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Systemic inflammatory response predicts oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient colorectal cancer.

Climent M, Ryan ÉJ, Stakelum Á, Khaw YL, Creavin B, Lloyd A, Alhassan D, Mohan HM, Kennelly R, Sheahan K, Winter DC.

Int J Colorectal Dis. 2019 Jun;34(6):1069-1078. doi: 10.1007/s00384-019-03274-6. Epub 2019 Apr 16.


Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme.

McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K.

Gastroenterol Res Pract. 2019 Feb 6;2019:1592306. doi: 10.1155/2019/1592306. eCollection 2019.


Significant polyps and early colorectal cancer: the importance of high-quality standardized histopathology.

West NP, Langman G, Haboubi N, Carey F, Henry J, Morgan M, Sheahan K.

Colorectal Dis. 2019 Mar;21 Suppl 1:53-56. doi: 10.1111/codi.14506. No abstract available.


A National Bowel Cancer Screening Programme using FIT: Achievements and Challenges.

O'Donoghue D, Sheahan K, MacMathuna P, Stephens RB, Fenlon H, Morrin M, Mooney J, Fahy LE, Mooney T, Smith A.

Cancer Prev Res (Phila). 2019 Feb;12(2):89-94. doi: 10.1158/1940-6207.CAPR-18-0182. Epub 2018 Dec 4.


Effects of CDX2 on prognosis and chemotherapy responsiveness in mismatch repair-deficient colorectal cancer.

Ryan ÉJ, Creavin B, Khaw YL, Kelly ME, Mohan HM, Geraghty R, Ryan EJ, Kennelly R, Hanly A, Martin ST, Fennelly D, McDermott R, Gibbons D, O'Connell PR, Sheahan K, Winter DC.

BJS Open. 2018 Jul 24;2(6):456-463. doi: 10.1002/bjs5.91. eCollection 2018 Dec.


A prospective study of faecal immunochemical testing following polypectomy in a colorectal cancer screening population.

Gibson DJ, Nolan B, Rea J, Buckley M, Horgan G, Sheahan K, Doherty GA, O'Donoghue D, Mulcahy HE, Smith A, Cullen G.

Frontline Gastroenterol. 2018 Oct;9(4):295-299. doi: 10.1136/flgastro-2017-100869. Epub 2017 Nov 4.


Histopathologic tumor regression grading in patients with gastric carcinoma submitted to neoadjuvant treatment: results of a Delphi survey.

Tsekrekos A, Detlefsen S, Riddell R, Conner J, Mastracci L, Sheahan K, Shetye J, Lundell L, Vieth M.

Hum Pathol. 2019 Feb;84:26-34. doi: 10.1016/j.humpath.2018.08.028. Epub 2018 Sep 12.


Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy.

Allen WL, Dunne PD, McDade S, Scanlon E, Loughrey M, Coleman H, McCann C, McLaughlin K, Nemeth Z, Syed N, Jithesh P, Arthur K, Wilson R, Coyle V, McArt D, Murray GI, Samuel L, Nuciforo P, Jimenez J, Argiles G, Dienstmann R, Tabernero J, Messerini L, Nobili S, Mini E, Sheahan K, Ryan E, Johnston PG, Van Schaeybroeck S, Lawler M, Longley DB.

JCO Precis Oncol. 2018 Jun 13;2018. doi: 10.1200/PO.17.00241.


Primary small bowel adenomas and adenocarcinomas-recent advances.

Maguire A, Sheahan K.

Virchows Arch. 2018 Sep;473(3):265-273. doi: 10.1007/s00428-018-2400-7. Epub 2018 Jul 11. Review.


Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment.

Noonan SA, Morrissey ME, Martin P, Biniecka M, Ó'Meachair S, Maguire A, Tosetto M, Nolan B, Hyland J, Sheahan K, O'Donoghue D, Mulcahy H, Fennelly D, O'Sullivan J.

Oncotarget. 2018 Jan 19;9(12):10536-10548. doi: 10.18632/oncotarget.24276. eCollection 2018 Feb 13.


Correlation of immunohistochemical mismatch repair protein status between colorectal carcinoma endoscopic biopsy and resection specimens.

O'Brien O, Ryan É, Creavin B, Kelly ME, Mohan HM, Geraghty R, Winter DC, Sheahan K.

J Clin Pathol. 2018 Jul;71(7):631-636. doi: 10.1136/jclinpath-2017-204946. Epub 2018 Feb 1.


Isolation and gene expression profiling of intestinal epithelial cells: crypt isolation by calcium chelation from in vivo samples.

