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Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration.

Ali SA, Hanks JE, Stebbins AW, Alkhalili O, Cohen ST, Chen JY, Smith DR, Dumont CM, Shea LD, Hogikyan ND, Feldman EL, Brenner MJ.

Laryngoscope. 2020 Mar 27. doi: 10.1002/lary.28629. [Epub ahead of print]


Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease.

Freitag TL, Podojil JR, Pearson RM, Fokta FJ, Sahl C, Messing M, Andersson LC, Leskinen K, Saavalainen P, Hoover LI, Huang K, Phippard D, Maleki S, King NJC, Shea LD, Miller SD, Meri SK, Getts DR.

Gastroenterology. 2020 Feb 4. pii: S0016-5085(20)30157-8. doi: 10.1053/j.gastro.2020.01.045. [Epub ahead of print]


Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model.

Smith DR, Dumont CM, Park J, Ciciriello AJ, Guo A, Tatineni R, Cummings BJ, Anderson AJ, Shea LD.

Tissue Eng Part A. 2020 Feb 25. doi: 10.1089/ten.TEA.2019.0321. [Epub ahead of print]


Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial properties.

Dye BR, Youngblood RL, Oakes RS, Kasputis T, Clough DW, Spence JR, Shea LD.

Biomaterials. 2020 Mar;234:119757. doi: 10.1016/j.biomaterials.2020.119757. Epub 2020 Jan 6.


Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development.

Bernabé BP, Woodruff T, Broadbelt LJ, Shea LD.

Reprod Sci. 2020 Feb;27(2):690-703. doi: 10.1007/s43032-019-00075-8. Epub 2020 Jan 14.


Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes.

Oakes RS, Bushnell GG, Orbach SM, Kandagatla P, Zhang Y, Morris AH, Hall MS, LaFaire P, Decker JT, Hartfield RM, Brooks MD, Wicha MS, Jeruss JS, Shea LD.

Cancer Res. 2020 Feb 1;80(3):602-612. doi: 10.1158/0008-5472.CAN-19-1932. Epub 2019 Oct 29.


High Frequency Spectral Ultrasound Imaging to Detect Metastasis in Implanted Biomaterial Scaffolds.

Bushnell GG, Hong X, Hartfield RM, Zhang Y, Oakes RS, Rao SS, Jeruss JS, Stegemann JP, Deng CX, Shea LD.

Ann Biomed Eng. 2020 Jan;48(1):477-489. doi: 10.1007/s10439-019-02366-2. Epub 2019 Sep 23.


Microporous scaffolds loaded with immunomodulatory lentivirus to study the contribution of immune cell populations to tumor cell recruitment in vivo.

Bushnell GG, Rao SS, Hartfield RM, Zhang Y, Oakes RS, Jeruss JS, Shea LD.

Biotechnol Bioeng. 2020 Jan;117(1):210-222. doi: 10.1002/bit.27179. Epub 2019 Oct 3.


Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease.

Saito E, Kuo R, Kramer KR, Gohel N, Giles DA, Moore BB, Miller SD, Shea LD.

Biomaterials. 2019 Nov;222:119432. doi: 10.1016/j.biomaterials.2019.119432. Epub 2019 Aug 17.


Cargo-less nanoparticles program innate immune cell responses to toll-like receptor activation.

Casey LM, Kakade S, Decker JT, Rose JA, Deans K, Shea LD, Pearson RM.

Biomaterials. 2019 Oct;218:119333. doi: 10.1016/j.biomaterials.2019.119333. Epub 2019 Jul 4.


Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury.

Park J, Zhang Y, Saito E, Gurczynski SJ, Moore BB, Cummings BJ, Anderson AJ, Shea LD.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14947-14954. doi: 10.1073/pnas.1820276116. Epub 2019 Jul 8.


Microporous scaffolds support assembly and differentiation of pancreatic progenitors into β-cell clusters.

Youngblood RL, Sampson JP, Lebioda KR, Shea LD.

Acta Biomater. 2019 Sep 15;96:111-122. doi: 10.1016/j.actbio.2019.06.032. Epub 2019 Jun 25.


Dynamic genome-scale cell-specific metabolic models reveal novel inter-cellular and intra-cellular metabolic communications during ovarian follicle development.

