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Dominant-negative inhibition of canonical Notch signaling in trophoblast cells does not disrupt placenta formation.

Shawber CJ, Brown-Grant DA, Wu T, Kitajewski JK, Douglas NC.

Biol Open. 2019 Apr 16;8(4). pii: bio037721. doi: 10.1242/bio.037721.


Lens differentiation is controlled by the balance between PDGF and FGF signaling.

Li H, Mao Y, Bouaziz M, Yu H, Qu X, Wang F, Feng GS, Shawber C, Zhang X.

PLoS Biol. 2019 Feb 4;17(2):e3000133. doi: 10.1371/journal.pbio.3000133. eCollection 2019 Feb.


Notch signaling pathway is a potential therapeutic target for extracranial vascular malformations.

Davis RB, Pahl K, Datto NC, Smith SV, Shawber C, Caron KM, Blatt J.

Sci Rep. 2018 Dec 20;8(1):17987. doi: 10.1038/s41598-018-36628-1.


Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia.

Sones JL, Merriam AA, Seffens A, Brown-Grant DA, Butler SD, Zhao AM, Xu X, Shawber CJ, Grenier JK, Douglas NC.

FASEB J. 2018 May;32(5):2574-2586. doi: 10.1096/fj.201701008R. Epub 2018 Jan 8.


NOTCH3 regulates stem-to-mural cell differentiation in infantile hemangioma.

Edwards AK, Glithero K, Grzesik P, Kitajewski AA, Munabi NC, Hardy K, Tan QK, Schonning M, Kangsamaksin T, Kitajewski JK, Shawber CJ, Wu JK.

JCI Insight. 2017 Nov 2;2(21). pii: 93764. doi: 10.1172/jci.insight.93764.


Fibrocartilage Stem Cells Engraft and Self-Organize into Vascularized Bone.

Nathan J, Ruscitto A, Pylawka S, Sohraby A, Shawber CJ, Embree MC.

J Dent Res. 2018 Mar;97(3):329-337. doi: 10.1177/0022034517735094. Epub 2017 Oct 11.


Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature.

Muley A, Odaka Y, Lewkowich IP, Vemaraju S, Yamaguchi TP, Shawber C, Dickie BH, Lang RA.

PLoS One. 2017 Aug 28;12(8):e0181549. doi: 10.1371/journal.pone.0181549. eCollection 2017.


Dynamic maternal and fetal Notch activity and expression in placentation.

Levin HI, Sullivan-Pyke CS, Papaioannou VE, Wapner RJ, Kitajewski JK, Shawber CJ, Douglas NC.

Placenta. 2017 Jul;55:5-12. doi: 10.1016/j.placenta.2017.04.014. Epub 2017 Apr 21.


Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts.

Werth M, Schmidt-Ott KM, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J.

Elife. 2017 Jun 3;6. pii: e24265. doi: 10.7554/eLife.24265.


History of the infantile hepatic hemangioma: From imaging to generating a differential diagnosis.

Gnarra M, Behr G, Kitajewski A, Wu JK, Anupindi SA, Shawber CJ, Zavras N, Schizas D, Salakos C, Economopoulos KP.

World J Clin Pediatr. 2016 Aug 8;5(3):273-80. doi: 10.5409/wjcp.v5.i3.273. eCollection 2016 Aug 8. Review.


Initial Experience With Propranolol Treatment of Lymphatic Anomalies: A Case Series.

Wu JK, Hooper ED, Laifer-Narin SL, Simpson LL, Kandel J, Shawber CJ; Lymphatics Work Group at CUMC.

Pediatrics. 2016 Sep;138(3). pii: e20154545. doi: 10.1542/peds.2015-4545. Epub 2016 Aug 25.


A new paradigm for the role of smooth muscle cells in the human cervix.

Vink JY, Qin S, Brock CO, Zork NM, Feltovich HM, Chen X, Urie P, Myers KM, Hall TJ, Wapner R, Kitajewski JK, Shawber CJ, Gallos G.

Am J Obstet Gynecol. 2016 Oct;215(4):478.e1-478.e11. doi: 10.1016/j.ajog.2016.04.053. Epub 2016 May 7.


Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus.

Shawber CJ, Lin L, Gnarra M, Sauer MV, Papaioannou VE, Kitajewski JK, Douglas NC.

Vasc Cell. 2015 Dec 1;7:9. doi: 10.1186/s13221-015-0034-y. eCollection 2015.


Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation.

Munabi NC, England RW, Edwards AK, Kitajewski AA, Tan QK, Weinstein A, Kung JE, Wilcox M, Kitajewski JK, Shawber CJ, Wu JK.

Stem Cells Transl Med. 2016 Jan;5(1):45-55. doi: 10.5966/sctm.2015-0076. Epub 2015 Nov 16.


Notch suppresses angiogenesis and progression of hepatic metastases.

Banerjee D, Hernandez SL, Garcia A, Kangsamaksin T, Sbiroli E, Andrews J, Forrester LA, Wei N, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ.

Cancer Res. 2015 Apr 15;75(8):1592-602. doi: 10.1158/0008-5472.CAN-14-1493. Epub 2015 Mar 5.


