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NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.

Ludlow AT, Wong MS, Robin JD, Batten K, Yuan L, Lai TP, Dahlson N, Zhang L, Mender I, Tedone E, Sayed ME, Wright WE, Shay JW.

Nat Commun. 2018 Aug 6;9(1):3112. doi: 10.1038/s41467-018-05582-x.


Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.

Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW.

Neoplasia. 2018 Aug;20(8):826-837. doi: 10.1016/j.neo.2018.06.002. Epub 2018 Jul 6.


Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation.

Kim SB, Zhang L, Yoon J, Lee J, Min J, Li W, Grishin NV, Moon YA, Wright WE, Shay JW.

Mol Cell Biol. 2018 Aug 15;38(17). pii: e00135-18. doi: 10.1128/MCB.00135-18. Print 2018 Sep 1.


Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function.

Peters-Hall JR, Coquelin ML, Torres MJ, LaRanger R, Alabi BR, Sho S, Calva-Moreno JF, Thomas PJ, Shay JW.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L313-L327. doi: 10.1152/ajplung.00355.2017. Epub 2018 May 3.


ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity.

Ludlow AT, Shelton D, Wright WE, Shay JW.

Methods Mol Biol. 2018;1768:513-529. doi: 10.1007/978-1-4939-7778-9_29.


Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma.

Reyes-Uribe P, Adrianzen-Ruesta MP, Deng Z, Echevarria-Vargas I, Mender I, Saheb S, Liu Q, Altieri DC, Murphy ME, Shay JW, Lieberman PM, Villanueva J.

Oncogene. 2018 Jul;37(30):4058-4072. doi: 10.1038/s41388-018-0247-7. Epub 2018 Apr 26.


Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors.

Sengupta S, Sobo M, Lee K, Senthil Kumar S, White AR, Mender I, Fuller C, Chow LML, Fouladi M, Shay JW, Drissi R.

Mol Cancer Ther. 2018 Jul;17(7):1504-1514. doi: 10.1158/1535-7163.MCT-17-0792. Epub 2018 Apr 13.


Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.

Zhang G, Wu LW, Mender I, Barzily-Rokni M, Hammond MR, Ope O, Cheng C, Vasilopoulos T, Randell S, Sadek N, Beroard A, Xiao M, Tian T, Tan J, Saeed U, Sugarman E, Krepler C, Brafford P, Sproesser K, Murugan S, Somasundaram R, Garman B, Wubbenhorst B, Woo J, Yin X, Liu Q, Frederick DT, Miao B, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Kwong LN, Amaravadi RK, Lu Y, Boland GM, Wei Z, Nathanson K, Herbig U, Mills GB, Flaherty KT, Herlyn M, Shay JW.

Clin Cancer Res. 2018 Mar 21. doi: 10.1158/1078-0432.CCR-17-2773. [Epub ahead of print]


Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells.

Zhang L, Kim SB, Luitel K, Shay JW.

Mol Cancer Ther. 2018 May;17(5):943-951. doi: 10.1158/1535-7163.MCT-17-0887. Epub 2018 Feb 21.


Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells.

Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM.

Cancer Res. 2018 Apr 15;78(8):1986-1999. doi: 10.1158/0008-5472.CAN-17-0315. Epub 2018 Feb 5.


Comparison of telomere length measurement methods.

Lai TP, Wright WE, Shay JW.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160451. doi: 10.1098/rstb.2016.0451. Review.


Reflections on telomere dynamics and ageing-related diseases in humans.

Aviv A, Shay JW.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160436. doi: 10.1098/rstb.2016.0436. Review.


Telomeres and aging.

Shay JW.

Curr Opin Cell Biol. 2018 Jun;52:1-7. doi: 10.1016/ Epub 2017 Dec 15. Review.


Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD).

Kim W, Shay JW.

Differentiation. 2018 Jan - Feb;99:1-9. doi: 10.1016/j.diff.2017.11.005. Epub 2017 Nov 22.


A method for measuring the distribution of the shortest telomeres in cells and tissues.

Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW.

Nat Commun. 2017 Nov 7;8(1):1356. doi: 10.1038/s41467-017-01291-z.


Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility.

Schäfer C, Mohan A, Burford W, Driscoll MK, Ludlow AT, Wright WE, Shay JW, Danuser G.

Converg Sci Phys Oncol. 2016 Sep;2(3):035004. doi: 10.1088/2057-1739/2/3/035004. Epub 2016 Sep 20.


New insights into melanoma development.

Shay JW.