Peñalver Bernabé B, Thiele I, Galdones E, Siletz A, Chandrasekaran S, Woodruff TK, Broadbelt LJ, Shea LD.

BMC Bioinformatics. 2019 Jun 10;20(1):307. doi: 10.1186/s12859-019-2825-2.


Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model.

Shah S, Daneshmandi S, Hughes KR, Yu S, Bedoya AM, Shea LD, Luo X.

Biomaterials. 2019 Jul;210:70-82. doi: 10.1016/j.biomaterials.2019.04.030. Epub 2019 May 1.


Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation.

Saito E, Kuo R, Pearson RM, Gohel N, Cheung B, King NJC, Miller SD, Shea LD.

J Control Release. 2019 Apr 28;300:185-196. doi: 10.1016/j.jconrel.2019.02.025. Epub 2019 Feb 27.


Biomaterial Scaffolds Recruit an Aggressive Population of Metastatic Tumor Cells In Vivo.

Bushnell GG, Hardas TP, Hartfield RM, Zhang Y, Oakes RS, Ronquist S, Chen H, Rajapakse I, Wicha MS, Jeruss JS, Shea LD.

Cancer Res. 2019 Apr 15;79(8):2042-2053. doi: 10.1158/0008-5472.CAN-18-2502. Epub 2019 Feb 26.


Generation of lung organoids from human pluripotent stem cells in vitro.

Miller AJ, Dye BR, Ferrer-Torres D, Hill DR, Overeem AW, Shea LD, Spence JR.

Nat Protoc. 2019 Feb;14(2):518-540. doi: 10.1038/s41596-018-0104-8.


Aligned hydrogel tubes guide regeneration following spinal cord injury.

Dumont CM, Carlson MA, Munsell MK, Ciciriello AJ, Strnadova K, Park J, Cummings BJ, Anderson AJ, Shea LD.

Acta Biomater. 2019 Mar 1;86:312-322. doi: 10.1016/j.actbio.2018.12.052. Epub 2019 Jan 2.


Localized immune tolerance from FasL-functionalized PLG scaffolds.

Skoumal M, Woodward KB, Zhao H, Wang F, Yolcu ES, Pearson RM, Hughes KR, García AJ, Shea LD, Shirwan H.

Biomaterials. 2019 Feb;192:271-281. doi: 10.1016/j.biomaterials.2018.11.015. Epub 2018 Nov 13.


Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles.

Pearson RM, Podojil JR, Shea LD, King NJC, Miller SD, Getts DR.

Nanomedicine. 2019 Jun;18:282-291. doi: 10.1016/j.nano.2018.10.001. Epub 2018 Oct 21. Review.


Microporous Polymer Scaffolds for the Transplantation of Embryonic Stem Cell Derived Pancreatic Progenitors to a Clinically Translatable Site for the Treatment of Type I Diabetes.

Kasputis T, Clough D, Noto F, Rychel K, Dye B, Shea LD.

ACS Biomater Sci Eng. 2018 May 14;4(5):1770-1778. doi: 10.1021/acsbiomaterials.7b00912. Epub 2018 Apr 17.


Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury.

Park J, Decker JT, Smith DR, Cummings BJ, Anderson AJ, Shea LD.

J Control Release. 2018 Nov 28;290:88-101. doi: 10.1016/j.jconrel.2018.10.003. Epub 2018 Oct 6.


Combinatorial lentiviral gene delivery of pro-oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury.

Smith DR, Margul DJ, Dumont CM, Carlson MA, Munsell MK, Johnson M, Cummings BJ, Anderson AJ, Shea LD.

Biotechnol Bioeng. 2019 Jan;116(1):155-167. doi: 10.1002/bit.26838. Epub 2018 Oct 27.


Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury.

Dumont CM, Munsell MK, Carlson MA, Cummings BJ, Anderson AJ, Shea LD.

Tissue Eng Part A. 2018 Nov;24(21-22):1588-1602. doi: 10.1089/ten.TEA.2018.0053. Epub 2018 Oct 19.


Design of Large-Scale Reporter Construct Arrays for Dynamic, Live Cell Systems Biology.

Decker JT, Hall MS, Peñalver-Bernabé B, Blaisdell RB, Liebman LN, Jeruss JS, Shea LD.