Aberrant lymphatic endothelial progenitors in lymphatic malformation development.

Wu JK, Kitajewski C, Reiley M, Keung CH, Monteagudo J, Andrews JP, Liou P, Thirumoorthi A, Wong A, Kandel JJ, Shawber CJ.

PLoS One. 2015 Feb 26;10(2):e0117352. doi: 10.1371/journal.pone.0117352. eCollection 2015.


Growth Hormone Induces Recurrence of Infantile Hemangiomas After Apparent Involution: Evidence of Growth Hormone Receptors in Infantile Hemangioma.

Munabi NC, Tan QK, Garzon MC, Behr GG, Shawber CJ, Wu JK.

Pediatr Dermatol. 2015 Jul-Aug;32(4):539-43. doi: 10.1111/pde.12530. Epub 2015 Feb 18.


NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth.

Kangsamaksin T, Murtomaki A, Kofler NM, Cuervo H, Chaudhri RA, Tattersall IW, Rosenstiel PE, Shawber CJ, Kitajewski J.

Cancer Discov. 2015 Feb;5(2):182-97. doi: 10.1158/2159-8290.CD-14-0650. Epub 2014 Nov 11.


Propranolol promotes accelerated and dysregulated adipogenesis in hemangioma stem cells.

England RW, Hardy KL, Kitajewski AM, Wong A, Kitajewski JK, Shawber CJ, Wu JK.

Ann Plast Surg. 2014 Sep;73 Suppl 1:S119-24. doi: 10.1097/SAP.0000000000000272.


VEGFR-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recruitment.

Douglas NC, Zimmermann RC, Tan QK, Sullivan-Pyke CS, Sauer MV, Kitajewski JK, Shawber CJ.

Vasc Cell. 2014 Aug 1;6:16. doi: 10.1186/2045-824X-6-16. eCollection 2014.


Notch signaling functions in lymphatic valve formation.

Murtomaki A, Uh MK, Kitajewski C, Zhao J, Nagasaki T, Shawber CJ, Kitajewski J.

Development. 2014 Jun;141(12):2446-51. doi: 10.1242/dev.101188.


NOTCH2 expression is decreased in epithelial ovarian cancer and is related to the tumor histological subtype.

Galic V, Shawber CJ, Reeves C, Shah M, Murtomaki A, Wright J, Herzog T, Tong GX, Kitajewski J.

Pathol Discov. 2013 Aug 16;1:4.


Abstract 70: Propranolol Effects on Hemangiomas are Mediated via Distinct Pathways.

England RW, Munabi NC, Glithero KJ, Kitajewski A, Kitajewski J, Shawber CJ, Wu JK.

Plast Reconstr Surg. 2014 Mar;133(3 Suppl):81-2. doi: 10.1097/01.prs.0000445103.16503.19. No abstract available.


Abstract 3: propranolol accelerates involution in a murine model of infantile hemangioma.

Munabi NC, England RW, Glithero KJ, Chang MM, Kitajewski A, Kitajewski JK, Shawber CJ, Wu JK.

Plast Reconstr Surg. 2014 Mar;133(3 Suppl):11. doi: 10.1097/01.prs.0000444916.92464.71. No abstract available.


Abstract 2: NOTCH3 Regulates Mural Cell Differentiation of HemSCs.

Glithero KJ, Munabi NC, England RW, Kitajewski A, Chang M, Kitajewski JK, Shawber CJ, Wu JK.

Plast Reconstr Surg. 2014 Mar;133(3 Suppl):11. doi: 10.1097/01.prs.0000444915.15335.22. No abstract available.


Delta-like ligand 4 regulates vascular endothelial growth factor receptor 2-driven luteal angiogenesis through induction of a tip/stalk phenotype in proliferating endothelial cells.

García-Pascual CM, Zimmermann RC, Ferrero H, Shawber CJ, Kitajewski J, Simón C, Pellicer A, Gómez R.

Fertil Steril. 2013 Dec;100(6):1768-76.e1. doi: 10.1016/j.fertnstert.2013.08.034. Epub 2013 Sep 26.


Notch and VEGF pathways play distinct but complementary roles in tumor angiogenesis.

Hernandez SL, Banerjee D, Garcia A, Kangsamaksin T, Cheng WY, Anastassiou D, Funahashi Y, Kadenhe-Chiweshe A, Shawber CJ, Kitajewski JK, Kandel JJ, Yamashiro DJ.

Vasc Cell. 2013 Sep 25;5(1):17. doi: 10.1186/2045-824X-5-17.


Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.

Valenti L, Mendoza RM, Rametta R, Maggioni M, Kitajewski C, Shawber CJ, Pajvani UB.

Diabetes. 2013 Dec;62(12):4052-62. doi: 10.2337/db13-0769. Epub 2013 Aug 29.


Lymphatics in health and disease: a new thematic series in vascular cell.

Kitajewski J, Shawber CJ, Simons M.

Vasc Cell. 2013 Jul 25;5(1):14. doi: 10.1186/2045-824X-5-14.


Intraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4).

