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Items: 1 to 50 of 202

1.

A systems mechanism for KRAS mutant allele-specific responses to targeted therapy.

McFall T, Diedrich JK, Mengistu M, Littlechild SL, Paskvan KV, Sisk-Hackworth L, Moresco JJ, Shaw AS, Stites EC.

Sci Signal. 2019 Sep 24;12(600). pii: eaaw8288. doi: 10.1126/scisignal.aaw8288.

PMID:
31551296
2.

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.

Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM.

Nat Immunol. 2019 Sep;20(9):1174-1185. doi: 10.1038/s41590-019-0449-3. Epub 2019 Aug 12.

PMID:
31406377
3.

Kinase domain dimerization drives RIPK3-dependent necroptosis.

Raju S, Whalen DM, Mengistu M, Swanson C, Quinn JG, Taylor SS, Webster JD, Newton K, Shaw AS.

Sci Signal. 2018 Aug 21;11(544). pii: eaar2188. doi: 10.1126/scisignal.aar2188.

4.

The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.

Raju S, Kometani K, Kurosaki T, Shaw AS, Egawa T.

PLoS Pathog. 2018 May 7;14(5):e1007053. doi: 10.1371/journal.ppat.1007053. eCollection 2018 May.

5.

Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer.

Germino EA, Miller JP, Diehl L, Swanson CJ, Durinck S, Modrusan Z, Miner JH, Shaw AS.

PLoS One. 2018 Mar 29;13(3):e0194998. doi: 10.1371/journal.pone.0194998. eCollection 2018.

6.

Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors.

Stites EC, Shaw AS.

CPT Pharmacometrics Syst Pharmacol. 2018 May;7(5):342-351. doi: 10.1002/psp4.12291. Epub 2018 Mar 25.

7.

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.

Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D.

Mol Cell. 2018 Feb 15;69(4):551-565.e7. doi: 10.1016/j.molcel.2018.01.016.

8.

Opposing Roles of Dendritic Cell Subsets in Experimental GN.

Brähler S, Zinselmeyer BH, Raju S, Nitschke M, Suleiman H, Saunders BT, Johnson MW, Böhner AMC, Viehmann SF, Theisen DJ, Kretzer NM, Briseño CG, Zaitsev K, Ornatsky O, Chang Q, Carrero JA, Kopp JB, Artyomov MN, Kurts C, Murphy KM, Miner JH, Shaw AS.

J Am Soc Nephrol. 2018 Jan;29(1):138-154. doi: 10.1681/ASN.2017030270. Epub 2017 Dec 7.

9.

TRP'ing up chronic kidney disease.

Chung JJ, Shaw AS.

Science. 2017 Dec 8;358(6368):1256-1257. doi: 10.1126/science.aar3572. No abstract available.

PMID:
29217557
10.

B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.

Kim AH, Chung JJ, Akilesh S, Koziell A, Jain S, Hodgin JB, Miller MJ, Stappenbeck TS, Miner JH, Shaw AS.

JCI Insight. 2017 Nov 2;2(21). pii: 81836. doi: 10.1172/jci.insight.81836.

11.

Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy.

Suleiman HY, Roth R, Jain S, Heuser JE, Shaw AS, Miner JH.

JCI Insight. 2017 Aug 17;2(16). pii: 94137. doi: 10.1172/jci.insight.94137. eCollection 2017 Aug 17.

12.

The FERM protein EPB41L5 regulates actomyosin contractility and focal adhesion formation to maintain the kidney filtration barrier.

Schell C, Rogg M, Suhm M, Helmstädter M, Sellung D, Yasuda-Yamahara M, Kretz O, Küttner V, Suleiman H, Kollipara L, Zahedi RP, Sickmann A, Eimer S, Shaw AS, Kramer-Zucker A, Hirano-Kobayashi M, Abe T, Aizawa S, Grahammer F, Hartleben B, Dengjel J, Huber TB.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4621-E4630. doi: 10.1073/pnas.1617004114. Epub 2017 May 23.

13.

Intravital and Kidney Slice Imaging of Podocyte Membrane Dynamics.

