R, Kailasam S, Glaister GD, Hudson AJ, Wieden HJ.

PLoS One. 2019 Jul 24;14(7):e0219961. doi: 10.1371/journal.pone.0219961. eCollection 2019.


Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase.

Brown AJ, Won JJ, Graham RL, Dinnon KH 3rd, Sims AC, Feng JY, Cihlar T, Denison MR, Baric RS, Sheahan TP.

Antiviral Res. 2019 Sep;169:104541. doi: 10.1016/j.antiviral.2019.104541. Epub 2019 Jun 21.


Is regulation preventing the development of therapeutics that may prevent future coronavirus pandemics?

Sheahan TP, Baric RS.

Future Virol. 2018 Mar;13(3):143-146. doi: 10.2217/fvl-2017-0143. Epub 2018 Feb 21. No abstract available.


Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT, Baric RS.

MBio. 2018 Oct 9;9(5). pii: e01753-18. doi: 10.1128/mBio.01753-18.


Kappa Opioid Receptor Distribution and Function in Primary Afferents.

Snyder LM, Chiang MC, Loeza-Alcocer E, Omori Y, Hachisuka J, Sheahan TD, Gale JR, Adelman PC, Sypek EI, Fulton SA, Friedman RL, Wright MC, Duque MG, Lee YS, Hu Z, Huang H, Cai X, Meerschaert KA, Nagarajan V, Hirai T, Scherrer G, Kaplan DH, Porreca F, Davis BM, Gold MS, Koerber HR, Ross SE.

Neuron. 2018 Sep 19;99(6):1274-1288.e6. doi: 10.1016/j.neuron.2018.08.044.


4-Hydroxy-tetrahydrodipicolinate reductase from Neisseria gonorrhoeae - structure and interactions with coenzymes and substrate analog.

Pote S, Pye SE, Sheahan TE, Gawlicka-Chruszcz A, Majorek KA, Chruszcz M.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1993-1999. doi: 10.1016/j.bbrc.2018.07.147. Epub 2018 Aug 6.


Small RNAs, but Sizable Itch: TRPA1 Activation by an Extracellular MicroRNA.

Sheahan TD, Hachisuka J, Ross SE.

Neuron. 2018 Aug 8;99(3):421-422. doi: 10.1016/j.neuron.2018.07.040.


Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.

Shepherd AJ, Copits BA, Mickle AD, Karlsson P, Kadunganattil S, Haroutounian S, Tadinada SM, de Kloet AD, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW 4th, Mohapatra DP.

J Neurosci. 2018 Aug 8;38(32):7032-7057. doi: 10.1523/JNEUROSCI.3542-17.2018. Epub 2018 Jul 5.


Metabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons.

Sheahan TD, Valtcheva MV, McIlvried LA, Pullen MY, Baranger DAA, Gereau RW 4th.

eNeuro. 2018 Apr 13;5(2). pii: ENEURO.0412-17.2018. doi: 10.1523/ENEURO.0412-17.2018. eCollection 2018 Mar-Apr.


Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.

Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR.

MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18.


Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion.

Lindesmith LC, Mallory ML, Debbink K, Donaldson EF, Brewer-Jensen PD, Swann EW, Sheahan TP, Graham RL, Beltramello M, Corti D, Lanzavecchia A, Baric RS.

mSphere. 2018 Feb 7;3(1). pii: e00518-17. doi: 10.1128/mSphere.00518-17. eCollection 2018 Jan-Feb.


Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain.

Sheahan TD, Siuda ER, Bruchas MR, Shepherd AJ, Mohapatra DP, Gereau RW 4th, Golden JP.

Neurobiol Pain. 2017 Aug-Dec;2:1-12. doi: 10.1016/j.ynpai.2017.09.001. Epub 2017 Sep 8.


Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.

Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653.


Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.

Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW 4th.

Nat Protoc. 2016 Oct;11(10):1877-88. doi: 10.1038/nprot.2016.111. Epub 2016 Sep 8.


Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC.

Frey F, Sheahan T, Finkl K, Stoehr G, Mann M, Benda C, Müller J.

Genes Dev. 2016 May 1;30(9):1116-27. doi: 10.1101/gad.279141.116.


Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN.

Virology. 2016 Jul;494:236-47. doi: 10.1016/j.virol.2016.04.020. Epub 2016 Apr 27.


SARS-like WIV1-CoV poised for human emergence.

Menachery VD, Yount BL Jr, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53. doi: 10.1073/pnas.1517719113. Epub 2016 Mar 14.


Multi-Modal Imaging with a Toolbox of Influenza A Reporter Viruses.