Balfe A, Lennon G, Lavelle A, Docherty NG, Coffey JC, Sheahan K, Winter DC, O'Connell PR.

Clin Exp Gastroenterol. 2018 Jan 12;11:29-37. doi: 10.2147/CEG.S145224. eCollection 2018.


Classification of eosinophilic disorders of the small and large intestine.

McCarthy AJ, Sheahan K.

Virchows Arch. 2018 Jan;472(1):15-28. doi: 10.1007/s00428-017-2249-1. Epub 2017 Nov 10.


Tumor Budding and PDC Grade Are Stage Independent Predictors of Clinical Outcome in Mismatch Repair Deficient Colorectal Cancer.

Ryan É, Khaw YL, Creavin B, Geraghty R, Ryan EJ, Gibbons D, Hanly A, Martin ST, O'Connell PR, Winter DC, Sheahan K.

Am J Surg Pathol. 2018 Jan;42(1):60-68. doi: 10.1097/PAS.0000000000000931.


An isolated cuboid dislocation. A case report.

Sheahan K, Pomeroy E, Bayer T.

Int J Surg Case Rep. 2017;39:1-4. doi: 10.1016/j.ijscr.2017.06.052. Epub 2017 Jun 29.


The current value of determining the mismatch repair status of colorectal cancer: A rationale for routine testing.

Ryan E, Sheahan K, Creavin B, Mohan HM, Winter DC.

Crit Rev Oncol Hematol. 2017 Aug;116:38-57. doi: 10.1016/j.critrevonc.2017.05.006. Epub 2017 May 20. Review.


Primary cutaneous post liver transplant lymphoproliferative disorder (PTLD) successfully treated with radiotherapy.

Murad A, Sheahan K, Kirby B.

J Dermatolog Treat. 2018 Mar;29(2):168-169. doi: 10.1080/09546634.2017.1341613. Epub 2017 Jun 30.


Health systems research in fragile and conflict affected states: a qualitative study of associated challenges.

Woodward A, Sheahan K, Martineau T, Sondorp E.

Health Res Policy Syst. 2017 Jun 7;15(1):44. doi: 10.1186/s12961-017-0204-x.


Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma.

Wouters J, Vizoso M, Martinez-Cardus A, Carmona FJ, Govaere O, Laguna T, Joseph J, Dynoodt P, Aura C, Foth M, Cloots R, van den Hurk K, Balint B, Murphy IG, McDermott EW, Sheahan K, Jirström K, Nodin B, Mallya-Udupi G, van den Oord JJ, Gallagher WM, Esteller M.

BMC Med. 2017 Jun 5;15(1):101. doi: 10.1186/s12916-017-0851-3.


Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016.

Lugli A, Kirsch R, Ajioka Y, Bosman F, Cathomas G, Dawson H, El Zimaity H, Fléjou JF, Hansen TP, Hartmann A, Kakar S, Langner C, Nagtegaal I, Puppa G, Riddell R, Ristimäki A, Sheahan K, Smyrk T, Sugihara K, Terris B, Ueno H, Vieth M, Zlobec I, Quirke P.

Mod Pathol. 2017 Sep;30(9):1299-1311. doi: 10.1038/modpathol.2017.46. Epub 2017 May 26. Review.


Screening for mismatch repair deficiency in colorectal cancer: data from three academic medical centers.

O'Kane GM, Ryan É, McVeigh TP, Creavin B, Hyland JM, O'Donoghue DP, Keegan D, Geraghty R, Flannery D, Nolan C, Donovan E, Mehigan BJ, McCormick P, Muldoon C, Farrell M, Shields C, Mulligan N, Kennedy MJ, Green AJ, Winter DC, MacMathuna P, Sheahan K, Gallagher DJ.

Cancer Med. 2017 Jun;6(6):1465-1472. doi: 10.1002/cam4.1025. Epub 2017 May 3.


Gastric foveolar dysplasia: a survey of reporting habits and diagnostic criteria.

Serra S, Ali R, Bateman AC, Dasgupta K, Deshpande V, Driman DK, Gibbons D, Grin A, Hafezi-Bakhtiari S, Sheahan K, Srivastava A, Szentgyorgyi E, Vajpeyi R, Walsh S, Wang LM, Chetty R.

Pathology. 2017 Jun;49(4):391-396. doi: 10.1016/j.pathol.2017.01.007. Epub 2017 Apr 21.


Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity.

Elliott LA, Doherty GA, Sheahan K, Ryan EJ.

Front Immunol. 2017 Feb 6;8:86. doi: 10.3389/fimmu.2017.00086. eCollection 2017. Review.


