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Items: 46


HTRA1 synergizes with oxidized phospholipids in promoting inflammation and macrophage infiltration essential for ocular VEGF expression.

Lu Z, Lin V, May A, Che B, Xiao X, Shaw DH, Su F, Wang Z, Du H, Shaw PX.

PLoS One. 2019 May 17;14(5):e0216808. doi: 10.1371/journal.pone.0216808. eCollection 2019.


Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis.

Gong B, Zhang H, Huang L, Chen Y, Shi Y, Tam PO, Zhu X, Huang Y, Lei B, Sundaresan P, Li X, Jiang L, Yang J, Lin Y, Lu F, Chen L, Li Y, Leung CK, Guo X, Zhang S, Huang G, Wu Y, Zhou T, Shuai P, Tham CC, Weisschuh N, Krishnadas SR, Mardin C, Reis A, Yang J, Zhang L, Zhou Y, Wang Z, Qu C, Shaw PX, Pang CP, Sun X, Zhu W, Li DY, Pasutto F, Yang Z.

Genet Med. 2019 Apr 19. doi: 10.1038/s41436-019-0507-0. [Epub ahead of print]


MicroRNA miR-24-3p Reduces Apoptosis and Regulates Keap1-Nrf2 Pathway in Mouse Cardiomyocytes Responding to Ischemia/Reperfusion Injury.

Xiao X, Lu Z, Lin V, May A, Shaw DH, Wang Z, Che B, Tran K, Du H, Shaw PX.

Oxid Med Cell Longev. 2018 Dec 2;2018:7042105. doi: 10.1155/2018/7042105. eCollection 2018.


The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH.

Sci Signal. 2018 Feb 13;11(517). pii: eaan5785. doi: 10.1126/scisignal.aan5785.


Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation.

Xiao X, Hou H, Lin V, Ho D, Tran K, Che B, May A, Zhang J, Lu Z, Lu Z, Shaw PX.

Oxid Med Cell Longev. 2017;2017:1284804. doi: 10.1155/2017/1284804. Epub 2017 Oct 30.


KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS.

Apara A, Galvao J, Wang Y, Blackmore M, Trillo A, Iwao K, Brown DP Jr, Fernandes KA, Huang A, Nguyen T, Ashouri M, Zhang X, Shaw PX, Kunzevitzky NJ, Moore DL, Libby RT, Goldberg JL.

J Neurosci. 2017 Oct 4;37(40):9632-9644. doi: 10.1523/JNEUROSCI.0643-16.2017. Epub 2017 Sep 4.


Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation.

Shaw PX, Fang J, Sang A, Wang Y, Kapiloff MS, Goldberg JL.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):5083-5092. doi: 10.1167/iovs.16-19465.


Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis.

Du H, Xiao X, Stiles T, Douglas C, Ho D, Shaw PX.

Open J Ophthalmol. 2016 Feb;6(1):43-50. Epub 2016 Feb 26.


Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury.

Shaw PX, Sang A, Wang Y, Ho D, Douglas C, Dia L, Goldberg JL.

Exp Eye Res. 2017 May;158:33-42. doi: 10.1016/j.exer.2016.07.006. Epub 2016 Jul 18.


Oxidative stress, innate immunity, and age-related macular degeneration.

Shaw PX, Stiles T, Douglas C, Ho D, Fan W, Du H, Xiao X.

AIMS Mol Sci. 2016;3(2):196-221. Epub 2016 May 11.


Krüppel-Like Factor 4 (KLF4) Is Not Required for Retinal Cell Differentiation.

Fang J, Shaw PX, Wang Y, Goldberg JL.

eNeuro. 2016 Feb 27;3(1). pii: ENEURO.0117-15.2016. doi: 10.1523/ENEURO.0117-15.2016. eCollection 2016 Jan-Feb.


Oxidative stress and aging diseases.

Shaw PX, Werstuck G, Chen Y.

Oxid Med Cell Longev. 2014;2014:569146. doi: 10.1155/2014/569146. Epub 2014 May 12. No abstract available.


TCF7L2 variation and proliferative diabetic retinopathy.