Tran V, Poole DS, Jeffery JJ, Sheahan TP, Creech D, Yevtodiyenko A, Peat AJ, Francis KP, You S, Mehle A.

Viruses. 2015 Oct 13;7(10):5319-27. doi: 10.3390/v7102873.


Voluntary Exercise Training: Analysis of Mice in Uninjured, Inflammatory, and Nerve-Injured Pain States.

Sheahan TD, Copits BA, Golden JP, Gereau RW 4th.

PLoS One. 2015 Jul 21;10(7):e0133191. doi: 10.1371/journal.pone.0133191. eCollection 2015.


The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.

Wood ER, Bledsoe R, Chai J, Daka P, Deng H, Ding Y, Harris-Gurley S, Kryn LH, Nartey E, Nichols J, Nolte RT, Prabhu N, Rise C, Sheahan T, Shotwell JB, Smith D, Tai V, Taylor JD, Tomberlin G, Wang L, Wisely B, You S, Xia B, Dickson H.

J Biol Chem. 2015 Aug 7;290(32):19681-96. doi: 10.1074/jbc.M115.653113. Epub 2015 Jun 8.


New Methods in Tissue Engineering: Improved Models for Viral Infection.

Ramanan V, Scull MA, Sheahan TP, Rice CM, Bhatia SN.

Annu Rev Virol. 2014 Nov;1:475-499. doi: 10.1146/annurev-virology-031413-085437.


Uptake of PCBs contained in marine sediments by the green macroalga Ulva rigida.

Cheney D, Rajic L, Sly E, Meric D, Sheahan T.

Mar Pollut Bull. 2014 Nov 15;88(1-2):207-14. doi: 10.1016/j.marpolbul.2014.09.004. Epub 2014 Sep 26.


Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.

Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LL, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H, Klose RJ.

Cell. 2014 Jun 5;157(6):1445-59. doi: 10.1016/j.cell.2014.05.004. Epub 2014 May 22.


Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness.

Sheahan T, Imanaka N, Marukian S, Dorner M, Liu P, Ploss A, Rice CM.

Cell Host Microbe. 2014 Feb 12;15(2):190-202. doi: 10.1016/j.chom.2014.01.007.


Bioavailability of hydrophobic organic compounds in thin-layered capped sediments.

Meric D, Alshawabkeh AN, Shine JP, Sheahan TC.

Chemosphere. 2014 May;103:281-9. doi: 10.1016/j.chemosphere.2013.12.017. Epub 2013 Dec 26.


Benchscale Assessment of the Efficacy of a Reactive Core Mat to Isolate PAH-spiked Aquatic Sediments.

Meric D, Barbuto S, Sheahan TC, Shine JP, Alshawabkeh AN.

Soil Sediment Contam. 2014;23(1). doi: 10.1080/15320383.2013.772093.


Single cell analysis of HCV-infected patient hepatocytes: the science is no longer science fiction.

Sheahan TP, Rice CM.

Gastroenterology. 2013 Dec;145(6):1199-202. doi: 10.1053/j.gastro.2013.10.035. Epub 2013 Oct 29. No abstract available.


KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, Lee S, Sims D, Cerase A, Sheahan TW, Koseki H, Brockdorff N, Ponting CP, Kessler BM, Klose RJ.

Elife. 2012 Dec 18;1:e00205. doi: 10.7554/eLife.00205.


Effect of reactive core mat application on bioavailability of hydrophobic organic compounds.

Meric D, Barbuto SM, Alshawabkeh AN, Shine JP, Sheahan TC.

Sci Total Environ. 2012 Apr 15;423:168-75. doi: 10.1016/j.scitotenv.2012.01.042. Epub 2012 Mar 2.


Modeling hepatitis C virus infection using human induced pluripotent stem cells.

Schwartz RE, Trehan K, Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice CM, Bhatia SN.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2544-8. doi: 10.1073/pnas.1121400109. Epub 2012 Jan 30.


Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells.

Andrus L, Marukian S, Jones CT, Catanese MT, Sheahan TP, Schoggins JW, Barry WT, Dustin LB, Trehan K, Ploss A, Bhatia SN, Rice CM.

Hepatology. 2011 Dec;54(6):1901-12. doi: 10.1002/hep.24557.


A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo.

Meuleman P, Catanese MT, Verhoye L, Desombere I, Farhoudi A, Jones CT, Sheahan T, Grzyb K, Cortese R, Rice CM, Leroux-Roels G, Nicosia A.

Hepatology. 2012 Feb;55(2):364-72. doi: 10.1002/hep.24692. Epub 2011 Dec 16.


Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures.

Marukian S, Andrus L, Sheahan TP, Jones CT, Charles ED, Ploss A, Rice CM, Dustin LB.

