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SLC43A3 is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2'-Deoxyguanosine.

Mender I, Batten K, Peyton M, Vemula A, Cornelius C, Girard L, Gao B, Minna JD, Shay JW.

Cancer Res. 2020 Jan 16. pii: canres.2257.2019. doi: 10.1158/0008-5472.CAN-19-2257. [Epub ahead of print]


Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings.

Peters-Hall JR, Min J, Tedone E, Sho S, Siteni S, Mender I, Shay JW.

FASEB J. 2020 Jan;34(1):386-398. doi: 10.1096/fj.201902376R. Epub 2019 Nov 22.


Sterile cerebrospinal fluid ascites presenting as high SAAG ascites: a case report.

Li DK, Platt JM, Shay JES, Yarze JC.

BMC Gastroenterol. 2019 Nov 27;19(1):200. doi: 10.1186/s12876-019-1116-8.


MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.

Wang S, Huang J, Li C, Zhao L, Wong CC, Zhai J, Zhou Y, Deng W, Zeng Y, Gao S, Zhang Y, Wang G, Guan XY, Wei H, Wong SH, He HH, Shay JW, Yu J.

Clin Cancer Res. 2019 Oct 29. doi: 10.1158/1078-0432.CCR-19-1611. [Epub ahead of print]


Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation.

Hao YH, Lafita-Navarro MC, Zacharias L, Borenstein-Auerbach N, Kim M, Barnes S, Kim J, Shay J, DeBerardinis RJ, Conacci-Sorrell M.

Cell Commun Signal. 2019 Oct 17;17(1):129. doi: 10.1186/s12964-019-0444-1.


Telomere clustering drives ALT.

Min J, Shay JW.

Aging (Albany NY). 2019 Oct 13;11(19):8046-8047. doi: 10.18632/aging.102369. Epub 2019 Oct 13. No abstract available.


Education News.

Scott-Herring M, Mendez A, Shay J, McCloskey J, Koka R.

AANA J. 2019 Apr;87(2):7-14.


Decellularized mice colons as models to study the contribution of the extracellular matrix to cell behavior and colon cancer progression.

Alabi BR, LaRanger R, Shay JW.

Acta Biomater. 2019 Dec;100:213-222. doi: 10.1016/j.actbio.2019.09.033. Epub 2019 Sep 25.


Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single-cell resolution.

O'Hara R, Tedone E, Ludlow A, Huang E, Arosio B, Mari D, Shay JW.

Genome Res. 2019 Nov;29(11):1878-1888. doi: 10.1101/gr.250480.119. Epub 2019 Sep 23.


MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.

Venkateswaran N, Lafita-Navarro MC, Hao YH, Kilgore JA, Perez-Castro L, Braverman J, Borenstein-Auerbach N, Kim M, Lesner NP, Mishra P, Brabletz T, Shay JW, DeBerardinis RJ, Williams NS, Yilmaz OH, Conacci-Sorrell M.

Genes Dev. 2019 Sep 1;33(17-18):1236-1251. doi: 10.1101/gad.327056.119. Epub 2019 Aug 15.


Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells.

Martin OCB, Bergonzini A, D'Amico F, Chen P, Shay JW, Dupuy J, Svensson M, Masucci MG, Frisan T.

Cell Microbiol. 2019 Dec;21(12):e13099. doi: 10.1111/cmi.13099. Epub 2019 Aug 26.


Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs).

Sayed ME, Cheng A, Yadav GP, Ludlow AT, Shay JW, Wright WE, Jiang QX.

J Biol Chem. 2019 Jul 26;294(30):11579-11596. doi: 10.1074/jbc.RA118.007234. Epub 2019 Jun 11.


Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52.

Min J, Wright WE, Shay JW.

Genes Dev. 2019 Jul 1;33(13-14):814-827. doi: 10.1101/gad.324905.119. Epub 2019 Jun 6.


Transient introduction of human telomerase mRNA improves hallmarks of progeria cells.

Li Y, Zhou G, Bruno IG, Zhang N, Sho S, Tedone E, Lai TP, Cooke JP, Shay JW.

Aging Cell. 2019 Aug;18(4):e12979. doi: 10.1111/acel.12979. Epub 2019 May 31.


Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC).

Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK.

J Med Chem. 2019 May 23;62(10):5217-5241. doi: 10.1021/acs.jmedchem.9b00532. Epub 2019 May 9.


In perspective: An update on telomere targeting in cancer.

Sugarman ET, Zhang G, Shay JW.

Mol Carcinog. 2019 Sep;58(9):1581-1588. doi: 10.1002/mc.23035. Epub 2019 May 6. Review.


Hepatic fibrosis: Avenues of investigation and clinical implications.

Shay JES, Hamilton JP.

Clin Liver Dis (Hoboken). 2018 Jun 5;11(5):111-114. doi: 10.1002/cld.702. eCollection 2018 May. Review. No abstract available.


2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state.