ACS Synth Biol. 2018 Sep 21;7(9):2063-2073. doi: 10.1021/acssynbio.8b00236. Epub 2018 Sep 10.


Correction to: Synergy of Paracrine Signaling During Early-Stage Mouse Ovarian Follicle Development In Vitro.

Zhou H, Decker JT, Lemke MM, Tomaszewski CE, Shea LD, Arnold KB, Shikanov A.

Cell Mol Bioeng. 2018 Aug 21;11(6):537. doi: 10.1007/s12195-018-0550-y. eCollection 2018 Dec.


It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies.

Youngblood RL, Truong NF, Segura T, Shea LD.

Mol Ther. 2018 Sep 5;26(9):2087-2106. doi: 10.1016/j.ymthe.2018.07.022. Epub 2018 Aug 4. Review.


Synergy of Paracrine Signaling During Early-Stage Mouse Ovarian Follicle Development In Vitro.

Zhou H, Decker JT, Lemke MM, Tomaszewski CE, Shea LD, Arnold KB, Shikanov A.

Cell Mol Bioeng. 2018 Aug 9;11(5):435-450. doi: 10.1007/s12195-018-0545-8. eCollection 2018 Oct. Erratum in: Cell Mol Bioeng. 2018 Aug 21;11(6):537.


Durable targeting of B-lymphocytes in living mice.

Cascalho M, Huynh D, Lefferts AR, Stein L, Lanigan T, Decker J, Shea LD, Platt JL.

Sci Rep. 2018 Jul 24;8(1):11143. doi: 10.1038/s41598-018-29452-0.


Dynamic microRNA activity identifies therapeutic targets in trastuzumab-resistant HER2+ breast cancer.

Decker JT, Hall MS, Blaisdell RB, Schwark K, Jeruss JS, Shea LD.

Biotechnol Bioeng. 2018 Oct;115(10):2613-2623. doi: 10.1002/bit.26791. Epub 2018 Aug 2.


Feasibility study on mouse live imaging after spinal cord injury and poly(lactide-co-glycolide) bridge implantation.

Anzalone A, Chacko JV, Nishi RA, Dumont C, Smith D, Shea LD, Digman MA, Cummings BJ, Anderson AJ.

J Biomed Opt. 2018 Jun;23(6):1-6. doi: 10.1117/1.JBO.23.6.065007.


Evaluation of encapsulating and microporous nondegradable hydrogel scaffold designs on islet engraftment in rodent models of diabetes.

Rios PD, Skoumal M, Liu J, Youngblood R, Kniazeva E, Garcia AJ, Shea LD.

Biotechnol Bioeng. 2018 Sep;115(9):2356-2364. doi: 10.1002/bit.26741. Epub 2018 Jun 25.


Evaluation of biomaterial scaffold delivery of IL-33 as a localized immunomodulatory agent to support cell transplantation in adipose tissue.

Liu JMH, Zhang X, Joe S, Luo X, Shea LD.

J Immunol Regen Med. 2018 Mar;1:1-12. doi: 10.1016/j.regen.2018.01.003. Epub 2018 Feb 22.


Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury.

Park J, Decker JT, Margul DJ, Smith DR, Cummings BJ, Anderson AJ, Shea LD.

Mol Ther. 2018 Jul 5;26(7):1756-1770. doi: 10.1016/j.ymthe.2018.04.022. Epub 2018 Apr 27.


Retrievable hydrogels for ovarian follicle transplantation and oocyte collection.

Rios PD, Kniazeva E, Lee HC, Xiao S, Oakes RS, Saito E, Jeruss JS, Shikanov A, Woodruff TK, Shea LD.

Biotechnol Bioeng. 2018 Aug;115(8):2075-2086. doi: 10.1002/bit.26721. Epub 2018 May 14.


Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment.

Aguado BA, Hartfield RM, Bushnell GG, Decker JT, Azarin SM, Nanavati D, Schipma MJ, Rao SS, Oakes RS, Zhang Y, Jeruss JS, Shea LD.

Adv Healthc Mater. 2018 May;7(10):e1700903. doi: 10.1002/adhm.201700903. Epub 2018 Mar 9.


Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells.

Prasad S, Neef T, Xu D, Podojil JR, Getts DR, Shea LD, Miller SD.

