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Items: 25

1.

Exome sequencing of an adolescent with nonalcoholic fatty liver disease identifies a clinically actionable case of Wilson disease.

Wattacheril J, Shea PR, Mohammad S, Behling C, Aggarwal V, Wilson LA, Yates KP, Ito J, Fishbein M, Stong N, Lavine JE, Goldstein DB.

Cold Spring Harb Mol Case Stud. 2018 Oct 1;4(5). pii: a003087. doi: 10.1101/mcs.a003087. Print 2018 Oct.

2.

Genome-wide association study (GWAS) of human host factors influencing viral severity of herpes simplex virus type 2 (HSV-2).

Kleinstein SE, Shea PR, Allen AS, Koelle DM, Wald A, Goldstein DB.

Genes Immun. 2019 Feb;20(2):112-120. doi: 10.1038/s41435-018-0013-4. Epub 2018 Feb 28.

3.
4.

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.

Martin MP, Naranbhai V, Shea PR, Qi Y, Ramsuran V, Vince N, Gao X, Thomas R, Brumme ZL, Carlson JM, Wolinsky SM, Goedert JJ, Walker BD, Segal FP, Deeks SG, Haas DW, Migueles SA, Connors M, Michael N, Fellay J, Gostick E, Llewellyn-Lacey S, Price DA, Lafont BA, Pymm P, Saunders PM, Widjaja J, Wong SC, Vivian JP, Rossjohn J, Brooks AG, Carrington M.

J Clin Invest. 2018 May 1;128(5):1903-1912. doi: 10.1172/JCI98463. Epub 2018 Apr 3.

5.

Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.

McLaren PJ, Pulit SL, Gurdasani D, Bartha I, Shea PR, Pomilla C, Gupta N, Gkrania-Klotsas E, Young EH, Bannert N, Del Amo J, Gill MJ, Gilmour J, Kellam P, Kelleher AD, Sönnerborg A, Zangerle R, Post FA, Fisher M, Haas DW, Walker BD, Porter K, Goldstein DB, Sandhu MS, de Bakker PIW, Fellay J.

J Infect Dis. 2017 Nov 27;216(9):1063-1069. doi: 10.1093/infdis/jix470. Erratum in: J Infect Dis. 2018 Jun 5;218(1):171.

6.

A39 Human exome sequencing to evaluate the impact of rare coding variation on HIV-1 control.

McLaren PJ, Shea PR, Bartha I, Fellay J.

Virus Evol. 2017 Mar 5;3(Suppl 1). pii: vew036.038. doi: 10.1093/ve/vew036.038. eCollection 2017 Mar. No abstract available.

7.

Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.

Moody MA, Pedroza-Pacheco I, Vandergrift NA, Chui C, Lloyd KE, Parks R, Soderberg KA, Ogbe AT, Cohen MS, Liao HX, Gao F, McMichael AJ, Montefiori DC, Verkoczy L, Kelsoe G, Huang J, Shea PR, Connors M, Borrow P, Haynes BF.

Sci Immunol. 2016 Jul 29;1(1):aag0851. doi: 10.1126/sciimmunol.aag0851. Epub 2016 Jul 29.

8.

No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS.

Abujaber R, Shea PR, McLaren PJ, Lakhi S, Gilmour J, Allen S, Fellay J, Hollox EJ; IAVI Africa HIV Prevention Partnership, Swiss HIV Cohort Study.

Ann Hum Genet. 2017 Jan;81(1):27-34. doi: 10.1111/ahg.12182.

9.

Single Intravenous Dose of Novel Flurbiprofen-Loaded Proniosome Formulations Provides Prolonged Systemic Exposure and Anti-inflammatory Effect.

Verma P, Prajapati SK, Yadav R, Senyschyn D, Shea PR, Trevaskis NL.

Mol Pharm. 2016 Nov 7;13(11):3688-3699. Epub 2016 Sep 29.

PMID:
27632682
10.

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.

McLaren PJ, Coulonges C, Bartha I, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington MN, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, Poli G, Sandhu MS, Schuitemaker H, Shea PR, Theodorou I, Walker BD, Weintrob AC, Winkler CA, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PI, Zagury JF, Fellay J.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14658-63. doi: 10.1073/pnas.1514867112. Epub 2015 Nov 9.

11.

Testing for risk and protective trends in genetic analyses of HIV acquisition.

Mccarthy JM, Shea PR, Goldstein DB, Allen AS.

Biostatistics. 2015 Apr;16(2):268-80. doi: 10.1093/biostatistics/kxu044. Epub 2014 Sep 29.

12.

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.

McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, O'Brien SJ, Pereyra F, Plummer FA, Poli G, Qi Y, Rucart P, Sandhu MS, Shea PR, Schuitemaker H, Theodorou I, Vannberg F, Veldink J, Walker BD, Weintrob A, Winkler CA, Wolinsky S, Telenti A, Goldstein DB, de Bakker PI, Zagury JF, Fellay J.

