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Items: 42

1.

Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP Efflux.

Carozzo A, Yaneff A, Gómez N, Di Siervi N, Sahores A, Diez F, Attorresi AI, Rodríguez-González Á, Monczor F, Fernández N, Abba M, Shayo C, Davio C.

Mol Pharmacol. 2019 Jul;96(1):13-25. doi: 10.1124/mol.118.115444. Epub 2019 May 1.

PMID:
31043460
2.

Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation.

Díaz Nebreda A, Zappia CD, Rodríguez González A, Sahores A, Sosa M, Burghi V, Monczor F, Davio C, Fernández N, Shayo C.

Eur J Pharmacol. 2019 Mar 15;847:42-52. doi: 10.1016/j.ejphar.2019.01.026. Epub 2019 Jan 24.

PMID:
30685431
3.

MRP4/ABCC4 As a New Therapeutic Target: Meta-Analysis to Determine cAMP Binding Sites as a Tool for Drug Design.

Yaneff A, Sahores A, Gómez N, Carozzo A, Shayo C, Davio C.

Curr Med Chem. 2019;26(7):1270-1307. doi: 10.2174/0929867325666171229133259. Review.

PMID:
29284392
4.

Effect of mutation of Phe 2436.44 of the histamine H2 receptor on cimetidine and ranitidine mechanism of action.

Granja-Galeano G, Zappia CD, Fabián L, Davio C, Shayo C, Fernández N, Monczor F.

Biochem Pharmacol. 2017 Dec 15;146:117-126. doi: 10.1016/j.bcp.2017.09.014. Epub 2017 Sep 28.

PMID:
28962836
5.

Histamine H2 Receptor in Blood Cells: A Suitable Target for the Treatment of Acute Myeloid Leukemia.

Monczor F, Copsel S, Fernandez N, Davio C, Shayo C.

Handb Exp Pharmacol. 2017;241:141-160. doi: 10.1007/164_2016_8. Review.

PMID:
27316911
6.

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells.

Alonso N, Diaz Nebreda A, Monczor F, Gutkind JS, Davio C, Fernandez N, Shayo C.

Biochim Biophys Acta. 2016 Sep;1860(9):1998-2007. doi: 10.1016/j.bbagen.2016.06.016. Epub 2016 Jun 15.

PMID:
27316323
7.

Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways.

Zappia CD, Granja-Galeano G, Fernández N, Shayo C, Davio C, Fitzsimons CP, Monczor F.

Sci Rep. 2015 Dec 4;5:17476. doi: 10.1038/srep17476.

8.

G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound.

Cabrera M, Gomez N, Remes Lenicov F, Echeverría E, Shayo C, Moglioni A, Fernández N, Davio C.

PLoS One. 2015 Sep 11;10(9):e0136878. doi: 10.1371/journal.pone.0136878. eCollection 2015.

9.

Physiological implications of biased signaling at histamine H2 receptors.

Alonso N, Zappia CD, Cabrera M, Davio CA, Shayo C, Monczor F, Fernández NC.

Front Pharmacol. 2015 Mar 10;6:45. doi: 10.3389/fphar.2015.00045. eCollection 2015.

10.

Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines.

Carozzo A, Diez F, Gomez N, Cabrera M, Shayo C, Davio C, Fernández N.

PLoS One. 2015 Mar 19;10(3):e0120651. doi: 10.1371/journal.pone.0120651. eCollection 2015.

11.

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia.

Copsel S, Bruzzone A, May M, Beyrath J, Wargon V, Cany J, Russel FG, Shayo C, Davio C.

Oncotarget. 2014 Oct 15;5(19):9308-21.

12.

Signal transduction mechanism of biased ligands at histamine H2 receptors.

Alonso N, Monczor F, Echeverría E, Davio C, Shayo C, Fernández N.

Biochem J. 2014 Apr 1;459(1):117-26. doi: 10.1042/BJ20131226.

PMID:
24417223
13.

Antihistaminergics and inverse agonism: potential therapeutic applications.

Monczor F, Fernandez N, Fitzsimons CP, Shayo C, Davio C.

Eur J Pharmacol. 2013 Sep 5;715(1-3):26-32. doi: 10.1016/j.ejphar.2013.06.027. Epub 2013 Jul 4. Review.

PMID:
23831018
14.

Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor.

Vázquez R, Riveiro ME, Mondillo C, Perazzo JC, Vermeulen M, Baldi A, Davio C, Shayo C.