Brähler S, Yu H, Suleiman H, Krishnan GM, Saunders BT, Kopp JB, Miner JH, Zinselmeyer BH, Shaw AS.

J Am Soc Nephrol. 2016 Nov;27(11):3285-3290. Epub 2016 Apr 1.

14.

NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo.

Raju S, Kretzmer LZ, Koues OI, Payton JE, Oltz EM, Cashen A, Polic B, Schreiber RD, Shaw AS, Markiewicz MA.

J Immunol. 2016 Jun 1;196(11):4805-13. doi: 10.4049/jimmunol.1501982. Epub 2016 May 2.

15.

New approaches in renal microscopy: volumetric imaging and superresolution microscopy.

Kim AH, Suleiman H, Shaw AS.

Curr Opin Nephrol Hypertens. 2016 May;25(3):159-67. doi: 10.1097/MNH.0000000000000220. Review.

16.

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.

Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, Yu C, Shaw AS, Manning G, Skelton NJ, Hymowitz SG, Malek S.

Cancer Cell. 2016 Apr 11;29(4):477-493. doi: 10.1016/j.ccell.2016.02.010. Epub 2016 Mar 17.

17.

A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.

Yu H, Artomov M, Brähler S, Stander MC, Shamsan G, Sampson MG, White JM, Kretzler M, Miner JH, Jain S, Winkler CA, Mitra RD, Kopp JB, Daly MJ, Shaw AS.

J Clin Invest. 2016 Apr 1;126(4):1603. doi: 10.1172/JCI87342. Epub 2016 Mar 1. No abstract available.

18.

A role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.

Yu H, Artomov M, Brähler S, Stander MC, Shamsan G, Sampson MG, White JM, Kretzler M, Miner JH, Jain S, Winkler CA, Mitra RD, Kopp JB, Daly MJ, Shaw AS.

J Clin Invest. 2016 Mar 1;126(3):1067-78. doi: 10.1172/JCI82592. Epub 2016 Feb 22. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1603.

19.

Radiologically Guided Placement of Mushroom-retained Gastrostomy Catheters: "Pull" and "Push" Techniques.

Sidhu PS, Ammar T, Lewis D, Shaw AS, Gregory S.

Radiology. 2016 Feb;278(2):632-3. doi: 10.1148/radiol.2015151736. No abstract available.

PMID:
26789606
20.

Real-Time Analysis of Calcium Signals during the Early Phase of T Cell Activation Using a Genetically Encoded Calcium Biosensor.

Le Borgne M, Raju S, Zinselmeyer BH, Le VT, Li J, Wang Y, Miller MJ, Shaw AS.

J Immunol. 2016 Feb 15;196(4):1471-9. doi: 10.4049/jimmunol.1502414. Epub 2016 Jan 8.

21.

Prospective study evaluating the relative sensitivity of 18F-NaF PET/CT for detecting skeletal metastases from renal cell carcinoma in comparison to multidetector CT and 99mTc-MDP bone scintigraphy, using an adaptive trial design.

Gerety EL, Lawrence EM, Wason J, Yan H, Hilborne S, Buscombe J, Cheow HK, Shaw AS, Bird N, Fife K, Heard S, Lomas DJ, Matakidou A, Soloviev D, Eisen T, Gallagher FA.

Ann Oncol. 2015 Oct;26(10):2113-8. doi: 10.1093/annonc/mdv289. Epub 2015 Jul 22.

22.

New lamp posts allow for new views of the immunological synapse.

Raju S, Shaw AS.

Immunity. 2015 May 19;42(5):781-3. doi: 10.1016/j.immuni.2015.05.008.

23.

What is the point of pseudokinases?

Raju S, Shaw AS.

Elife. 2015 May 6;4:e07771. doi: 10.7554/eLife.07771.

24.

Albumin-associated free fatty acids induce macropinocytosis in podocytes.

Chung JJ, Huber TB, Gödel M, Jarad G, Hartleben B, Kwoh C, Keil A, Karpitskiy A, Hu J, Huh CJ, Cella M, Gross RW, Miner JH, Shaw AS.

