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Items: 49


Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8.

Kolachala VL, Palle SK, Shen M, Shenoi A, Shayakhmetov DM, Gupta NA.

Hepatol Commun. 2019 Apr 25;3(7):925-942. doi: 10.1002/hep4.1352. eCollection 2019 Jul.


Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.

Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES.

Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011.


Inflammasome components caspase-1 and adaptor protein apoptosis-associated speck-like proteins are important in resistance to Cryptosporidium parvum.

McNair NN, Bedi C, Shayakhmetov DM, Arrowood MJ, Mead JR.

Microbes Infect. 2018 Jun - Jul;20(6):369-375. doi: 10.1016/j.micinf.2018.04.006. Epub 2018 May 26.


Adenovirus sensing by the immune system.

Atasheva S, Shayakhmetov DM.

Curr Opin Virol. 2016 Dec;21:109-113. doi: 10.1016/j.coviro.2016.08.017. Epub 2016 Sep 14. Review.


Interleukin 1α and the inflammatory process.

Di Paolo NC, Shayakhmetov DM.

Nat Immunol. 2016 Jul 19;17(8):906-13. doi: 10.1038/ni.3503. Review.


Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo.

Ciraci C, Janczy JR, Jain N, Haasken S, Pecli E Silva C, Benjamim CF, Sadler JJ, Olivier AK, Iwakura Y, Shayakhmetov DM, Sutterwala FS, Cassel SL.

PLoS One. 2016 Mar 15;11(3):e0151252. doi: 10.1371/journal.pone.0151252. eCollection 2016.


Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis Infection.

Di Paolo NC, Shafiani S, Day T, Papayannopoulou T, Russell DW, Iwakura Y, Sherman D, Urdahl K, Shayakhmetov DM.

Immunity. 2015 Dec 15;43(6):1125-36. doi: 10.1016/j.immuni.2015.11.016. Erratum in: Immunity. 2016 Feb 16;44(2):438. Papayannoupoulou, Thalia [corrected to Papayannopoulou, Thalia].


Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo.

Zaiss AK, Foley EM, Lawrence R, Schneider LS, Hoveida H, Secrest P, Catapang AB, Yamaguchi Y, Alemany R, Shayakhmetov DM, Esko JD, Herschman HR.

J Virol. 2015 Oct 21;90(1):412-20. doi: 10.1128/JVI.01939-15. Print 2016 Jan 1.


Mycobacterium tuberculosis strains lacking surface lipid phthiocerol dimycocerosate are susceptible to killing by an early innate host response.

Day TA, Mittler JE, Nixon MR, Thompson C, Miner MD, Hickey MJ, Liao RP, Pang JM, Shayakhmetov DM, Sherman DR.

Infect Immun. 2014 Dec;82(12):5214-22. doi: 10.1128/IAI.01340-13. Epub 2014 Oct 6.


Retinal transduction profiles by high-capacity viral vectors.

Puppo A, Cesi G, Marrocco E, Piccolo P, Jacca S, Shayakhmetov DM, Parks RJ, Davidson BL, Colloca S, Brunetti-Pierri N, Ng P, Donofrio G, Auricchio A.

Gene Ther. 2014 Oct;21(10):855-65. doi: 10.1038/gt.2014.57. Epub 2014 Jul 3.


Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

Weng D, Marty-Roix R, Ganesan S, Proulx MK, Vladimer GI, Kaiser WJ, Mocarski ES, Pouliot K, Chan FK, Kelliher MA, Harris PA, Bertin J, Gough PJ, Shayakhmetov DM, Goguen JD, Fitzgerald KA, Silverman N, Lien E.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6. doi: 10.1073/pnas.1403477111. Epub 2014 May 5.


IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells.

Di Paolo NC, Baldwin LK, Irons EE, Papayannopoulou T, Tomlinson S, Shayakhmetov DM.

PLoS Pathog. 2014 Mar 20;10(3):e1004035. doi: 10.1371/journal.ppat.1004035. eCollection 2014 Mar.


Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice.

Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1072-7. doi: 10.1073/pnas.1318685111. Epub 2014 Jan 6.


The analysis of innate immune response to adenovirus using antibody arrays.

Di Paolo NC, Shayakhmetov DM.

Methods Mol Biol. 2014;1089:133-41. doi: 10.1007/978-1-62703-679-5_10.


Coagulation factor binding orientation and dimerization may influence infectivity of adenovirus-coagulation factor complexes.

Irons EE, Flatt JW, Doronin K, Fox TL, Acchione M, Stewart PL, Shayakhmetov DM.

J Virol. 2013 Sep;87(17):9610-9. doi: 10.1128/JVI.01070-13. Epub 2013 Jun 26.


The transcription factor IRF3 triggers "defensive suicide" necrosis in response to viral and bacterial pathogens.

Di Paolo NC, Doronin K, Baldwin LK, Papayannopoulou T, Shayakhmetov DM.

Cell Rep. 2013 Jun 27;3(6):1840-6. doi: 10.1016/j.celrep.2013.05.025. Epub 2013 Jun 13.


FX and host defense evasion tactics by adenovirus.

Baker AH, Nicklin SA, Shayakhmetov DM.

Mol Ther. 2013 Jun;21(6):1109-11. doi: 10.1038/mt.2013.100. No abstract available.


Interleukin-1 receptor 2 keeps the lid on interleukin-1α.

Di Paolo NC, Shayakhmetov DM.

Immunity. 2013 Feb 21;38(2):203-5. doi: 10.1016/j.immuni.2013.02.001.