Zhang Z, Zhang T, Ge Y, Tang M, Ma W, Zhang Q, Gong S, Wright WE, Shay J, Liu H, Zhao Y.

J Biol Chem. 2019 Apr 19;294(16):6645-6656. doi: 10.1074/jbc.RA119.007677. Epub 2019 Feb 28.


Telomeres and telomerase: three decades of progress.

Shay JW, Wright WE.

Nat Rev Genet. 2019 May;20(5):299-309. doi: 10.1038/s41576-019-0099-1. Review.


NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells.

Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT.

Oncogene. 2019 Apr;38(16):2937-2952. doi: 10.1038/s41388-018-0639-8. Epub 2018 Dec 19.


Inducing rapid telomere irreparable damage in telomerase-expressing cancers.

Zhang G, Shay JW.

Oncotarget. 2018 Nov 9;9(88):35803-35804. doi: 10.18632/oncotarget.26317. eCollection 2018 Nov 9. No abstract available.


Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians.

Tedone E, Huang E, O'Hara R, Batten K, Ludlow AT, Lai TP, Arosio B, Mari D, Wright WE, Shay JW.

Aging Cell. 2019 Feb;18(1):e12859. doi: 10.1111/acel.12859. Epub 2018 Nov 28.


Proton radiation-induced cancer progression.

Luitel K, Bozeman R, Kaisani A, Kim SB, Barron S, Richardson JA, Shay JW.

Life Sci Space Res (Amst). 2018 Nov;19:31-42. doi: 10.1016/j.lssr.2018.08.002. Epub 2018 Aug 18.


Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.

Lin N, Shay JES, Xie H, Lee DSM, Skuli N, Tang Q, Zhou Z, Azzam A, Meng H, Wang H, FitzGerald GA, Simon MC.

Front Immunol. 2018 Nov 5;9:2565. doi: 10.3389/fimmu.2018.02565. eCollection 2018.


Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends.

Mukherjee AK, Sharma S, Sengupta S, Saha D, Kumar P, Hussain T, Srivastava V, Roy SD, Shay JW, Chowdhury S.

PLoS Genet. 2018 Nov 15;14(11):e1007782. doi: 10.1371/journal.pgen.1007782. eCollection 2018 Nov.


The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells.

Lafita-Navarro MC, Kim M, Borenstein-Auerbach N, Venkateswaran N, Hao YH, Ray R, Brabletz T, Scaglioni PP, Shay JW, Conacci-Sorrell M.

Genes Dev. 2018 Oct 1;32(19-20):1303-1308. doi: 10.1101/gad.313007.118. Epub 2018 Sep 25.


Cardiac Events Within the 30-Day Postoperative Period Is Associated With Increased 1-Year Mortality Among Deceased-Donor Liver Transplant Recipients.

James TW, Shay JES, Furfaro D, Ozseker B, Russell SD, Pustavoitau A, Rizkalla N, Saberi B, Philosophe B, Cameron AM, Gurakar A.

Exp Clin Transplant. 2019 Jun;17(3):370-374. doi: 10.6002/ect.2017.0276. Epub 2018 Aug 6.


NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.

Ludlow AT, Wong MS, Robin JD, Batten K, Yuan L, Lai TP, Dahlson N, Zhang L, Mender I, Tedone E, Sayed ME, Wright WE, Shay JW.

Nat Commun. 2018 Aug 6;9(1):3112. doi: 10.1038/s41467-018-05582-x.


Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance.

Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, Minna JD, Wright WE, Shay JW.

Neoplasia. 2018 Aug;20(8):826-837. doi: 10.1016/j.neo.2018.06.002. Epub 2018 Jul 6.


Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation.

Kim SB, Zhang L, Yoon J, Lee J, Min J, Li W, Grishin NV, Moon YA, Wright WE, Shay JW.

Mol Cell Biol. 2018 Aug 15;38(17). pii: e00135-18. doi: 10.1128/MCB.00135-18. Print 2018 Sep 1.


Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function.

Peters-Hall JR, Coquelin ML, Torres MJ, LaRanger R, Alabi BR, Sho S, Calva-Moreno JF, Thomas PJ, Shay JW.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L313-L327. doi: 10.1152/ajplung.00355.2017. Epub 2018 May 3.


ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity.

Ludlow AT, Shelton D, Wright WE, Shay JW.

Methods Mol Biol. 2018;1768:513-529. doi: 10.1007/978-1-4939-7778-9_29.


Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma.

Reyes-Uribe P, Adrianzen-Ruesta MP, Deng Z, Echevarria-Vargas I, Mender I, Saheb S, Liu Q, Altieri DC, Murphy ME, Shay JW, Lieberman PM, Villanueva J.

Oncogene. 2018 Jul;37(30):4058-4072. doi: 10.1038/s41388-018-0247-7. Epub 2018 Apr 26.


Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors.

Sengupta S, Sobo M, Lee K, Senthil Kumar S, White AR, Mender I, Fuller C, Chow LML, Fouladi M, Shay JW, Drissi R.