Hepatology. 2011 Dec;54(6):1913-23. doi: 10.1002/hep.24580.


Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus.

Sheahan T, Whitmore A, Long K, Ferris M, Rockx B, Funkhouser W, Donaldson E, Gralinski L, Collier M, Heise M, Davis N, Johnston R, Baric RS.

J Virol. 2011 Jan;85(1):217-30. doi: 10.1128/JVI.01805-10. Epub 2010 Oct 27.


Advances and challenges in studying hepatitis C virus in its native environment.

Sheahan T, Jones CT, Ploss A.

Expert Rev Gastroenterol Hepatol. 2010 Oct;4(5):541-50. doi: 10.1586/egh.10.53. Review.


Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus.

Rockx B, Donaldson E, Frieman M, Sheahan T, Corti D, Lanzavecchia A, Baric RS.

J Infect Dis. 2010 Mar 15;201(6):946-55. doi: 10.1086/651022.


A novel L1 retrotransposon marker for HeLa cell line identification.

Rahbari R, Sheahan T, Modes V, Collier P, Macfarlane C, Badge RM.

Biotechniques. 2009 Apr;46(4):277-84. doi: 10.2144/000113089.


Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection.

Rockx B, Baas T, Zornetzer GA, Haagmans B, Sheahan T, Frieman M, Dyer MD, Teal TH, Proll S, van den Brand J, Baric R, Katze MG.

J Virol. 2009 Jul;83(14):7062-74. doi: 10.1128/JVI.00127-09. Epub 2009 May 6. Erratum in: J Virol. 2009 Sep;83(17):9022.


MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.

Sheahan T, Morrison TE, Funkhouser W, Uematsu S, Akira S, Baric RS, Heise MT.

PLoS Pathog. 2008 Dec;4(12):e1000240. doi: 10.1371/journal.ppat.1000240. Epub 2008 Dec 12.


Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19944-9. doi: 10.1073/pnas.0808116105. Epub 2008 Nov 26.


Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus.

Sheahan T, Rockx B, Donaldson E, Corti D, Baric R.

J Virol. 2008 Sep;82(17):8721-32. doi: 10.1128/JVI.00818-08. Epub 2008 Jun 25.


A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters.

Lamirande EW, DeDiego ML, Roberts A, Jackson JP, Alvarez E, Sheahan T, Shieh WJ, Zaki SR, Baric R, Enjuanes L, Subbarao K.

J Virol. 2008 Aug;82(15):7721-4. doi: 10.1128/JVI.00304-08. Epub 2008 May 7.


Structural basis for potent cross-neutralizing human monoclonal antibody protection against lethal human and zoonotic severe acute respiratory syndrome coronavirus challenge.

Rockx B, Corti D, Donaldson E, Sheahan T, Stadler K, Lanzavecchia A, Baric R.

J Virol. 2008 Apr;82(7):3220-35. doi: 10.1128/JVI.02377-07. Epub 2008 Jan 16.


Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium.

Sheahan T, Rockx B, Donaldson E, Sims A, Pickles R, Corti D, Baric R.

J Virol. 2008 Mar;82(5):2274-85. Epub 2007 Dec 19.


Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies.

Zhu Z, Chakraborti S, He Y, Roberts A, Sheahan T, Xiao X, Hensley LE, Prabakaran P, Rockx B, Sidorov IA, Corti D, Vogel L, Feng Y, Kim JO, Wang LF, Baric R, Lanzavecchia A, Curtis KM, Nabel GJ, Subbarao K, Jiang S, Dimitrov DS.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12123-8. Epub 2007 Jul 9.


Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice.

Rockx B, Sheahan T, Donaldson E, Harkema J, Sims A, Heise M, Pickles R, Cameron M, Kelvin D, Baric R.

J Virol. 2007 Jul;81(14):7410-23. Epub 2007 May 16.


Animal models and vaccines for SARS-CoV infection.

Roberts A, Lamirande EW, Vogel L, Jackson JP, Paddock CD, Guarner J, Zaki SR, Sheahan T, Baric R, Subbarao K.

Virus Res. 2008 Apr;133(1):20-32. Epub 2007 May 11.


Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease.

Enjuanes L, Dediego ML, Alvarez E, Deming D, Sheahan T, Baric R.

Virus Res. 2008 Apr;133(1):45-62. Epub 2007 Apr 9.


A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice.

Roberts A, Deming D, Paddock CD, Cheng A, Yount B, Vogel L, Herman BD, Sheahan T, Heise M, Genrich GL, Zaki SR, Baric R, Subbarao K.

PLoS Pathog. 2007 Jan;3(1):e5.

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