PLoS Pathog. 2013;9(7):e1003515. doi: 10.1371/journal.ppat.1003515. Epub 2013 Jul 25.

13.

Host genetics of HIV acquisition and viral control.

Shea PR, Shianna KV, Carrington M, Goldstein DB.

Annu Rev Med. 2013;64:203-17. doi: 10.1146/annurev-med-052511-135400. Epub 2012 Sep 27. Review.

14.

Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus.

Fittipaldi N, Beres SB, Olsen RJ, Kapur V, Shea PR, Watkins ME, Cantu CC, Laucirica DR, Jenkins L, Flores AR, Lovgren M, Ardanuy C, Liñares J, Low DE, Tyrrell GJ, Musser JM.

Am J Pathol. 2012 Apr;180(4):1522-34. doi: 10.1016/j.ajpath.2011.12.037. Epub 2012 Feb 11.

PMID:
22330677
15.

Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus.

Olsen RJ, Laucirica DR, Watkins ME, Feske ML, Garcia-Bustillos JR, Vu C, Cantu C, Shelburne SA 3rd, Fittipaldi N, Kumaraswami M, Shea PR, Flores AR, Beres SB, Lovgren M, Tyrrell GJ, Efstratiou A, Low DE, Van Beneden CA, Musser JM.

J Infect Dis. 2012 Jun;205(11):1719-29. doi: 10.1093/infdis/jir825. Epub 2012 Jan 18.

16.

Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010.

Shea PR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Beres SB, Flores AR, Low DE, Willey BM, Musser JM.

Emerg Infect Dis. 2011 Nov;17(11):2010-7. doi: 10.3201/eid1711.110159.

17.

Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.

Carroll RK, Shelburne SA 3rd, Olsen RJ, Suber B, Sahasrabhojane P, Kumaraswami M, Beres SB, Shea PR, Flores AR, Musser JM.

J Clin Invest. 2011 May;121(5):1956-68. doi: 10.1172/JCI45169. Epub 2011 Apr 1.

18.

Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations.

Shea PR, Beres SB, Flores AR, Ewbank AL, Gonzalez-Lugo JH, Martagon-Rosado AJ, Martinez-Gutierrez JC, Rehman HA, Serrano-Gonzalez M, Fittipaldi N, Ayers SD, Webb P, Willey BM, Low DE, Musser JM.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5039-44. doi: 10.1073/pnas.1016282108. Epub 2011 Mar 7.

19.

Lower respiratory tract infection in cynomolgus macaques (Macaca fascicularis) infected with group A Streptococcus.

Olsen RJ, Ashraf M, Gonulal VE, Ayeras AA, Cantu C, Shea PR, Carroll RK, Humbird T, Greaver JL, Swain JL, Chang E, Ragasa W, Jenkins L, Lally KP, Blasdel T, Cagle P, Musser JM.

Microb Pathog. 2010 Dec;49(6):336-47. doi: 10.1016/j.micpath.2010.06.012. Epub 2010 Jul 30.

PMID:
20674736
20.

Interactome analysis of longitudinal pharyngeal infection of cynomolgus macaques by group A Streptococcus.

Shea PR, Virtaneva K, Kupko JJ 3rd, Porcella SF, Barry WT, Wright FA, Kobayashi SD, Carmody A, Ireland RM, Sturdevant DE, Ricklefs SM, Babar I, Johnson CA, Graham MR, Gardner DJ, Bailey JR, Parnell MJ, Deleo FR, Musser JM.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4693-8. doi: 10.1073/pnas.0906384107. Epub 2010 Feb 23.

21.

Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics.

Beres SB, Carroll RK, Shea PR, Sitkiewicz I, Martinez-Gutierrez JC, Low DE, McGeer A, Willey BM, Green K, Tyrrell GJ, Goldman TD, Feldgarden M, Birren BW, Fofanov Y, Boos J, Wheaton WD, Honisch C, Musser JM.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4371-6. doi: 10.1073/pnas.0911295107. Epub 2010 Feb 8.

22.

RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.

Shea PR, Ishwad CS, Bunker CH, Patrick AL, Kuller LH, Ferrell RE.

Prostate. 2008 Mar 1;68(4):354-9. doi: 10.1002/pros.20687.

PMID:
18189233
23.

Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men.

Walsh S, Zmuda JM, Cauley JA, Shea PR, Metter EJ, Hurley BF, Ferrell RE, Roth SM.

J Appl Physiol (1985). 2005 Jan;98(1):132-7. Epub 2004 Sep 17.

24.

Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men.

Roth SM, Zmuda JM, Cauley JA, Shea PR, Ferrell RE.

J Gerontol A Biol Sci Med Sci. 2004 Jan;59(1):10-5.

PMID:
14718481
25.

ELAC2 and prostate cancer risk in Afro-Caribbeans of Tobago.

Shea PR, Ferrell RE, Patrick AL, Kuller LH, Bunker CH.

Hum Genet. 2002 Oct;111(4-5):398-400. Epub 2002 Aug 21.

PMID:
12384782

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