Mol Cancer Ther. 2018 Jul;17(7):1504-1514. doi: 10.1158/1535-7163.MCT-17-0792. Epub 2018 Apr 13.


Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.

Zhang G, Wu LW, Mender I, Barzily-Rokni M, Hammond MR, Ope O, Cheng C, Vasilopoulos T, Randell S, Sadek N, Beroard A, Xiao M, Tian T, Tan J, Saeed U, Sugarman E, Krepler C, Brafford P, Sproesser K, Murugan S, Somasundaram R, Garman B, Wubbenhorst B, Woo J, Yin X, Liu Q, Frederick DT, Miao B, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Kwong LN, Amaravadi RK, Lu Y, Boland GM, Wei Z, Nathanson K, Herbig U, Mills GB, Flaherty KT, Herlyn M, Shay JW.

Clin Cancer Res. 2018 Oct 1;24(19):4771-4784. doi: 10.1158/1078-0432.CCR-17-2773. Epub 2018 Mar 21.


Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells.

Zhang L, Kim SB, Luitel K, Shay JW.

Mol Cancer Ther. 2018 May;17(5):943-951. doi: 10.1158/1535-7163.MCT-17-0887. Epub 2018 Feb 21.


Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells.

Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, Minna JD, Hong LS, Fishbein MC, Dubinett SM.

Cancer Res. 2018 Apr 15;78(8):1986-1999. doi: 10.1158/0008-5472.CAN-17-0315. Epub 2018 Feb 5.


Comparison of telomere length measurement methods.

Lai TP, Wright WE, Shay JW.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160451. doi: 10.1098/rstb.2016.0451. Review.


Reflections on telomere dynamics and ageing-related diseases in humans.

Aviv A, Shay JW.

Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741). pii: 20160436. doi: 10.1098/rstb.2016.0436.


Telomeres and aging.

Shay JW.

Curr Opin Cell Biol. 2018 Jun;52:1-7. doi: 10.1016/ Epub 2017 Dec 15. Review.


Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD).

Kim W, Shay JW.

Differentiation. 2018 Jan - Feb;99:1-9. doi: 10.1016/j.diff.2017.11.005. Epub 2017 Nov 22.


Opioid Prescribing for the Treatment of Acute Pain in Children on Hospital Discharge.

Monitto CL, Hsu A, Gao S, Vozzo PT, Park PS, Roter D, Yenokyan G, White ED, Kattail D, Edgeworth AE, Vasquenza KJ, Atwater SE, Shay JE, George JA, Vickers BA, Kost-Byerly S, Lee BH, Yaster M.

Anesth Analg. 2017 Dec;125(6):2113-2122. doi: 10.1213/ANE.0000000000002586.


Transmission of Bacterial Endophytes.

Frank AC, Saldierna Guzmán JP, Shay JE.

Microorganisms. 2017 Nov 10;5(4). pii: E70. doi: 10.3390/microorganisms5040070. Review.


A method for measuring the distribution of the shortest telomeres in cells and tissues.

Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW.

Nat Commun. 2017 Nov 7;8(1):1356. doi: 10.1038/s41467-017-01291-z.


Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility.

Schäfer C, Mohan A, Burford W, Driscoll MK, Ludlow AT, Wright WE, Shay JW, Danuser G.

Converg Sci Phys Oncol. 2016 Sep;2(3):035004. doi: 10.1088/2057-1739/2/3/035004. Epub 2016 Sep 20.


New insights into melanoma development.

Shay JW.

Science. 2017 Sep 29;357(6358):1358-1359. doi: 10.1126/science.aao6963. Epub 2017 Sep 28. No abstract available.


Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas.

Evenepoel L, van Nederveen FH, Oudijk L, Papathomas TG, Restuccia DF, Belt EJT, de Herder WW, Feelders RA, Franssen GJH, Hamoir M, Maiter D, Ghayee HK, Shay JW, Perren A, Timmers HJLM, van Eeden S, Vroonen L, Aydin S, Robledo M, Vikkula M, de Krijger RR, Dinjens WNM, Persu A, Korpershoek E.

J Clin Endocrinol Metab. 2018 Jan 1;103(1):46-55. doi: 10.1210/jc.2017-01314.


Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells.

Saunier E, Antonio S, Regazzetti A, Auzeil N, Laprévote O, Shay JW, Coumoul X, Barouki R, Benelli C, Huc L, Bortoli S.

Sci Rep. 2017 Jul 31;7(1):6945. doi: 10.1038/s41598-017-07006-0.


Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.

Min J, Wright WE, Shay JW.

Mol Cell Biol. 2017 Sep 26;37(20). pii: e00226-17. doi: 10.1128/MCB.00226-17. Print 2017 Oct 15.


The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation.

Huang EE, Tedone E, O'Hara R, Cornelius C, Lai TP, Ludlow A, Wright WE, Shay JW.

Sci Rep. 2017 Jul 28;7(1):6785. doi: 10.1038/s41598-017-05174-7.

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