Coagulation factor X activates innate immunity to human species C adenovirus.

Doronin K, Flatt JW, Di Paolo NC, Khare R, Kalyuzhniy O, Acchione M, Sumida JP, Ohto U, Shimizu T, Akashi-Takamura S, Miyake K, MacDonald JW, Bammler TK, Beyer RP, Farin FM, Stewart PL, Shayakhmetov DM.

Science. 2012 Nov 9;338(6108):795-8. doi: 10.1126/science.1226625. Epub 2012 Sep 27.


Construction of targeted and armed oncolytic adenoviruses.

Doronin K, Shayakhmetov DM.

Methods Mol Biol. 2012;797:35-52. doi: 10.1007/978-1-61779-340-0_3.


Recognition of virus infection and innate host responses to viral gene therapy vectors.

Shayakhmetov DM, Di Paolo NC, Mossman KL.

Mol Ther. 2010 Aug;18(8):1422-9. doi: 10.1038/mt.2010.124. Epub 2010 Jun 15. Review.


Virus infection recognition and early innate responses to non-enveloped viral vectors.

Shayakhmetov DM.

Viruses. 2010 Jan;2(1):244-61. doi: 10.3390/v2010244. Epub 2010 Jan 19.


Adenovirus de-targeting from the liver.

Di Paolo NC, Shayakhmetov DM.

Curr Opin Mol Ther. 2009 Oct;11(5):523-31. Review.


Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.

Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM.

Immunity. 2009 Jul 17;31(1):110-21. doi: 10.1016/j.immuni.2009.04.015. Epub 2009 Jul 2.


Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver.

Di Paolo NC, van Rooijen N, Shayakhmetov DM.

Mol Ther. 2009 Apr;17(4):675-84. doi: 10.1038/mt.2008.307. Epub 2009 Feb 17.


Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo.

Kalyuzhniy O, Di Paolo NC, Silvestry M, Hofherr SE, Barry MA, Stewart PL, Shayakhmetov DM.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5483-8. doi: 10.1073/pnas.0711757105. Epub 2008 Apr 7.


Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells.

Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH.

Nature. 2007 Nov 1;450(7166):110-4. Epub 2007 Oct 14.


Fiber shaft-chimeric adenovirus vectors lacking the KKTK motif efficiently infect liver cells in vivo.

Di Paolo NC, Kalyuzhniy O, Shayakhmetov DM.

J Virol. 2007 Nov;81(22):12249-59. Epub 2007 Sep 12.


The influence of blood on in vivo adenovirus bio-distribution and transduction.

Baker AH, Mcvey JH, Waddington SN, Di Paolo NC, Shayakhmetov DM.

Mol Ther. 2007 Aug;15(8):1410-6. Epub 2007 May 15. Review.


Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes.

Parker AL, Waddington SN, Nicol CG, Shayakhmetov DM, Buckley SM, Denby L, Kemball-Cook G, Ni S, Lieber A, McVey JH, Nicklin SA, Baker AH.

Blood. 2006 Oct 15;108(8):2554-61. Epub 2006 Jun 20.


A capsid-modified helper-dependent adenovirus vector containing the beta-globin locus control region displays a nonrandom integration pattern and allows stable, erythroid-specific gene expression.

Wang H, Shayakhmetov DM, Leege T, Harkey M, Li Q, Papayannopoulou T, Stamatoyannopolous G, Lieber A.

J Virol. 2005 Sep;79(17):10999-1013.


Localization of regions in CD46 that interact with adenovirus.

Gaggar A, Shayakhmetov DM, Liszewski MK, Atkinson JP, Lieber A.

J Virol. 2005 Jun;79(12):7503-13.


Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity.

Shayakhmetov DM, Gaggar A, Ni S, Li ZY, Lieber A.

J Virol. 2005 Jun;79(12):7478-91.


The effect of sequestration by nontarget tissues on anti-tumor efficacy of systemically applied, conditionally replicating adenovirus vectors.

Bernt KM, Ni S, Gaggar A, Li ZY, Shayakhmetov DM, Lieber A.

Mol Ther. 2003 Nov;8(5):746-55. Erratum in: Mol Ther. 2004 Jan;9(1):139.


CD46 is a cellular receptor for group B adenoviruses.

Gaggar A, Shayakhmetov DM, Lieber A.

Nat Med. 2003 Nov;9(11):1408-12. Epub 2003 Oct 19.


Generation of adenovirus vectors devoid of all viral genes by recombination between inverted repeats.

Stecher H, Carlson CA, Shayakhmetov DM, Lieber A.

Methods Mol Med. 2003;76:135-52. No abstract available.


An adenoviral expression system for AAV rep78 using homologous recombination.

Carlson CA, Shayakhmetov DM, Lieber A.

Mol Ther. 2002 Jul;6(1):91-8.


Rearrangements in adenoviral genomes mediated by inverted repeats.

Carlson CA, Steinwaerder DS, Stecher H, Shayakhmetov DM, Lieber A.

Methods Enzymol. 2002;346:277-92. No abstract available.


A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells.

Shayakhmetov DM, Carlson CA, Stecher H, Li Q, Stamatoyannopoulos G, Lieber A.

J Virol. 2002 Feb;76(3):1135-43.


Dependence of adenovirus infectivity on length of the fiber shaft domain.

Shayakhmetov DM, Lieber A.

J Virol. 2000 Nov;74(22):10274-86.


Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector.

Shayakhmetov DM, Papayannopoulou T, Stamatoyannopoulos G, Lieber A.

J Virol. 2000 Mar;74(6):2567-83.

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