Science. 2017 Sep 29;357(6358):1358-1359. doi: 10.1126/science.aao6963. Epub 2017 Sep 28. No abstract available.


Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas.

Evenepoel L, van Nederveen FH, Oudijk L, Papathomas TG, Restuccia DF, Belt EJT, de Herder WW, Feelders RA, Franssen GJH, Hamoir M, Maiter D, Ghayee HK, Shay JW, Perren A, Timmers HJLM, van Eeden S, Vroonen L, Aydin S, Robledo M, Vikkula M, de Krijger RR, Dinjens WNM, Persu A, Korpershoek E.

J Clin Endocrinol Metab. 2018 Jan 1;103(1):46-55. doi: 10.1210/jc.2017-01314.


Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells.

Saunier E, Antonio S, Regazzetti A, Auzeil N, Laprévote O, Shay JW, Coumoul X, Barouki R, Benelli C, Huc L, Bortoli S.

Sci Rep. 2017 Jul 31;7(1):6945. doi: 10.1038/s41598-017-07006-0.


Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.

Min J, Wright WE, Shay JW.

Mol Cell Biol. 2017 Sep 26;37(20). pii: e00226-17. doi: 10.1128/MCB.00226-17. Print 2017 Oct 15.


The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation.

Huang EE, Tedone E, O'Hara R, Cornelius C, Lai TP, Ludlow A, Wright WE, Shay JW.

Sci Rep. 2017 Jul 28;7(1):6785. doi: 10.1038/s41598-017-05174-7.


Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells.

LaRanger R, Peters-Hall JR, Coquelin M, Alabi BR, Chen CT, Wright WE, Shay JW.

Tissue Eng Part A. 2018 Apr;24(7-8):559-568. doi: 10.1089/ten.TEA.2017.0114. Epub 2017 Sep 25.


Mutations, Cancer and the Telomere Length Paradox.

Aviv A, Anderson JJ, Shay JW.

Trends Cancer. 2017 Apr;3(4):253-258. doi: 10.1016/j.trecan.2017.02.005. Epub 2017 Mar 27. Review.


Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling.

Yoon J, Kim SB, Ahmed G, Shay JW, Terman JR.

Dev Cell. 2017 Jul 24;42(2):117-129.e8. doi: 10.1016/j.devcel.2017.06.007. Epub 2017 Jul 6.


Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.

Zhang L, Shay JW.

J Natl Cancer Inst. 2017 Aug 1;109(8). doi: 10.1093/jnci/djw332. Review.


Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps.

Druliner BR, Ruan X, Johnson R, Grill D, O'Brien D, Lai TP, Rashtak S, Felmlee-Devine D, Washechek-Aletto J, Malykh A, Smyrk T, Oberg A, Liu H, Shay JW, Ahlquist DA, Boardman LA.

Clin Transl Gastroenterol. 2017 Apr 13;8(4):e88. doi: 10.1038/ctg.2017.16. No abstract available.


Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In.

Zhao Y, Shay JW, Wright WE.

Methods Mol Biol. 2017;1587:71-82. doi: 10.1007/978-1-4939-6892-3_7.


Telomere G-Rich Overhang Length Measurement: DSN Method.

Zhao Y, Shay JW, Wright WE.

Methods Mol Biol. 2017;1587:55-62. doi: 10.1007/978-1-4939-6892-3_5.


Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention.

Jafri MA, Al-Qahtani MH, Shay JW.

Semin Cancer Biol. 2017 Jun;44:117-131. doi: 10.1016/j.semcancer.2017.02.004. Epub 2017 Feb 8. Review.


c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA.

Liu J, Hu J, Ludlow AT, Pham JT, Shay JW, Rothstein JD, Corey DR.

Cell Chem Biol. 2017 Feb 16;24(2):141-148. doi: 10.1016/j.chembiol.2016.12.018. Epub 2017 Jan 26.


Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.

Min J, Wright WE, Shay JW.

Nucleic Acids Res. 2017 Mar 17;45(5):2615-2628. doi: 10.1093/nar/gkw1295.


Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions.

Gao B, Huang C, Kernstine K, Pelekanou V, Kluger Y, Jiang T, Peters-Hall JR, Coquelin M, Girard L, Zhang W, Huffman K, Oliver D, Kinose F, Haura E, Teer JK, Rix U, Le AT, Aisner DL, Varella-Garcia M, Doebele RC, Covington KR, Hampton OA, Doddapaneni HV, Jayaseelan JC, Hu J, Wheeler DA, Shay JW, Rimm DL, Gazdar A, Minna JD.