J Clin Invest. 2015 Jun;125(6):2307-16. doi: 10.1172/JCI79641. Epub 2015 Apr 27.

25.

Integration of signaling in the kinome: Architecture and regulation of the αC Helix.

Taylor SS, Shaw AS, Kannan N, Kornev AP.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1567-74. doi: 10.1016/j.bbapap.2015.04.007. Epub 2015 Apr 17.

26.

Pillars article: The immunological synapse: a molecular machine controlling T cell activation. Science. 1999. 285: 221-227.

Grakoui A, Bromley SK, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML.

J Immunol. 2015 May 1;194(9):4066-72. No abstract available.

27.

Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.

Liao F, Jiang H, Srivatsan S, Xiao Q, Lefton KB, Yamada K, Mahan TE, Lee JM, Shaw AS, Holtzman DM.

Mol Neurodegener. 2015 Mar 19;10:12. doi: 10.1186/s13024-015-0006-y.

28.

Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease.

Anyaegbu EI, Shaw AS, Hruska KA, Jain S.

Pediatr Nephrol. 2015 Jun;30(6):983-9. doi: 10.1007/s00467-014-3031-0. Epub 2014 Dec 23.

29.

Kinase regulation by hydrophobic spine assembly in cancer.

Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS.

Mol Cell Biol. 2015 Jan;35(1):264-76. doi: 10.1128/MCB.00943-14. Epub 2014 Oct 27.

30.

Role of NKG2D in obesity-induced adipose tissue inflammation and insulin resistance.

Chung JJ, Markiewicz MA, Polić B, Shaw AS.

PLoS One. 2014 Oct 15;9(10):e110108. doi: 10.1371/journal.pone.0110108. eCollection 2014.

31.

Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.

Malone AF, Phelan PJ, Hall G, Cetincelik U, Homstad A, Alonso AS, Jiang R, Lindsey TB, Wu G, Sparks MA, Smith SR, Webb NJ, Kalra PA, Adeyemo AA, Shaw AS, Conlon PJ, Jennette JC, Howell DN, Winn MP, Gbadegesin RA.

Kidney Int. 2014 Dec;86(6):1253-9. doi: 10.1038/ki.2014.305. Epub 2014 Sep 17.

32.

Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.

Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH.

Sci Signal. 2014 Aug 5;7(337):ra74. doi: 10.1126/scisignal.2005147.

33.

Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.

Sandoval GJ, Graham DB, Gmyrek GB, Akilesh HM, Fujikawa K, Sammut B, Bhattacharya D, Srivatsan S, Kim A, Shaw AS, Yang-Iott K, Bassing CH, Duncavage E, Xavier RJ, Swat W.

Cancer Immunol Res. 2013 Dec;1(6):426-37. doi: 10.1158/2326-6066.CIR-13-0065. Epub 2013 Oct 7.

34.

Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.

Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP.

J Am Soc Nephrol. 2014 Sep;25(9):1991-2002. doi: 10.1681/ASN.2013090976. Epub 2014 Mar 27.

35.

Kinases and pseudokinases: lessons from RAF.

Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS.

Mol Cell Biol. 2014 May;34(9):1538-46. doi: 10.1128/MCB.00057-14. Epub 2014 Feb 24. Review.

36.

Neonatal Fc receptor promotes immune complex-mediated glomerular disease.

Olaru F, Luo W, Suleiman H, St John PL, Ge L, Mezo AR, Shaw AS, Abrahamson DR, Miner JH, Borza DB.

J Am Soc Nephrol. 2014 May;25(5):918-25. doi: 10.1681/ASN.2013050498. Epub 2013 Dec 19.

37.

Immunology. Do T cells have a cilium?

Le Borgne M, Shaw AS.

Science. 2013 Dec 6;342(6163):1177-8. doi: 10.1126/science.1248078. No abstract available.

PMID:
24311670
38.

CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production.

Srivatsan S, Swiecki M, Otero K, Cella M, Shaw AS.