Jovanovic VP, Sauer CM, Shawber CJ, Gomez R, Wang X, Sauer MV, Kitajewski J, Zimmermann RC.

Reprod Biol Endocrinol. 2013 May 15;11:43. doi: 10.1186/1477-7827-11-43.


Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium.

Murtomaki A, Uh MK, Choi YK, Kitajewski C, Borisenko V, Kitajewski J, Shawber CJ.

Development. 2013 Jun;140(11):2365-76. doi: 10.1242/dev.083865. Epub 2013 Apr 24.


Propranolol accelerates adipogenesis in hemangioma stem cells and causes apoptosis of hemangioma endothelial cells.

Wong A, Hardy KL, Kitajewski AM, Shawber CJ, Kitajewski JK, Wu JK.

Plast Reconstr Surg. 2012 Nov;130(5):1012-21. doi: 10.1097/PRS.0b013e318267d3db.


Notch signaling in developmental and tumor angiogenesis.

Kofler NM, Shawber CJ, Kangsamaksin T, Reed HO, Galatioto J, Kitajewski J.

Genes Cancer. 2011 Dec;2(12):1106-16. doi: 10.1177/1947601911423030.


Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.

Quante M, Bhagat G, Abrams JA, Marache F, Good P, Lee MD, Lee Y, Friedman R, Asfaha S, Dubeykovskaya Z, Mahmood U, Figueiredo JL, Kitajewski J, Shawber C, Lightdale CJ, Rustgi AK, Wang TC.

Cancer Cell. 2012 Jan 17;21(1):36-51. doi: 10.1016/j.ccr.2011.12.004.


Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.

Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D.

Nat Med. 2011 Jul 31;17(8):961-7. doi: 10.1038/nm.2378.


Notch modulates VEGF action in endothelial cells by inducing Matrix Metalloprotease activity.

Funahashi Y, Shawber CJ, Sharma A, Kanamaru E, Choi YK, Kitajewski J.

Vasc Cell. 2011 Jan 18;3(1):2. doi: 10.1186/2045-824X-3-2.


Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7.

Nichol D, Shawber C, Fitch MJ, Bambino K, Sharma A, Kitajewski J, Stuhlmann H.

Blood. 2010 Dec 23;116(26):6133-43. doi: 10.1182/blood-2010-03-274860. Epub 2010 Oct 14. Erratum in: Blood. 2011 Jun 16;117(24):6738-9.


Notch regulates the angiogenic response via induction of VEGFR-1.

Funahashi Y, Shawber CJ, Vorontchikhina M, Sharma A, Outtz HH, Kitajewski J.

J Angiogenes Res. 2010 Jan 26;2(1):3. doi: 10.1186/2040-2384-2-3.


Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.

Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S.

Cell Stem Cell. 2010 Mar 5;6(3):251-64. doi: 10.1016/j.stem.2010.02.001.


Arterial regulators taken up by lymphatics.

Shawber CJ, Kitajewski J.

Lymphat Res Biol. 2008;6(3-4):139-43. doi: 10.1089/lrb.2008.1024. Review.


A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis.

Funahashi Y, Hernandez SL, Das I, Ahn A, Huang J, Vorontchikhina M, Sharma A, Kanamaru E, Borisenko V, Desilva DM, Suzuki A, Wang X, Shawber CJ, Kandel JJ, Yamashiro DJ, Kitajewski J.

Cancer Res. 2008 Jun 15;68(12):4727-35. doi: 10.1158/0008-5472.CAN-07-6499.


Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression.

Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J.

J Clin Invest. 2007 Nov;117(11):3369-82.


A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.

Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D.

J Clin Invest. 2007 Sep;117(9):2477-85.


Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling.

Lee A, Frischer J, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Glade Bender J, Kandel JJ, Yamashiro DJ.

Cancer Res. 2006 Apr 15;66(8):4378-84.


Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay.

Cheng YW, Shawber C, Notterman D, Paty P, Barany F.

Genome Res. 2006 Feb;16(2):282-9. Epub 2005 Dec 20.


Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells.

Masckauchán TN, Shawber CJ, Funahashi Y, Li CM, Kitajewski J.

Angiogenesis. 2005;8(1):43-51.


Unique patterns of Notch1, Notch4 and Jagged1 expression in ovarian vessels during folliculogenesis and corpus luteum formation.

Vorontchikhina MA, Zimmermann RC, Shawber CJ, Tang H, Kitajewski J.

Gene Expr Patterns. 2005 Jun;5(5):701-9. Epub 2005 Apr 13.


Notch function in the vasculature: insights from zebrafish, mouse and man.

Shawber CJ, Kitajewski J.

Bioessays. 2004 Mar;26(3):225-34. Review.


Notch signaling in primary endothelial cells.

Shawber CJ, Das I, Francisco E, Kitajewski J.

Ann N Y Acad Sci. 2003 May;995:162-70.


CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand.

Haritunians T, Boulter J, Hicks C, Buhrman J, DiSibio G, Shawber C, Weinmaster G, Nofziger D, Schanen C.

Circ Res. 2002 Mar 22;90(5):506-8.

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