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Items: 28

1.

New anthra[2,3-b]furancarboxamides: A role of positioning of the carboxamide moiety in antitumor properties.

Volodina YL, Dezhenkova LG, Tikhomirov AS, Tatarskiy VV, Kaluzhny DN, Moisenovich AM, Moisenovich MM, Isagulieva AK, Shtil AA, Tsvetkov VB, Shchekotikhin AE.

Eur J Med Chem. 2019 Jan 8;165:31-45. doi: 10.1016/j.ejmech.2018.12.068. [Epub ahead of print]

PMID:
30659997
2.

Draft Genome Sequence of Streptomyces xinghaiensis (fradiae) OlgR, a Strain Resistant to Oligomycin A.

Bekker OB, Vatlin AA, Zakharevich NV, Lysenkova LN, Shchekotikhin AE, Danilenko VN.

Microbiol Resour Announc. 2019 Jan 10;8(2). pii: e01531-18. doi: 10.1128/MRA.01531-18. eCollection 2019 Jan.

3.

Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties.

Tikhomirov AS, Tsvetkov VB, Kaluzhny DN, Volodina YL, Zatonsky GV, Schols D, Shchekotikhin AE.

Eur J Med Chem. 2018 Nov 5;159:59-73. doi: 10.1016/j.ejmech.2018.09.054. Epub 2018 Sep 22.

PMID:
30268824
4.

Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties.

Olsufyeva EN, Shchekotikhin AE, Bychkova EN, Pereverzeva ER, Treshalin ID, Mirchink EP, Isakova EB, Chernobrovkin MG, Kozlov RS, Dekhnich AV, Preobrazhenskaya MN.

Drug Des Devel Ther. 2018 Sep 10;12:2875-2885. doi: 10.2147/DDDT.S173923. eCollection 2018.

5.

Semi-Synthetic Derivatives of Heliomycin with an Antiproliferative Potency.

Nadysev GY, Tikhomirov AS, Dezhenkova LG, Shchekotikhin AE.

Recent Pat Anticancer Drug Discov. 2018 Oct 3;13(4):469-472. doi: 10.2174/1574892813666180723150542. Review.

PMID:
30039764
6.

A functional study of the global transcriptional regulator PadR from a strain Streptomyces fradiae-nitR+bld, resistant to nitrone-oligomycin.

Vatlin AA, Bekker OB, Lysenkova LN, Shchekotikhin AE, Danilenko VN.

J Basic Microbiol. 2018 Sep;58(9):739-746. doi: 10.1002/jobm.201800095. Epub 2018 Jul 2.

PMID:
29963725
7.

Novel Quinoxaline-2-Carbonitrile-1,4-Dioxide Derivatives Suppress HIF1α Activity and Circumvent MDR in Cancer Cells.

Scherbakov AM, Borunov AM, Buravchenko GI, Andreeva OE, Kudryavtsev IA, Dezhenkova LG, Shchekotikhin AE.

Cancer Invest. 2018 Mar 16;36(3):199-209. doi: 10.1080/07357907.2018.1453072. Epub 2018 Apr 6.

PMID:
29624460
8.

New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship.

Tikhomirov AS, Lin CY, Volodina YL, Dezhenkova LG, Tatarskiy VV, Schols D, Shtil AA, Kaur P, Chueh PJ, Shchekotikhin AE.

Eur J Med Chem. 2018 Mar 25;148:128-139. doi: 10.1016/j.ejmech.2018.02.027. Epub 2018 Feb 10.

PMID:
29459273
9.

Advances in the Discovery of Anthraquinone-Based Anticancer Agents.

Tikhomirov AS, Shtil AA, Shchekotikhin AE.

Recent Pat Anticancer Drug Discov. 2018;13(2):159-183. doi: 10.2174/1574892813666171206123114. Review.

PMID:
29210664
10.

Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.

Nadysev GY, Tikhomirov AS, Lin MH, Yang YT, Dezhenkova LG, Chen HY, Kaluzhny DN, Schols D, Shtil AA, Shchekotikhin AE, Chueh PJ.