Luo J, Zhao L, Chen AY, Zhang X, Zhu J, Zhao J, Ouyang H, Luo H, Song Y, Lee J, Patel SH, Shaw PX, Sadda S, Zhuo Y, Rosenfeld MG, Zhang K.

Diabetes. 2013 Jul;62(7):2613-7. doi: 10.2337/db12-1093. Epub 2013 Feb 22.


Association of LIPC and advanced age-related macular degeneration.

Lee J, Zeng J, Hughes G, Chen Y, Grob S, Zhao L, Lee C, Krupa M, Quach J, Luo J, Zeng J, Wei X, Zhang X, Zhu J, Duan Y, Ferreyra H, Goldbaum M, Haw W, Shaw PX, Tang L, Zhang K.

Eye (Lond). 2013 Feb;27(2):265-70; quiz 271. doi: 10.1038/eye.2012.276. Epub 2013 Jan 25.


JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.

Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2377-82. doi: 10.1073/pnas.1221729110. Epub 2013 Jan 22.


Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

Shaw PX, Zhang L, Zhang M, Du H, Zhao L, Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell M, Nelson MH, Lu F, Krupa M, Luo J, Ouyang H, Tu Z, Su Z, Zhu J, Wei X, Feng Z, Duan Y, Yang Z, Ferreyra H, Bartsch DU, Kozak I, Zhang L, Lin F, Sun H, Feng H, Zhang K.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13757-62. doi: 10.1073/pnas.1121309109. Epub 2012 Aug 8.


A novel compound heterozygous mutation in the BEST1 gene causes autosomal recessive Best vitelliform macular dystrophy.

Zhao L, Grob S, Corey R, Krupa M, Luo J, Du H, Lee C, Hughes G, Lee J, Quach J, Zhu J, Shaw PX, Kozak I, Zhang K.

Eye (Lond). 2012 Jun;26(6):866-71. doi: 10.1038/eye.2012.27. Epub 2012 Mar 16.


High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.

Zhang L, Lim SL, Du H, Zhang M, Kozak I, Hannum G, Wang X, Ouyang H, Hughes G, Zhao L, Zhu X, Lee C, Su Z, Zhou X, Shaw R, Geum D, Wei X, Zhu J, Ideker T, Oka C, Wang N, Yang Z, Shaw PX, Zhang K.

J Biol Chem. 2012 Jan 6;287(2):1520-6. doi: 10.1074/jbc.M111.275990. Epub 2011 Nov 2.


Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression.

Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL.

J Am Coll Cardiol. 2011 Oct 11;58(16):1715-27. doi: 10.1016/j.jacc.2011.07.017.


Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration.

Sommer JR, Estrada JL, Collins EB, Bedell M, Alexander CA, Yang Z, Hughes G, Mir B, Gilger BC, Grob S, Wei X, Piedrahita JA, Shaw PX, Petters RM, Zhang K.

Br J Ophthalmol. 2011 Dec;95(12):1749-54. doi: 10.1136/bjophthalmol-2011-300417. Epub 2011 Aug 26.


Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity.

Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL.

Circ Res. 2011 Jan 21;108(2):235-48. doi: 10.1161/CIRCRESAHA.110.223875. Review.


An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy.

Zhang K, Harada Y, Wei X, Shukla D, Rajendran A, Tawansy K, Bedell M, Lim S, Shaw PX, He X, Yang Z.

J Biol Chem. 2011 Mar 25;286(12):10210-5. doi: 10.1074/jbc.M110.194399. Epub 2010 Dec 22.


Targeted iron oxide particles for in vivo magnetic resonance detection of atherosclerotic lesions with antibodies directed to oxidation-specific epitopes.

Briley-Saebo KC, Cho YS, Shaw PX, Ryu SK, Mani V, Dickson S, Izadmehr E, Green S, Fayad ZA, Tsimikas S.

J Am Coll Cardiol. 2011 Jan 18;57(3):337-47. doi: 10.1016/j.jacc.2010.09.023. Epub 2010 Nov 23.


4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice.

Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS.

FASEB J. 2011 Jan;25(1):290-300. doi: 10.1096/fj.10-165670. Epub 2010 Sep 27.


Using the Utah Population Database to assess familial risk of primary open angle glaucoma.