Organ preservation with local excision or active surveillance following chemoradiotherapy for rectal cancer.

Creavin B, Ryan E, Martin ST, Hanly A, O'Connell PR, Sheahan K, Winter DC.

Br J Cancer. 2017 Jan 17;116(2):169-174. doi: 10.1038/bjc.2016.417. Epub 2016 Dec 20.


Microsatellite instability is associated with reduced disease specific survival in stage III colon cancer.

Mohan HM, Ryan E, Balasubramanian I, Kennelly R, Geraghty R, Sclafani F, Fennelly D, McDermott R, Ryan EJ, O'Donoghue D, Hyland JM, Martin ST, O'Connell PR, Gibbons D, Winter D, Sheahan K.

Eur J Surg Oncol. 2016 Nov;42(11):1680-1686. doi: 10.1016/j.ejso.2016.05.013. Epub 2016 Jun 22.


Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer.

Murphy AG, Casey R, Maguire A, Tosetto M, Butler CT, Conroy E, Reynolds AL, Sheahan K, O'Donoghue D, Gallagher WM, Fennelly D, Kennedy BN, O'Sullivan J.

Sci Rep. 2016 Oct 14;6:34523. doi: 10.1038/srep34523.


Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer.

Rogers AC, Winter DC, Heeney A, Gibbons D, Lugli A, Puppa G, Sheahan K.

Br J Cancer. 2016 Sep 27;115(7):831-40. doi: 10.1038/bjc.2016.274. Epub 2016 Sep 6. Review.


The lymph node ratio does not provide additional prognostic information compared with the N1/N2 classification in Stage III colon cancer.

Mohan HM, Walsh C, Kennelly R, Ng CH, O'Connell PR, Hyland JM, Hanly A, Martin S, Gibbons D, Sheahan K, Winter DC.

Colorectal Dis. 2017 Feb;19(2):165-171. doi: 10.1111/codi.13410.


A radiological and pathological assessment of ileocolic pedicle length as a predictor of lymph node retrieval following right hemicolectomy for caecal cancer.

Solon JG, Cahalane A, Burke JP, Gibbons D, McCann JW, Martin ST, Sheahan K, Winter DC.

Tech Coloproctol. 2016 Aug;20(8):545-50. doi: 10.1007/s10151-016-1483-x. Epub 2016 May 26.


Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1.

Dunne MR, Ryan C, Nolan B, Tosetto M, Geraghty R, Winter DC, O'Connell PR, Hyland JM, Doherty GA, Sheahan K, Ryan EJ, Fletcher JM.

Front Oncol. 2016 Mar 7;6:50. doi: 10.3389/fonc.2016.00050. eCollection 2016.


Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.

Flood B, Oficjalska K, Laukens D, Fay J, O'Grady A, Caiazza F, Heetun Z, Mills KH, Sheahan K, Ryan EJ, Doherty GA, Kay E, Creagh EM.

Clin Exp Immunol. 2015 Jul;181(1):39-50. doi: 10.1111/cei.12617. Epub 2015 May 6.


Blood and lymphatic vessel invasion in pT1 colorectal cancer: an international concordance study.

Kojima M, Puppa G, Kirsch R, Basturk O, Frankel WL, Vieth M, Lugli A, Sheahan K, Yeh M, Lauwers GY, Risio M, Shimazaki H, Iwaya K, Kage M, Akiba J, Ohkura Y, Horiguchi S, Shomori K, Kushima R, Nomura S, Ajioka Y, Adsay V, Ochiai A.

J Clin Pathol. 2015 Aug;68(8):628-32. doi: 10.1136/jclinpath-2014-202805. Epub 2015 Apr 30.


Visceral Adiposity is a Risk Factor for Poor Prognosis in Colorectal Cancer Patients Receiving Adjuvant Chemotherapy.

Lee CS, Murphy DJ, McMahon C, Nolan B, Cullen G, Mulcahy H, Sheahan K, Barnes E, Fennelly D, Ryan EJ, Doherty GA.

J Gastrointest Cancer. 2015 Sep;46(3):243-50. doi: 10.1007/s12029-015-9709-0.


Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies.

Caiazza F, Elliott L, Fennelly D, Sheahan K, Doherty GA, Ryan EJ.

Biomark Med. 2015;9(4):363-75. doi: 10.2217/bmm.15.5. Review.


Erratum to: Malignant melanoma: factors affecting the surgical interval from excision biopsy to definitive surgical management.

Boland MR, Prichard RS, Bass GA, Al-Hilli Z, Levendale A, Gibbons D, Sheahan K, Kirby B, McDermott EW, Evoy D.