J Immunol. 2013 Dec 15;191(12):5933-40. doi: 10.4049/jimmunol.1300454. Epub 2013 Nov 11.

39.

Encapsulating peritoneal sclerosis--correlation of radiological findings at CT with underlying pathogenesis.

Upponi S, Butler AJ, Watson CJ, Shaw AS.

Clin Radiol. 2014 Jan;69(1):103-9. doi: 10.1016/j.crad.2013.09.004. Epub 2013 Oct 24. Review.

PMID:
24209872
40.

Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin.

Russo LM, Srivatsan S, Seaman M, Suleiman H, Shaw AS, Comper WD.

FEBS Lett. 2013 Nov 15;587(22):3738-41. doi: 10.1016/j.febslet.2013.09.045. Epub 2013 Oct 15.

41.

Nanoscale protein architecture of the kidney glomerular basement membrane.

Suleiman H, Zhang L, Roth R, Heuser JE, Miner JH, Shaw AS, Dani A.

Elife. 2013 Oct 8;2:e01149. doi: 10.7554/eLife.01149. Erratum in: Elife. 2013;2:e1663.

42.

Rac1 activation in podocytes induces rapid foot process effacement and proteinuria.

Yu H, Suleiman H, Kim AH, Miner JH, Dani A, Shaw AS, Akilesh S.

Mol Cell Biol. 2013 Dec;33(23):4755-64. doi: 10.1128/MCB.00730-13. Epub 2013 Sep 23.

43.

Allosteric activation of functionally asymmetric RAF kinase dimers.

Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS.

Cell. 2013 Aug 29;154(5):1036-1046. doi: 10.1016/j.cell.2013.07.046.

44.

Heterogeneous distribution of natural zinc isotopes in mice.

Moynier F, Fujii T, Shaw AS, Le Borgne M.

Metallomics. 2013 Jun;5(6):693-9. doi: 10.1039/c3mt00008g.

PMID:
23589059
45.

Kinase suppressor of Ras 1 is not required for the generation of regulatory and memory T cells.

Le Borgne M, Filbert EL, Shaw AS.

PLoS One. 2013;8(2):e57137. doi: 10.1371/journal.pone.0057137. Epub 2013 Feb 19.

46.

Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming.

Banchereau J, Zurawski S, Thompson-Snipes L, Blanck JP, Clayton S, Munk A, Cao Y, Wang Z, Khandelwal S, Hu J, McCoy WH 4th, Palucka KA, Reiter Y, Fremont DH, Zurawski G, Colonna M, Shaw AS, Klechevsky E.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18885-90. doi: 10.1073/pnas.1205785109. Epub 2012 Oct 29.

47.

CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia.

Zhao J, Bruck S, Cemerski S, Zhang L, Butler B, Dani A, Cooper JA, Shaw AS.

Mol Cell Biol. 2013 Jan;33(1):38-47. doi: 10.1128/MCB.00734-12. Epub 2012 Oct 22.

48.

Re: Multicentre survey of radiologically inserted gastrostomy feeding tube (RIG) in the UK.

Sidhu PS, Shaw AS, Lewis D, Ammar T.

Clin Radiol. 2013 Feb;68(2):214-5. doi: 10.1016/j.crad.2012.08.026. Epub 2012 Oct 3. No abstract available.

PMID:
23041119
49.

Expression of the CD2AP adaptor molecule in normal, reactive and neoplastic human tissue.

Rizvi H, Paterson JC, Tedoldi S, Ramsay A, Calaminici M, Natkunam Y, Lonardi S, Tan SY, Campbell L, Hansmann ML, Jones D, Dikic I, Shaw AS, Pileri SA, Stein H, Mason DY, Facchetti F, Marafioti T.

Pathologica. 2012 Apr;104(2):56-64.

PMID:
22953501
50.

Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.

Wasik AA, Polianskyte-Prause Z, Dong MQ, Shaw AS, Yates JR 3rd, Farquhar MG, Lehtonen S.

Mol Biol Cell. 2012 Sep;23(17):3370-9. doi: 10.1091/mbc.E11-12-1010. Epub 2012 Jul 18.

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