Wang X, Harmon J, Zabrieskie N, Chen Y, Grob S, Williams B, Lee C, Kasuga D, Shaw PX, Buehler J, Wang N, Zhang K.

Vision Res. 2010 Nov 23;50(23):2391-5. doi: 10.1016/j.visres.2010.09.018. Epub 2010 Sep 19.


Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans.

Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ.

J Clin Invest. 2009 May;119(5):1335-49. doi: 10.1172/JCI36800. Epub 2009 Apr 13.


The role of innate immunity in atherogenesis.

Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL.

J Lipid Res. 2009 Apr;50 Suppl:S388-93. doi: 10.1194/jlr.R800100-JLR200. Epub 2008 Dec 22. Review.


Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes.

Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA.

Circulation. 2008 Jun 24;117(25):3206-15. doi: 10.1161/CIRCULATIONAHA.107.757120. Epub 2008 Jun 9.


Oxidation-specific epitopes are important targets of innate immunity.

Chou MY, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL.

J Intern Med. 2008 May;263(5):479-88. doi: 10.1111/j.1365-2796.2008.01968.x. Review.


Natural antibodies in murine atherosclerosis.

Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL.

Curr Drug Targets. 2008 Mar;9(3):190-5. Review.


Emerging approaches for imaging vulnerable plaques in patients.

Choi SH, Chae A, Chen CH, Merki E, Shaw PX, Tsimikas S.

Curr Opin Biotechnol. 2007 Feb;18(1):73-82. Epub 2007 Jan 17. Review.


The role of natural antibodies in atherogenesis.

Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL.

J Lipid Res. 2005 Jul;46(7):1353-63. Epub 2005 May 16. Review.


Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus.

Chen Z, Mi L, Xu J, Yu J, Wang X, Jiang J, Xing J, Shang P, Qian A, Li Y, Shaw PX, Wang J, Duan S, Ding J, Fan C, Zhang Y, Yang Y, Yu X, Feng Q, Li B, Yao X, Zhang Z, Li L, Xue X, Zhu P.

J Infect Dis. 2005 Mar 1;191(5):755-60. Epub 2005 Jan 25.


Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization.

Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S.

Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2307-12. Epub 2004 Nov 4.


Rethinking oxidized low-density lipoprotein, its role in atherogenesis and the immune responses associated with it.

Shaw PX.

Arch Immunol Ther Exp (Warsz). 2004 Jul-Aug;52(4):225-39. Review.


Oxidized low density lipoprotein and innate immune receptors.

Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL.

Curr Opin Lipidol. 2003 Oct;14(5):437-45. Review.


The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells.

Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ.

J Immunol. 2003 Jun 15;170(12):6151-7.


Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.

Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ.

Nat Med. 2003 Jun;9(6):736-43. Epub 2003 May 12.


Innate and acquired immunity in atherogenesis.

Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL.

Nat Med. 2002 Nov;8(11):1218-26. Review. No abstract available.


Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo.

Shaw PX, Hörkkö S, Tsimikas S, Chang MK, Palinski W, Silverman GJ, Chen PP, Witztum JL.

Arterioscler Thromb Vasc Biol. 2001 Aug;21(8):1333-9.


Neo-self antigens and the expansion of B-1 cells: lessons from atherosclerosis-prone mice.

Silverman GJ, Shaw PX, Luo L, Dwyer D, Chang M, Horkko S, Palinski W, Stall A, Witztum JL.

Curr Top Microbiol Immunol. 2000;252:189-200. Review.


Immunological responses to oxidized LDL.

Hörkkö S, Binder CJ, Shaw PX, Chang MK, Silverman G, Palinski W, Witztum JL.

Free Radic Biol Med. 2000 Jun 15;28(12):1771-9. Review.


Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity.

Shaw PX, Hörkkö S, Chang MK, Curtiss LK, Palinski W, Silverman GJ, Witztum JL.

J Clin Invest. 2000 Jun;105(12):1731-40.


Evidence of activation of 2 herpesviruses, Epstein-Barr virus and cytomegalovirus, in systemic sclerosis and normal skins.

Vaughan JH, Shaw PX, Nguyen MD, Medsger TA Jr, Wright TM, Metcalf JS, Leroy EC.

J Rheumatol. 2000 Mar;27(3):821-3. No abstract available.


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