Ir J Med Sci. 2015 Sep;184(3):723-4. doi: 10.1007/s11845-015-1262-0. No abstract available.


High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients.

van den Hurk K, Balint B, Toomey S, O'Leary PC, Unwin L, Sheahan K, McDermott EW, Murphy I, van den Oord JJ, Rafferty M, FitzGerald DM, Moran J, Cummins R, MacEneaney O, Kay EW, O'Brien CP, Finn SP, Heffron CC, Murphy M, Yela R, Power DG, Regan PJ, McDermott CM, O'Keeffe A, Orosz Z, Donnellan PP, Crown JP, Hennessy BT, Gallagher WM.

Melanoma Res. 2015 Jun;25(3):189-99. doi: 10.1097/CMR.0000000000000149.


Cocaine, a culprit in anetoderma?

O'Gorman SM, Sheahan K, Collins P.

Clin Exp Dermatol. 2015 Aug;40(6):695-6. doi: 10.1111/ced.12602. Epub 2015 Feb 22. No abstract available.


Estrogen receptors and their implications in colorectal carcinogenesis.

Caiazza F, Ryan EJ, Doherty G, Winter DC, Sheahan K.

Front Oncol. 2015 Feb 2;5:19. doi: 10.3389/fonc.2015.00019. eCollection 2015. Review.


Iatrogenic pathology of the intestines.

McCarthy AJ, Lauwers GY, Sheahan K.

Histopathology. 2015 Jan;66(1):15-28. doi: 10.1111/his.12598. Review.


Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers.

Lavelle A, Lennon G, O'Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy HE, Doherty G, O'Donoghue D, Hyland J, Ross RP, Coffey JC, Sheahan K, Cotter PD, Shanahan F, Winter DC, O'Connell PR.

Gut. 2015 Oct;64(10):1553-61. doi: 10.1136/gutjnl-2014-307873. Epub 2015 Jan 16.


Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer.

Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, O'Donoghue D, Fennelly D, O'Sullivan J.

BMC Cancer. 2014 Nov 27;14:887. doi: 10.1186/1471-2407-14-887.


Coeliac-like duodenal pathology in orthotopic liver transplant patients on mycophenolic acid therapy.

Cotter MB, AbuShanab A, Merriman R, McCormick A, Sheahan K.

Histopathology. 2015 Mar;66(4):500-7. doi: 10.1111/his.12541. Epub 2015 Jan 21.


Controversies in the pathological assessment of colorectal cancer.

Maguire A, Sheahan K.

World J Gastroenterol. 2014 Aug 7;20(29):9850-61. doi: 10.3748/wjg.v20.i29.9850. Review.


Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive.

O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ.

Br J Cancer. 2014 Aug 26;111(5):927-32. doi: 10.1038/bjc.2014.367. Epub 2014 Jul 24.


Lynch syndrome: an updated review.

Sehgal R, Sheahan K, O'Connell PR, Hanly AM, Martin ST, Winter DC.

Genes (Basel). 2014 Jun 27;5(3):497-507. doi: 10.3390/genes5030497.


Malignant melanoma: factors affecting the surgical interval from excision biopsy to definitive surgical management.

Boland MR, Prichard RS, Bass GA, Al-Hilli Z, Levendale A, Gibbons D, Sheahan K, Kirby B, McDermott EW, Evoy D.

Ir J Med Sci. 2015 Jun;184(2):511-5. doi: 10.1007/s11845-014-1157-5. Epub 2014 Jun 11. Erratum in: Ir J Med Sci. 2015 Sep;184(3):723-4.


Anal intraepithelial neoplasia: a single centre 19 year review.

Cotter MB, Kelly ME, O'Connell PR, Hyland J, Winter DC, Sheahan K, Gibbons D.

Colorectal Dis. 2014 Oct;16(10):777-82. doi: 10.1111/codi.12679.


Determinants of short- and long-term survival from colorectal cancer in very elderly patients.

Sheridan J, Walsh P, Kevans D, Cooney T, O'Hanlon S, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J, Mulcahy H, Doherty G.

J Geriatr Oncol. 2014 Oct 1;5(4):376-83. doi: 10.1016/j.jgo.2014.04.005. Epub 2014 May 18.


Microscopic colitis: clinical characteristics, treatment and outcomes in an Irish population.

O'Toole A, Coss A, Holleran G, Keegan D, Doherty G, Sheahan K, Mulcahy H, O'Donoghue D.

Int J Colorectal Dis. 2014 Jul;29(7):799-803. doi: 10.1007/s00384-014-1860-8. Epub 2014 Apr 18.


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