Biochem Pharmacol. 2013 Jul 15;86(2):210-21. doi: 10.1016/j.bcp.2013.04.021. Epub 2013 May 9.

PMID:
23665351
15.

Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.

Alonso N, Fernandez N, Notcovich C, Monczor F, Simaan M, Baldi A, Gutkind JS, Davio C, Shayo C.

Mol Pharmacol. 2013 May;83(5):1087-98. doi: 10.1124/mol.112.083394. Epub 2013 Mar 5.

16.

Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.

Vázquez R, Riveiro ME, Vermeulen M, Alonso E, Mondillo C, Facorro G, Piehl L, Gómez N, Moglioni A, Fernández N, Baldi A, Shayo C, Davio C.

Bioorg Med Chem. 2012 Sep 15;20(18):5537-49. doi: 10.1016/j.bmc.2012.07.043. Epub 2012 Aug 2.

PMID:
22925447
17.

Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells.

Vázquez R, Riveiro ME, Vermeulen M, Mondillo C, Coombes PH, Crouch NR, Ismail F, Mulholland DA, Baldi A, Shayo C, Davio C.

Phytomedicine. 2012 Jun 15;19(8-9):737-46. doi: 10.1016/j.phymed.2012.03.008. Epub 2012 Apr 25.

PMID:
22537907
18.

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.

Fernandez N, Gottardo FL, Alonso MN, Monczor F, Shayo C, Davio C.

J Biol Chem. 2011 Aug 19;286(33):28697-706. doi: 10.1074/jbc.M111.269613. Epub 2011 Jun 24.

19.

Synthesis, structural characterization, and pro-apoptotic activity of 1-indanone thiosemicarbazone platinum(II) and palladium(II) complexes: potential as antileukemic agents.

Gómez N, Santos D, Vázquez R, Suescun L, Mombrú A, Vermeulen M, Finkielsztein L, Shayo C, Moglioni A, Gambino D, Davio C.

ChemMedChem. 2011 Aug 1;6(8):1485-94. doi: 10.1002/cmdc.201100060. Epub 2011 May 23.

PMID:
21608131
20.

Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation.

Copsel S, Garcia C, Diez F, Vermeulem M, Baldi A, Bianciotti LG, Russel FG, Shayo C, Davio C.

J Biol Chem. 2011 Mar 4;286(9):6979-88. doi: 10.1074/jbc.M110.166868. Epub 2011 Jan 4.

21.

Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: experimental evidence for a spontaneous GPCR constitutive inactive form.

Tubio MR, Fernandez N, Fitzsimons CP, Copsel S, Santiago S, Shayo C, Davio C, Monczor F.

J Biol Chem. 2010 May 14;285(20):14990-8. doi: 10.1074/jbc.M109.099689. Epub 2010 Mar 18.

22.

Coumarins: old compounds with novel promising therapeutic perspectives.

Riveiro ME, De Kimpe N, Moglioni A, Vázquez R, Monczor F, Shayo C, Davio C.

Curr Med Chem. 2010;17(13):1325-38. Review.

PMID:
20166938
23.

Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways.

Notcovich C, Diez F, Tubio MR, Baldi A, Kazanietz MG, Davio C, Shayo C.

Exp Cell Res. 2010 Feb 1;316(3):401-11. doi: 10.1016/j.yexcr.2009.11.002. Epub 2009 Nov 11.

PMID:
19913013
24.

Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells.

Riveiro ME, Maes D, Vázquez R, Vermeulen M, Mangelinckx S, Jacobs J, Debenedetti S, Shayo C, De Kimpe N, Davio C.

Bioorg Med Chem. 2009 Sep 15;17(18):6547-59. doi: 10.1016/j.bmc.2009.08.002. Epub 2009 Aug 8.

PMID:
19716307
25.

Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization.

Fernandez N, Monczor F, Baldi A, Davio C, Shayo C.

Mol Pharmacol. 2008 Oct;74(4):1109-18. doi: 10.1124/mol.108.045336. Epub 2008 Jul 10.

PMID:
18617631
26.

Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells.

Riveiro ME, Moglioni A, Vazquez R, Gomez N, Facorro G, Piehl L, de Celis ER, Shayo C, Davio C.

Bioorg Med Chem. 2008 Mar 1;16(5):2665-75. Epub 2007 Nov 19.

PMID:
18060791
27.