Oncotarget. 2017 Feb 14;8(7):11114-11126. doi: 10.18632/oncotarget.14366.


Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer.

Kim W, Ludlow AT, Min J, Robin JD, Stadler G, Mender I, Lai TP, Zhang N, Wright WE, Shay JW.

PLoS Biol. 2016 Dec 15;14(12):e2000016. doi: 10.1371/journal.pbio.2000016. eCollection 2016 Dec.


Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.

Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW.

Sci Transl Med. 2016 Oct 19;8(361):361ra140.


Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency.

Holohan B, Kim W, Lai TP, Hoshiyama H, Zhang N, Alazami AM, Wright WE, Meyn MS, Alkuraya FS, Shay JW.

BMC Genomics. 2016 Oct 17;17(Suppl 9):749.


The Third International Genomic Medicine Conference (3rd IGMC, 2015): overall activities and outcome highlights.

Abu-Elmagd M, Assidi M, Dallol A, Buhmeida A, Pushparaj PN, Kalamegam G, Al-Hamzi E, Shay JW, Scherer SW, Agarwal A, Budowle B, Gari M, Chaudhary A, Abuzenadah A, Al-Qahtani M.

BMC Genomics. 2016 Oct 17;17(Suppl 9):747.


DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP.

Mimmler M, Peter S, Kraus A, Stroh S, Nikolova T, Seiwert N, Hasselwander S, Neitzel C, Haub J, Monien BH, Nicken P, Steinberg P, Shay JW, Kaina B, Fahrer J.

Nucleic Acids Res. 2016 Dec 1;44(21):10259-10276. Epub 2016 Sep 5.


Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps.

Druliner BR, Ruan X, Johnson R, Grill D, O'Brien D, Lai TP, Rashtak S, Felmlee-Devine D, Washechek-Aletto J, Malykh A, Smyrk T, Oberg A, Liu H, Shay JW, Ahlquist DA, Boardman LA.

Clin Transl Gastroenterol. 2016 Sep 1;7(9):e188. doi: 10.1038/ctg.2016.48.


Organotypic culture in three dimensions prevents radiation-induced transformation in human lung epithelial cells.

El-Ashmawy M, Coquelin M, Luitel K, Batten K, Shay JW.

Sci Rep. 2016 Aug 19;6:31669. doi: 10.1038/srep31669.


Telomere Restriction Fragment (TRF) Analysis.

Mender I, Shay JW.

Bio Protoc. 2015 Nov 20;5(22). pii: e1658.


Telomere Dysfunction Induced Foci (TIF) Analysis.

Mender I, Shay JW.

Bio Protoc. 2015 Nov 20;5(22). pii: e1656.


Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, McDonald J, Wistuba II, DeBerardinis RJ, Scaglioni PP.

Cell Rep. 2016 Aug 9;16(6):1614-1628. doi: 10.1016/j.celrep.2016.07.009. Epub 2016 Jul 28.


hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor.

Liu N, Ding D, Hao W, Yang F, Wu X, Wang M, Xu X, Ju Z, Liu JP, Song Z, Shay JW, Guo Y, Cong YS.

Nucleic Acids Res. 2016 Oct 14;44(18):8693-8703. Epub 2016 Jun 20.


Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.

Jafri MA, Ansari SA, Alqahtani MH, Shay JW.

Genome Med. 2016 Jun 20;8(1):69. doi: 10.1186/s13073-016-0324-x. Review.


Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity.

Lai TP, Wright WE, Shay JW.

Biotechniques. 2016 Jun 1;60(6):306-9. doi: 10.2144/000114427. eCollection 2016.


Telomere-associated aging disorders.

Opresko PL, Shay JW.

Ageing Res Rev. 2017 Jan;33:52-66. doi: 10.1016/j.arr.2016.05.009. Epub 2016 May 20. Review.


Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner.

Frink RE, Peyton M, Schiller JH, Gazdar AF, Shay JW, Minna JD.

Oncotarget. 2016 May 31;7(22):31639-51. doi: 10.18632/oncotarget.9335.


Telomerase Repeated Amplification Protocol (TRAP).

Mender I, Shay JW.

Bio Protoc. 2015 Nov 20;5(22). pii: e1657.


Comparison of DNA Quantification Methods for Next Generation Sequencing.

Robin JD, Ludlow AT, LaRanger R, Wright WE, Shay JW.

Sci Rep. 2016 Apr 6;6:24067. doi: 10.1038/srep24067.

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