J Autoimmun. 2018 May;89:112-124. doi: 10.1016/j.jaut.2017.12.010. Epub 2017 Dec 16.


Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone.

Roca H, Jones JD, Purica MC, Weidner S, Koh AJ, Kuo R, Wilkinson JE, Wang Y, Daignault-Newton S, Pienta KJ, Morgan TM, Keller ET, Nör JE, Shea LD, McCauley LK.

J Clin Invest. 2018 Jan 2;128(1):248-266. doi: 10.1172/JCI92466. Epub 2017 Nov 27.


Conjugation of Transforming Growth Factor Beta to Antigen-Loaded Poly(lactide- co-glycolide) Nanoparticles Enhances Efficiency of Antigen-Specific Tolerance.

Casey LM, Pearson RM, Hughes KR, Liu JMH, Rose JA, North MG, Wang LZ, Lei M, Miller SD, Shea LD.

Bioconjug Chem. 2018 Mar 21;29(3):813-823. doi: 10.1021/acs.bioconjchem.7b00624. Epub 2017 Nov 30.


Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer.

Rao SS, Stoehr J, Dokic D, Wan L, Decker JT, Konopka K, Thomas AL, Wu J, Kaklamani VG, Shea LD, Jeruss JS.

Oncotarget. 2017 Aug 10;8(48):83925-83939. doi: 10.18632/oncotarget.20202. eCollection 2017 Oct 13.


Embryonic stem cell secreted factors decrease invasiveness of triple-negative breast cancer cells through regulome modulation.

Tarasewicz E, Oakes RS, Aviles MO, Straehla J, Chilton KM, Decker JT, Wu J, Shea LD, Jeruss JS.

Cancer Biol Ther. 2018 Apr 3;19(4):271-281. doi: 10.1080/15384047.2017.1385681. Epub 2018 Mar 13.


Engineering the pre-metastatic niche.

Aguado BA, Bushnell GG, Rao SS, Jeruss JS, Shea LD.

Nat Biomed Eng. 2017;1. pii: 0077. doi: 10.1038/s41551-017-0077. Epub 2017 Jun 13.


Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites.

Weaver JD, Headen DM, Aquart J, Johnson CT, Shea LD, Shirwan H, García AJ.

Sci Adv. 2017 Jun 2;3(6):e1700184. doi: 10.1126/sciadv.1700184. eCollection 2017 Jun.


Phosphate regulates chondrogenesis in a biphasic and maturation-dependent manner.

Wu B, Durisin EK, Decker JT, Ural EE, Shea LD, Coleman RM.

Differentiation. 2017 May - Jun;95:54-62. doi: 10.1016/j.diff.2017.04.002. Epub 2017 May 8.


Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates.

Pearson RM, Casey LM, Hughes KR, Wang LZ, North MG, Getts DR, Miller SD, Shea LD.

Mol Ther. 2017 Jul 5;25(7):1655-1664. doi: 10.1016/j.ymthe.2017.04.015. Epub 2017 May 5.


Advances in islet encapsulation technologies.

Desai T, Shea LD.

Nat Rev Drug Discov. 2017 Apr 28;16(5):367. doi: 10.1038/nrd.2017.67. No abstract available.


In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance.

Pearson RM, Casey LM, Hughes KR, Miller SD, Shea LD.

Adv Drug Deliv Rev. 2017 May 15;114:240-255. doi: 10.1016/j.addr.2017.04.005. Epub 2017 Apr 14. Review.


Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance.

Kuo R, Saito E, Miller SD, Shea LD.

Mol Ther. 2017 Jul 5;25(7):1676-1685. doi: 10.1016/j.ymthe.2017.03.032. Epub 2017 Apr 10.


Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells.

Decker JT, Hobson EC, Zhang Y, Shin S, Thomas AL, Jeruss JS, Arnold KB, Shea LD.

Biotechnol Bioeng. 2017 Sep;114(9):2085-2095. doi: 10.1002/bit.26293. Epub 2017 May 18.


Advances in islet encapsulation technologies.

Desai T, Shea LD.

Nat Rev Drug Discov. 2017 May;16(5):338-350. doi: 10.1038/nrd.2016.232. Epub 2016 Dec 23. Review. Erratum in: Nat Rev Drug Discov. 2017 Apr 28;16(5):367.


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