Eur J Med Chem. 2018 Jan 1;143:1553-1562. doi: 10.1016/j.ejmech.2017.10.055. Epub 2017 Oct 19.

PMID:
29137865
11.

Development and pharmaceutical evaluation of the anticancer Anthrafuran/Cavitron complex, a prototypic parenteral drug formulation.

Treshalina HM, Romanenko VI, Kaluzhny DN, Treshalin MI, Nikitin AA, Tikhomirov AS, Shchekotikhin AE.

Eur J Pharm Sci. 2017 Nov 15;109:631-637. doi: 10.1016/j.ejps.2017.09.025. Epub 2017 Sep 18.

PMID:
28927751
12.

Verification of oligomycin A structure: synthesis and biological evaluation of 33-dehydrooligomycin A.

Lysenkova LN, Saveljev OY, Grammatikova NE, Tsvetkov VB, Bekker OB, Danilenko VN, Dezhenkova LG, Bykov EE, Omelchuk OA, Korolev AM, Shchekotikhin AE.

J Antibiot (Tokyo). 2017 Jul;70(8):871-877. doi: 10.1038/ja.2017.48. Epub 2017 Apr 19.

PMID:
28420869
13.

[Sequencing and analysis of the resistome of Streptomyces fradiae ATCC19609 in order to develop a test system for screening of new antimicrobial agents].

Vatlin AA, Bekker OB, Lysenkova LN, Korolev AM, Shchekotikhin AE, Danilenko VN.

Genetika. 2016 Jun;52(6):723-7. Russian.

PMID:
29368834
14.

Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.

Shchekotikhin AE, Dezhenkova LG, Tsvetkov VB, Luzikov YN, Volodina YL, Tatarskiy VV Jr, Kalinina AA, Treshalin MI, Treshalina HM, Romanenko VI, Kaluzhny DN, Kubbutat M, Schols D, Pommier Y, Shtil AA, Preobrazhenskaya MN.

Eur J Med Chem. 2016 Apr 13;112:114-129. doi: 10.1016/j.ejmech.2016.01.050. Epub 2016 Feb 4.

PMID:
26890118
15.

Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.

Tikhomirov AS, Shchekotikhin AE, Lee YH, Chen YA, Yeh CA, Tatarskiy VV Jr, Dezhenkova LG, Glazunova VA, Balzarini J, Shtil AA, Preobrazhenskaya MN, Chueh PJ.

J Med Chem. 2015 Dec 24;58(24):9522-34. doi: 10.1021/acs.jmedchem.5b00859. Epub 2015 Dec 15.

PMID:
26633734
16.

Potent Apoptotic Response Induced by Chloroacetamidine Anthrathiophenediones in Bladder Cancer Cells.

Cogoi S, Zorzet S, Shchekotikhin AE, Xodo LE.

J Med Chem. 2015 Jul 23;58(14):5476-85. doi: 10.1021/acs.jmedchem.5b00409. Epub 2015 Jun 30.

17.

Synthesis and evaluation of new antitumor 3-aminomethyl-4,11-dihydroxynaphtho[2,3-f]indole-5,10-diones.

Shchekotikhin AE, Glazunova VA, Dezhenkova LG, Luzikov YN, Buyanov VN, Treshalina HM, Lesnaya NA, Romanenko VI, Kaluzhny DN, Balzarini J, Agama K, Pommier Y, Shtil AA, Preobrazhenskaya MN.

Eur J Med Chem. 2014 Oct 30;86:797-805. doi: 10.1016/j.ejmech.2014.09.021. Epub 2014 Sep 8.

PMID:
25244612
18.

Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties.

Ilyinsky NS, Shchyolkina AK, Borisova OF, Mamaeva OK, Zvereva MI, Azhibek DM, Livshits MA, Mitkevich VA, Balzarini J, Sinkevich YB, Luzikov YN, Dezhenkova LG, Kolotova ES, Shtil AA, Shchekotikhin AE, Kaluzhny DN.