Biochemical mechanisms underlying the pro-apoptotic activity of 7,8-dihydroxy-4-methylcoumarin in human leukemic cells.

Riveiro ME, Vazquez R, Moglioni A, Gomez N, Baldi A, Davio C, Shayo C.

Biochem Pharmacol. 2008 Feb 1;75(3):725-36. Epub 2007 Oct 5.

PMID:
17996847
28.

Regulatory mechanisms underlying GKR2 levels in U937 cells: evidence for GRK3 involvement.

Fernandez N, Monczor F, Tubio MR, Shayo C, Davio C.

Biochem Pharmacol. 2007 Jun 1;73(11):1758-67. Epub 2007 Jan 18.

PMID:
17433264
29.

Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling.

Monczor F, Fernandez N, Riveiro E, Mladovan A, Baldi A, Shayo C, Davio C.

Biochem Pharmacol. 2006 Apr 14;71(8):1219-28. Epub 2006 Feb 3.

PMID:
16458858
30.

Mepyramine, a histamine H1 receptor inverse agonist, binds preferentially to a G protein-coupled form of the receptor and sequesters G protein.

Fitzsimons CP, Monczor F, Fernández N, Shayo C, Davio C.

J Biol Chem. 2004 Aug 13;279(33):34431-9. Epub 2004 Jun 10.

31.

Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum.

Riveiro ME, Shayo C, Monczor F, Fernández N, Baldi A, De Kimpe N, Rossi J, Debenedetti S, Davio C.

Cancer Lett. 2004 Jul 16;210(2):179-88.

PMID:
15183533
32.

The time-course of cyclic AMP signaling is critical for leukemia U-937 cell differentiation.

Shayo C, Legnazzi BL, Monczor F, Fernández N, Riveiro ME, Baldi A, Davio C.

Biochem Biophys Res Commun. 2004 Feb 13;314(3):798-804.

PMID:
14741706
33.
34.

Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation.

Fernández N, Monczor F, Lemos B, Notcovich C, Baldi A, Davio C, Shayo C.

Mol Pharmacol. 2002 Dec;62(6):1506-14.

PMID:
12435819
35.

H1 and H2 histamine receptors mediate the production of inositol phosphates but not cAMP in human breast epithelial cells.

Davio C, Mladovan A, Lemos B, Monczor F, Shayo C, Rivera E, Baldi A.

Inflamm Res. 2002 Jan;51(1):1-7.

PMID:
11845995
36.

Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases.

Shayo C, Fernandez N, Legnazzi BL, Monczor F, Mladovan A, Baldi A, Davio C.

Mol Pharmacol. 2001 Nov;60(5):1049-56.

PMID:
11641433
37.

Rapid desensitization and slow recovery of the cyclic AMP response mediated by histamine H(2) receptors in the U937 cell line.

Lemos Legnazzi B, Shayo C, Monczor F, Martin ME, Fernandez N, Brodsky A, Baldi A, Davio C.

Biochem Pharmacol. 2000 Jul 15;60(2):159-66.

PMID:
10825460
38.

Forskolin induces U937 cell line differentiation as a result of a sustained cAMP elevation.

Brodsky A, Davio C, Shayo C, Lemos Legnazzi B, Barbosa M, Lardo M, Morelli A, Baldi A, Sanchez Avalos JC, Rivera E.

Eur J Pharmacol. 1998 May 29;350(1):121-7.

PMID:
9683023
39.

Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.

Shayo C, Davio C, Brodsky A, Mladovan AG, Legnazzi BL, Rivera E, Baldi A.

Mol Pharmacol. 1997 Jun;51(6):983-90.

PMID:
9187264
40.

Differentiating agents modulate topoisomerase I activity in U-937 promonocytic cells.

Shayo CC, Mladovan AG, Baldi A.

Eur J Pharmacol. 1997 Apr 11;324(1):129-33.

PMID:
9137923
41.

Histamine receptors in neoplastic transformation: studies in human cell lines.

Davio C, Mladovan A, Shayo C, Lemos B, Baldi A, Rivera E.

Inflamm Res. 1996 Mar;45 Suppl 1:S62-3. No abstract available.

PMID:
8696934
42.

H1 and H2 histamine receptors in histiocytic lymphoma cell line U-937.

Davio C, Baldi A, Shayo C, Brodsky A, Cricco G, Bergoc R, Rivera E.

Inflamm Res. 1995 Apr;44 Suppl 1:S72-3. No abstract available.

PMID:
8521010

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