Eur J Med Chem. 2014 Oct 6;85:605-14. doi: 10.1016/j.ejmech.2014.08.030. Epub 2014 Aug 8.

PMID:
25127152
19.

HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property.

Cogoi S, Shchekotikhin AE, Xodo LE.

Nucleic Acids Res. 2014 Jul;42(13):8379-88. doi: 10.1093/nar/gku574. Epub 2014 Jul 10.

20.

Guanidino anthrathiophenediones as G-quadruplex binders: uptake, intracellular localization, and anti-Harvey-Ras gene activity in bladder cancer cells.

Cogoi S, Shchekotikhin AE, Membrino A, Sinkevich YB, Xodo LE.

J Med Chem. 2013 Apr 11;56(7):2764-78. doi: 10.1021/jm3019063. Epub 2013 Mar 21.

PMID:
23458775
21.

The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics.

Shchekotikhin AE, Glazunova VA, Dezhenkova LG, Shevtsova EK, Traven' VF, Balzarini J, Huang HS, Shtil AA, Preobrazhenskaya MN.

Eur J Med Chem. 2011 Jan;46(1):423-8. doi: 10.1016/j.ejmech.2010.11.017. Epub 2010 Nov 19.

PMID:
21144624
22.

Synthesis and cytotoxic properties of 4,11-bis[(aminoethyl)amino]anthra[2,3-b]thiophene-5,10-diones, novel analogues of antitumor anthracene-9,10-diones.

Shchekotikhin AE, Glazunova VA, Dezhenkova LG, Luzikov YN, Sinkevich YB, Kovalenko LV, Buyanov VN, Balzarini J, Huang FC, Lin JJ, Huang HS, Shtil AA, Preobrazhenskaya MN.

Bioorg Med Chem. 2009 Mar 1;17(5):1861-9. doi: 10.1016/j.bmc.2009.01.047. Epub 2009 Jan 27.

PMID:
19208482
23.

Naphtho[2,3-f]indole-5,10-dione aminoalkyl derivatives: a new class of topoisomerase I inhibitors.

Dezhenkova LG, Susova OY, Shchekotikhin AE, Preobrazhenskaya MN, Shtil AA.

Bull Exp Biol Med. 2008 Mar;145(3):334-7.

PMID:
19039937
24.

Naphthoindole-based analogues of tryptophan and tryptamine: synthesis and cytotoxic properties.

Shchekotikhin AE, Dezhenkova LG, Susova OY, Glazunova VA, Luzikov YN, Sinkevich YB, Buyanov VN, Shtil AA, Preobrazhenskaya MN.

Bioorg Med Chem. 2007 Apr 1;15(7):2651-9. Epub 2007 Jan 23.

PMID:
17276690
25.

Synthesis and structure-activity relationship studies of 4,11-diaminonaphtho[2,3-f]indole-5,10-diones.

Shchekotikhin AE, Glazunova VA, Luzikov YN, Buyanov VN, Susova OY, Shtil AA, Preobrazhenskaya MN.

Bioorg Med Chem. 2006 Aug 1;14(15):5241-51. Epub 2006 May 2.

PMID:
16631372
26.

3-Aminomethyl derivatives of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione for circumvention of anticancer drug resistance.

Shchekotikhin AE, Shtil AA, Luzikov YN, Bobrysheva TV, Buyanov VN, Preobrazhenskaya MN.

Bioorg Med Chem. 2005 Mar 15;13(6):2285-91.

PMID:
15727877
27.

Synthesis of 1-(omega-aminoalkyl)naphthoindolediones with antiproliferative properties.

Shchekotikhin AE, Buyanov VN, Preobrazhenskaya MN.

Bioorg Med Chem. 2004 Jul 15;12(14):3923-30.

PMID:
15210159
28.

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.

Pearlstein RA, Vaz RJ, Kang J, Chen XL, Preobrazhenskaya M, Shchekotikhin AE, Korolev AM, Lysenkova LN, Miroshnikova OV, Hendrix J, Rampe D.

Bioorg Med Chem Lett. 2003 May 19;13(10):1829-35.

PMID:
12729675

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